Ibaraki, Japan
Ibaraki, Japan

Time filter

Source Type

Patent
Banyu Pharmaceutical Co. | Date: 2010-10-06

[Problem] To provide a compound that is useful as an agent in the prevention and treatment of circulatory system, nervous system, metabolic, reproductive system, and gastrointestinal diseases. [Means for Resolution] A compound or a pharmaceutically acceptable salt thereof represented by the following Formula (I):Y represents CR^(3) or N, R^(1) represents a C_(1-6) alkyl, C_(3-8) cycloalkyl, etc., R^(2) represents phenyl or a heteroaryl, etc., R^(3) and R^(4) each independently represent a hydrogen atom, a C_(1-6) alkyl, etc., M_(1), M_(2), M_(3), and M_(4) each independently represent a hydrogen atom, a C_(1-6) alkyl, etc.]


[Problem] To provide a melanin-concentrating hormone receptor antagonist useful as a pharmaceutical agent for central diseases, circulatory diseases, and metabolic diseases. [Means for Resolution] Provided is a diarylmethylamide derivative represented by formula (I):^(1a), R^(1b), R^(2a), R^(2b), R^(3a), and R^(3b) independently represent a hydrogen atom or the like, R^(4) represents a hydrogen atom, C_(1-6) alkyl, or the like, R^(5) represents a hydrogen atom or the like, Z represents C_(1-6) alkyl or the like, or R^(4) and Z together form a 4- to 6-membered nitrogen-containing hetero ring, Y_(1) represents H or the like, Y_(2) represents H, or Y_(1) and Y_(2) together form - O-CH_(2)-, W represents C, SO, or the like, Ar_(1) represents 6-membered aryl or the like, Ar_(2) represents 6-membered aryl or the like, and ring A represents a benzene ring, a pyridine ring, or the like.


Patent
Banyu Pharmaceutical Co. | Date: 2011-03-30

[Problem] To provide a melanin concentrating hormone receptor antagonist useful as medicines for central system disorders, cardiovascular disorders, metabolic disorders. [Means for Resolution] Provided are compound of a formula (I): ^(1 a) and R^(1 b) each are a hydrogen atom, etc.; R^(2) is a hydrogen atom, a C_(1-6) alkyl, etc.; Ar_(1) is a 6-membered aromatic carbocyclic group or a 6-membered aromatic nitrogen-containing heterocyclic group; Ar_(2) is a group to be formed by removing two hydrogen atoms from a 6-membered aromatic carbon ring, a 6-membered aromatic nitrogen-containing hetero ring, etc.; Ar_(3) is a mono- or bi-cyclic aromatic carbon ring or aromatic hetero ring; m1, m2, m3 and m4 each are independently 0, 1, 2, 3 or 4, provided that the total of m1 and m2 is from 2 to 6, the total of m3 and m4 is from 2 to 6]. The compounds are useful as medicines for central system disorders, cardiovascular disorders, metabolic disorders.


Patent
Banyu Pharmaceutical Co. | Date: 2010-07-28

[PROBLEMS] To provide a compound useful as an agent for the treatment of circulatory diseases, nervous system diseases, metabolic diseases, reproductive system diseases, and digestive tract diseases. [MEANS FOR SOLVING PROBLEMS] The compound, which is for use as an active ingredient, is represented by the formula (I):^(1) represents optionally halogenated C_(1-6) alkyl, etc.; R^(2) represents, e.g., a group represented by the formula (II-1) or (II-4)_(1-6) alkylene, etc. and R represents C_(1-6) alkyl, etc.); R^(3) represents hydrogen, C_(1-6) alkyl, etc.; X represents -O-, -NH-, etc.; and Y_(1), Y_(2), Y_(3), and Y_(4) each independently represents -CH-, -N-, etc.].


Patent
Banyu Pharmaceutical Co. | Date: 2011-03-07

The present invention provides the compounds represented by formula (I): or pharmaceutical salts thereof, wherein:


Patent
Banyu Pharmaceutical Co. | Date: 2010-01-20

A compound represented by the general formula (I-a):^(1a) and R^(2a) each means hydrogen, lower cycloalkyl, lower alkyl, etc.; R^(3a) means hydrogen, lower cycloalkyl, lower alkyl, etc.; R^(4a) and R^(5a) each means lower alkyl, lower cycloalkyl, etc. or R^(4a) and R^(5a) are bonded to each other to form lower cycloalkylidene; and R^(6a) means lower alkyl, lower haloalkyl, etc.]. This compound functions as an LCE inhibitor and is useful as a therapeutic agent for various circulatory diseases, nervous diseases, metabolic diseases, reproductive diseases, digestive tract diseases, neoplasm, infectious diseases, etc.


Patent
Banyu Pharmaceutical Co. | Date: 2010-07-07

[PROBLEMS] To provide compounds useful as preventives or remedies for circulatory diseases, nervous diseases, metabolic diseases, reproductive system diseases, and digestive diseases. [MEANS FOR SOLVING PROBLEMS]Compounds represented by the general formula (I) or pharmaceutically acceptable salts thereof:


Patent
Banyu Pharmaceutical Co. | Date: 2010-08-04

The invention relates to a compound of general formula (I-0):^(1) means a C1-C6 alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, or a C3-C6 cycloalkyl group; R2, R3, R4 and R5 mean a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C1-C6 alkoxy group, or a halo-C1-C6 alkoxy group; R^(6) means a hydrogen atom, or a C1-C6 alkyl group; R^(7a) means a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C1-C6 alkoxy group, a hydroxy-C1-C6 alkyl group, -Q^(2)-N(R^(1c))R^(1d) or a nitrogen-containing heterocyclic group; R^(8a) means a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C1-C6 alkoxy group or a hydroxy-C1-C6 alkyl group; or R^(7a) and R^(8a) form, as taken together, a C2-C6 alkylene group, or R^(7a) and R^(8a) and the ring atoms to which they bond may form a spiro ring or a bicyclo ring; and X and Y mean a methine group or a nitrogen atom. The compound of the invention has, based on its excellent Wee1 kinase-inhibitory effect, a cell growth-inhibitory effect and an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.


Patent
Banyu Pharmaceutical Co. | Date: 2010-03-31

The invention relates to a compound of a general formula (I):^(1) and A^(2) each mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; R^(1) means a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; R^(2) means an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of =NH or =O, etc. Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.


[Problem] To provide compounds useful as preventives or remedies for circular system disorders, nervous system disorders, metabolic disorders, reproduction system disorders, digestive system disorders, neoplasm, infectious diseases, etc., or as herbicides. [Means for Solution] A long-chain fatty acyl elongase inhibitor comprising, as the active ingredient thereof, a compound or a pharmaceutically-active salt thereof of a formula (I):_(1-6) alkyl, etc.; X represents an aryl, a heteroaryl, etc.; n indicates 0 or 1; Z represents a hydrogen atom, a C_(1-6) alkyl, etc.; A_(1), A_(2), A_(3) and A_(4) each independently represent CH or N].

Loading Banyu Pharmaceutical Co. collaborators
Loading Banyu Pharmaceutical Co. collaborators