Oakland, CA, United States
Oakland, CA, United States

Bartholomew JoJo "Bart" Simpson is a fictional character in the animated television series The Simpsons and part of the Simpson family. He is voiced by actress Nancy Cartwright and first appeared on television in The Tracey Ullman Show short "Good Night" on April 19, 1987. Bart was created and designed by cartoonist Matt Groening while he was waiting in the lobby of James L. Brooks' office. Groening had been called to pitch a series of shorts based on Life in Hell but instead decided to create a new set of characters. While the rest of the characters were named after Groening's family members, Bart's name was an anagram of the word brat. After appearing on The Tracey Ullman Show for three years, the Simpson family received its own series on Fox, which debuted December 17, 1989.At ten years old, Bart is the eldest child and only son of Homer and Marge, and the brother of Lisa and Maggie. His birth date is formally stated in season 26 episode "Simpsorama" as February 23 but this date is contradicted in earlier episodes. Bart's most prominent character traits are his mischievousness, rebelliousness and disrespect for authority. He has appeared in other media relating to The Simpsons, including video games, The Simpsons Movie, The Simpsons Ride, commercials, and comic books; he has also inspired an entire line of merchandise. In casting, Nancy Cartwright originally planned to audition for the role of Lisa, while Yeardley Smith tried out for Bart. Smith's voice was too high for a boy, so she was given the role of Lisa. Cartwright found that Lisa was not interesting at the time, so instead auditioned for Bart, which she thought was a better role. Hallmarks of the character include his chalkboard gags in the opening sequence; his prank calls to Moe; and his catchphrases "Eat my shorts", "¡Ay, caramba!", and "Don't have a cow, man!"During the first two seasons of The Simpsons , Bart was the show's breakout character and "Bartmania" ensued. Bart Simpson T-shirts sporting various slogans and catchphrases became popular, selling at a rate of a million per day at their peak. The song "Do the Bartman" became a number one charting single and the seventh best-selling song of 1991 in the United Kingdom. Bart's rebellious attitude and pride at underachieving caused many parents and educators to cast him as a bad role model for children. A T-shirt reading "I'm Bart Simpson. Who the hell are you?" was banned in several public schools. Around the third season, the series started to focus more on the family as a group, although Bart remains one of the most prominent characters on the series. Time named Bart one of the 100 most important people of the 20th century, and he was named "entertainer of the year" in 1990 by Entertainment Weekly. Nancy Cartwright has won several awards for voicing Bart, including a Primetime Emmy Award in 1992 and an Annie Award in 1995. In 2000, Bart, along with the rest of his family, was awarded a star on the Hollywood Walk of Fame. Wikipedia.


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Patent
Bart and Bellon | Date: 2017-01-04

A modular device for wireless communication between a transmitter and a receiver, the latter being mounted on a fastener to be worn by an animal/a human being or to be in contact therewith, comprising a string of individual separate elements or modules (210, 310), each containing at least either the PCB (213, 313), the battery (214, 314) or one or more contact points (220, 320) of same polarity respectively, said separate individual elements (210, 310) being attached to one another thanks to at least two substantially parallel flexible tubes (31, 32 ; 331, 332) containing said wires, so that the specific location of the modules (220, 320) containing the contact points and the order or sequence thereof in the string define an extension length for the contact points.


The invention relates to a spiral pump and a device for treating water comprising this spiral pump, and associated method. The spiral pump comprises:- a housing provided with an inlet (8a, 8b, 8c) for water; and- a pump body (2) which is accommodated in the housing and rotatable around an axis (12), wherein the pump body (2) comprises at least one spiral channel,wherein a first outer end (8a, 8b, 8c) of the at least one spiral channel is located on an outer side of the pump body and forms an entrance opening for alternately taking in water and air through rotation of the pump body in the housing, and a second outer end of the at least one spiral channel debouches into an outlet (10) close to the axis, wherein the housing is embodied as pressure chamber.


