Chaudhari M.A.,Government Medical College |
Shah S.M.,Baroda Medical College
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2017
Background: A number of studies have been carried out in India and worldwide reporting different incidence rates of surgical site infections (SSIs), various pathogens isolated, and their antibiotic sensitivity pattern. The difference incidence rates of SSIs may be due to differences in the hospital set-up, preventive measures taken and the prophylactic use of antibiotics. Even in the same hospital, the same type of survey at different periods may report different incidence rates of SSIs depending on prevailing conditions at the time of survey. Aims and Objectives: To find out the current rate of incidence of SSI with common pathogen causing SSI and their susceptibility pattern in Sir Sayajirao General Hospital (SSGH), Vadodara. Materials and Methods: This prospective study included 953 patients undergoing major operations in major surgical departments of Shri Sayajirao General Hospital, Vadodara over a period of 8-month. Results: Out of 953 patients, 35 developed clinical signs and symptoms suggesting SSI (3.67%). Out of these 35 cases, no pathogen was isolated from 22 cases which may be due to subjective errors in collection and processing of samples. The predominant organisms isolated were Gram-negative organisms (84.6%), while Staphylococcus aureus-the only Gram-positive organism isolated contributed 15.4%. Imipenem, ampicillin+sulbactam, cefotaxime, and amikacin were the most sensitive antibiotic for Gram-negative organisms. Vancomycin, cloxacillin, oxacillin, and amoxicillin-clavulanic acid combination were most sensitive antibiotic for Gram-positive organisms. Most of the commonly used antibiotics have got resistance for isolated organisms. Among them, the predominant is cefazolin, chloramphenicol, ofloxacin (OFX), erythromycin, roxithromycin and penicillin for Gram-positive organisms and netilmicin, tobramycin, piperacillin, OFX and gatifloxacin for Gram-negative organisms. Conclusion: Regarding SSI, nowadays there is a trend toward comparative studies in the same hospital over years. In SSGH, Vadodara, there is a decrease in rate of incidence of SSI over years. © 2016 Mayur A Chaudhari and Shreya M Shah.
Patel S.,B J Medical College And Civil Hospital |
Kinariwala D.,B J Medical College And Civil Hospital |
Javadekar T.,Baroda Medical College
Indian Journal of Sexually Transmitted Diseases | Year: 2011
Objectives: The present study was undertaken to determine the prevalence of respiratory, gastrointestinal and other pathogens in 100 Human Immunodeficiency Virus (HIV) seropositive patients. Settings: This study was carried out on randomly selected 100 HIV seropositive patients from S. S. G. Hospital during the period from Jan 2006 to Jan 2007. Materials and Methods: Sputum samples, stool samples and oral swabs were collected from all the patients and cerebrospinal fluid (CSF) was collected from symptomatic patients and processed as per the standard protocol. Sputum samples were examined by microscopy and cultured for bacterial respiratory pathogens. Stool samples were concentrated and examined by microscopy for enteric parasites. Oral swabs and CSF were also examined microscopically and cultured for fungal pathogens. CSF was also examined for bacterial pathogens. Results: A total of 101 pathogens were detected in 60 patients. More than one pathogen was observed in 30 patients. Candida was the commonest isolate (32.67%), followed by Mycobacterium tuberculosis (22.71%) and Cryptosporidium parvum (19.8%). Conclusions: Since opportunistic infections are a major cause of mortality and morbidity in HIV seropositive patients, an early diagnosis and effective treatment are required to tackle them. The type of pathogens infecting HIV patients varies from region to region, and therefore such patients should be constantly screened for these pathogens.
