Entity

Time filter

Source Type

Banī Suwayf, Egypt

Badrey M.G.,Fayoum University | Abdel-Aziz H.M.,Bani Suef University | Gomha S.M.,Cairo University | Abdalla M.M.,Saco Pharm. Co. | Mayhoub A.S.,Al - Azhar University of Egypt
Molecules | Year: 2015

The usefulness of non-steroidal anti-inflammatory drugs (NSAIDs) is hampered by their gastrointestinal side effects. Non-selective cyclooxygenases inhibitors interfere with both COX-1 and COX-2 isozymes. Since COX-1 mediates cytoprotection of gastric mucosa, its inhibition leads to the undesirable side effects. On the other hand, COX-2 is undetectable in normal tissues and selectively induced by inflammatory stimuli. Therefore, it is strongly believed that the therapeutic benefits derive from inhibition of COX-2 only. The presence of a strong connection between reported COX-2 inhibitors and cardiac toxicity encourages medicinal chemists to explore new scaffolds. In the present study, we introduced imidazopyrazolopyridines as new potent and selective COX-2 inhibitors that lack the standard pharmacophoric binding features to hERG. Starting from our lead compound 5a, structure-based drug-design was conducted and more potent analogues were obtained with high COX-2 selectivity and almost full edema protection, in carrageenan-induced edema assay, in case of compound 5e. Increased bulkiness around imidazopyrazolopyridines by adding a substituted phenyl ring(s) afforded less active compounds. Source


Piness J.,University of Southern Mississippi | Hassan M.K.,University of Southern Mississippi | Hassan M.K.,Bani Suef University | Wiggins J.S.,University of Southern Mississippi
International SAMPE Technical Conference | Year: 2014

Novel nanocomposite particles polyhedral oligomeric silsesquioxanes (POSS) have demonstrated potential to protect polymers from environmental degradation including UV radiation, ozone, and atomic oxygen. This is most effective when surface rich regions of the particulate form due to incompatibilities between matrix and the eight organic functional pendants attached to the POSS moiety. Epoxy monomer diglycidyl ether of bisphenol-A (DGEBA) and amine crosslinker 4,4′-diaminodiphenyl sulfone (44DDS) were mixed with either octamethyl, isooctyl or octaphenyl POSS at various weight percents These systems were then analyzed with FT-IR spectroscopy, dynamic mechanic analysis, dielectric spectroscopy, and optical microscopy. Results from FT-spectroscopy indicate that complete network conversion was delayed and eventually prevented at high enough levels of the additive. In addition, POSS induced a 5-10 °C increase in glass transition temperature while increasing the cure rate compared to the neat 825-44DDS system. Morphology was also altered with a lack of ductility attributed to particle-rich aggregations observed primarily at the tool-sample interface. These effects are all hypothesized to be related to the ability of the relatively large POSS molecule to disrupt chain interactions and system free volume. Copyright 2014 by Jessica Piness, Mohammad K. Hassan, Jeffrey S. Wiggins. Source


Khalaf A.A.M.,Minia University | Mustafa F.M.,Bani Suef University
Journal of Optical Communications | Year: 2016

Due to the benefits of Raman amplifier (RA) for long-haul Ultra Wideband (UW)-WDM optical communications systems, we are studying and investigating how to widen the bandwidth and flatten the gain of RA by testing it in a new wider range of wavelengths (1.4 μm≤λsignal≤1.7 μm) instead of the benchmark range (1.45 μm≤λsignal≤1.65 μm). Four different ranges of signal wavelengths are used in this paper with the aim of testing the performance of RA model proposed in [13-15]: 1. 1.4 μm≤λsignal≤1.45 μm 2. 1.45 μm≤λsignal≤1.65 μm 3. 1.65 μm≤λsignal≤1.75 μm 4. 1.43 μm≤λsignal≤1.7 μm Different model sizes are used and analyzed to get wider bandwidth and more flat gain. © 2016 by De Gruyter. Source


Ezz-Eldin R.,Bani Suef University | El-Moursy M.A.,Mentor Graphics | Hamed H.F.A.,Minia University
Proceedings of the IEEE International Conference on Electronics, Circuits, and Systems | Year: 2013

Asynchronous NoC switch is proposed as a robust design to mitigate the impact of process variation. Asynchronous and synchronous network on chip design are implemented to evaluate the impact of process variation on the network throughput. Network on chip interconnects and clock distribution network are considered under process variation with the advance in technology. The variation in logic and interconnect are included to evaluate the delay and throughput variation with different technologies. The throughput negligibly decreases under high process variation conditions in asynchronous NoC switch, while rapidly decreases by up to 25% in synchronous design at the same variation conditions. © 2013 IEEE. Source


Ezz-Eldin R.,Bani Suef University | El-Moursy M.A.,Mentor Graphics | Hamed H.F.A.,Minia University
2013 8th IEEE Design and Test Symposium, IDT 2013 | Year: 2013

Asynchronous NoC switch is proposed as a robust design to mitigate the impact of process variation. Circuit analysis is used to evaluate the influence of process variation on both synchronous and asynchronous designs. The delay and throughput variation are evaluated with different technologies. Although the asynchronous switch has large delay variation as compared to synchronous switch, high throughput is achieved under high process variation conditions. The throughput remains unchanged under high process variation conditions in asynchronous NoC switch, while the throughput of synchronous switch is rapidly reduced at the same conditions. © 2013 IEEE. Source

Discover hidden collaborations