SALT LAKE CITY, Feb. 17, 2017 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (NASDAQ:MYGN), a leader in molecular diagnostics and personalized medicine, today announced new findings from the OlympiAD study that show its BRACAnalysis CDx®  test successfully identified patients with HER2-negative metastatic breast cancer who have BRCA mutations and who had improved response with Lynparza (olaparib), AstraZeneca’s PARP inhibitor. The high level results – announced earlier today from AstraZeneca – are the first reported clinical data from the OlympiAD study (NCT02000622), which assessed the efficacy and safety of olaparib monotherapy versus physicians’ choice of chemotherapy (i.e., capecitabine, vinorelbine or eribulin) in the treatment of metastatic breast cancer.  Of the 302 patients in the study, 98 percent (297/302) tested positive for germline BRCA1/2 mutations as determined by Myriad’s FDA-approved BRACAnalysis CDx test.  The results demonstrated a statistically-significant improvement of progression-free survival (PFS) among BRCA-mutated patients treated with olaparib compared to those treated with physicians’ choice. “We believe the results of the OlympiAD trial support use of the BRACAnalysis CDx test to help inform treatment decisions in the metastatic breast cancer setting and will expand the patient population who can benefit from BRCA testing,” said Johnathan Lancaster, M.D., Ph.D., chief medical officer of Myriad Genetic Laboratories.  “This study underscores Myriad’s commitment to our pharmaceutical partners and to advancing the field of personalized medicine so that new effective treatment options are available to patients.” It is estimated there are approximately 60,000 patients with metastatic breast cancer, two thirds of whom are not currently eligible for BRCA testing based upon family and personal history alone or current testing criteria.  If approved as a new indication this would triple the number of patients with metastatic breast cancer who would benefit from BRCA testing. The ongoing collaboration between Myriad and AstraZeneca to develop a novel companion diagnostic test to identify candidates for treatment with olaparib began in 2007.  In Dec. 2014, Myriad received FDA approval for BRACAnalysis CDx to help identify patients with advanced ovarian cancer who are eligible for fourth-line treatment with olaparib.  BRACAnalysis CDx is Myriad’s first FDA-approved companion diagnostic and was the first-ever laboratory developed test reviewed and approved by the FDA. About BRACAnalysis CDx® BRACAnalysis CDx is an in vitro diagnostic device intended for the qualitative detection and classification of variants in the protein coding regions and intron/exon boundaries of the BRCA1 and BRCA2 genes using genomic DNA obtained from whole blood specimens collected in EDTA.  Single nucleotide variants and small insertions and deletions (indels) are identified by polymerase chain reaction (PCR) and Sanger sequencing.  Large deletions and duplications in BRCA1 and BRCA2 are detected using multiplex PCR.  Results of the test are used as an aid in identifying ovarian cancer patients with deleterious or suspected deleterious germline BRCA variants eligible for treatment with Lynparza™ (olaparib).  This assay is for professional use only and is to be performed only at Myriad Genetic Laboratories, a single laboratory site located at 320 Wakara Way, Salt Lake City, UT 84108. About Lynparza Lynparza (olaparib) is an innovative, first-in-class oral poly ADP-ribose polymerase (PARP) inhibitor that may exploit tumour DNA damage response (DDR) pathway deficiencies to preferentially kill cancer cells. Lynparza is the foundation of AstraZeneca’s industry-leading portfolio of compounds targeting DNA damage response (DDR) mechanisms in cancer cells. Lynparza is currently approved by regulatory health authorities in the EU for use as monotherapy for the maintenance treatment of adult patients with platinum-sensitive relapsed BRCA-mutated (germline and/or somatic) high grade serous epithelial ovarian, fallopian tube or primary peritoneal cancer who are in response (complete or partial) to platinum-based chemotherapy. It is also approved in the US as monotherapy in patients with deleterious or suspected deleterious germline BRCA-mutated (as detected by an FDA- test) advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy. Lynparza is currently being investigated in another separate non-metastatic breast cancer Phase III study called OLYMPIA. This study is still open and recruiting patients internationally. About Myriad Genetics Myriad Genetics Inc. is a leading personalized medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics.  Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs.  