Bashkirian State Medical University

Ufa, Russia

Bashkirian State Medical University

Ufa, Russia
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Urakov A.L.,Izhevsk State Medical Academy | Samorodov A.V.,Bashkirian State Medical University | Kamilov F.Kh.,Bashkirian State Medical University | Khaliullin F.A.,Bashkirian State Medical University | Khalimov A.R.,Bashkirian State Medical University
Biomedical and Pharmacology Journal | Year: 2017

This paper presents the results of the assessment of the adequacy of the inferior vena cava thrombosis model in rats with the definition of the main markers that can be used to study the efficacy of antithrombotic agents means at the stage of preclinical studies. The first stage of the study examined the processes of clottage and hemostasis system in rats exposed to total occlusion of inferior vena cava on the 1st and 7th days after the operation. The second phase of the experimental work through the example of pentoxifylline rated adequacy of inferior vena cava thrombosis of rats as a model for preclinical studies. The research work covered the functional activity of platelets, coagulation component of hemostasis, thrombosis markers, thromboelastograms and histological material of rats on the 1st and 7th days of acute thrombosis inferior vena cava. It is established that hemostasis system during modeling of the inferior vena cava thrombosis in rats is characterised by natural changes that are platelets hyperaggregation, the emergence of circulating platelet aggregates and hypercoagulation on coagulative component of hemostasis system. These indicators are recorded quite efficiently by method of classical aggregatometry, thromboelastometry and histological studies. The study of preventive effect of pentoxifylline demonstrates that inferior vena cava thrombosis model can be used in preclinical studies.


Kutlubaev M.A.,Kuvatov Republic Clinical Hospital | Akhmadeeva L.R.,Bashkirian State Medical University
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

Delirium is a serious complication of disorders of nervous system and requires early detection for successful treatment. Confusion assessment method for intensive care unit (CAM-ICU) is a fast and reliable tool for detection of delirium. We performed screening for delirium among patients of neurological ward using CAM-ICU. Our experience showed that CAM-ICU could be used for the identification of delirium in neurological patients excluding those who suffer from severe aphasia.


Kutlubaev M.A.,Bashkirian State Medical University
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2016

Benign paroxysmal positional vertigo (BPPV) is the most common cause of vestibular vertigo. It is caused by dislodged otoconia that enters the semicircular canals. Its main symptom is relapsing positional vertigo. The provocative tests, in particular the Dix— Hallpike maneuver, are used to confirm the diagnosis. In case of positive result of the test, one of the maneuvers is peformed depending on the affected semicircular canal, for instance the Epley maneuver. It is important to differentiate BPPV from the vertigo of central origin. © 2016, Media Sphera. All rights reserved.


Kamilov F.K.,Bashkirian State Medical University | Timirkhanova G.A.,Bashkirian State Medical University | Samorodov A.V.,Bashkirian State Medical University | Khaliullin F.A.,Bashkirian State Medical University
Biology and Medicine | Year: 2013

The authors have studied the influence of dissolution media of potential antiaggregant in order to further carry out preclinical research of their impact on functional activity of platelets. There has been defined different impact of ethanol, dimethylsufoxide (DMSO), dimethylformamide (DMFA), and dioxane on the hemostasis system. It has been verified that dioxane, DMFA, and DMSO exert evident influence on adenosine diphosphate (ADP)- and collagen-induced aggregation of platelets, which is determined by turbidimetric method. The findings enable using ethanol as a solvent in maximum 50% exposure (vol/vol) in order to study the impact on aggregation of platelets of water-insoluble substances by this method.


Meshcheryakova S.A.,Bashkirian State Medical University | Kataev V.A.,Bashkirian State Medical University | Nikolaeva K.V.,Bashkirian State Medical University | Perfilova V.N.,Volgograd State University | And 2 more authors.
Russian Journal of Bioorganic Chemistry | Year: 2014

By the reaction of 2-[6-methyl-1-(thiethane-3-yl)uracil-3-yl]acetic acid hydrazide with aryl aldehydes and acetophenone derivatives, acylhydrazones have been obtained, which exist in DMSO solutions as a mixture of two stereoisomers of an EC=N-isomer, due to the hindered internal rotation around the hydrazide bond. It has been found that the compounds synthesized exhibit a hypotensive activity. © 2014 Pleiades Publishing, Ltd.


