Basaveshwar Science College

Bagalkot, India

Basaveshwar Science College

Bagalkot, India

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Deshpande S.R.,Basaveshwar Science College | Shankar Naik B.,Government Science College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Objective: The use of plants for medicinal remedies is an integral part of the Indian cultural life, and the traditional background of Indian medicine shows widespread use of plant products in cancer treatment. In this study, stem extracts of some selected Cassia species have been evaluated for their cytotoxic activities under in vitro conditions. Methods: The stems were shade dried at room temperature. The dried and coarsely powdered plant material were extracted with petroleum ether (60-80°C), chloroform, and ethanol using soxhlet apparatus. The cytotoxicity was evaluated by [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. Results: Stem extracts of three Cassia species, viz., Cassia glauca, Cassia Obtusifolia, and Cassia sophera have been evaluated for their cytotoxic activities with chloroform, ethanol and pet ether against HeLa and breast cancer cell lines. Among the three different solvents used at different concentrations, the chloroform extracts of all Cassia species exhibited maximum cytotoxicity (%) against both cell lines. The CTC50 values are revealed the cytotoxic potential of C. glauca chloroform extracts against HeLa cell line and breast cancer cell lines with CTC50 values 180.00±3.0 and 146.67±0.5, respectively. Chloroform extracts of C. Obtusifolia and C. sophera showed maximum activity against HeLa (380.00±1.1 and 800.00±1.7, respectively) and breast cancer cell lines (310.00±1.1 and 633.33±0.6). Conclusion: The results of this study demonstrate the potent cytotoxic activity of chloroform extracts of stems of Cassia species against HeLa and Breast cancer cell lines. © 2017 The Authors.


Kulkarni N.V.,Karnatak University | Revankar V.K.,Karnatak University | Kirasur B.N.,Basaveshwar Science College
Medicinal Chemistry Research | Year: 2012

New transition metal complexes of quinoxaline-thiosemicarbazone ligands were prepared and characterised by spectroanalytical techniques. The ligands L 1H 2 and L 2H 2 were obtained by the reaction of quinoxaline-2.3(1,4H)-dione with methyl and phenyl thiosemicarbazide, respectively. All the complexes are found to be monomeric in nature and have tetrahedral geometry. The copper complexes have shown redox responses in the applied voltage range, whereas the ligands and other complexes are electrochemically innocent. The ligands, copper and zinc complexes are explored for antidiabetic activity in the diabetes-induced Wister rats. Evaluation of antidiabetic activity was done by blood-glucose test and oral glucose tolerance test; few compounds have exhibited significant antidiabetic activity and posses low toxicity with a high safety profile. © Springer Science+Business Media, LLC 2011.


Melavanki R.M.,M.S. Ramaiah Institute of Technology | Nagaraja D.,Bangalore Institute of Technology | Patil H.D.,Basaveshwar Science College | Sanningannavar F.M.,Karnatak Science College Dharwad
Journal of Molecular Liquids | Year: 2013

The fluorescence quenching studies of carboxamide namely (E)-N-(3-Chlorophenyl)-2-(3,4-dimethoxybenzylideneamino)-4,5,6, 7-tetrahydrobenzo[b]thiophene-3-carboxamide [ENCDTTC] by aniline and carbon tetrachloride in six different solvents namely toluene, cyclohexane, n-hexane, n-heptane, n-decane and n-pentane have been carried out at room temperature with a view to understand the quenching mechanisms. The Stern-Volmer (S-V) plots have been found to be nonlinear with a positive deviation for all the solvents studied. In order to interpret these results we have invoked the ground state complex formation and sphere of action static quenching models. Using these models various quenching rate parameters have been determined. The magnitudes of these parameters suggest that sphere of action static quenching model agrees well with the experimental results. Hence the positive deviation is attributed to the static and dynamic quenching. Further, with the use of Finite Sink approximation model, it was possible to check these bimolecular reactions as diffusion-limited and to estimate independently distance parameter R′ and mutual diffusion coefficient D. Finally an effort has been made to correlate the values of R′ and D with the values of the encounter distance R and the mutual coefficient D determined using the Edward's empirical relation and Stokes Einstein relation. © 2013 Elsevier B.V.