Myriad is focused on three strategic imperatives:  transitioning and expanding its hereditary cancer testing markets, diversifying its product portfolio through the introduction of new products and increasing the revenue contribution from international markets.  For more information on how Myriad is making a difference, please visit the Company's website: www.myriad.com. Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, myPath, myRisk, Myriad myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, Vectra, Prolaris and GeneSight are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G             Safe Harbor Statement This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including statements related to the ability of the BRACAnalysis CDx test to successfully identify metastatic breast cancer patients with improved outcomes from olaparib;  the results of the study demonstrating a statistically-significant improvement of progression-free survival (PFS) among BRCA-mutated patients treated with olaparib compared to those treated with physicians’ choice; the Company’s belief that the results of the OlympiAD trial support use of the BRACAnalysis CDx test to help inform treatment decisions in the metastatic breast cancer setting and will expand the patient population who can benefit from BRCA testing; the importance of the BRACAnalysis CDx test for this patient population and the ability to identify patients likely to benefit from PARP inhibition therapy; the number of patients with metastatic breast cancer who would benefit from BRCA testing if approved as a new indication; the Company’s ongoing collaboration with AstraZeneca to develop a novel companion diagnostic test to identify candidates for treatment with olaparib; and the Company's strategic directives under the captions “About BRACAnalysis CDx,” and "About Myriad Genetics."  These "forward-looking statements" are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by forward-looking statements. These risks and uncertainties include, but are not limited to: the risk that sales and profit margins of our molecular diagnostic tests and pharmaceutical and clinical services may decline; risks related to our ability to transition from our existing product portfolio to our new tests, including unexpected costs and delays; risks related to decisions or changes in governmental or private insurers’ reimbursement levels for our tests or our ability to obtain reimbursement for our new tests at comparable levels to our existing tests; risks related to increased competition and the development of new competing tests and services; the risk that we may be unable to develop or achieve commercial success for additional molecular diagnostic tests and pharmaceutical and clinical services in a timely manner, or at all; the risk that we may not successfully develop new markets for our molecular diagnostic tests and pharmaceutical and clinical services, including our ability to successfully generate revenue outside the United States; the risk that licenses to the technology underlying our molecular diagnostic tests and pharmaceutical and clinical services and any future tests and services are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with operating our laboratory testing facilities and our healthcare clinic; risks related to public concern over genetic testing in general or our tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to our ability to obtain new corporate collaborations or licenses and acquire new technologies or businesses on satisfactory terms, if at all; risks related to our ability to successfully integrate and derive benefits from any technologies or businesses that we license or acquire; risks related to our projections about our business, results of operations and financial condition; risks related to the potential market opportunity for our products and services; the risk that we or our licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying our tests; the risk of patent-infringement claims or challenges to the validity of our patents or other intellectual property; risks related to changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries, such as the Supreme Court decision in the lawsuit brought against us by the Association for Molecular Pathology et al; risks of new, changing and competitive technologies and regulations in the United States and internationally; and other factors discussed under the heading "Risk Factors" contained in Item 1A of our most recent Annual Report on Form 10-K for the fiscal year ended June 30, 2016, which has been filed with the Securities and Exchange Commission, as well as any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.  All information in this press release is as of the date of the release, and Myriad undertakes no duty to update this information unless required by law.