PubMed | Baroda Medical College and GMERS Medical College
Type: Journal Article | Journal: Journal of family medicine and primary care | Year: 2016
National AIDS Control Organization (NACO) has expanded the reach of anti retroviral therapy (ART) to combat the epidemic of HIV/AIDS in India which has one of the largest populations of people living with HIV/AIDS (PLWHA) in the world. One of the major challenges related to ART is a lifelong commitment by patients to adhere diligently to daily medication dosing schedules and scheduled visits to the ART center. Hence, the current study is carried out to assess the drug adherence rate and loss to follow-up (LFU) among PLWHA attending ART centre of a tertiary care hospital in Western India.The current cross-sectional study was carried out using medical records of all patients registered at ART Center, Shree Sayaji General Hospital, Vadodara after taking Ethical Clearance from Local IRB. LFU was classified according to NACO guidelines. Data were collected using a standardized data extraction form as per NACO treatment card. Data entry and analysis were performed using Epi Info software.Of 755 PLWHA registered at ART center, 534 (70.7%) subjects were alive on ART, 61 (8%) were transferred out, 68 (9%) died, and 92 (17%) were LFU. Nearly, 57% PLWHA have drug adherence rate of more than 95%. Education status of the participant showed independent and significant association with drug adherence.This study showed 57.3% were adherent to ART among PLWHA, whereas 17.22% were lost to follow-up. Hence, there is a need to emphasize on increasing drug adherence rate and on outreach activities to combat LFU.
Rajapurkar M.M.,Muljibhai Patel Urological Hospital |
Hegde U.,Muljibhai Patel Urological Hospital |
Bhattacharya A.,Baroda Medical College |
Alam M.G.,University of Arkansas for Medical Sciences |
Shah S.V.,University of Arkansas for Medical Sciences
Toxicology Mechanisms and Methods | Year: 2013
Compelling experimental evidence exists for the role of oxidants and iron in glomerular disease. In preliminary studies, we confirmed increased urinary catalytic iron in patients with glomerulonephritis and diabetic nephropathy. We conducted two separate single-center, prospective, single-armed, open-labeled, proof-of-concept studies to evaluate the safety and efficacy of an oral iron chelator in patients with glomerulonephritis and diabetic nephropathy. Study 1 comprised 15 patients with biopsy-proven glomerulonephritis who had persistent proteinuria despite treatment with steroids and/or cyclophosphamides. Study 2 comprised 38 adult patients with diabetic nephropathy. Patients in Study 1 were treated with deferiprone (50mg/kg/day) in three divided doses for 6 months and Study 2 patients were treated for 9 months. In Study 1, two patients had severe gastrointestinal intolerance and withdrew from the study after one dose and are not included in the results. There was a significant reduction (47±9% mean) in 24-h urinary protein (4.01±1.61 to 2.21±1.62 [p = 0.009]), with no significant changes in serum creatinine. In Study 2, treatment with deferiprone resulted in a marked, persistent drop in the mean albumin/creatinine ratio (187±47 at baseline to 25±7mg/g, [p = 0.01]) and stable renal function over a 9-month period. No clinically significant adverse events were observed in either study. Although these are small, open-labeled, and non-randomized studies, our results suggest that future randomized, double-blind trials examining the utility of deferiprone to treat glomerular diseases appear warranted. © 2013 Informa Healthcare USA, Inc.
Chavali V.H.,Baroda Medical College |
Chavali K.H.,Government Medical College
Journal of Forensic and Legal Medicine | Year: 2013
Kirschner's wires (popularly known as 'K-wires' or 'pins') are used commonly in various orthopaedic surgical fixations. Around the shoulder joint such pins are used for fixation of acromioclavicular joint, sternoclavicular joint, proximal humerus and clavicle. In such fixations, spontaneous loosening and extraction of pins would not cause as much anxiety and worry to the surgeon as a pin which breaks and migrates within the body. Such alarm is not just due to the potential damage that the migrating pin can cause, but also due to fear of misinterpretation of the event in legal suits as negligence and the subsequent claims for heavy damages. We present here a case where a patient attempted to raise allegation of negligence (probably planning subsequent claim for damages) by fabricating pin migration. The literature of such an unusual case is reviewed in brief. © 2012 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.
Chavali V.H.,Baroda Medical College
Journal of Clinical Orthopaedics and Trauma | Year: 2012
Accessory ossicles and sesamoid bones are skeletal variations, more commonly seen in the region of foot and ankle. Most such accessory and sesamoid bones remain asymptomatic. However overuse and trauma can make such feet symptomatic. Knowledge of such bony ossicles is essential in the management of patients presenting with foot pain.Dorsal foot pain can be caused by a symptomatic Os intermetatarseum - an accessory ossicle found between the bases of first and second metatarsals and the medial cuneiform. Its incidence has not been well established because of insufficient appropriate multi-centric anatomical, radiological and orthopaedic studies. A case of dorsal foot pain in a soccer player, caused by an Os intermetatarseum is reported here. A brief review of the literature is also presented. © 2012 Delhi Orthopaedic Association.