Melavanki R.M.,M.S. Ramaiah Institute of Technology | Sanningannavar F.M.,Karnatak Science College | Kusanur R.A.,Rashtreeya Vidyalaya College of Engineering | Nagaraja D.,Bangalore Institute of Technology | And 2 more authors.
Indian Journal of Pure and Applied Physics | Year: 2013

Solvent effect of fluorescence quenching of biologically active studies of 6-methoxy-4-azidomethyl coumarin (6MAMC) by aniline in five different solvents namely dioxane, tetrahydrofuran, dichloroethane, dimethylformamide and acetonitrile has been carried out at room temperature with a view to understand the quenching mechanisms. The Stern-Volmer (S-V) plot has been found to be non-linear with a positive deviation for all the solvents studied. In order to interpret these results, we have invoked the ground state complex formation and sphere of action static quenching models. Using these models, various quenching rate parameters have been determined. The magnitudes of these parameters suggest that sphere of action static quenching model agrees well with the experimental results. Hence, the positive deviation is attributed to the static and dynamic quenching. Further, with the use of Finite Sink approximation model, it was possible to check these bimolecular reactions as diffusion-limited and to estimate independently distance parameter R′ and mutual diffusion coefficient D. Finally, an effort has been made to correlate the values of R′ and D with the values of the encounter distance R and the mutual coefficient D determined using the Edward's empirical relation and Stokes-Einstein relation.


Melavanki R.M.,M.S. Ramaiah Institute of Technology | Patil H.D.,Basaveshwar Science College | Kusanur R.A.,Karnatak University | Kadadevaramath J.S.,Karnatak University
Indian Journal of Pure and Applied Physics | Year: 2011

Studies of steady state and time resolved methods of fluorescence quenching of excitation energy of three coumarin dyes by aniline were carried out in toluene solvent only to understand the role of diffusion in the quenching mechanism. The coumarin dyes (dye1, dye2 and dye3) were excited directly by UV radiation of 350 nm and probabilities of quenching per encounter p (or p') were determined in the toluene solvent. Further, the activation energy E'a (or E'a) of quenching was determined using the literature values of activation energy of diffusion Ed and the experimentally determined values of p (or p'). Magnitudes of p (or p') as well as the values of Ea (or E'a) suggest that the quenching reaction is predominantly controlled by material diffusion.


Sreekantha D.K.,Basaveshwar Science College | Kulkarni R.V.,Chh Shahu Institute Of Business Education And Research
International Journal of Applied Engineering Research | Year: 2014

Improvement of health and nutritional status of the society has been one of the thrust areas for social developments programmes of the country. The present state of healthcare facilities in India are inadequate when compared to international standards. The average Indian spending on healthcare is muchbelow the globalaveragespending. Indian healthcare Industry is growing at the rapid pace of more than 18%,the fastest in the world. The prospects for Indian healthcare are to the tune of USD 40 billion, while global market is USD 1660 trillion. India has all the prospects to becomemedical tourismdestination of the world,because it has a large pool of lowcost scientifically trained technicalpersonal and is one of the favored counties for cost effective healthcare. The banks and financial institutions have a big role to play in promoting India as a preferred medical tourism destination by extendingcredit to investorsin healthcare industry. Over the past few years, the credit risk evaluation of Micro, Small and Medium scale Enterprises(MSME) by banks and financial institutions has been an active area of research under the joint pressure of regulators and shareholders. This paper discusses the credit risk parameters in lending to healthcare industry with case study of establishinga nursing home. The authors aim at designing expert system model for credit risk evaluation of healthcare industry using a soft computing frameworkcalled evolutionary neuro fuzzy logic to support thecredit risk executives in banks in their credit decision making. © Research India Publications.


Melavanki R.M.,M.S. Ramaiah Institute of Technology | Patil H.D.,Basaveshwar Science College | Umapathy S.,Indian Institute of Science | Kadadevarmath J.S.,Karnatak University
Journal of Fluorescence | Year: 2012

The absorption and emission spectra of two coumarins namely 7, 8 benzo-4-azidomethyl coumarin (C 1) and 6-methoxy-4-azidomethyl coumarin (C 2) have been recorded at room temperature in solvents of different polarities. The ground state dipole moments (μg) of two coumarins were determined experimentally by Guggenheim method. The exited state (μe) dipole moments were estimated from Lippert's, Bakhshievs and Chamma- Viallet's equations by using the variation of Stoke's shift with the solvent dielectric constant and refractive index. The ground and excited state dipole moments were calculated by means of solvatochromic shift method and also the excited state dipole moments are determined in combination with ground state dipole moments. It was observed that dipole moments of excited state were higher than those of the ground state, indicating a substantial redistribution of the π-electron densities in a more polar excited state for two coumarins. © 2011 Springer Science+Business Media, LLC.


