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Saha R.,Bankura Sammilani Medical College and Hospital | Misra R.,Post Graduate Institute of Medical Education and Research | Saha I.,IQ City Medical College and Narayana Hrudayalaya Hospitals
Indian Journal of Pediatrics | Year: 2015

Objective: To assess the quality of life among thalassemic children and to find out association of quality of life (QOL) with the socio-demographic factors, and clinico-therapeutic profile. Methods: This cross sectional descriptive epidemiological study was conducted from July 2011 through June 2012 on 365 admitted thalassemic patients of 5 to 12 y of age in the Burdwan Medical College and Hospital. Parents of the children were interviewed using Paediatric Quality of Life Inventory 4.0 Generic Core Scale. Statistically significant variables in bivariate analysis were considered for correlation matrix where independent variables were found inter related. So, partial correlation was done and statistically significant variables in partial correlation were considered for linear regression. Results: The mean age of 365 thalassemic children was 8.3 ± 2.4 y. Multiple linear regressions predicted that only 70.5 % variation of total summary score depended on duration since splenectomy (31.2 % variation), last pre transfusion Hb level (20.7 %), family history of thalassemia (17.3 %) and frequency of blood transfusions (1.3 %). After splenectomy, thalassemic children could lead a better quality of life upto 5 y only. The betterment of the quality of life needs maintaining pre transfusion Hb level above 7 g/dl. Previous experience of the disease among the family members enriches the awareness among them and helps them to take correct decisions timely about the child and that leads to better QOL. Conclusions: More awareness regarding the maintenance of pre transfusion Hb level should be built up among parents and families where such disease has occurred for the first time. © 2015, Dr. K C Chaudhuri Foundation.

Maity P.P.,Indian Institute of Technology Kharagpur | Chatterjee S.,Institute of Engineering and Management | Das R.K.,Indian Institute of Technology Kharagpur | Mukhopadhyay S.,Medical College and Hospital | And 5 more authors.
Micron | Year: 2013

Purpose: Benign phyllodes and fibroadenoma are two well-known breast tumors with remarkable diagnostic ambiguity. The present study is aimed at determining an optimum set of immuno-histochemical features to distinguish them by analyzing important observations on expressions of important genes in fibro-glandular tissue. Methods: Immuno-histochemically, the expressions of p63 and α-SMA in myoepithelial cells and collagen I, III and CD105 in stroma of tumors and their normal counterpart were studied. Semi-quantified features were analyzed primarily by ANOVA and ranked through F-scores for understanding relative importance of group of features in discriminating three classes followed by reduction in F-score arranged feature space dimension and application of inter-class Bhattacharyya distances to distinguish tumors with an optimum set of features. Results: Among thirteen studied features except one all differed significantly in three study classes. F-Ranking of features revealed highest discriminative potential of collagen III (initial region). F-Score arranged feature space dimension and application of Bhattacharyya distance gave rise to a feature set of lower dimension which can discriminate benign phyllodes and fibroadenoma effectively. Conclusions: The work definitely separated normal breast, fibroadenoma and benign phyllodes, through an optimal set of immuno-histochemical features which are not only useful to address diagnostic ambiguity of the tumors but also to spell about malignant potentiality. © 2013 Elsevier Ltd.

Kundu S.,Jawaharlal Institute of Postgraduate Medical Education & Research | Mitra S.,Calcutta National Medical College and Hospital | Ganguly J.,Murshidabad Medical College and Hospital | Ray S.,Bankura Sammilani Medical College and Hospital | Mitra R.,Jawaharlal Institute of Postgraduate Medical Education & Research
Lung India | Year: 2014

Objective: To evaluate the clinical spectrum of diffuse parenchymal lung diseases (DPLD) encountered in the Indian setting and to compare idiopathic pulmonary fibrosis (IPF) and connective tissue disease associated DPLD (CTD-DPLD), the two commonest aetiologies. Materials and Methods: A prospective study of clinical, imaging and laboratory parameters of patients diagnosed as DPLD and followed up in the Pulmonary Medicine Department of a tertiary-care teaching institution in eastern India was conducted over a period of one year. Results: 92 patients of DPLD were diagnosed in the study period with IPF (n = 35, 38.04%), CTD-DPLD (n = 29, 31.5%), hypersensitivity pneumonitis (n = 10, 10.9%), sarcoidosis (n = 5, 5.4%) and silicosis (n = 5, 5.4%) being the common causes. The CTD-DPLD group had a lower mean age (39.5 ± 1.86 vs 56.9 ± 1.12 years), a longer duration of symptoms (3.5 ± 0.27 vs 2.5 ± 0.26 years), more extra pulmonary manifestations, significantly more base line FVC and 6-minute-walk-distance than the IPF patients. 19 patients of IPF (54%) opted for treatment. All the IPF patients had a significant fall in FVC after six months (mean change -0.203 ± 0.01 litres) compared to the CTD-DPLD group (mean change - 0.05 ± 0.04 litres.) Conclusion: CTD-DPLD patients belong to a younger age group, with longer duration of symptoms, more extrapulmonary features, better physiological parameters and better response to therapy than IPF patients. Larger prospective epidemiological studies and enrolment in clinical trials are necessary for better understanding of the spectrum of diffuse parenchymal lung disorders and their therapeutic options.