Dharaiya N.,Baroda Medical College |
Maitra N.,Baroda Medical College
Journal of Obstetrics and Gynecology of India | Year: 2014
Introduction: Cervical cancer is the most common cancer among Indian women. Only 5 % of women in developing countries have ever been screened for cervical abnormalities.Objectives: To study the correlation of cytology and colposcopy in VIA-positive women attending the Gynaecology clinic.Materials and Methods: This prospective cross-sectional study on 200 symptomatic women compares the role of cytology and colposcopy in the assessment of subjects testing positive for acetowhite lesions on the cervix after application of 5 % acetic acid (VIA).Results: 200/637 women screened in OPD tested VIA positive, giving a positivity rate of 31 %. Six smears were reported as LGSIL or HGSIL giving a cytological abnormality rate of 3 %. The association between cytology and Reid’s score was statistically significant at a p value of 0.02. Of the 4 cases with biopsy-confirmed invasive cancer, cytology reported 2 as LGSIL and 2 as HGSIL. Colposcopy reported all these women as CIN 2/3.Conclusion: The accuracies of Pap smear cytology and colposcopy in the diagnosis of precancerous and cancerous lesions of cervix were good. © 2014, Federation of Obstetric & Gynecological Societies of India.
Prashanth V.,Baroda Medical College |
Pandya V.K.,Baroda Medical College
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2011
The existence of complications of suppurative otitis media and efforts to control it go far back into history. Early diagnosis and management have been greatly modified by the extensive use of CT scan and higher antibiotics. Despite an overall decline in the incidence of complications of otitis media, severe complications still exist with high mortality. Suggested reasons are decrease in physician's experience and changing of the virulence and susceptibility of causative organism. This series is a prospective study of 18 cases of otogenic brain abscess, carried out in Department of ENT and Head & Neck Surgery, SSG Hospital, Baroda from June 2005 to June 2008. We emphasize on confirmation of resolution of brain abscess by CT scan. This will eliminate recurrent/residual abscess and help in reduced overall mortality and morbidity. © 2011 Association of Otolaryngologists of India.
Naswa S.,Fortis Hospital Mulund |
Marfatia Y.,Baroda Medical College
Indian Journal of Dermatology | Year: 2015
Carcinoma of the cervix is the second to fourth most common malignancy in women. It metastasizes most often to the lungs, bones, and liver. Skin involvement originating from cervical cancer is rare, even in the terminal stages of the disease. Cutaneous metastasis of cervical cancer usually presents as cutaneous nodules, papules/plaques, maculopapular rash, and diffuse inflammatory rash. We report a rare case (only the second reported case to the best of our knowledge) of a 50-year-old woman with cutaneous metastasis in form of fungating ulcerative growth on mons pubis as presenting feature of carcinoma cervix. © 2015 Indian Journal of Dermatology | Published by Wolters Kluwer - Medknow.
Bharti A.H.,Baroda Medical College |
Chotaliya K.,Baroda Medical College |
Marfatia Y.S.,Baroda Medical College
Indian Journal of Sexually Transmitted Diseases | Year: 2013
Human papillomavirus (HPV) constitutes the majority of newly acquired sexually transmitted infections (STIs) in United States as per the centers for disease control factsheet 2013. Genital HPV is the most common STI with incidence of about 5.5 million world-wide, nearly 75% of sexually active men and women have been exposed to HPV at some point in their lives. Oral Sexual behavior is an important contributor to infection of HPV in the oral mucosa especially in cases known to practice high risk behavior and initiating the same at an early age. HPV infection of the oral mucosa currents is believed to affect 1-50% of the general population, depending on the method used for diagnosis. The immune system clears most HPV naturally within 2 years (about 90%), but the ones that persist can cause serious diseases. HPV is an essential carcinogen being implicated increasingly in association with cancers occurring at numerous sites in the body. Though there does not occur any specific treatment for the HPV infection, the diseases it causes are treatable such as genital warts, cervical and other cancers.