Baoshan Hospital of Integrated Traditional Chinese and Western Medicine

Shanghai, China

Baoshan Hospital of Integrated Traditional Chinese and Western Medicine

Shanghai, China
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Wu J.,Shanghai University of Traditional Chinese Medicine | Lu B.,Tongji University | Yang D.-D.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Wu C.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2017

Aim: This study aimed to investigate the effects of BuzhongYiqi decoction (BYD) on the wound flora and explore the mechanism of BYD in promoting wound healing by metagenomics with Miseq sequencing platform. Methods: 12 patients meeting the inclusion criteria were recruited after surgery for anal fistula and randomly divided into BYD group (BYD + food allergy; n=6), and positive control group (food allergy; n=6). Six patients without food allergy were assigned into negative control group. Results: 1) At the phylum level, the proportion of Cyanobacteria and Fusobacteria in BYD group was significantly lower than that in positive control group, while that of Bacteroidetes and Proteobacteria was significantly higher (P<0.05). The proportion of Fusobacteria in BYD group was significantly lower than those in negative control group (P<0.05). The proportion of Cyanobacteria and Fusobacteria in BYD group was significantly lower than in positive control group (P<0.05). The proportion of Fusobacteria in negative control group was significantly higher than in positive control group (P<0.05). 2) At the genus level, the proportion of Corynebacterium, Dermatophilus, CandidatusRhodoluna, Saccharopolyspora, Emticicia, Bacillus, Clostridium, Bradyrhizobium, Rubellimicrobium, Alcaligenes, Comamonas, Morganella, Serratia, Stenotrophomonas in positive control group was significantly higher than in negative control group, but that of Eggerthella and Dialister in positive control group was significantly lower than in negative control group (P<0.05). The proportion of Eggerthella, Dorea, Dialister, Janthinobacterium and Bilophila in positive control group was significantly higher than in BYD group (P<0.05), but that of Rhodococcus and Serratia in positive control group was significantly lower than in BYD group (P<0.05). There was significant difference in the time to wound healing among these three groups (P<0.05). Conclusion: BYD may regulate the microbial diversity and population structure and make their metabolites to promote wound healing in patients with food allergy after surgery for anal fistula. © 2017, E-Century Publishing Corporation. All rights reserved.


Xiong Y.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Zhao J.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine
International Eye Science | Year: 2015

AIM: To investigatethe prevalence and awareness of diabetic retinopathy (DR), as well as its influential factors, among patients with diabetes mellitus in the Songnan Community of Shanghai. METHODS: Residents with diabetes mellitus were randomly sampled in Shanghai's Songnan Community. These patients received full physical examinations. DR was diagnosed using non-mydriatic fundus photography. The patients completed a survey concerning their general knowledge and awareness of DR. RESULTS: A total of 1120 valid questionnaires and fundus photographs were collected. The incidence of DR among patients with diabetes was 23.6%; 17.1% had mild DR, 5.1% had moderate DR and 1.4% had severe DR. Of the survey participants, 14.1% received ophthalmic examinations over the last year, 71.5% knew their normal blood glucose levels, 85.7% were aware of the possibility of systemic complications caused by diabetes, 77.2% were aware of ocular complications, 47.9% were aware of the need for regular fundus examinations, 58.0% were aware that the early treatment of DR is an important measure to prevent visual impairment, and 59.9% were willing to participate in regular health education seminars. A univariate analysis indicated that the knowledge and awareness scores regarding DR were correlated with age, education level, type of medical insurance, duration of diabetes, diet control, blood glucose monitoring, fasting blood glucose level, exercise frequency and DR stage. A logistic regression analysis indicated that the factors affecting the DR awareness scores were age, education level, type of medical insurance, stage of diabetes, diet control, exercise frequency and DR stage. CONCLUSION: The patients with diabetes in the Songnan Community lacked sufficient awareness of DR prevention and treatment methods. The existing awareness of DR among the survey participants did not lead to effective prevention or treatment actions associated with this condition. It is necessary to educate patients with diabetes in local communities regarding DR. © 2015 by the IJO Press.


