Baqiyatallah Medical Sciences University
Tehran, Iran

Baqiyatallah University of Medical science is a public and special medical university in Tehran, Iran.The BMSU was founded in 1994 as the primary medical institution for the Army of the Guardians of the Islamic Revolution . The BMSU as well as the Institute of Research for Military Medicine is operated by the IRGC and currently trains students up to Ph.D.The BMSU operates three hospitals, among them the large Baqiyatallah Hospital near Vanak, Tehran, as well as a dental hospital. Wikipedia.

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Oliveira M.R.D.,Federal University of Mato Grosso | Nabavi S.F.,Baqiyatallah Medical Sciences University | Daglia M.,University of Pavia | Rastrelli L.,University of Salerno | Nabavi S.M.,Baqiyatallah Medical Sciences University
Pharmacological Research | Year: 2016

Epigallocatechin gallate (EGCG) is a flavonoid belonging to the chemical class of falvan-3-ols (catechins) esterified with gallic acid. It is the main catechin found in green tea (Camellia sinensis L.) accounting for about 50% of its total polyphenols. Extensive research performed in recent years has revealed that green tea demonstrates a wide range of positive biological activities against serious chronic diseases such as cardiovascular and neurodegenerative pathologies, cancer, metabolic syndrome and type 2 diabetes. These protective properties can be traced back to the potent antioxidant and anti-inflammatory activities of EGCG. Recent studies have suggested that it may exert its beneficial effects by modulating mitochondrial functions impacting mitochondrial biogenesis, bioenergetic control (ATP production and anabolism), alteration of the cell cycle, and mitochondria-related apoptosis. This review evaluates recent evidence on the ability of EGCG to exert critical influence on the above mentioned pathways. © 2015 Elsevier Ltd. All rights reserved.

Cheraghali A.M.,Baqiyatallah Medical Sciences University
DARU, Journal of Pharmaceutical Sciences | Year: 2013

Iran in recent decade faced several regional and international sanctions in foreign trade, financial and banking services. Iran national pharmaceutical industry has always played a major role in providing medicines to the Iranian patients. However, following the sanctions it has faced profound difficulties for importing of both finished products and pharmaceutical raw materials. Although medicines are exempted from sanctions, due to restriction on money transaction and proper insurance Iranian pharmaceutical companies have to pay cash in advance for imports of medicines and raw materials or to secure offshore funds at very high risks. Current situation in Iran pharmaceutical market confirms that the sanctions against Iran are affecting ordinary citizens and national health sector which resulted to reduction of availability of lifesaving medicines in the local market and has caused increasing pain and suffering for Iranian patients. © 2013 Cheraghali; licensee BioMed Central Ltd.

Khedmat H.,Baqiyatallah Medical Sciences University
Annals of Transplantation | Year: 2010

Background: Post-transplant lymphoproliferative disorders (PTLDs) can occur within the allograft, representing a differential diagnosis for an acute rejection episode; in this study, we collected data from PTLD patients involving kidney allografts, and compared their characteristics with other renal transplant patients from the same centers who developed PTLDs localized elsewhere. Material/Methods: A comprehensive search was made by Pubmed and Google Scholar for reports of lymphoproliferative disorders after renal transplantation. Data from 17 studies were included into analysis. Having at least 1 patient with renal allograft involvement by PTLD was inclusion criterion. Data for patients was collected by use of a standard questionnaire. Results: PTLD complicated renal allograft in 46 (37%) of our study population. Renal transplant recipients with allograft localization of PTLD had better survival than other PTLD patients unless they developed multi-organ involvement (p=0.007). Five-year survival rate was 73% for graft PTLD and 42% for other localizations. Graft PTLD patients had shorter time from transplant to PTLD (p=0.01) and were more likely to present as polyclonal and polymorph in their histological evaluations (p<0.05). Conclusions: Renal transplant recipients who develop allograft dysfunction during the early post-transplantation period should get full evaluations for a potential PTLD development at their allograft site. Before development of multi-organ involvement allograft PTLD in renal transplant patients has a benign behavior; therefore it is crucial to evaluate renal recipients with initial symptoms of PTLDs. © Ann Transplant.