Sreekantha D.K.,Basaveshwar Science College | Kulkarni R.V.,Shivaji University
Expert Systems | Year: 2012

Over the past few years, the credit risk evaluation of micro-, small-and medium-scale enterprises by banks and financial institutions has been an active area of research under the joint pressure of regulators and shareholders. The credit rating assessment forms an important part of credit risk assessment, involving risk parameters such as financial, business, industry and management areas. The mathematical models of evaluation are at the core of modern credit risk management systems. This paper focuses on the use of fuzzy logic and neural network techniques to design a methodology for evaluating the credit worthiness of the entrepreneur. The neuro-fuzzy logic approach takes into account the minute details of credit rating expert's thought process to arrive at the final decision. A flexible credit rating framework (CRF) has been designed to organize all the facts of the client in a hierarchical fashion. The neural networks provide self-learning capability to the CRF. The CRF can be customized to suit different business and industrial interests. © 2012 Blackwell Publishing Ltd.


Deshpande S.R.,Basaveshwar science college | Naik B.S.,Government science college
Journal of Applied Pharmaceutical Science | Year: 2016

Cassia species have been of medicinal interest due to their good therapeutic value in folk medicine. In the present study petroleum ether, ethanol and chloroform extracts from leaf and stems of Cassia obtusifolia and Senna sophera were investigated for their antimicrobial activities against some pathogenic microbes in vitro. The C. Obtusifolia leaf extracts in pet ether and chloroform showed more sensitivity against E. faecalis (MIC 0.2725mg/ml and MIC 0.2647) and ethanol extracts against A. fumigatus (MIC 0.3116mg/ml). Similarly the stem extracts of C. Obtusifolia in pet ether showed more sensitivity against E. faecalis (MIC 0.407mg/ml), ethanol extracts against E. faecalis (MIC 0.3009mg/ml) and chloroform extracts against E. faecalis MIC 0.4946mg/ml). The leaf extracts of S. sophera in pet ether showed more sensitivity against C. albicans (MIC 0.3524mg/ml), ethanol extracts against E. faecalis (MIC 0.2738mg/ml) and chloroform extracts against C. Albicans (MIC 0.4239). C. sophera stem extracts in Pet ether showed more sensitivity against E. faecalis (MIC 0.254mg/ml), ethanol extracts against E. faecalis (MIC 0.2987mg/ml) and chloroform extracts against E. faecalis (MIC 0.5899mg/ml). This finding provides an insight into the usage of the leaves of Cassia species in traditional treatment of wounds or burns associated with bacterial and fungal infections. However, further work is needed in the form of phytochemical screening and pharmacological activity of some more extracts before one could conclude anything definite about the therapeutic potential of these extracts. © 2016 Surekha R Deshpande and B. Shankar Naik.


Fattepur R.H.,Basaveshwar Science College | Ayachit N.H.,Rani Channamma University
Proceedings of the 2014 IEEE 18th International Conference on Dielectric Liquids, ICDL 2014 | Year: 2014

The dielectric relaxation studies of liquids and liquid mixtures is a tool to understand intermolecular interaction along with molecular dynamics. Although m-Fluoroaniline (MFA) has higher dipole moment than methanol (MT) has dielectric constant less than that of methanol. H-bonds appear in methanol but not in m-Fluoroaniline. The dielectric behavior, dielectric relaxation mechanism of these pure liquids and their binary mixtures helps to understand nature of interactions between dipoles and effects of molecular bonding. Higher dielectric constant and relaxation time of of pure methanol compared to those of m-Fluoroaniline are due to presence of H-bonding and parallel alignment of electric dipoles. In pure m-Fluoroaniline spatial correlation between molecules appear only through dipole-dipole interactions. To study these aspects the Time domain Reflectometry technique has been used to obtain complex dielectric spectra of binary mixture of MT and MFA in the frequency range of 10 MHz to 10 GHz at various temperatures the results are presented © 2014 IEEE.

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