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Schreiber F.,University of Duisburg - Essen | Schreiber F.,Center for Nanointegration Duisburg Essen | Kahnert S.,Fraunhofer Institute for Microelectronic Circuits and Systems | Goehlich A.,Fraunhofer Institute for Microelectronic Circuits and Systems | And 10 more authors.
Technisches Messen | Year: 2016

In this contribution we present the development of various physical sorting algorithms, each of which is represented by a corresponding sorter topology for a microfluidic-based cell sorter chip using electrowetting on dielectric (EWOD) as transport mechanism. One of the main tasks of this novel cell sorter is devoted to the study of specific cell mechansims using cell selection in the research on tumor genesis with respect to e.g. the development of leukemias or lymphomas. The development of the multi-layer chip has been carried out in the framework of the EU founded (EFRE) joint research project .,MINAPSO" (Mikrochip Navigierte Parallel Sortier-Anlage) and encompasses a control chip in standard CMOS technology together with the corresponding mictrofluidic packaging. The hereby realized sorter topology consists of an optimized so-called .,2-3-Sequential-Divider-Sorter" with a numerically estimated performance (i.e. cell throughput) between 0.6 bis 1.85 cells/clock (future chip architectures such as the so-called .,Smart-Diffusion-Sorter" achieve even higher cell throughputs up to 5 cells/clock). For the modeling and optimization of the sorter architectures (aka sorter algorithms) a simulation platform has been developed and implemented in MATLAB. Here the EWOD-based droplet manipulations and subsequent operators have been represented and handled within a sort of data paradigm in order to closely conform to the essentials of digital microfluidics. To estimate the characteristic time delays and the impact of the EWOD-based operators on the overall cell throughput together with the quest for hidden optimization potentials the previous numerical logistic analysis is paralleled by extensive computational fluid dynamics (CFD) simulations using COMSOL Multiphysics as well as by corresponding droplet actuation experiments. It's worth noting that the presented cell sorter stands-to the best of our knowledge-for the currently most complex EWOD microfluidic chip. © 2016 Walter de Gruyter Berlin/Boston.


Woitschach O.,University of Bremen | Sosna C.,University of Bremen | Lang W.,University of Bremen | Uckelmann J.,Bartels Mikrotechnik GmbH
Proceedings of IEEE Sensors | Year: 2010

In this paper a prototype of an intelligent micropump is presented. The electrical parameters of the micropump are regulated by measuring the actual flow rate with an integrated thermal flow sensor. The micropump moves liquids with a regulated flow rate with a range of 100 μl/min to several ml/min. The accuracy is better than 10 %. The micropump and flow sensor are controlled via integrated electronics to form a fully integrated system. The flow sensor is placed directly into the path of the fluid of the micropump, to minimize the complexity of the system and maximize its robustness. Further the system was manufactured using low cost methods. The gained flexibility of the system opens the door to a wide range of applications such as the dosage of fluids e.g. in the biomedical and pharmaceutical industry. ©2010 IEEE.


Rawert J.,Advanced Display Technology GmbH ADT | Jerosch D.,Advanced Display Technology GmbH ADT | Blankenbach K.,Pforzheim University | Bartels F.,Bartels Mikrotechnik GmbH
Digest of Technical Papers - SID International Symposium | Year: 2010

D 3-Displays electrowetting displays ("Droplet-Driven- Displays"; developed by advanced display technology (ADT) Deutschland GmbH) have features like bistability and highest reflectivity, which offer unique application options in the area of non-emissive displays. This paper deals with the "No Power" (green) display technology and its applications for indicators and character displays including optical performance comparison. © 2010 SID.


Goellner B.,Bartels Mikrotechnik GmbH | Kerkhoff D.,Bartels Mikrotechnik GmbH | Michelsen U.,Bartels Mikrotechnik GmbH | Padberg M.,Bartels Mikrotechnik GmbH | And 2 more authors.
Biomedizinische Technik | Year: 2012

In this paper fast but simple physical sorting algorithms for high-volume cell sorting based on the microfluidic electrowetting platform are analyzed and further optimized. Relying on both, hardware demonstrations of the underlying sorting operators and simulations of different generic sorter topologies, first design studies for the realization of an efficient cell sorter chip platform are carried out. © 2012 by Walter de Gruyter Berlin Boston.