Aalaei-Andabili S.H.,Baqiyatallah Medical Sciences University | Alavian S.M.,Baqiyatallah Medical Sciences University
Vaccine | Year: 2012

Introduction: Association of increased levels of CD4+CD25+ regulatory T cells (Tregs) with impaired immune response and hepatitis B infection progression has been proposed. For determination of Tregs various effects among hepatitis B infected patients we performed a meta-analysis of the available literature. Methods: Current content, abstract books of congresses, and electronic databases were searched. Critical appraisal has been done. According to the result of heterogeneity tests (Q, I-squared, and Tau-squared), we used fix/random model for analysis. Result: Twelve studies that fulfilled inclusion criteria entered to analysis. Pooled estimation of reported results showed that CD4+CD25+ Tregs have higher expression of forkhead box P3 (FoxP3) versus CD4+CD25- Tregs, odd ratio (OR) was 31.49 (95% Confidence Intervals (CI): 5.09-194.94). Tregs level among chronic hepatitis B (CHB) patients was 77% (OR=1.77 95% CI: 1.43-2.19) higher than healthy controls. Patients with more than 10,000,000 HBV copies/ml have higher level of Tregs (OR: 1.24 95% CI: 1.08-1.41) comparing subjects with less than that. CHB patients have increased level of Tregs versus acute hepatitis B patients (OR=1.33 95% CI: 1.16-1.52). CD8 cells activity increased significantly after depletion of circulating Tregs (OR=1.93 CI: 1.37-2.73). Also, Tregs reduce response to treatment and non-responders to INF-α had higher level of Tregs (OR=1.60 95% CI: 1.09-2.36). In addition, Tregs increase risk of hepatocellular carcinoma (HCC) (OR=1.36 95%CI: 1.10-1.69). Conclusion: Tregs influence HBV infected patients in various states. Tregs determine the disease prognosis by leading to infection progression and impairing immune response. So, Tregs are therapeutic target for immunotherapy of HBV infection. © 2012 Elsevier Ltd.

Ghamar-Chehreh M.E.,Baqiyatallah Medical Sciences University
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia | Year: 2014

Despite the introduction of strict hygienic precautions preventing infection spread of hepatitis C virus (HCV) in dialysis settings, this infection is still prevalent among dialysis patients due to procedures making the patients vulnerable to infection through blood contamination. Treatment of HCV infection in dialysis patients is also less successful than that in the non-uremic population due to contraindication of using ribavirin, a main drug, in the infected patients. In this review article we aim to investigate the feasibility of the current antiviral therapies in dialysis patients infected with HCV infection.

Panahi Y.,Baqiyatallah Medical Sciences University
Current pharmaceutical biotechnology | Year: 2015

Premature ejaculation (PE) is an important and common sexual issue in male adults, since its etiology is still unknown. There are many suggested treatments such as paroxetine, clomipramine, dapoxetine, tramadol and topical agents; all of them have stigma or considerable side effects. Therefore, present study aimed to examine the effect of on-demand caffeine consumption on treating patients with PE. In this double blind RCT, 40 otherwise healthy individuals with PE were allocated into 2 groups of caffeine and placebo group. The caffeine group received 100 mg encapsulated caffeine for 3 weeks, 2 hours prior to each intercourse. Intravaginal ejaculation latency time (IELT) and index of sexual satisfaction (ISS) were measured before and after treatment in both groups. Suitable statistical analysis was performed. (Registration code: IRCT2013091614677N1). Mean age of the participants was 39.88±8.72 years. No significant difference was found between pre-treatment and post-treatment values of both IELT and ISS in the placebo group, but significant difference was seen in post treatment values between our two groups and pre-treatment and post-treatment values of the caffeine group (IELT: 144s vs 312s, p<0.001 and ISS: 77 vs 97, p<0.001; respectively). Furthermore, high significant correlation was found in post-treatment values (r>0.07, p<0.05). There are negligible scientific evidences regarding the beneficial effects of caffeine on several aspects of sexual life, which makes comparison impossible. Considering the fact that caffeine is a well-known and widely used drug in common disease, using this compound will not result in any stigma. Our study demonstrates that 100mg on-demand caffeine can significantly increase both IELT and ISS. Furthermore, the slope of these increasings is correlated with each other. More studies are needed to make stronger conclusions.

Cheraghali A.M.,Baqiyatallah Medical Sciences University
Iranian Journal of Public Health | Year: 2012

Despite importance of blood transfusion services as life saving procedures, some countries are unable to meet their national requirements for blood and blood components in a timely manner. Since establishment of Iran Blood Transfusion Organization (IBTO) in 1974 as an integral part of national health system, Iran has experienced a drastic improvement both in availability and safety of blood and blood products. Iran now has not only reached to a 100% non remunerated voluntary blood donation but also secured a national self sufficiency of blood and blood components. Efforts of IBTO as the sole player of transfusion medicines in Iran enabled the country for timely providing of life saving blood transfusion services for all Iranian patients in need of such services. In order to meet the country's demand in 2011 about 2 million units of whole blood for a population of about 75 million collected by IBTO. This indicates 26.2 donations per 1000 population. Currently about 94% of blood donors in Iran are 25-35 years old males and contribution of female donors in blood donation is less than 6%. IBTO screen all donated blood for important transfusion transmissible infections such as HBV, HIV, HCV and syphilis. Prevalence of HBsAg, HCV and HIV in donated blood in IBTO in 2011 was 0.20%, 0.06% and 0.004% respectively.