SALT LAKE CITY, Feb. 17, 2017 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc. (NASDAQ:MYGN), a global leader in personalized medicine, today announced new data demonstrating the utility of the Prolaris® test to more accurately classify mortality risk and guide the management of newly diagnosed men with prostate cancer. The data are being presented at the 2017 Genitourinary Cancers Symposium (ASCO GU) meeting in Orlando, Fla. “Myriad is pioneering personalized medicine for prostate cancer and is committed to helping men achieve their treatment goals,” said Michael Brawer, M.D., vice president of Medical Affairs, Myriad Genetic Laboratories.  “We are excited about the new data on prostate cancer reclassification being presented at ASCO GU, which adds to the growing body of evidence supporting the Prolaris test and will help urologists to match treatment options with patients’ risk profiles.” This study evaluated the prognostic information provided by the Prolaris test plus CAPRA (i.e., clinical features) to generate an estimate of prostate cancer mortality within 10 years of diagnosis versus NCCN risk category as determined by clinical features alone.  The analysis included data from 16,442 men who received the Prolaris test.  Based on clinical features alone, men were classified according to NCCN guidelines as low (n=8,695), favorable intermediate (n=3,347), intermediate (n=3,086) or high risk (n=1,224).  After recalculating the risk of prostate cancer mortality using the Prolaris test plus CAPRA, approximately one third of patients were reassigned to a different 10-year mortality risk category.  The specific reclassifications by NCCN category were as follows: “Clinical features alone are useful, but as this study illustrates, and was demonstrated by our numerous prior clinical validation studies, the Prolaris test is a powerful and independent predictor of clinical outcome that can substantially improve the risk classification of newly diagnosed men with prostate cancer,” said Brawer. Follow Myriad on Twitter via @MyriadGenetics and stay informed about symposium news and updates by using the hashtag #GU17. About Prolaris®  Prolaris is a novel 46-gene RNA-expression test that directly measures tumor cell growth characteristics for stratifying the risk of disease-specific mortality in patients with prostate cancer. Prolaris provides a quantitative measure of the RNA expression levels of genes involved in the progression of tumor growth.  Low gene expression is associated with a low risk of disease-specific mortality in men who may be candidates for active surveillance and high gene expression is associated with a higher risk of disease-specific mortality in patients who may benefit from additional therapy.  For more information visit: www.prolaris.com. About Myriad Genetics Myriad Genetics Inc., is a leading personalized medicine company dedicated to being a trusted advisor transforming patient lives worldwide with pioneering molecular diagnostics.  Myriad discovers and commercializes molecular diagnostic tests that: determine the risk of developing disease, accurately diagnose disease, assess the risk of disease progression, and guide treatment decisions across six major medical specialties where molecular diagnostics can significantly improve patient care and lower healthcare costs.  Myriad is focused on three strategic imperatives:  transitioning and expanding its hereditary cancer testing markets, diversifying its product portfolio through the introduction of new products and increasing the revenue contribution from international markets.  For more information on how Myriad is making a difference, please visit the Company's website: www.myriad.com. Myriad, the Myriad logo, BART, BRACAnalysis, Colaris, Colaris AP, myPath, myRisk, Myriad myRisk, myRisk Hereditary Cancer, myChoice, myPlan, BRACAnalysis CDx, Tumor BRACAnalysis CDx, myChoice HRD, EndoPredict, Vectra, GeneSight and Prolaris are trademarks or registered trademarks of Myriad Genetics, Inc. or its wholly owned subsidiaries in the United States and foreign countries. MYGN-F, MYGN-G. Safe Harbor Statement        This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995, including statements relating to data being presented at the at the 2017 Genitourinary Cancers Symposium;  the ability of the Prolaris test to more accurately classify mortality risk and guide the management of newly diagnosed men with prostate cancer; the ability to help urologists to match treatment options with patients’ risk profiles; and the Company’s strategic directives under the caption “About Myriad Genetics.”  These “forward-looking statements” are based on management’s current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those described or implied in the forward-looking statements. These risks include, but are not limited to: the risk that sales and profit margins of our existing molecular diagnostic tests and pharmaceutical and clinical services may decline or will not continue to increase at historical rates; risks related to our ability to transition from our existing product portfolio to our new tests; risks related to changes in the governmental or private insurers’ reimbursement levels for our tests or our ability to obtain reimbursement for our new tests at comparable levels to our existing tests; risks related to increased competition and the development of new competing tests and services; the risk that we may be unable to develop or achieve commercial success for additional molecular diagnostic tests and pharmaceutical and clinical services in a timely manner, or at all; the risk that we may not successfully develop new markets for our molecular diagnostic tests and pharmaceutical and clinical services, including our ability to successfully generate revenue outside the United States; the risk that licenses to the technology underlying our molecular diagnostic tests and pharmaceutical and clinical services tests and any future tests are terminated or cannot be maintained on satisfactory terms; risks related to delays or other problems with operating our laboratory testing facilities; risks related to public concern over our genetic testing in general or our tests in particular; risks related to regulatory requirements or enforcement in the United States and foreign countries and changes in the structure of the healthcare system or healthcare payment systems; risks related to our ability to obtain new corporate collaborations or licenses and acquire new technologies or businesses on satisfactory terms, if at all; risks related to our ability to successfully integrate and derive benefits from any technologies or businesses that we license or acquire, including but not limited to our acquisition of Assurex, Sividon and the Clinic; risks related to our projections about the potential market opportunity for our products; the risk that we or our licensors may be unable to protect or that third parties will infringe the proprietary technologies underlying our tests; the risk of patent-infringement claims or challenges to the validity of our patents; risks related to changes in intellectual property laws covering our molecular diagnostic tests and pharmaceutical and clinical services and patents or enforcement in the United States and foreign countries, such as the Supreme Court decision in the lawsuit brought against us by the Association for Molecular Pathology et al; risks of new, changing and competitive technologies and regulations in the United States and internationally; the risk that we may be unable to comply with financial operating covenants under our credit or lending agreements;  the risk that we will be unable to pay, when due, amounts due under our credit or lending agreements; and other factors discussed under the heading “Risk Factors” contained in Item 1A of our Annual report on Form 10-K for the fiscal year ended June 30, 2016, which has been filed with the Securities and Exchange Commission, as well as any updates to those risk factors filed from time to time in our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K.


