Baoshan Hospital of Integrated Traditional Chinese and Western Medicine

Shanghai, China

Baoshan Hospital of Integrated Traditional Chinese and Western Medicine

Shanghai, China

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Zhang Y.,Shandong University | Zhang Y.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Zhang B.-C.,Shandong University | Xu J.,Shandong University | And 7 more authors.
Acta pharmacologica Sinica | Year: 2016

AIM: The eicosanoids derived from phospholipids play key roles in inflammation. However, the profiles of serum eicosanoids in subclinical hypothyroidism (SH) patients and the effects of thyroxine replacement therapy (TRT) on these eicosanoids remain unclear. Many studies show that TSH regulates lipid metabolism. As eicosanoids derived from phospholipids play key roles in oxidative stress and immune function and inflammatory process, it was necessary to explore the profiles of serum eicosanoids in SH patients and the effects of thyroxine replacement therapy (TRT) on the eicosanoids.METHODS: A total of 50 Chinese SH patients and 22 healthy volunteers were recruited. SH patients received TRT (L-T4, 25 and 50 mcg/d for patients with TSH≤10.0 mIU/L and TSH>10.0 mIU/L, respectively) for 3 months. Serum levels of major eicosanoids and cPLA2 were analyzed using LC-MS and clinical biochemical assays.RESULTS: The serum levels of cPLA2, eicosanoids (8-isoPGF2a, 11-dehydroTXB2 and 12-HETE) and 11-dehydroTXB2/6-Keto-PGF1a were significantly elevated in SH patients. The serum TSH levels were significantly correlated with the levels of cPLA2 (r=+0.65), 11-dehydroTXB2 (r=+0.32) and 11-dehydroTXB2/6-Keto-PGF1a (r=+0.37). After 3-month TRT, the serum levels of TSH, cPLA2 and the above-mentioned eicosanoids in SH patients were significantly decreased.CONCLUSION: The metabolism of eicosanoids is significantly altered in Chinese SH patients, and TRT can ameliorate the abnormalities of serum eicosanoid levels.


Xiong Y.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Zhao J.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine
International Eye Science | Year: 2015

AIM: To investigatethe prevalence and awareness of diabetic retinopathy (DR), as well as its influential factors, among patients with diabetes mellitus in the Songnan Community of Shanghai. METHODS: Residents with diabetes mellitus were randomly sampled in Shanghai's Songnan Community. These patients received full physical examinations. DR was diagnosed using non-mydriatic fundus photography. The patients completed a survey concerning their general knowledge and awareness of DR. RESULTS: A total of 1120 valid questionnaires and fundus photographs were collected. The incidence of DR among patients with diabetes was 23.6%; 17.1% had mild DR, 5.1% had moderate DR and 1.4% had severe DR. Of the survey participants, 14.1% received ophthalmic examinations over the last year, 71.5% knew their normal blood glucose levels, 85.7% were aware of the possibility of systemic complications caused by diabetes, 77.2% were aware of ocular complications, 47.9% were aware of the need for regular fundus examinations, 58.0% were aware that the early treatment of DR is an important measure to prevent visual impairment, and 59.9% were willing to participate in regular health education seminars. A univariate analysis indicated that the knowledge and awareness scores regarding DR were correlated with age, education level, type of medical insurance, duration of diabetes, diet control, blood glucose monitoring, fasting blood glucose level, exercise frequency and DR stage. A logistic regression analysis indicated that the factors affecting the DR awareness scores were age, education level, type of medical insurance, stage of diabetes, diet control, exercise frequency and DR stage. CONCLUSION: The patients with diabetes in the Songnan Community lacked sufficient awareness of DR prevention and treatment methods. The existing awareness of DR among the survey participants did not lead to effective prevention or treatment actions associated with this condition. It is necessary to educate patients with diabetes in local communities regarding DR. © 2015 by the IJO Press.


Zhao Y.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Yang X.,Shanghai Changning Maternity Infant Health Hospital | Hao X.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Pan X.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | And 4 more authors.
Tumor Biology | Year: 2014