Ranjbar R.,Baqiyatallah Medical Sciences University
The new microbiologica | Year: 2014

Microbial typing is often employed to determine the source and routes of infections, confirm or rule out outbreaks, trace cross-transmission of healthcare-associated pathogens, recognize virulent strains and evaluate the effectiveness of control measures. Conventional microbial typing methods have occasionally been useful in describing the epidemiology of infectious diseases. However, these methods are generally considered too variable, labour intensive and time-consuming to be of practical value in epidemiological investigations. Moreover, these approaches have proved to be insufficiently discriminatory and poorly reproducible. DNA-based typing methods rely on the analysis of the genetic material of a microorganism. In recent years, several methods have been introduced and developed for investigation of the molecular epidemiology of microbial pathogens. Each of them has advantages and limitations that make them useful in some studies and restrictive in others. The choice of a molecular typing method therefore will depend on the skill level and resources of the laboratory and the aim and scale of the investigation. This study reviews the most popular DNA-based molecular typing methods used in the epidemiology of bacterial pathogens together with their advantages and limitations.

Inflammation is a key component in the pathogenesis of sulfur mustard (SM)-induced skin complications. Here, the levels of interleukin (IL) -2, IL-4, IL-6, and IL-10 were evaluated in patients with chronic SM-induced complications. Seventy-four serum samples were collected from SM-injured veterans (SM group; n = 37) and nonchemically injured patients (control group; n = 37) with skin pruritus. The levels of IL-2, IL-4, IL-6, and IL-10 were evaluated by sandwich enzyme-linked immunosorbant assay technique in both nil and mitogen medium. No significant difference was found in pruritus score between SM (74.16 +/- 5.93) and control (74.48 +/- 6.15) groups (P > .05). The mean serum concentrations of IL-2 and IL-6 were found to be significantly elevated in the control compared with the SM group (P < .05). However, no significant difference was observed between the study groups regarding serum levels of IL-4 and IL-10 (P > .05). Serum IL-2 (in both SM and control groups) and IL-6 (in the control group) concentrations were significantly correlated with pruritus score while no significant association was found for IL-4 and IL-10. Serum concentrations of IL-2, IL-6, and IL-10 are significantly decreased in SM-exposed patients with chronic pruritus. Such alterations might represent a plausible mechanism for tissue damage and skin itching following SM exposure. Therefore, variation of ILs may also contribute to skin pruritus induced by SM.

Nabavi S.M.,Baqiyatallah Medical Sciences University
Current pharmaceutical biotechnology | Year: 2015

Atherosclerosis is a multifactorial disease mainly caused by deposition of low-density lipoprotein (LD) cholesterol in macrophages of arterial walls. Atherosclerosis leads to heart attacks as well as stroke. Epidemiological studies showed that there is an inverse correlation between fruit and vegetable consumption and the risk of atherosclerosis. The promising effect of high vegetable and fruit containing diet on atherosclerosis is approved by several experimental studies on isolated phytochemicals such as flavonoids. Flavonoids are known to up-regulate endogenous antioxidant system, suppress oxidative and nitrosative stress, decrease macrophage oxidative stress through cellular oxygenase inhibition as well as interaction with several signal transduction pathways and from these ways, have therapeutic effects against atherosclerosis. Naringenin is a well known flavonoid belonging to the chemical class of flavanones. It is especially abundant in citrus fruits, especially grapefruits. A plethora of evidences ascribes to naringenin antiatherosclerotic effects. Naringenin abilities to decrease LDL and triglycerides as well as inhibit glucose uptake; increase high-density lipoprotein (HDL); co-oxidation of NADH; suppress protein oxidation; protect against intercellular adhesion molecule-1(ICAM-1); suppress macrophage inflammation; inhibit leukotriene B4, monocyte adhesion and foam cell formation; induce of HO-1 and G 0/G 1 cell cycle arrest in vascular smooth muscle cells (VSMC) and down regulate atherosclerosis related genes are believed to have crucial role in the promising role against atherosclerosis. In the present review, we have summarized the available literature data on the anti-atherosclerotic effects of naringenin and its possible mechanisms of action.

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