Zhao Y.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Yang X.,Shanghai Changning Maternity Infant Health Hospital | Hao X.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Pan X.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | And 4 more authors.
Tumor Biology | Year: 2014

Due to its important biological function as a key negative regulator of p53, the mouse double minute 2 homologue (MDM2) gene has been extensively studied. A functional variant in the MDM2 gene promoter, single-nucleotide polymorphism 309 (SNP309) T > G (rs2279744), has been reported to cause an increase in MDM2 protein levels and impairment of p53 tumor suppressor activity, which may be associated with the development of cancer. A number of studies were performed to investigate the relationship between this SNP and endometrial cancer. But, the results remain controversial. Thus, we performed a comprehensive meta-analysis to derive a more precise estimation of this susceptibility. There were seven eligible articles with a total of 1,278 patients and 2,189 controls included in the meta-analysis. In the present study, we found significant associations under the allele contrast and recessive model. The G allele was associated with elevated risk for endometrial cancer [allele contrast OR = 1.33, 95 % confidence interval (CI) = 1.12–1.58, P(Z) = 0.0009, P(Q) = 0.02)], while the homozygous GG genotype may also increase the risk of endometrial cancer [OR = 1.88, 95 % CI = 1.40–2.52, P(Z) < 0.0001, P(Q) = 0.02]. In the subgroup analysis by ethnicity, we found similar significant results for both Caucasians [allele contrast OR = 1.41, 95 % CI = 1.04–1.92, P(Z) = 0.03, P(Q) = 0.001; recessive model OR = 1.89, 95 % CI = 1.10–3.23, P(Z) = 0.02, P(Q) = 0.002] and Asians [allele contrast OR = 1.24, 95 % CI = 1.01–1.53, P(Z) = 0.04, P(Q) = 0.86; recessive model OR = 1.75, 95 % CI = 1.24–2.45, P(Z) = 0.001, P(Q) = 0.75]. Overall, the meta-analysis demonstrated that the MDM2 SNP309 polymorphism may be associated with increased risk of endometrial cancer. © 2014, International Society of Oncology and BioMarkers (ISOBM).


Guo S.-S.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Zhou Y.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Zhu J.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Wang F.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2017

Our study investigated the effect of combination treatment of experimental stroke with Breviscapine, an extract from an important traditional herb-plant of china, Erigeron breviscapus (vant.) Hand-Mazz., and Netrin-1 which is a secreted molecule related with laminin that has been perceived as a neuronal guidance cue, on functional outcome, and the pathological lesions in the cerebral ischemic rats. Middle cerebral artery occlusion (MCAO) can induce cerebral ischemia in Wistar rats. Adult male rats were randomly separated into 5 groups: Netrin-1, Sham, Breviscapine, MCAO and combinational treatment groups. The effects of multi-drug on neurological deficits, water content of brain, size of cerebral infarction, and the malondialdehyde (MDA), the levels of Ca2+ and Na+-K+-ATPase and SOD activities in the brain tissue were analyzed. Expression of prostaglandin EP2 & EP4 were detected as well. Furthermore, the analysis of Bcl 2 expression was performed by using western blotting. Both the neurological deficit score and the infarct size were greatly decreased and the water content of brain was reduced from 83.11 to 80.26% (P<0.05) with both pretreatment with Breviscapine, Netrin-1 and combination. Intervention drugs remarkably increased the activities of superoxide dismutase and Na+-K+-ATPase and reduced Ca2+ and MDA levels in the brain tissue (P<0.05) in comparison with those in the MCAO group. Pretreatment with combinational drugs increased the protein expression level of Bcl-2 in comparison with that in the MCAO group. The histo-morphological study revealed that Breviscapine & Netrin-1 has protective effect on ischemic injury. The experimental results showed the protective effects of combinational therapy on rats with ischemic injury. The mechanism might have something to do with the inhibition of oxidative stress and apoptosis, and inducing prostaglandin EP2 & EP4 receptor activation. © 2017, E-Century Publishing Corporation. All rights reserved.


Xu Q.,Shanghai University of Traditional Chinese Medicine | Xu Q.,Fenghua Hospital of Traditional Chinese Medicine | Chen B.,Shanghai University of Traditional Chinese Medicine | Chen B.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | And 8 more authors.
Pain Physician | Year: 2017

