Bangabandhu Sheikh Mujib Medical University
Dhaka, Bangladesh

Bangabandhu Sheikh Mujib Medical University is the first and only medical university in Bangladesh. It is a public university, established in 1998. The university offers MD, PhD, MS, MPhil, MDS, Diploma and FCPS Courses. The vice chancellor is Prof. Pran Gopal Datta. Wikipedia.

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Selim S.,Bangabandhu Sheikh Mujib Medical University
Diabetes and Metabolic Syndrome: Clinical Research and Reviews | Year: 2017

Background: The study was conducted in diabetes care centers to explore association of chronic complications of diabetes with glycemic status along with their frequency and pattern among adult patients with type 2 diabetes. Methods: A cross-sectional study was conducted at outpatient departments of eight diabetes care centers in Dhaka. Data were collected by face to face interview by trained research physicians. Disease related information was recorded in the checklist from diabetes guide books of the patients. Chronic complications of diabetes were recorded from the records of expert consultation. Results: Records of 5215 patients with type diabetes (59.4% males) were analyzed. Mean age of the male and female subjects was 52.7 and 50.6 years, respectively. Hypertriglyceridemia [OR 1.74, 95% CI (1.18-2.57)], increased LDL [OR 1.27, 95% CI (0.78-2.07)] and decreased HDL [OR 0.81, 95% CI (0.43-1.53)] and diabetic foot ulcers [OR 2.32, 95% CI (1.14-4.01)] were significantly associated with poor glycemic control, whereas hypertriglyceridemia [OR 2.39, 95% CI (1.42-4.03)] diabetic foot ulcer [OR 2.32, 95% CI (1.14-4.01)], hypetension [OR 1.65, 95% CI (1.15-2.43)] and coronary artery diasease [OR 1.23, 95% CI (0.77-2.13) were significantly associated with poor glycemic control according to FPG. Conclusion: The study finds association of chronic complications of diabetes with glycemic control among type 2 diabetes patients in Bangladesh. © 2017 Diabetes India.

Bulbul T.,Center for Communicable Diseases | Hoque M.,Bangabandhu Sheikh Mujib Medical University
BMC Pediatrics | Year: 2014

Background: Obesity has been declared an epidemic in many high income countries. In low income countries, the coexistence of obesity and underweight makes the situation more grievous. The priority is to explore the overall pictures of body weight status in low income countries and countries that are in transitional phase. Through this country wide cross sectional study we would like to capture the current body weight status among the school aged children, both in urban and rural areas in Bangladesh. Methods: We conducted a countrywide cross sectional study, from June to September 2009. By random sampling, we selected 10,135 students from 6 to 15 years from both the urban and rural schools. We categorized the students into overweight, obese and underweight by using the values for age and sex at +1SD, +2SD and -2 SD of Z scores of BMI respectively. Results: We observed among 6 to 15 year olds from both the urban and rural areas 3.5% were obese, 9.5% were overweight and 17.6% were underweight. The proportion of obese and overweight students were greater among the students from urban schools (5.6%, 10.6%) compared to the students from rural schools (1.2%, 8.6%) (RD = 4.3, 95% CI = 3.6, 5.0; RD = 2.0, 95% CI = 0.1, 3.1). The proportion of underweight students were lower in the urban schools (16.1%) compared to the rural schools (19.2%) (RD = -3.1; 95% CI = -4.6, -1.6). Conclusions: The rate of obesity and overweight is alarming among school aged children in Bangladesh. Overweight and underweight are coexisting which needs special attention to minimize the dual burden. © 2014 Bulbul and Hoque; licensee BioMed Central Ltd.

Kabir M.A.,Bangabandhu Sheikh Mujib Medical University
Mymensingh medical journal : MMJ | Year: 2011

Several studies with probiotics have shown promising results in the treatment of IBS. One of the probiotics used was saccharomyces boulardii. This is a randomized double blind placebo controlled clinical trial of S. boulardii in diarrhoea predominant IBS and was carried out in the hospital of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from June 2004 to July 2005. Thirty five (35) patients were included in each of the control and study groups. The study group was treated with S. boulardii 250 mg twice daily orally for one month. Patients were evaluated before therapy, at the end of therapy and 30 days after end of therapy by a scoring system which included symptoms as well as personal and professional life. No significant difference between the two groups was found in any of the parameters evaluated on any of the observation days. S. boulardii treatment for 30 days in diarrhoea predominant IBS patients did not result in any improvement in this study.

