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Ward K.A.,University of Minnesota | Lazovich D.,Bank of The West | Hordinsky M.K.,University of Minnesota
Journal of the American Academy of Dermatology | Year: 2012

In recent years, there have been increasing efforts to identify germline genetic variants that may alter melanoma susceptibility and prognosis. The findings of these studies have indicated the presence of rare, high-penetrance alleles with large effects, such as CDKN2A and CDK4, more common, moderately penetrant genes like MC1R, and very common, low-penetrance polymorphisms with small effects that are related to pigmentation, nevus count, immune responses, DNA repair, metabolism, and the vitamin D receptor. The study of these low-penetrance single nucleotide polymorphisms is relatively new; thus many of them are termed 'candidate melanoma susceptibility or prognostic genes.' This review summarizes the research on germline polymorphisms that have been implicated in melanoma susceptibility and prognosis in order to provide a framework for additional studies to meet the ultimate goal of predicting a patient's risk of, and prognosis in, cutaneous malignant melanoma. © 2012 by the American Academy of Dermatology, Inc.

Gokhale N.S.,Bank of The West
Cornea | Year: 2011

PURPOSE:: To report a case of severe corneal endothelial damage after collagen cross-linking treatment in a 37-year-old man with progressive keratoconus with a corneal thickness of more than 400 μm. METHODS:: After central epithelial debridement, the left cornea was cross-linked for 25 minutes using dextran-riboflavin solution and UV-A light of 370 nm with an irradiance of 3.0 mW/cm. One month after cross-linking treatment, the patient presented with massive corneal edema. He was treated with 1% prednisolone and carboxymethylcellulose 1% eyedrops 4 times a day for 3 months. Specular microscopy with endothelial cell counting was performed after resolution of the corneal edema 6 months after cross-linking. RESULTS:: Despite intense treatment, a ring-shaped corneal scar remained, and uncorrected visual acuity was finger counting. Cell density after resolution was 1776 cells per square millimeter in the affected eye compared with 2978 cells per square millimeter in the untreated fellow eye. CONCLUSIONS:: Corneal thickness is not the only factor for corneal endothelial damage after cross-linking procedure. Copyright © 2011 by Lippincott Williams & Wilkins.

The study examines extent of women's dependence on forest and their participation in gender sensitive planning of joint forest management programme in West Bengal, where the provincial government made pioneer attempt during early 1990s by establishing separate female forest management unit to accommodate women's preference, needs, knowledge and values on forest resources providing separate provision in institutions. It suggests that women's participation in their own management unit is substantially higher than men's in the general (joint) forest management unit, and the former ensures women's major contribution to their household's income with women's greater physical involvement in forestry works. © 2010 Department of Forest Economics, SLU Umeå, Sweden.

Thweib N.,Bank of The West
Journal of Pediatric Hematology/Oncology | Year: 2011

Cancer is known to be one of the worst diseases on the planet; it highly affects Palestinians; it is the third leading cause of death in Palestine. The main purpose of the research is to highlight the concept of Quality of Life (QOL) for Palestinian cancer patients through providing an understanding about influences of cancer and chemotherapy on QOL of cancer patient. QOL was measured using European Organization for Research and Treatment of Cancer questionnaire EORTC QLQ-C30 (version 3.0) which founded to be valid and reliable in diverse cultures, including, the United Arab Emirates, Iran, Turkey, Japan, India, China, Korea, and Nigeria. Results about QOL were low in all aspects; most of them were less than the half of full function, and, more intense symptoms and negative effects were found to be in Palestinian cancer patients. Copyright © 2011 by Lippincott Williams & Wilkins.

The aim of this article is to reflect on the historical background on what urged the authors in the 1980s to investigate the prolonged storage of whole blood at ambient temperature before component preparation, the routine implementation of the method in the Netherlands, and the effect on logistics and plasma procurement. © 2010 American Association of Blood Banks.

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