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Kannabiran J.,Bangalore Institute of Dental science and Hospital
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy which is a major cause for cancer morbidity and mortality worldwide. Early diagnosis and intervention improves the overall survival rate. Aim: The current study was done to evaluate the accuracy of salivary LDH as a potential biomarker for diagnosis of OSCC and to correlate the levels of salivary LDH with the histological differentiation of the tumour. Materials and Methods: Thirty patients visiting the outpatient department diagnosed clinically and histologically with OSCC were selected for the study with a control group of 20 patients. Unstimulated salivary samples collected from the selected patients were centrifuged and processed. Readings of enzyme activity in the salivary samples was established through auto analysis using International Federation of Clinical Chemistry (IFCC) method. Levels of the enzyme activity in both the control and the study group were compared and statistically analysed using student t-test. The three subgroups were also compared and statistically analysed. Results: The results showed a mean value of 497.00 with a SD of 51.75 among the control group and a mean value of 1225.40 with a SD of 221.79 among the cases with a p-value of 0.0001 which was statistically significant. Furthermore, when the LDH values for the various grades of OSCC were compared, the mean values were 1049.07, 1309.50 and 1586.20 respectively, for well differentiated, moderately differentiated and poorly differentiated carcinoma. Conclusion: The p-value thus obtained revealed LDH values which were significantly higher in patients with OSCC and furthermore the levels significantly correlated with the histopathological grade of the tumour. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved. Source


Dominic A.,Bangalore Institute of Dental science and Hospital | Sundaresh K.J.,Km Shah Dental College And Hospital | Manish N.,Bangalore Institute of Dental science | Mallikarjuna R.,Km Shah Dental College And Hospital
BMJ Case Reports | Year: 2013

A 40-year-old male patient presented with a 3-week history of a painless ulcer on the dorsum of the tongue. He was a chronic smoker since the age of 15 years. The ulcer was well-defined, non-tender and indurated. An incisional biopsy was performed and the diagnosis of atypical histiocytic granuloma was made after histopathological examination. The lesion resolved spontaneously after the incisional biopsy and the patient was on follow-up for 6 months and no recurrences were observed. Here we report a rare case of atypical histiocytic granuloma. Hence, it must be borne in mind in the differential diagnosis of ulcers on the tongue. Copyright 2013 BMJ Publishing Group. All rights reserved. Source


Kanji M.,Bangalore Institute of Dental science and Hospital | Poduval S.T.,Bangalore Institute of Dental science and Hospital | Sharma R.,Sharda University | Mishra G.S.,Bangalore Institute of Dental science and Hospital | Ayesha S.,Bangalore Institute of Dental science and Hospital
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Sensory organs play a significant role in our lives. Loss of eye has a crippling effect on the psychology of the patient. Treatment of such cases includes implants and acrylic eye prosthesis. This clinical report describes the successful prosthetic rehabilitation of a patient who had undergoneenucleation followed by radiation therapy and adjunctive chemotherapy to treat the primary diagnosis of squamous cell. This was accomplished with the help ofa pre-fabricated eye shell having an acceptable fit, adaptation and esthetics. Source

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