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Banglore, India

Shemshaki H.,Kerman Medical University | Nourian S.M.A.,California State University, Stanislaus | Shemshaki G.,Banglore University | Fereidan-Esfahani M.,Isfahan University of Medical Sciences
Life Science Journal | Year: 2013

Tendon injuries are common injuries which usually occurred by open injury. These injuries can lead to single; multiple or other structures injuries like blood vessels, bone and other soft tissues. Knowledge of molecular mechanism of injury and drugs which affected of them may get the examiner to better diagnosing and in consequence better treatment. Tendinopathy is the result of imbalance between protection and pathologic processes, after any trauma to tendons. As this important need, we concluded a review article which molecularly surveys the tendone injury. The goal of this review study is to guide orthopedic surgeons and sports physicians to select better approaches and to design better future studies that are less limited. Source


Shemshaki H.,Kerman Medical University | Nourian S.M.A.,California State University | Shemshaki G.,Banglore University | Fereidan-Esfahani M.,Isfahan University of Medical Sciences
Life Science Journal | Year: 2013

By the end of forty decade, wondrous evolution occurred in medical science which caused to give a medical novel gift to Hench and colleagues due to characterization of corticosteroids effects on rheumatoid cartilage. Therefore, many researches were done to find out the properties of this fantastic hormone. Therefore, many researches were done to find out the properties of this fantastic hormone. Followed by identifying the side effects, Topical using of corticosteroids showed lower side effects compared with systemic uses. We evaluated the impacts of corticosteroids on different tissues which involved in injuries, focusing on the mechanisms, advantages and disadvantages. The goal of this review study is to guide the orthopedic surgeons and sport physicians to select better approach and to design better future studies without limitations. Source


Rad S.M.A.H.,Tarbiat Modares University | Rad S.M.A.H.,Stem Cell Technology Research Center | Rad S.M.A.H.,University of Tehran | Rad S.M.A.H.,Royan Institute for Stem Cell Biology and Technology | And 32 more authors.
Tumor Biology | Year: 2015

Transcription factor decoys (TFDs) are exogenous oligonucleotides which can compete by cis-elements in promoters or enhancers for binding to TFs and downregulating gene expression in a specific manner. It is believed that tumor mass originates from cancer stem cells (CSCs) which the same with embryonic stem cells (ESCs) have the properties of both pluripotency and self-renewal (stemness). Many transcription factors such as Nanog, Oct-4, Sox2, Klf4, and Sall4 act as master regulators in the maintenance of stemness in both cell types. Differentiation therapy is based on this theory that by differentiation of CSCs, tumor mass can be eliminated with common cancer therapy methods. To our knowledge, the present study is the first report of a TFD approach against master regulator of stemness, Nanog, Oct-4, and Klf4, for downregulation purposes in P19 embryonic carcinoma stem cell. Different simple and complex decoys against Nanog, OCT-4, Sox2, and Klf4 were designed and used for this purpose. The results showed that the applied decoys especially Nanog-specific decoy decreased the expression of downstream genes. © 2014, International Society of Oncology and BioMarkers (ISOBM). Source

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