Basavatarakam Indo American Cancer Hospital and Research Institute

Hyderabad, India

Basavatarakam Indo American Cancer Hospital and Research Institute

Hyderabad, India

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PubMed | Basavatarakam Indo American Cancer Hospital and Research Institute
Type: Journal Article | Journal: Indian journal of pathology & microbiology | Year: 2016

Adequate lymph node harvest in resected colorectal cancer (CRC) specimens is important in staging and choosing appropriate therapeutic options. The yield of lymph nodes and metastatic nodes by methylene blue dye injection in 30 randomly selected resected CRC specimens was compared with an equal number of CRC specimens (control) with matched grade and stage.The mean number of lymph nodes retrieved in the study group was 22 9 compared to 17 8 in the control group which was statistically significant (P = 0.04).Methylene blue technique is an effective aid in increasing the yield of lymph nodes in the resected CRC specimens.


PubMed | University of California at Los Angeles, CARE Hospitals and Basavatarakam Indo American Cancer Hospital and Research Institute
Type: | Journal: International journal of cardiology | Year: 2016

Cardiac sarcoidosis (CS) is increasingly being recognized. Immunosuppression with corticosteroids is the mainstay of therapy. But the optimal dose of steroids and how to assess response to therapy is not known. Prognosis is poor if these patients are untreated or undertreated. Fluorine-18-flurodeoxyglucose positron emission computed tomography (We identified 15 patients (6 women; mean age, 42.912.5years) based on histopathological diagnosis. All had a baseline and follow-up fasting Of the 15 patients, 4 were clinical non-responders to steroid therapy. Follow-up Serial


Shanmugavadivu P.,Gandhigram Rural Institute | Sivakumar V.,Gandhigram Rural Institute | Sudhir R.,Basavatarakam Indo American Cancer Hospital and Research Institute
European Physical Journal: Special Topics | Year: 2016

A new Fractal Dimension-based diagnosis technique for the change detection and time-series analysis of masses in the temporal digital mammogram is presented in this paper. As the digital mammograms are confirmed as a reliable source for the prognosis of breast cancer, the demand for the development of precise computer aided detection techniques is constantly on the increase. This formed the basis for the development of this method using Fractal geometry, which is an efficient mathematical approach that deals with self-similar and irregular geometric objects called fractals. This work comprises of the detection of spatial masses using Fractal Hurst bound enhancement and segmentation of those temporal masses using Fractal Thresholding. The consultant radiologist’s assessment of mass lesions forms the baseline for comparison and validation of the detected masses. Further, this research work performs temporal analysis of mass lesions, detected from the mammograms of the current and the respective prior view using the principle of Fractal Dimension. The precision of Fractal-dimension based temporal texture analysis of malignant masses of digital mammograms subsequently attributes to their characterization. © 2016, EDP Sciences and Springer.


Bajwa H.K.,Basavatarakam Indo American Cancer Hospital and Research Institute | Singareddy R.,Basavatarakam Indo American Cancer Hospital and Research Institute | Alluri K.R.,Basavatarakam Indo American Cancer Hospital and Research Institute
Brachytherapy | Year: 2016

Purpose: The aim of the study was to assess the impact of high-dose-rate (HDR) interstitial brachytherapy on quality of life (QOL) in oral cancer. Methods and Materials: Thirty-two patients of oral cancer treated at our institute from January 2010 to December 2014 with radical radiotherapy (external beam radiotherapy + brachytherapy) were included for analysis; 30 patients received external beam radiotherapy (50-54 Gy) and HDR brachytherapy boost (18-24.5 Gy); 2 patients received radical HDR brachytherapy (31.5 Gy). Quality of life (QOL) was assessed by Telugu, Hindi, and English versions of EORTC Quality of Life Core-30 and EORTC Quality of Life Head and Neck Module (QLQ H&N35) before treatment, at 3 months, 6 months, 1 year, and 2 years after treatment. Results: Of the 32 patients, 2 patients died and 1 patient progressed on followup; 2 patients were re-irradiation cases. On excluding these cases, 27 patients were available for analysis. The followup duration was 6-55 months. At the time of analysis, 91% (29) patients were disease free, 3% (1) progressed, and 6% (2) died. At the end of 2 years, none of the QLQ-C30 functional scores fell below the baseline. Pain, swallowing, sensory, speech, social contact, and social eating worsened at 3 months but improved over 2 years (p < 0.001). Sexuality and financial status showed delayed improvement (p < 0.001). Among the head and neck parameters, dry mouth and sticky saliva were significant determinants of QOL with delayed improvement (p < 0.001). The impact of age, sex, and tumor stage and on QOL was analyzed. Women reported a poorer QOL for physical and emotional parameters, social eating, weight loss, and fatigue. Tumor stage significantly affected QOL, with early stages showing a better QOL. Conclusions: Almost all patients regained normal function after treatment and reported an excellent QOL at 2 years. However, tumor stage significantly affected the QOL. © 2016 American Brachytherapy Society.