Mukherjee S.,Calcutta National Medical College and Hospital | Sarkar B.S.,Bankura Sammilani Medical College and Hospital | Das K.K.,Calcutta National Medical College and Hospital | Bhattacharyya A.,Calcutta National Medical College and Hospital | And 2 more authors.
Journal of Clinical and Diagnostic Research | Year: 2013

Background: The poor glycaemic control among the patients with type 2 diabetes constitutes a major public health problem and a major risk factor for the development of diabetes com- plications. Aim of the Study: To study the compliance rate of the patients with type 2 diabetes to the prescribed medications, to find out its correlation with different socio-demographic factors and other patient characteristics and to find out the reasons behind the non-compliance, if any. Settings and Design: This cross sectional study was con- ducted on the patients with type 2 diabetes, who Attended the Diabetic Clinic of a Medical College in Kolkata, India. Methods and Material: The patients of type 2 diabetes who attended the diabetes clinic between April to August 2012 were recruited in the study by systematic random sampling and they were interviewed by using the help of a structured interview schedule. The patients who reported taking less than 80% of their prescribed anti-diabetes medicines in the preced- ing week and had HbA1C of > 7% were considered to be non- compliant. Statistical Analysis Used: The data was analyzed by using the SPSS software. The Chi-square test was used to assess the association of the compliance with the different study vari-ables. A binary logistic regression analysis helped in identifying the factors which contributed to the non-compliance. Results: The compliance rate to the anti-diabetic drugs was found to be 57.7%. A univariate analysis showed that it de- creased significantly with increasing age and that it was also significantly lower among males, illiterates, those with a poor per capita monthly income and those who had a longer duration of diabetes. It varied significantly with the type of drugs, being lowest with an oral drug and insulin combination (43.4%). No knowledge on the complications of diabetes was significantly associated with a lower compliance. The binary logistic regres- sion also helped in identifying these as the significant contribu- tory factors. The common reasons behind the non-compliance were forgetfulness (44.7%) and financial constraints (32.7%). Conclusion: It can be concluded that the compliance to anti- diabetic drugs was quite poor among the participants. Increas- ing age, the male sex, illiteracy, a low monthly income and a longer duration of diabetes were significantly associated with the non compliance. A more concerning fact was the signifi- cant association of the non-compliance with the types of drug regimens and a lack of knowledge on the complications of dia- betes, which emphasized the role of a repeated patient educa- tion regarding the basic aspects of diabetes.

Deb A.,Mata Gujri Memorial Medical College And Lsk Hospital | Deb A.,asthma and COPD care unit | Mukherjee S.,Calcutta National Medical College and Hospital | Kumar Saha B.,North Bengal Medical College and Hospital | And 4 more authors.
Journal of Clinical and Diagnostic Research | Year: 2014

Background: Allergic Rhinitis (AR) though quite common in India, does not receive its due importance as it deserves. Aim of the Study: To identify the demographic and clinical profile of the patients with AR and to find the association of pre-dominant disease symptoms with common allergens, type and severity of the disease and other co-morbidities. Settings and Design: This clinic-based cross-sectional, observational study was conducted among adult patients presenting with signs and symptoms suggestive of Allergic Rhinitis. Methods and Material: Consecutive 548 patients were initially screened for possible cases of Allergic Rhinitis by proper history taking and physical examination and confirmation was done by a battery of investigations, including modified skin prick test. A total of 462 patients who were finally diagnosed with Allergic Rhinitis were included in the study. Categorization of these patients was done following Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. Pulmonary function tests and X-ray/CT-scan of the para-nasal sinuses were done to confirm the presence of bronchial asthma and sinusitis, respectively. Statistical Analysis Used: Data were analyzed by Statistical Package for Social Scientists (SPSS version 10). Z-test was applied to compare between two rates, at 5% level of significance. Results: Proportion of "blockers" was found to be much higher than that of "sneezers-runners" (64.1% vs. 35.9%). "Blockers" had significantly more sensitization to polyvalent house dust, house dust mites and fungi (p < 0.05), while, "sneezers-runners" had more sensitization to pollens (p < 0.05). Significantly more "blockers" had "moderate/severe persistent" and "mild persistent" types of the disease (p < 0.05), while "mild intermittent" and moderate/severe intermittent" type of disease were significantly more common among "sneezers-runners" (p < 0.05). Both bronchial asthma and sinusitis were significantly more common among the "blockers" (p < 0.05). Conclusion: It can be concluded from the present study that the clinical profiles of the two main categories of AR namely "sneezers-runners" and "blockers" were distinct from each other. This knowledge can be useful to physicians at all levels for better management of patients with AR.

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