Islam M.S.,Bangabandhu Sheikh Mujib Medical University
Mymensingh medical journal : MMJ | Year: 2013

This prospective study was conducted in rheumatology clinic under the department of medicine of Bangabandhu Sheikh Mujib Medical University from December 2004 to December 2005 to asses the efficacy, safety and compliance of subcutaneous methotrexate (MTX) in active rheumatoid arthritis (RA) patients. A total of 92 active rheumatoid arthritis patients according to American College of Rheumatology (ACR) criteria were recruited for the trial for six months. Among them 46 cases belonged to injectable MTX group and 46 cases belonged to oral MTX group. Mean±SD age of patients was 45.54±12.42 vs. 44.63±13.99 years in subcutaneous group and oral group respectively. In the subcutaneous group 41 were female and 5 male; in the oral group 34 were female and 12 male. Mean duration of the disease was 49.74 months in subcutaneous group and 49 months in oral group. RA test was positive in 35 cases in both groups whereas Rose Waaler test was positive in 19 patients in subcutaneous group and 14 patients in oral group. At 24 week, response rate of ACR 20 was significantly higher in subcutaneous MTX than oral MTX group (93% vs. 80%, p=0.02). Similarly ACR 50 response was significantly higher in subcutaneous MTX than in oral group (89% vs. 72%, p=0.03). ACR 70 response was not significantly higher in SCMTX group then oral group (11% vs. 9 %, p=0.72). Adverse effects were relatively less in subcutaneous MTX and most common side effects were nausea (37% vs. 63%), vomiting (11% vs. 30%), dyspepsia (29% vs. 48%), dizziness (4l% vs. 52%) and alopecia (72% vs. 85%). The results of the study demonstrated that subcutaneous MTX was significantly more effective than oral MTX at the same dosage in active Rheumatoid arthritis patients with no increase in side effects.

Alam S.,Bangabandhu Sheikh Mujib Medical University
Liver international : official journal of the International Association for the Study of the Liver | Year: 2011

Serum alanine transaminase (ALT), hepatitis B virus (HBV) DNA level and age are used in the evaluation of chronic hepatitis B (CHB). We designed this study to evaluate liver histology with ALT and its relation with age and HBV DNA. During the period of October 2006 to July 2009, 499 CHB patients were included in this study with detectable HBV DNA at PCR. Of these, 181 had normal ALT, 200 had ALT [>(1 × ULN) < (2 ULN)] and 118 had ALT ≥ 2 ULN and were labelled as Group 1, 2 and 3 respectively. A strong positive correlation was found between ALT and histological activity index (HAI) and fibrosis. However, 29 (52.7%) and five (9.1%) in Group 1 with positive HBeAg status had HAI ≥4 and fibrosis ≥2 respectively. Among those with HBeAg-negative status, 66 (23.1%) had HAI >4 and 31 (10.8%) had fibrosis ≥2. In Group 2, 14 (15.7%) had moderate-to-severe HAI and 19 (21.2%) had fibrosis ≥2 when HBeAg was positive, in those with HBeAg negative 34 (30.6%) had moderate-to-severe HAI and 38 (34.2%) had fibrosis ≥2. An ALT value of ≥58.5 U/l had higher sensitivity than that of 80 U/l in predicting significant histological changes. Further, HAI and fibrosis were significantly greater in the age of >30 years. We recommend liver biopsy in HBeAg-negative CHB over 30 years of age regardless of ALT level and starting treatment at ALT 1.5 × ULN instead of 2 × ULN. © 2011 John Wiley & Sons A/S.

Faruque M.S.,Bangabandhu Sheikh Mujib Medical University
Mymensingh medical journal : MMJ | Year: 2012

Evaluating short-term (03 months) efficacy and safety of transurethral intraprostatic injection of absolute ethanol to treat benign prostatic hyperplasia (BPH). This intervention study was conducted to evaluate 30 patients with benign prostatic hyperplasia treated by transurethral injection of dehydrated ethanol. Mean age was 69.96 years. Endoscopic injection of 6-13.5 ml ethanol was carried out at 4-8 sites in the prostate. International Prostate Symptom Score (IPSS), maximum flow rate, prostate volume, postvoid residual and side effects or complications were measured postoperatively. Mean IPSS (SD) improved significantly from 18.43 ± 2.38 preoperatively to 6.80 ± 1.34 at 03 months of follow-up, mean peak urinary flow rate increased from 7.33 ± 1.19 ml/s to 16.31 ± 1.69 ml/s after 3 months, mean residual urine volume had decreased from 54.16 ± 30.93 ml to 17.01 ± 9.59 ml after 3 months (p<0.05). The prostate volume decreased from 44.66 ± 9.52 gm preoperatively to 32.46 ± 7.78 gm after 3 months (statistically significant at 5% level). There were no intra-operative complications but post-operative haematuria occurred in two patients, urinary retention occurred in two patients after removal of the catheter. Urinary tract infection developed in one patient. Transurethral ethanol ablation of prostate appears to be safe and cost effective. No occurrence of retrograde ejaculation was detected. The short-term effects of ethanol injection at prostate were satisfactory and acceptable as a minimally invasive therapeutic modality in selected patients.