Due to its important biological function as a key negative regulator of p53, the mouse double minute 2 homologue (MDM2) gene has been extensively studied. A functional variant in the MDM2 gene promoter, single-nucleotide polymorphism 309 (SNP309) T > G (rs2279744), has been reported to cause an increase in MDM2 protein levels and impairment of p53 tumor suppressor activity, which may be associated with the development of cancer. A number of studies were performed to investigate the relationship between this SNP and endometrial cancer. But, the results remain controversial. Thus, we performed a comprehensive meta-analysis to derive a more precise estimation of this susceptibility. There were seven eligible articles with a total of 1,278 patients and 2,189 controls included in the meta-analysis. In the present study, we found significant associations under the allele contrast and recessive model. The G allele was associated with elevated risk for endometrial cancer [allele contrast OR = 1.33, 95 % confidence interval (CI) = 1.12–1.58, P(Z) = 0.0009, P(Q) = 0.02)], while the homozygous GG genotype may also increase the risk of endometrial cancer [OR = 1.88, 95 % CI = 1.40–2.52, P(Z) < 0.0001, P(Q) = 0.02]. In the subgroup analysis by ethnicity, we found similar significant results for both Caucasians [allele contrast OR = 1.41, 95 % CI = 1.04–1.92, P(Z) = 0.03, P(Q) = 0.001; recessive model OR = 1.89, 95 % CI = 1.10–3.23, P(Z) = 0.02, P(Q) = 0.002] and Asians [allele contrast OR = 1.24, 95 % CI = 1.01–1.53, P(Z) = 0.04, P(Q) = 0.86; recessive model OR = 1.75, 95 % CI = 1.24–2.45, P(Z) = 0.001, P(Q) = 0.75]. Overall, the meta-analysis demonstrated that the MDM2 SNP309 polymorphism may be associated with increased risk of endometrial cancer. © 2014, International Society of Oncology and BioMarkers (ISOBM).


Pan Y.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Wang F.,Shanghai JiaoTong University | Qiu Q.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Ding R.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | And 2 more authors.
PLoS ONE | Year: 2013

The insertion/deletion (I/D) polymorphism of the gene encoding angiotensin converting enzyme is a controversial risk factor for restenosis after percutaneous transluminal coronary angioplasties (PTCA) in patients. Genetic association studies can be problematic to reproduce due to insufficient power, phenotypic heterogeneity, population stratification, small effect of the variant and even publication biases. To derive a more precise estimation of the relationship as well as to quantify the between-study heterogeneity and potential bias, a meta-analysis including 11,193 patients from 33 published cohort studies was performed. In a combined analysis, the summary per-allele odds ratio for restenosis was 1.31 (95% CI: 1.08-1.58, P = 0.006), and 1.22 (95% CI: 0.95-1.56, P = 0.12), for PTCA-stent and PTCA-balloon, respectively. In the subgroup analysis by ethnicity, significantly increased restenosis risks after PTCA-stent were found in Asians for the polymorphism; whereas no significant associations were found among Caucasians. As for restenosis risks after PTCA-balloon, no evidence of any gene-disease association was obtained in the stratified analyses according to ethnicity and study size. In conclusion, this meta-analysis demonstrated that the DD homozygous of ACE I/D polymorphism was significantly associated with elevated restenosis susceptibility after PTCA-stent among Asian populations. © 2013 Yang Pan.


Lu X.,Fudan University | Yang L.,BaoShan Hospital of Integrated Traditional Chinese and Western Medicine | Chen J.,Shanghai JiaoTong University | Zhou J.,Fudan University | And 4 more authors.
Journal of Natural Medicines | Year: 2016

Myrislignan is a natural compound with little pharmacological study. In our investigation, we investigated the effect of myrislignan in the induction of apoptosis in A549 cells in vitro and in vivo. Myrislignan inhibited the proliferation of A549 cells in a dose- and time-dependent manner assayed by MTT. In addition, Hoechst flow cytometry showed that myrislignan significantly induced apoptosis and cell cycle arrest in A549 cells. The apoptosis and anti-cell proliferation was mediated by the activation of mitogen-activated protein kinase and the inhibition of epidermal growth factor receptor signal pathway, change of mitochondrial membrane potential, the releasing of c-Myc, the downregulation of the level of the anti-apoptotic protein Bcl-2, and the upregulation of the level of the pro-apoptotic protein Bax. In conclusion, those results reveal a potential mechanism for the anti-cancer effect of myrislignan on human lung cancer, while suggesting that myrislignan may be a promising compound for the treatment of lung cancer. © 2016 The Japanese Society of Pharmacognosy and Springer Japan


PubMed | Fudan University, Shanghai JiaoTong University and BaoShan Hospital of Integrated Traditional Chinese and Western Medicine
Type: Journal Article | Journal: Journal of natural medicines | Year: 2016

Myrislignan is a natural compound with little pharmacological study. In our investigation, we investigated the effect of myrislignan in the induction of apoptosis in A549 cells in vitro and in vivo. Myrislignan inhibited the proliferation of A549 cells in a dose- and time-dependent manner assayed by MTT. In addition, Hoechst flow cytometry showed that myrislignan significantly induced apoptosis and cell cycle arrest in A549 cells. The apoptosis and anti-cell proliferation was mediated by the activation of mitogen-activated protein kinase and the inhibition of epidermal growth factor receptor signal pathway, change of mitochondrial membrane potential, the releasing of c-Myc, the downregulation of the level of the anti-apoptotic protein Bcl-2, and the upregulation of the level of the pro-apoptotic protein Bax. In conclusion, those results reveal a potential mechanism for the anti-cancer effect of myrislignan on human lung cancer, while suggesting that myrislignan may be a promising compound for the treatment of lung cancer.


