Bashkiria State Medical University

Ufa, Russia

Bashkiria State Medical University

Ufa, Russia
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Kutlubaev M.A.,Bashkiria State Medical University | Zakirova E.N.,Gg Kuvatovs Republican Clinical Hospital | Akhmadeeva L.R.,Bashkiria State Medical University
Kardiologiya | Year: 2016

Cerebral microbleeds (CM) are widely spread among people with different vascular risk factors. They look like small round or ovoid hypotensive foci less than 10 mm in diameter, which can be revealed with T2 and susceptibility-weighted imaging sequences of magnetic resonance imaging (MRI). The development of CM may be associated with hypertensive angiopathy and cerebral amyloid angiopathy. According to some data taking antithrombotic drugs may predispose to the development of CM, however, the main role play to age, presence of arterial hypertension, chronic brain ischemia and other factors. Cerebral microbleeds increases the risk of hemorrhagic stroke in patients taking antithrombotic agents. In patients with high number of CM the risk of hemorrhagic stroke may outweigh the benefit from antithrombotic drugs as agents decreasing the risk of the development of ischemic stroke. Further studies are needed to clarify the place of CM in the process of decision making regarding prescription of antithrombotic drugs.


Zagidullin N.Sh.,Bashkiria State Medical University | Valeeva K.F.,Bashkiria State Medical University | Cassanov N.,Bashkiria State Medical University | Zagidullin Sh.Z.,Bashkiria State Medical University
Kardiologiya | Year: 2010

Vascular endothelium is not simply a barrier between blood and extra vascular bed but is a source of large number of mediators regulating various functions of the body among which nitrous oxide appears to be one of most important. Endothelial dysfunction (ED) develops in a number of processes: diabetes mellitus, smoking, arterial hypertension, hypercholesterolemia. ED promotes increase of rate development of cardiovascular diseases. One of most well known markers of ED is microalbuminuria (MAU). Drug and nondrug means are used for the treatment of ED. Calcium antagonists and angiotensin converting enzyme inhibitors both separately and as components of combination therapy are able to maximally diminish MAU.


Zagidullin N.Sh.,Bashkiria State Medical University | Valeeva K.F.,Bashkiria State Medical University | Gassanov F.,Bashkiria State Medical University | Zagidullin Sh.Z.,Bashkiria State Medical University
Kardiologiya | Year: 2010

Recently the pleiotropic effects of angiotensin-converting enzyme inhibitors which lay beyond their pure antihypertensive effects are widely discussed. Antiproliferative, antiatherosclerotic, antiproliferative and antiarrhythmic properties, as well as positive effects on hemostasis and endothelial function allows angiotensin-converting enzyme inhibitors to occupy very important position among other cardiovascular medications and to have a number of indications: arterial hypertension, congestive heart failure, myocardial infarction, left ventricular hypertrophy and patients with high risk of cardiovascular disease.


Mirsaev T.R.,Bashkiria State Medical University
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2015

Objective — to analyze clinical characteristics of syringomyelia based on the data of the Bashkir Disease Cluster. Material and methods. Authors present the results of examination of 712 patients from the population of Bashkortostan. Disease duration varied in the wide range. In most of the patients, first symptoms usually occurred between 10 and 30 years old. Results and conclusion. Clinical symptoms included sensory and motor disorders, trophic changes of the skin, joint and bone deformations. A mixed form with lesion localization in the cervical-thoracic region of the spine and slowly progressive course was most frequent. © 2015, Media Sphera. All rights reserved.


Sharafutdinova L.R.,Bashkiria State Medical University | Magzhanov R.V.,Bashkiria State Medical University | Rakhmatullin A.R.,Bashkiria State Medical University | Bakhtiyarova K.Z.,Bashkiria State Medical University
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2013

Epidemiological data on smoking influence on the development and course of multiple sclerosis (MS) are presented. The relative risk (RR) of MS for smokers was calculated as 1.3-1.8 in various cohort studies. Smoking was positively correlated with MS progression. The RR of the transition of remitting-relapsing MS to secondary progressive MS was in the range of 2.5-3.6. The RR of the transition to clinically isolated syndrome authentic MS was 1.8. Results of the MRI study of 239 MS patients (102 smokers and 137 non-smokers) revealed the higher level of disability on EDSS, higher rate of disease progression and lesser cases with remitting course in the group of smokers. The primary progressive MS course was more often observed in the group of smoking patients. The more favorable prognosis in terms of sensitivity and visual symptoms of disease onset were found in nonsmokers. Forms with a late onset prevailed in smokers.


Akhmetzyanova E.Kh.,Bashkiria State Medical University | Gainitdinova V.V.,Bashkiria State Medical University | Bakirov A.B.,Bashkiria State Medical University | Bogoroditskaya O.A.,Bashkiria State Medical University | Timershina I.R.,Bashkiria State Medical University
Kardiologiya | Year: 2012

In order to assess effect of If-channel blocker ivabradine on severity of pulmonary hypertension in chronic obstructive pulmonary disease (COPD) we studied 60 patients with 111-IV stage COPD. We divided these patients into 2 groups with similar clinical characteristics and therapy. Patients of one of these groups received ivabradine (10 mg/day) for 2 weeks, patients of another served as controls. The use of ivabradine was associated with statistically significant lowering of pulmonary hypertension, heart rate, and increase of exercise tolerance without negative effects on myocardial contractility, electrophysiological parameters, or data of spirometry.


Aim: To elucidate effect of β-adrenoblockers on remodeling of myocardium and adhesive function of endothelium in with ischemic heart disease with chronic heart failure (CHF) and addition of atrial fibrillation (AF). Material and methods. We included into the study 77 patients with functional class 11-111 CHF and AF of ischemic genesis randomized in 2 groups, In group 1 were included 40 patients who during 24 weeks used Carvedilol at the background of basic therapy, in group 2-37 patients receiving metoprolol tartrate. In the work we used clinico-instrumental (echocardiography, test with 60 minute walk), immunoenzymatic (soluble intercellular adhesion molecules (sVCAM, SE - selectin) methods of investigation. Results. Application of both BAB improved clinical state and physical working capacity of patients with CHF and AF. Carvedilol more significantly than metoprolol tartrate prevented remodeling of myocardium, inhibited expression of cellular adhesion molecules. Levels of sE-selectin and VCAM-1 decreased under action of Carvedilol. Conclusion. Carvedilol in long term therapy of CHF with AF exerts substantial influence on adhesive function of endothelium and improves hemodynamics.


PubMed | Bashkiria State Medical University
Type: Journal Article | Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Year: 2015

To analyze clinical characteristics of syringomyelia based on the data of the Bashkir Disease Cluster.Authors present the results of examination of 712 patients from the population of Bashkortostan. Disease duration varied in the wide range. In most of the patients, first symptoms usually occurred between 10 and 30 years old.Clinical symptoms included sensory and motor disorders, trophic changes of the skin, joint and bone deformations. A mixed form with lesion localization in the cervical-thoracic region of the spine and slowly progressive course was most frequent.

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