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Ramanath Royal B.,Basaveshwara Medical College and Hospital
International Journal of Pharma and Bio Sciences

Tapentadol is a centrally acting FDA approved analgesic for the treatment of moderate to severe acute pain with a dual mode of action as an agonist at the μ-opioid receptor and as a nor epinephrine reuptake inhibitor. It is used in chronic pain like, post operative, Neuropathic pain and End- stage degenerative joint disease. Oral dosages of 50 mg, 75 mg, or 100 mg /six hours tablets are available. Common side effects nausea, vomiting, dizziness, somnolence, headache, decreased seizure thresh hold, fatigue and also has dependence liability. Source

Ravikumar V.,Mvj Medical College And Research Hospital | Rajshankar S.,Karnataka Institute of Medical science | Nagendra Gowda M.R.,Basaveshwara Medical College and Hospital
Journal of Clinical and Diagnostic Research

Background: Inguinal and scrotal swellings are frequently encountered in the surgical practice, especially in children. It is also important to study the factors which are associated with inguinal hernia, especially in children, for its effective management. Objective: To study the factors which are associated with inguinal hernia in children. Setting and Design: A prospective hospital based study was undertaken in the Department of Surgery for a period of one year between 2001 to 2002. Children who were aged one day to 12 years were selected for the study. Out of 960 children who were admitted to the surgical ward, 50 children had inguinal hernia and they constituted the sample. Methodology: The details regarding the clinical history and the examination details were collected by using a predesigned proforma. The data which was thus collected was analyzed by using the appropriate statistical tests. Results: The inguinal hernia in the study group was common in the 1-5 years age group. 90% of the study group was males; a swelling in the inguinal region was the commonest symptom. 70% of the study group was term deliveries; the swelling of the inguinal hernia was elastic in consistency in 35 cases. The swelling of the inguinal hernia was irreducible in two cases. The testis was palpable in 48 cases; a cough impulse was seen and felt in 48 cases. Tenderness of the swelling was present in 2 cases. Conclusions: Inguinal hernia is a common congenital condition in children. Difficulties are commonly encountered by the surgeons to identify and to confirm the presence of inguinal hernia. This study will help in a better management of hernia in the paediatric age group by understanding the features of inguinal hernia. Source

Yuvaraj B.Y.,SS Institute of Medical science | Nagendra Gowda M.R.,Basaveshwara Medical College and Hospital | Umakantha A.G.,J J M Medical College
Indian Journal of Community Medicine

Objective: To study the prevalence, awareness, treatment, and control of hypertension in the rural areas of Davanagere. Type of Study: Cross-sectional community-based study. Setting: Villages belonging to six sectors of the Davanagere Taluk. Materials and Methods: General population above 18 years. Methodology: A community-based sample was chosen by a multistage sampling technique. Subjects were screened for hypertension by a house-to-house survey. Subjects with systolic blood pressure more than 140 and diastolic blood pressure more than 90 mm of Hg, on hypertensive treatment, and history of hypertension were classified as hypertensives. The data thus obtained was compiled and analyzed. Results: The prevalence rate of hypertension in the study population was 18.3% (95% CI, 16.7-19.9%). Prevalence of hypertension was more in males 19.1% (95% CI, 16.7-21.5%) than in females 17.5% (95% CI, 14.9-20.1%); 11.6%, 5.6%, and 1.2% of the total subjects had Grade I, Grade II, and Grade III, respectively. Only 33.8% of them were aware of their hypertensive status. Hypertensives of 32.1% were on treatment, and 12.5% adequately controlled their BP. About 6.9% of the total hypertensives had severe hypertension. Statistical Analysis: Proportions, One way Analysis of Variance, Chi-square test. Source

Venkataiah V.,Vijayanagara Institute of Medical science | Vickram,DMWIMS | Thirumalarao K.R.,SSIMC and RC | Raiker V.G.,Basaveshwara Medical College and Hospital | Puttaswamy S.H.,VIMS
Journal of Clinical and Diagnostic Research

Introduction: Plasma sialic acid levels are elevated in Diabetes Mellitus (DM) patients with proteinuria. Renal damage is mainly caused by free radicals that are excessively generated in DM. Thiols play an important role in the cellular antioxidative defence mechanisms mainly through thiol-disulphide exchange reaction. Diallyl disulphide, a garlic oil principle component, is known for its anti-diabetic properties. Its structural analogue, Diaceto-Dipropyl Disulphide (DADPDS), is a less toxic and more palatable disulphide and possesses similar anti-diabetic actions. Aim: This study was undertaken to assess the usefulness of DADPDS in prevention of de-sialation of Glomerular Basement Membrane (GBM) in alloxan diabetic rats and to assess effect of DADPDS on renal tissue thiol levels. Materials and Methods: Rats were divided into Normal, Diabetic and DADPDS treated diabetic groups. Diabetes was induced by intraperitoneal injection (IP) of alloxan. DADPDS was fed by gastric intubation. Plasma Sialic acid was determined by Ehrlich’s method and renal tissue thiol levels by Nitroprusside reaction method. Results: This study showed a significant decrease (p<0.001) in plasma sialic acid, plasma glucose and renal tissue TBARS levels along with significant increase (p<0.001) in renal tissue thiol levels in DADPDS treated alloxan diabetic rats when compared to diabetic control rats. Conclusion: Hence it may be concluded that DADPDS helps in preventing de-sialation of GBM in alloxan diabetic rats and improves renal tissue antioxidant defence mechanisms, may be through thiol-disulphide exchange reaction and thereby exhibits a possible clinical use in prevention of renal complications like diabetic nephropathy. © 2016, Journal of Clinical and Diagnostic Research. All Rights Reserved. Source

Katageri S.,Basaveshwara Medical College and Hospital | Hanumantha,Chennai Medical College Hospital and Research Center
Journal of South India Medicolegal Association

Suicide is a tragic incident for the family and the society. The rate of suicide is increasing alarmingly particularly among adolescents and young adults. An autopsy study of suicides among adolescents and young adults was conducted in the Department of Forensic Medicine, Victoria Hospital, Bangalore Medical College and Research Institute, Bangalore from January 2008 to June 2009. Out of 5448 autopsies conducted, 266 cases belonged to suicidal victims aged between 15-24 years. Majority of the victims were females belonging to urban area and were unmarried. Majority of them were students, employees and house wives. Hanging was the commonest method used to commit suicide, followed by poisoning, burns and drowning. Family conflict was the main reason for committing suicide. © 2012 South India Medico-Legal Association. Source

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