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Baotou, China

Li L.,Tianjin Medical University | Zhang M.-F.,Tianjin Medical University | Wang B.-M.,Tianjin Medical University | Bai X.,Tianjin Medical University | And 2 more authors.
World Chinese Journal of Digestology | Year: 2011

Aim: To summarize the histological features of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and chronic virus hepatitis of type B (CHB), and to investigate the significance of ERα and TGF-β1 expression in the above liver diseases. Methods: Histological examination was performed using liver biopsy specimens from 29 patients with AIH, 18 patients with PBC, and 15 patients with CHB. Immunohistochemistry was used to detect the expression of ERα and TGF-β1 in the above specimens and 8 normal liver tissue specimens. Results: The incidences of feathery degeneration, bile thrombus, and bile duct hyperplasia were significantly different among AIH, PBC, and CHB (33.33% vs 3.45%, 6.67%; 44.44% vs 6.92%, 6.67%; 61.11% vs 34.48%, 13.33%; all P < 0.05). In patients with PBC, the expression of TGF-β1 was significantly higher in the portal area than in the hepatic lobule (31.80 ± 15.92 vs 16.00 ± 6.28, P < 0.05). The expression of TGF-β1 in the portal area was significantly higher in PBC than in the other three groups (31.80 ± 15.92 vs 10.00 ± 12.15, 13.44 ± 13.51, 3.20 ± 3.20, all P < 0.01). In normal controls, the expression of TGF-β1 was significantly higher in the hepatic lobule than in the portal area (16.85 ± 3.48 vs 3.20 ± 3.20, P < 0.01). The expression of ERα was significantly different among the four groups. The expression of ERα was significantly higher in AIH and PBC than in normal controls (94.78 ± 48.36, 110.40 ± 36.66 vs 28.98 ± 24.60, both P < 0.01). Conclusion: Different autoimmune liver diseases have different histological features. AIH is characterized by interface hepatitis, and PBC by destructive cholangitis. ERα and TGF-β1 may mediate and promote the development and progression of autoimmune liver diseases. Source

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