Patent
Russell, Johnson, Bart and Petka | Date: 2012-11-21

A method for conducting secure transactions is disclosed, the method comprising receiving from a customer a customer identifier and a value for at least one prescribed personal data field different from the customer identifier; certifying that the value of the at least one prescribed personal data field is associated with the customer; and reducing the price of a deliverable by a prescribed discount in exchange for the value for the at least one prescribed personal data field. An apparatus for use in carrying out the comprises a biometric sensor configured to receive a biometric input; a memory configured to store a biometric template associated with a user, the memory configured to store a value associated with the user, the value being associated with a prescribed personal data field; and a processor coupled to the biometric sensor and the memory, the processor configured to authenticate a biometric input based on the biometric template, the processor configured to output to a receiving party associated with a deliverable the value associated with the user such that the receiving party reduces a price of the deliverable by a prescribed discount when the biometric input is authentic.


Vitolins M.Z.,BART
Journal of clinical oncology : official journal of the American Society of Clinical Oncology | Year: 2013

Hot flashes occur in approximately 80% of androgen-deprived men. Few intervention studies have been conducted to relieve hot flashes in men. Eligible androgen-deprived men were randomly assigned to one of four daily regimens (2 × 2 factorial design) for 12 weeks: milk protein powder and placebo pill, venlafaxine and milk protein powder, soy protein powder and placebo pill, or venlafaxine and soy protein powder. The primary end point was hot flash symptom severity score (HFSSS), defined as number of hot flashes times severity. The secondary end point was quality of life (QoL), assessed by using the Functional Assessment of Cancer Therapy-Prostate. In all, 120 men age 46 to 91 years participated. Most were white (78%) and overweight or obese (83%). Toxicity was minimal. Neither venlafaxine nor soy protein alone or in combination had a significant effect on HFSSS. Soy protein, but not venlafaxine, improved measures of QoL. In androgen-deprived men, neither venlafaxine nor soy proved effective in reducing hot flashes. Interventions that appear effective for decreasing hot flashes in women may not always turn out to be effective in men.


An intra-oral device for protecting oral tissues during radiation treatment is disclosed. In an embodiment, the device includes substantially a U-shaped upper member and lower members coupled to the upper member at their first and the second ends, and a substantially oval-shaped protective element disposed between the first ends of the upper and lower members and the second ends of the upper and lower members and movably coupled with one of the upper or lower members so as to provide for a three-dimensional spatial adjustment of the protective element between the first and second ends of the upper and lower members. The upper and lower members are configured to receive upper and lower teeth of a patient and the protective element is configured to engage a tongue of the patient so that the tongue is selectively positioned for treatment and/or diagnostic procedures.


Patent
Bart | Date: 2011-08-10

The invention concerns an apparatus (1) and a method for the handling of plates or sheets (2) on a surface (3). The apparatus includes a moveable loading platform (6) for the plates, which platform is moveable by driving means (8) for the plates. The platform is carried by a vertical suspension beam (5). Upon the suspension beam (5) a first carrying arm (16) is mounted perpendicularly to the beam. The said arm (16) is surrounded by an element (26) and has a fixed connection to the loading platform (6). First control means (22) allow the required rotation at an angle A of the element (26) with the loading platform (6) around the first carrying arm. The suspension beam has a second carrying arm (17) mounted crosswise to this beam (5). Its free top end (19) can be connected to a hook (20) of a hoist cable (4) as part of a hoisting device.


There is disclosed a vehicle comprising a chassis (1) provided with a suspension by means of which at least one rigid wheel axle (3) is steerably mounted to the chassis, being capable of spring movement in the vertical direction of the vehicle, wherein said suspension comprises at least one leaf spring (4,5), which leaf spring is supported by the wheel axle in a manner in which the wheel axle is movable in a direction transversely to the longitudinal direction of the wheel axle, in the horizontal plane, relative to the leaf spring. The leaf spring may be mounted for free spring movement at one of its ends, where it is supported by the wheel axle, and the leaf spring may comprise a part in the form of a curved circular segment.


Patent
Bart | Date: 2016-05-16

A firearm safety system and method is described herein. The system may include a tracking system, a smart firearm and/or a smart magazine, and a smart tracking unit. The tracking system is in communication with satellites that monitor specific locations, a smart firearm and a portable electronic device. The tracking system includes an internal geographical database of specific monitored locations. The smart firearm includes a microprocessor and a receiver. The motor operates in response to a signal received, which may indicate that the firearm is approaching a no gun safety zone, whereby the signal causes the microprocessor to operate the automatic safety lock to prevent the apparatus from operating. The receiver monitors signals and receives location data from the satellites. The method of operating a smart firearm includes receiving a signal at the at least one receiver and responding to the signal by locking the automatic safety lock.

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