Mannan M.A.,Bangabandhu Sheikh Mujib Medical University
Mymensingh medical journal : MMJ | Year: 2012

The study was done to determine the renal function in preterm and term newborn infants in the neonatology unit of the Department of Paediatrics and Labour Ward of the Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU) during the period of February 2002 to February 2003. Sixty physiologically stable newborn infants were enrolled in this study, 40 of those were preterm and 20 were term. The gestational ages of preterm and term babies were 35.6±4.7 and 39.10±1.41 weeks respectively. Mean weight of preterm babies was 1840±410 gm and term babies was 3150±340 gm respectively. Male to female ratio was1.6:1. The concentration of serum creatinine was high during the first week of life in both the term and preterm babies. The concentration decreased in both the groups during the subsequent 3 weeks. Although creatinine values were significantly high in preterm babies than the term babies at first week (p<0.001), the values reach to almost similar at 3rd week of life. A negative correlation was found between serum creatinine and gestational age (r=0.86, p<0.001). Creatinine clearance was found low at birth, the lowest values being observed in the most premature infants (p<0.0001) and was increased in the subsequent 3 weeks of the study period. Creatinine clearance showed a positive correlation to gestational age from the first week onwards (r=0.87, p<0.001). Fifteen percent preterm babies were hyponatraemic and in all term babies serum level of sodium was within normal limit. Fractional excretion of sodium was high in preterm neonate than the term neonate especially in early weeks of life (p<0.001). The value correlated negatively to gestational age (r=0.67, p<0.001). It was evident from the present study that the renal function is significantly lower in preterm neonates than term neonates. The study also indicates that the maturation of renal function occurs earlier in the term babies than the preterm babies.

Naher Z.U.,Bangabandhu Sheikh Mujib Medical University
Mymensingh medical journal : MMJ | Year: 2013

Infertility is a medical and social problem all over the world. Infertility results from abnormality of the male partners in almost 50% of cases. Oxidative stress is involved with many chronic pathological conditions and the current study was designed to evaluate any association that may exist between male infertility and oxidative stress. Infertile male patients (having female partners with normal fertility parameters; n=31) and age- matched healthy male fertile control subjects (n=30) were randomly selected from the Infertility Unit of the Gynaecology and Obstetrics Department of Bangabandhu Sheikh Mujib Medical University. As a marker of oxidative stress-induced lipid peroxidation, erythrocyte and seminal plasma malondialdehyde (MDA) levels were measured in fertile and otherwise healthy infertile male subjects. In addition, antioxidant capacity was evaluated by measuring erythrocyte and seminal plasma glutathione (reduced form, GSH) concentrations in fertile and infertile male subjects. The MDA and GSH levels were measured by thiobarbituric acid method and Elmans method respectively. The median (range) MDA level of erythrocyte was found significantly higher in infertile male subjects compared with healthy fertile male subjects 24.23(3.71-42.21) vs. 12.84(1.30-24.00)nmol/gm Hb p<0.001. However, the erythrocyte GSH level did not differ between the two groups 12.62(0.67-29.82) versus 13.93 (2.10-21.08)mg/gm Hb. In case of seminal plasma, the median (range) MDA level was found significantly higher in infertile group 3.17 (1.20-6.21) versus 1.88(0.50-5.37)nmol/ml, p<0.001. In addition, the seminal plasma GSH level was found markedly suppressed in infertile group compared with fertile group 1.64(0.23-7.50) versus 4.26(2.32-7.50)mg/dl, p<0.001. Taken together, infertile male patients show an elevation of oxidative stress markers both in the erythrocytes and in the seminal plasma. Indicating that male infertility might be associated with increased oxidative stress.

Rahman M.M.,Bangabandhu Sheikh Mujib Medical University
Mymensingh medical journal : MMJ | Year: 2012

This prospective randomized, controlled trial was done to evaluate the efficacy of trimetazidine in the prevention of contrast induced nephropathy in patients with raised serum creatinine levels undergoing coronary angiogram. This study was performed in the Department of Cardiology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh from April 2009 to March 2010. Contrast-induced nephropathy (CIN) is a serious complication of coronary angiography that is associated with considerably increased mortality and morbidity, including the need for short-term haemodialysis, extended hospitalisation and permanent impairment of renal function. Trimetazidine (TMZ) has been described as a cellular anti-ischaemic agent. This study was trial with 400 patients. Among them 200 patients treated with trimetazidine plus hydration with normal saline and 200 patients (control) given hydration by normal saline only. It was found that the incidence of CIN was significantly (p<0.05) reduced by trimetazidine administration with saline in comparison with saline alone in patients undergoing coronary angiogram (4% vs. 14%).

Khondker L.,Bangabandhu Sheikh Mujib Medical University
Mymensingh medical journal : MMJ | Year: 2014

Sebum production is stimulated by androgens and is the key in the development of acne vulgaris. Several investigators have looked for direct relationships between serum androgen levels, sebum secretion rate and the presence of acne. The presence of acne in prepubertal girls and sebum production in both sexes correlate with serum dehydroepiandrosterone sulfate (DHEAS) levels. Although increased serum androgen levels correlate with the presence of severe nodular acne in men and women, these levels are often within the normal range in mild to moderate acne. This raises the question of whether there is an increased local production of androgens within the sebaceous gland of patients with acne vulgaris that leads to increased sebum secretion.

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