Kahnert S.,Fraunhofer Institute for Microelectronic Circuits and Systems | Goehlich A.,Fraunhofer Institute for Microelectronic Circuits and Systems | Greifendorf D.,Fraunhofer Institute for Microelectronic Circuits and Systems | Vogt H.,Fraunhofer Institute for Microelectronic Circuits and Systems | And 8 more authors.
Biomedizinische Technik | Year: 2014

Cell sorting is broadly utilized in the field of biological and clinical research. Scientists frequently apply the technique to investigate the biology of stem cells or to develop therapies against neurodegenerative diseases [1]. Currently flow cytometry is the state of the art procedure to cope with cell separation tasks. In comparison to these commonly used systems, which rely on a serial sorting concept, the microchip based cell sorting device promises an increasing sorting velocity due to a parallel cell throughput, a more gentle cell treatment and an improved protection against biohazardous materials by encapsulating the sorting process in a microfluidic channel. The planned sorting device should be capable to sort droplets, which contain fluorescent cells by using the electrowetting effect. We present preliminary fluorescent microscopic investigations on a microfluidic system to demonstrate first separation events of different fluorescent labelled beads. In addition a layout and first images of the intended microchip will be introduced. © 2014 by Walter de Gruyter Berlin Boston.


Blankenbach K.,Pforzheim University | Jentsch M.,Pforzheim University | Rawert J.,Advanced display technology adt | Jerosch D.,Advanced display technology adt | And 2 more authors.
Digest of Technical Papers - SID International Symposium | Year: 2011

adt's electrowetting displays are designed for bistability ("green") and capable of all backlight modes (reflective, transflective and transmissive). Compared to LED indicators, our pixels draw no power and are sunlight readable. Using CMY stacks we achieved a superior color gamut and high reflectivity (both topics are essential for electronic billboards). © 2011 SID.


Blankenbach K.,Pforzheim University | Bartels F.,Bartels Mikrotechnik GmbH | Rawert J.,Advanced Display Technology ADT | Jerosch D.,Advanced Display Technology ADT
IDW'10 - Proceedings of the 17th International Display Workshops | Year: 2010

High reflectivity and transmissive backlight mode are advantages of electrowetting displays; ADTs approach is the only bistable one. This paper deals with LED replacements for energy-saving systems. Achievements are fully compatible integration into LED housings, superior optical performance of electrowetting indicators in bright light compared to LEDs and "in-cell" touch. © 2010 ITE and SID.


Michalow A.,Microfluidics | Michalow A.,Bartels Mikrotechnik GmbH
Sensors (Peterborough, NH) | Year: 2011

A robust, postage-stamp-sized micropump, with low energy consumption and a use life of more than 10,000 hours, enables new applications for both gas and liquid chemical sensor systems by facilitating their use in networked installations and handheld systems. The important technical features of the micropump are based a dual-membrane pump mechanism actuated by a double configuration of piezo elements in combination with passive valves. Only a single polymeric material, polyphenylene sulfone (PPSU), comes into contact with the pumping medium. Regarding medical-field applications, the material is certified in accordance to ISO 10993 and USP class VI. When the voltage decreases, the piezoceramic's corresponding deformation causes the membrane to flex upwards, sucking in the fluid and refilling the chamber. The pump can perform several hundred such pumping cycles per second. The pump's simple design integrates numerous features into a few injection-molded components, which means that the dual-membrane micropump systems can be produced at a low cost.


PubMed | Bartels Mikrotechnik GmbH
Type: Journal Article | Journal: Medical device technology | Year: 2010

The small size, low power consumption and attractive price of micropumps make them ideal for use in medical delivery systems. This article discusses two designs of closed-loop controlled micropumps that can be employed to meet differing levels of accuracy and portability.

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