Banats University Of Agricultural Science And Veterinary Medicine Regele Mihai Romaniei From Timisoara

Timişoara, Romania

Banats University Of Agricultural Science And Veterinary Medicine Regele Mihai Romaniei From Timisoara

Timişoara, Romania

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Ciorsac A.A.,Polytechnic University of Timişoara | Popescu I.,Banats University Of Agricultural Science And Veterinary Medicine Regele Mihai Romaniei From Timisoara | Isvoran A.,West University of Timișoara
Romanian Journal of Physics | Year: 2015

Within this study we assess the affinity binding of a few synthetic anabolic oral administrable steroids: oxymetholone, oxandrolone, methandrostenolone and stanozolol to the human androgen receptor (hARLBD) and a few nonspecific receptors. Molecular docking studies reveal that all these steroids are able to bind to the hARLBD and other nuclear and hormone receptors, despite the law sequence similarity between these receptors. The highest binding energy is registered for methandrostenolone binding to hARLBD, its molecular properties being the most similar to those of the natural ligand, testosterone. Stanozolol provides higher interaction energies for nonspecific receptors in comparison to its interaction with hARLBD. As the molecular properties of all investigated steroids are comparable, these results also illustrate that even small differences in the ligand properties have impact on the interaction strength. Also, computational characterization of structural properties of the hARLBD reveals that androgenic synthetic steroids binding cavity is highly hydrophobic suggesting their possible binding to hydrophobic cavities in various proteins in correlation with their observed side effects. © 2015, Editura Academiei Romane. All rights reserved.


Samfira I.,Banats University Of Agricultural Science And Veterinary Medicine Regele Mihai Romaniei From Timisoara | Rodino S.,Romanian National Institute for Research and Development for Biological Sciences | Rodino S.,University of Bucharest | Petrache P.,University of Bucharest | And 3 more authors.
Digest Journal of Nanomaterials and Biostructures | Year: 2015

Characterization and confirmation of identity as part of the structural interaction perspective of essential oils biostructure from lavender (Lavandula officinalis), peppermint (Mentha piperita), green Douglas (Pseudotsuga menziesii), fir (Abies alba) and chicory (Cichorium intybus) has been addressed by qualitative detection and quantification of specific natural clusters, by infrared absorption spectrophotometry. The method allows the identification of structural components that are characteristic to essential oils, due to steric and electronic effects of vibrational coupling (neighbouring bonds acting on force constant of the bond, changing the position of the absorption band). Through this research the essential oil identity was confirmed by quantifying the structural components and by assigning characteristic absorption bands in the spectrum measured. Comparisons of spectra by calculating the correlation coefficient is a convenient, fast and secure method for objective confirmation of essential oils identity. © 2015, Inst Materials Physics. All rights reserved.


Pentea M.,Banats University Of Agricultural Science And Veterinary Medicine Regele Mihai Romaniei From Timisoara | Butu M.,Romanian National Institute for Research and Development for Biological Sciences | Samfira I.,Banats University Of Agricultural Science And Veterinary Medicine Regele Mihai Romaniei From Timisoara | Cristina R.T.,Banats University Of Agricultural Science And Veterinary Medicine Regele Mihai Romaniei From Timisoara | Butnariu M.,Banats University Of Agricultural Science And Veterinary Medicine Regele Mihai Romaniei From Timisoara
Digest Journal of Nanomaterials and Biostructures | Year: 2015

Brain-imaging studies in animals provided evidence that salvinorin A biostructure, in addition to hallucinations and impairment of motor function in humans, could become a popular drug. Salvia divinorum samples were analyzed by gas chromatography, after being dried at 40°. For extraction was used analytical grade purity acetone and recrystallisation was achieved with methanol of chromatographic purity. Preliminary processing of crude extract allowed enriching the final solution composition in salvinorin A. The large number of signals showed that under ionization an advanced fragmentation of the molecule occurred. By the advanced fragmentation of S. divinorum it was obtained a sample image, with the mass spectrometer, which may constitute a specific footprint of the component salvinorin A. © 2015, Inst Materials Physics. All rights reserved.


Butnariu M.,Banats University Of Agricultural Science And Veterinary Medicine Regele Mihai Romaniei From Timisoara | Samfira I.,Banats University Of Agricultural Science And Veterinary Medicine Regele Mihai Romaniei From Timisoara | Sarac I.,Banats University Of Agricultural Science And Veterinary Medicine Regele Mihai Romaniei From Timisoara | Negrea A.,Banats University Of Agricultural Science And Veterinary Medicine Regele Mihai Romaniei From Timisoara | And 3 more authors.
Allelopathy Journal | Year: 2015

The effects of P. aquilinum alcoholic extract on germination, growth and development of P. pratensis seedlings were examined. The extract decreased the germination and seedling growth, decreased chlorophyll, caretenoid and protein content depending on the extract concentration. Increasing concentrations decreased all these parameters proportionately simulating the effects of allelopathy in ecosystem. The GCMS analysis of alcoholic extract showed the presence of pterosin B and pterosin F which are inhibitory to the seed germination and development P. pratensis. © International Allelopathy Foundation 2015.

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