Background: Knee osteoarthritis (KOA) is the most common form of arthritis, leading to pain disability in seniors and increased health care utilization. Manual therapy is one widely used physical treatment for KOA. Objective: To evaluate the effectiveness and adverse events (AEs) of manual therapy compared to other treatments for relieving pain, stiffness, and physical dysfunction in patients with KOA. Study Design: A systematic review and meta-analysis of manual therapy for KOA. Methods: We searched PubMed, EMBASE, the Cochrane Library, and Chinese databases for relevant randomized controlled trials (RCTs) of manual therapy for patients with KOA from the inception to October 2015 without language restrictions. RCTs compared manual therapy to the placebo or other interventional control with an appropriate description of randomization. Two reviewers independently conducted the search results identification, data extraction, and methodological quality assessment. The methodological quality was assessed by PEDro scale. Pooled data was expressed as standard mean difference (SMD), with 95% confident intervals (CIs) in a random effects model. The meta-analysis of manual therapy for KOA on pain, stiffness, and physical function were conducted. Results: Fourteen studies involving 841 KOA participants compared to other treatments were included. The methodological quality of most included RCTs was poor. The mean PEDro scale score was 6.6. The meta-analyses results showed that manual therapy had statistically significant effects on relieving pain (standardized mean difference, SMD = -0.61, 95% CI -0.95 to -0.28, P = 76%), stiffness (SMD = -0.58, 95% CI -0.95 to -0.21, P = 81%), improving physical function (SMD = -0.49, 95% CI -0.76 to -0.22, P = 65%), and total score (SMD = -0.56, 95% CI -0.78 to -0.35, P = 50%). But in the subgroups, manual therapy did not show significant improvements on stiffness and physical function when treatment duration was less than 4 weeks. And the long-term information for manual therapy was insufficient. Limitations: The limitations of this systematic review include the paucity of literature and inevitable heterogeneity between included studies. Conclusion: The preliminary evidence from our study suggests that manual therapy might be effective and safe for improving pain, stiffness, and physical function in KOA patients and could be treated as complementary and alternative options. However, the evidence may be limited by potential bias and poor methodological quality of included studies. High-quality RCTs with longterm follow-up are warranted to confirm our findings. © 2017, American Society of Interventional Pain Physicians. All rights reserved.


Pan Y.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Wang F.,Shanghai JiaoTong University | Qiu Q.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Ding R.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | And 2 more authors.
PLoS ONE | Year: 2013

The insertion/deletion (I/D) polymorphism of the gene encoding angiotensin converting enzyme is a controversial risk factor for restenosis after percutaneous transluminal coronary angioplasties (PTCA) in patients. Genetic association studies can be problematic to reproduce due to insufficient power, phenotypic heterogeneity, population stratification, small effect of the variant and even publication biases. To derive a more precise estimation of the relationship as well as to quantify the between-study heterogeneity and potential bias, a meta-analysis including 11,193 patients from 33 published cohort studies was performed. In a combined analysis, the summary per-allele odds ratio for restenosis was 1.31 (95% CI: 1.08-1.58, P = 0.006), and 1.22 (95% CI: 0.95-1.56, P = 0.12), for PTCA-stent and PTCA-balloon, respectively. In the subgroup analysis by ethnicity, significantly increased restenosis risks after PTCA-stent were found in Asians for the polymorphism; whereas no significant associations were found among Caucasians. As for restenosis risks after PTCA-balloon, no evidence of any gene-disease association was obtained in the stratified analyses according to ethnicity and study size. In conclusion, this meta-analysis demonstrated that the DD homozygous of ACE I/D polymorphism was significantly associated with elevated restenosis susceptibility after PTCA-stent among Asian populations. © 2013 Yang Pan.


PubMed | Fudan University, Shanghai JiaoTong University and BaoShan Hospital of Integrated Traditional Chinese and Western Medicine
Type: Journal Article | Journal: Journal of natural medicines | Year: 2016

Myrislignan is a natural compound with little pharmacological study. In our investigation, we investigated the effect of myrislignan in the induction of apoptosis in A549 cells in vitro and in vivo. Myrislignan inhibited the proliferation of A549 cells in a dose- and time-dependent manner assayed by MTT. In addition, Hoechst flow cytometry showed that myrislignan significantly induced apoptosis and cell cycle arrest in A549 cells. The apoptosis and anti-cell proliferation was mediated by the activation of mitogen-activated protein kinase and the inhibition of epidermal growth factor receptor signal pathway, change of mitochondrial membrane potential, the releasing of c-Myc, the downregulation of the level of the anti-apoptotic protein Bcl-2, and the upregulation of the level of the pro-apoptotic protein Bax. In conclusion, those results reveal a potential mechanism for the anti-cancer effect of myrislignan on human lung cancer, while suggesting that myrislignan may be a promising compound for the treatment of lung cancer.