Sharafutdinova L.R.,Bashkirian State Medical University | Zaplakhova O.V.,Bashkirian State Medical University | Magzhanov R.V.,Bashkirian State Medical University | Bakhtiyarova K.Z.,Bashkirian State Medical University
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

A database on patients with multiple sclerosis (MS) of the Republican center of multiple sclerosis (Ufa city) is analyzed. The database includes 1436 patients. For the period 2005-2012, 4 female patients with cancer, including 2 patients with thyroid gland cancer, 1 patient with rectum tumor and 1 patient with breast cancer, were identified. Clinical features of MS in these cases were studied. In two patients, cancer developed during the treatment with β-interferon-1b. A possible association of cancer with MS and multiple sclerosis disease modifying drugs is discussed.


Novikova L.B.,Bashkirian State Medical University | Akopyan A.P.,Bashkirian State Medical University
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2015

Objective — to analyze clinical characteristics of pain syndrome in patients with dorsalgia. Material and methods. Authors studied 43 patients (mean age 41.9±1.2 years), 34 women and 9 men, with acute and subacute chronic back pain. The study included neurological examination, MRI and/or CT of the spine, measurement of anxiety and depression with the Hospital Anxiety and Depression Scale (HADS), The Brief Pain Inventory (BPI) and the McGill Pain Inventory. Results and conclusion. Chronic myofascial pain syndrome (MFPS) was frequently associated with anxiety-depressive disorders found in patients with cervical and cervical/pectoral pain, fibromyalgia with minimal neurological symptoms and no signs of neural structure compression according to MRI and CT. The results of the study of chronic MFPS should be taken into account in the choice of tactics of treatment of MFPS patients. The use of amelotex in the combination with compligam B in patients with dorsopathy and MFPS is effective together with correction of emotional disorders and treatment with chondroprotectors. © 2015, Media Sphera. All rights reserved.


PubMed | Bashkirian State Medical University
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2015

To analyze clinical characteristics of pain syndrome in patients with dorsalgia.Authors studied 43 patients (mean age 41.91.2 years), 34 women and 9 men, with acute and subacute chronic back pain. The study included neurological examination, MRI and/or CT of the spine, measurement of anxiety and depression with the Hospital Anxiety and Depression Scale (HADS), The Brief Pain Inventory (BPI) and the McGill Pain Inventory.Chronic myofascial pain syndrome (MFPS) was frequently associated with anxiety-depressive disorders found in patients with cervical and cervical/pectoral pain, fibromyalgia with minimal neurological symptoms and no signs of neural structure compression according to MRI and CT. The results of the study of chronic MFPS should be taken into account in the choice of tactics of treatment of MFPS patients. The use of amelotex in the combination with compligam B in patients with dorsopathy and MFPS is effective together with correction of emotional disorders and treatment with chondroprotectors.


PubMed | Bashkirian State Medical University
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2016

Benign paroxysmal positional vertigo (BPPV) is the most common cause of vestibular vertigo. It is caused by dislodged otoconia that enters the semicircular canals. Its main symptom is relapsing positional vertigo. The provocative tests, in particular the Dix-Hallpike maneuver, are used to confirm the diagnosis. In case of positive result of the test, one of the maneuvers is peformed depending on the affected semicircular canal, for instance the Epley maneuver. It is important to differentiate BPPV from the vertigo of central origin.


PubMed | Kuvatov Republikan Clinical Hospital and Bashkirian State Medical University
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2016

To study the relationship between impairment of attention and development of pathological fatigue and depression after non-disabling stroke.Thirty patients were examined. Attention was assessed by the Attention Network Test (ANT). Pathological fatigue and depression were assessed by the Fatigue assessment scale and depression subscale of the Hospital Anxiety and Depression Scale, respectively.The association between the severity of depression and fatigue after stroke and reduction of mean reaction time in ANT was found. A decrease in the reaction time may be one of the factors reducing working ability in patients with post-stroke fatigue and depression even in the absence of severe neurological deficit. This has to be taken into account when planning rehabilitation.

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