Prasad V.V.T.S.,Basavatarakam Indo American Cancer Hospital and Research Institute | Wilkhoo H.,Basavatarakam Indo American Cancer Hospital and Research Institute
Onkologie | Year: 2011

Background: Polymorphisms of the gene encoding methylenetetrahydrofolate reductase (MTHFR) have been studied widely in various cancers, excluding thyroid cancer. However, reports on the association of various polymorphisms with certain cancers are contradictory. Materials and Methods: We have investigated whether the prevalence of the most common polymorphism (C677T) in the MTHFR gene has any link with various cancers, using genomic DNA and polymerase chain reaction restriction fragment length polymorphism (PCRRFLP) analysis. Results: The frequency of the heterozygous variant (677CT) but not that of 677TT was found to be significantly higher in colorectal cancer cases than in controls (p < 0.039; odds ratio 2.35 and 95% confidence interval 1.02-5.415). The frequencies for 677CT were 11.0 and 5.0% in colorectal cancer samples and controls, respectively. In ovarian cancer, the frequency of the 677TT variant was 6.0% which differed significantly (p < 0.026) from the control value of 1.0%. However, the frequencies of the variants in cervical, thyroid, and breast cancer cases did not differ from controls. Conclusions: Our data taken together with other reports indicates that the polymorphism C677T of MTHFR is a risk factor for developing colorectal cancer but not cervical, thyroid, and breast cancers. The present study also reconfirms that frequencies of the variants are not gender-specific. Copyright © 2011 S. Karger AG, Basel.


Aurangabadkar H.U.,Basavatarakam Indo American Cancer Hospital and Research Institute | Palle L.,Basavatarakam Indo American Cancer Hospital and Research Institute | Ali Z.,Basavatarakam Indo American Cancer Hospital and Research Institute
Nuclear Medicine Communications | Year: 2013

Tumour thrombosis (TT) is a very rare but serious complication in oncologic patients. The presence of TT has a significant impact on tumour staging, treatment decisions and prognosis in many malignancies. Current diagnostic techniques show poor ability to differentiate between bland and malignant thrombi; tumour thrombi are also usually inaccessible for biopsies, making their diagnosis difficult. In recent times, fluorine-18 fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) has well established its role in oncological imaging because of the high metabolic contrast of 18F-FDG between malignant and normal tissue. Patients with tumour thrombi may benefit from 18F-FDG PET/CT imaging when TT cannot be diagnosed precisely by other conventional imaging modalities. Here we provide a pictorial review of a few common and unusual sites of tumour thrombus in different malignancies and their patterns of F-FDG uptake. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.


PubMed | Basavatarakam Indo American Cancer Hospital and Research Institute
Type: | Journal: Clinical medicine insights. Pathology | Year: 2016

Phyllodes tumor is attributed to a small fraction of primary tumors of the breast. Such tumors occur rarely in pregnancy and lactation. We report a case of a 25-year-old lactating mother presenting with a lump in the left breast. Core needle biopsy was opined as phyllodes tumor with lactational changes, and subsequent wide local excision confirmed the diagnosis of benign phyllodes tumor with lactational changes. The characteristic gross and microscopic findings of a well-circumscribed lesion with leaf-like fibroepithelial growth pattern and typical nonuniform or diffuse stromal proliferation with periductal accentuation even in the absence of mitotic figures can help clinch the diagnosis. Benign phyllodes is known for its recurrence and requires wide excision and close follow-up. It is vital to identify these lesions even on limited biopsies as therapeutic options differ. This case is presented for its rarity and the diagnostic challenge it poses in limited biopsy.


PubMed | Basavatarakam Indo American Cancer Hospital and Research Institute
Type: Journal Article | Journal: Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists | Year: 2016

Alvimopan is an US-FDA approved, peripherally acting mu opioid receptor antagonist which when started pre-operatively has been shown to hasten intestinal motility and reduce the duration of post-operative ileus. However the logistics involved in procuring, storing and dispensing the drug and the cost of the drug for fifteen doses as approved by FDA prohibits the use of it on a regular basis.


PubMed | Basavatarakam Indo American Cancer Hospital and Research Institute and Employees State Insurance Corporation
Type: Journal Article | Journal: Contemporary clinical dentistry | Year: 2016

Infantile hemangiomas (IHs) are common, benign vascular tumors of infancy, with more than half affecting the head and neck region. IHs involving the lips and oral cavity can often present to the oral surgeon and the pedodontist. Till date, several doubts exist among clinicians regarding the use of propranolol to treat infantile hemangiomas in neonates and small infants, appropriate dose, treatment duration, side effects, response, and long-term follow-up. We present a 2-month-old male infant with extensive hemangioma involving the face, orbit, buccal mucosa and palate with feeding difficulties, and risk of life-threatening complications such as airway compromise, aspiration, and visual loss which showed excellent response with high-dose propranolol and had no side effects. We also reviewed literature for the mechanism of action of propranolol and possible minor and serious side effects.


PubMed | Basavatarakam Indo American Cancer Hospital and Research Institute
Type: Journal Article | Journal: Journal of surgical oncology | Year: 2016

There is a general notion that, total glossectomy with laryngeal preservation leads to high dependency of tracheostomy and/or feeding tube. The objective of this study is to analyze the quality of life in terms of tube dependency following total glossectomy with a modified pectoralis major myocutaneous flap (PMMC) reconstruction and laryngeal suspension.The retrospective study included consecutive patients operated from July 2012 to February 2015 proven advanced Carcinoma of tongue. We analyzed the time to wean off tracheostomy and feeding tube in 56 patients who underwent total glossectomy and a modified technique of PMMC reconstruction.The median time for tracheostomy weaning was 10 days and nasogastric tube was 16 days.Modified technique of reconstruction with PMMC in total glossectomy is a viable option with minimal functional morbidity. Quality of life in terms of tracheostomy and feeding tube dependency is minimal. J. Surg. Oncol. 2016;114:32-35. 2016 Wiley Periodicals, Inc.

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