PubMed | Shanghai JiaoTong University and Baoshan Hospital of Integrated Traditional Chinese and Western Medicine
Type: Journal Article | Journal: PloS one | Year: 2013

The insertion/deletion (I/D) polymorphism of the gene encoding angiotensin converting enzyme is a controversial risk factor for restenosis after percutaneous transluminal coronary angioplasties (PTCA) in patients. Genetic association studies can be problematic to reproduce due to insufficient power, phenotypic heterogeneity, population stratification, small effect of the variant and even publication biases. To derive a more precise estimation of the relationship as well as to quantify the between-study heterogeneity and potential bias, a meta-analysis including 11,193 patients from 33 published cohort studies was performed. In a combined analysis, the summary per-allele odds ratio for restenosis was 1.31 (95% CI: 1.08-1.58, P = 0.006), and 1.22 (95% CI: 0.95-1.56, P = 0.12), for PTCA-stent and PTCA-balloon, respectively. In the subgroup analysis by ethnicity, significantly increased restenosis risks after PTCA-stent were found in Asians for the polymorphism; whereas no significant associations were found among Caucasians. As for restenosis risks after PTCA-balloon, no evidence of any gene-disease association was obtained in the stratied analyses according to ethnicity and study size. In conclusion, this meta-analysis demonstrated that the DD homozygous of ACE I/D polymorphism was significantly associated with elevated restenosis susceptibility after PTCA-stent among Asian populations.


Cui Y.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine | Li S.,Baoshan Hospital of Integrated Traditional Chinese and Western Medicine
Chinese Journal of Gastroenterology | Year: 2013

Background: Gastric outlet obstruction (GOO) is commonly seen in patients with advanced gastric cancer. Patients with malignant GOO are usually inoperable with a short remaining lifespan and a poor quality of life. Aims: To evaluate the palliative effect of endoscopic placement of pyloric stent for malignant GOO in patients with advanced gastric antral cancer. Methods: From Jan. 2012 to May 2013, 32 cases of advanced gastric antral cancer patients presenting with unable to take food and intractable emesis were treated with endoscopic placement of pyloric stent in Baoshan Hospital of Integrated Traditional Chinese and Western Medicine. Malignant GOO was confirmed by contrast gastroenterography in all 32 patients. GOO scoring system (GOOSS), self-rating anxiety and depression scales (SAS and SDS) were employed to assess the pre- and post-procedure obstruction and mental status. Post-procedure complications were observed. Results: Successful stent placement and deployment was achieved in all 32 patients. GOOSS score was increased within 1 and 4 weeks after the stent placement, while scores of SAS and SDS were decreased. Differences between the pre- and post-procedure parameters were statistically significant (P<0.05). Stent migration occurred in 1 patient and stent obstruction occurred in 2 cases. No procedure-related perforation and obvious bleeding were observed. Conclusions: Endoscopic placement of pyloric stent is a safe and effective minimally invasive palliative treatment modality for malignant GOO in patients with inoperable advanced gastric antral cancer. It might be beneficial for relieving obstruction and anxious and depressed mental status.


PubMed | Baoshan Hospital of Integrated Traditional Chinese and Western Medicine
Type: Journal Article | Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | Year: 2014

Due to its important biological function as a key negative regulator of p53, the mouse double minute 2 homologue (MDM2) gene has been extensively studied. A functional variant in the MDM2 gene promoter, single-nucleotide polymorphism 309 (SNP309) T > G (rs2279744), has been reported to cause an increase in MDM2 protein levels and impairment of p53 tumor suppressor activity, which may be associated with the development of cancer. A number of studies were performed to investigate the relationship between this SNP and endometrial cancer. But, the results remain controversial. Thus, we performed a comprehensive meta-analysis to derive a more precise estimation of this susceptibility. There were seven eligible articles with a total of 1,278 patients and 2,189 controls included in the meta-analysis. In the present study, we found significant associations under the allele contrast and recessive model. The G allele was associated with elevated risk for endometrial cancer [allele contrast OR=1.33, 95 % confidence interval (CI)=1.12-1.58, P(Z)=0.0009, P(Q)=0.02)], while the homozygous GG genotype may also increase the risk of endometrial cancer [OR=1.88, 95 % CI=1.40-2.52, P(Z)<0.0001, P(Q)=0.02]. In the subgroup analysis by ethnicity, we found similar significant results for both Caucasians [allele contrast OR=1.41, 95 % CI=1.04-1.92, P(Z)=0.03, P(Q)=0.001; recessive model OR=1.89, 95 % CI=1.10-3.23, P(Z)=0.02, P(Q)=0.002] and Asians [allele contrast OR=1.24, 95 % CI=1.01-1.53, P(Z)=0.04, P(Q)=0.86; recessive model OR=1.75, 95 % CI=1.24-2.45, P(Z)=0.001, P(Q)=0.75]. Overall, the meta-analysis demonstrated that the MDM2 SNP309 polymorphism may be associated with increased risk of endometrial cancer.

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