PubMed | Shanghai JiaoTong University and Baoshan Hospital of Integrated Traditional Chinese and Western Medicine
Type: Journal Article | Journal: PloS one | Year: 2013

The insertion/deletion (I/D) polymorphism of the gene encoding angiotensin converting enzyme is a controversial risk factor for restenosis after percutaneous transluminal coronary angioplasties (PTCA) in patients. Genetic association studies can be problematic to reproduce due to insufficient power, phenotypic heterogeneity, population stratification, small effect of the variant and even publication biases. To derive a more precise estimation of the relationship as well as to quantify the between-study heterogeneity and potential bias, a meta-analysis including 11,193 patients from 33 published cohort studies was performed. In a combined analysis, the summary per-allele odds ratio for restenosis was 1.31 (95% CI: 1.08-1.58, P = 0.006), and 1.22 (95% CI: 0.95-1.56, P = 0.12), for PTCA-stent and PTCA-balloon, respectively. In the subgroup analysis by ethnicity, significantly increased restenosis risks after PTCA-stent were found in Asians for the polymorphism; whereas no significant associations were found among Caucasians. As for restenosis risks after PTCA-balloon, no evidence of any gene-disease association was obtained in the stratied analyses according to ethnicity and study size. In conclusion, this meta-analysis demonstrated that the DD homozygous of ACE I/D polymorphism was significantly associated with elevated restenosis susceptibility after PTCA-stent among Asian populations.


Cui Y.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Li S.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine
Chinese Journal of Gastroenterology | Year: 2013

Background: Gastric outlet obstruction (GOO) is commonly seen in patients with advanced gastric cancer. Patients with malignant GOO are usually inoperable with a short remaining lifespan and a poor quality of life. Aims: To evaluate the palliative effect of endoscopic placement of pyloric stent for malignant GOO in patients with advanced gastric antral cancer. Methods: From Jan. 2012 to May 2013, 32 cases of advanced gastric antral cancer patients presenting with unable to take food and intractable emesis were treated with endoscopic placement of pyloric stent in Baoshan Hospital of Integrated Traditional Chinese and Western Medicine. Malignant GOO was confirmed by contrast gastroenterography in all 32 patients. GOO scoring system (GOOSS), self-rating anxiety and depression scales (SAS and SDS) were employed to assess the pre- and post-procedure obstruction and mental status. Post-procedure complications were observed. Results: Successful stent placement and deployment was achieved in all 32 patients. GOOSS score was increased within 1 and 4 weeks after the stent placement, while scores of SAS and SDS were decreased. Differences between the pre- and post-procedure parameters were statistically significant (P<0.05). Stent migration occurred in 1 patient and stent obstruction occurred in 2 cases. No procedure-related perforation and obvious bleeding were observed. Conclusions: Endoscopic placement of pyloric stent is a safe and effective minimally invasive palliative treatment modality for malignant GOO in patients with inoperable advanced gastric antral cancer. It might be beneficial for relieving obstruction and anxious and depressed mental status.


PubMed | Baoshan Hospital of Integrated Traditional Chinese and Western Medicine
Type: Journal Article | Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | Year: 2014

Due to its important biological function as a key negative regulator of p53, the mouse double minute 2 homologue (MDM2) gene has been extensively studied. A functional variant in the MDM2 gene promoter, single-nucleotide polymorphism 309 (SNP309) T > G (rs2279744), has been reported to cause an increase in MDM2 protein levels and impairment of p53 tumor suppressor activity, which may be associated with the development of cancer. A number of studies were performed to investigate the relationship between this SNP and endometrial cancer. But, the results remain controversial. Thus, we performed a comprehensive meta-analysis to derive a more precise estimation of this susceptibility. There were seven eligible articles with a total of 1,278 patients and 2,189 controls included in the meta-analysis. In the present study, we found significant associations under the allele contrast and recessive model. The G allele was associated with elevated risk for endometrial cancer [allele contrast OR=1.33, 95 % confidence interval (CI)=1.12-1.58, P(Z)=0.0009, P(Q)=0.02)], while the homozygous GG genotype may also increase the risk of endometrial cancer [OR=1.88, 95 % CI=1.40-2.52, P(Z)<0.0001, P(Q)=0.02]. In the subgroup analysis by ethnicity, we found similar significant results for both Caucasians [allele contrast OR=1.41, 95 % CI=1.04-1.92, P(Z)=0.03, P(Q)=0.001; recessive model OR=1.89, 95 % CI=1.10-3.23, P(Z)=0.02, P(Q)=0.002] and Asians [allele contrast OR=1.24, 95 % CI=1.01-1.53, P(Z)=0.04, P(Q)=0.86; recessive model OR=1.75, 95 % CI=1.24-2.45, P(Z)=0.001, P(Q)=0.75]. Overall, the meta-analysis demonstrated that the MDM2 SNP309 polymorphism may be associated with increased risk of endometrial cancer.

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