Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 3.16M | Year: 2016
INFRASTAR aims to develop knowledge, expertise and skill for optimal and reliable management of structures. The generic methodology will be applied to bridges and wind turbines in relation to fatigue offering the opportunity to deal with complementary notions (such as old and new asset management, unique and similar structures, wind and traffic actions) while addressing 3 major challenges: 1/advanced modelling of concrete fatigue behaviour, 2/new non destructive testing methods for early aged damage detection and 3/probabilistic approach of structure reliability under fatigue. Benefit of cross-experience and inter-disciplinary synergies will create new knowledge. INFRASTAR proposes innovative solutions for civil infrastructure asset management so that young scientists will acquire a high employment profile in close dialogue between industry and academic partners. Modern engineering methods, including probabilistic approaches, risk and reliability assessment tools, will take into account the effective structural behaviour of existing bridges and wind turbines by exploiting monitored data. Existing methods and current state-of -the art is based on excessive conservatism which produces high costs and hinders sustainability. INFRASTAR will improve knowledge for optimising the design of new structures, for more realistic verification of structural safety and more accurate prediction of future lifetime of the existing structures. That is a challenge for a sustainable development because it reduces building material and energy consumption as well as CO2 production. Within the global framework of optimal infrastructure asset management, INFRASTAR will result in a multi-disciplinary body of knowledge covering generic problems from the design stage process of the new civil infrastructures up to recycling after dismantlement. This approach and the proposed methods and tools are new and will allow a step forward for innovative and effective process.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 2.98M | Year: 2016
The overall objective of BioCapture is to develop novel robust assays for proteinaceous biomarkers associated with cancer and to develop innovative tools for assaying elusive cancer related posttranslational modifications in proteins. This will be achieved by exploiting robust glycan, peptide and protein binders in the form of Molecularly Imprinted Polymers (MIPs) or plastic antibodies alongside generic enrichment combined with selected reaction monitoring-based mass spectrometry assays. In addition, sequence specific MIPs for multiple proteotypic peptides will be developed for use as capture phases in array format followed by MS or fluorescence based readout as well as a coupling of both detection techniques. The artificial receptors will be developed by various Molecular Imprinting techniques. The research results will lead to technological advances having a major impact on 1) health care since it will profit from methods for earlier, more reliable diagnosis of diseases, 2) drug discovery allowing a faster target or biomarker identification; and 3) biochemistry research laboratories in resulting in improved protein fractionation tools for revealing low abundant post translational modifications. The training of researchers will be performed by a consortium consisting of in total 15 partners whereof 6 polymer/materials research groups, 5 protein/glycan chemistry/analysis groups, 1 separation technology companies, 2 expert groups on platforms for multiplex analysis and one diagnostic company. This forms the basis for a very exciting interdisciplinary training program. Thus 11 early stage researchers (ESRs) working on specific tasks within five work packages will follow a rich training program providing a well-balanced spectrum of scientific, business and entrepreneurial skills.
Agency: European Commission | Branch: H2020 | Program: IA | Phase: MG-4.1-2014 | Award Amount: 25.11M | Year: 2015
The project HERCULES-2 is targeting at a fuel-flexible large marine engine, optimally adaptive to its operating environment. The objectives of the HERCULES-2 project are associated to 4 areas of engine integrated R&D: Improving fuel flexibility for seamless switching between different fuel types, including non-conventional fuels. Formulating new materials to support high temperature component applications. Developing adaptive control methodologies to retain performance over the powerplant lifetime. Achieving near-zero emissions, via combined integrated aftertreatment of exhaust gases. The HERCULES-2 is the next phase of the R&D programme HERCULES on large engine technologies, which was initiated in 2004 as a joint vision by the two major European engine manufacturer groups MAN and WARTSILA. Three consecutive projects namely HERCULES - A, -B, -C spanned the years 2004-2014. These three projects produced exceptional results and received worldwide acclaim. The targets of HERCULES-2 build upon and surpass the targets of the previous HERCULES projects, going beyond the limits set by the regulatory authorities. By combining cutting-edge technologies, the Project overall aims at significant fuel consumption and emission reduction targets using integrated solutions, which can quickly mature into commercially available products. Focusing on the applications, the project includes several full-scale prototypes and shipboard demonstrators. The project HERCULES-2 comprises 4 R&D Work Package Groups (WPG): - WPG I: Fuel flexible engine - WPG II: New Materials (Applications in engines) - WPG III: Adaptive Powerplant for Lifetime Performance - WPG IV: Near-Zero Emissions Engine The consortium comprises 32 partners of which 30% are Industrial and 70% are Universities / Research Institutes. The Budget share is 63% Industry and 37% Universities. The HERCULES-2 proposal covers with authority and in full the Work Programme scope B1 of MG.4.1-2014.
Agency: European Commission | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 877.50K | Year: 2017
Additive manufacturing (AM) technologies and overall numerical fabrication methods have been recognized by stakeholders as the next industrial revolution bringing customers needs and suppliers offers closer. It cannot be dissociated to the present trends in increased virtualization, cloud approaches and collaborative developments (i.e. sharing of resources). AM is likely to be one good option paving the way to Europe re-industrialization and increased competitiveness. AMITIE will reinforce European capacities in the AM field applied to ceramic-based products. Through its extensive programme of transnational and intersectoral secondments, AMITIE will promote fast technology transfer and enable as well training of AM experts from upstream research down to more technical issues. This will provide Europe with specialists of generic skills having a great potential of knowledge-based careers considering present growing needs for AM industry development. To do that, AMITIE brings together leading academic and industrial European players in the fields of materials science/processes, materials characterizations, AM technologies and associated numerical simulations, applied to the fabrication of functional and/or structural ceramic-based materials for energy/transport, and ICTs applications, as well as biomaterials. Those players will develop a new concept of smart factory for the future based on 3D AM technologies (i.e. powder bed methods, robocasting, inkjet printing, stereolithography, etc.) and their possible hybridization together or with subtractive technologies (e.g. laser machining). It will allow for the production of parts whose dimensions, shapes, functionality and assembly strategies may be tailored to address todays key technological issues of the fabrication of high added value objects following a fully-combinatorial route. This is expected to lead to a new paradigm for production of multiscale, multimaterial and multifunctional components and systems
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC5-13-2016-2017 | Award Amount: 7.71M | Year: 2016
Scandium (Sc) is one of the highest valued elements in the periodic table and an element which is usually grouped in REEs as it shares many characteristics with Yttrium. Scandium technological applications are unique, as it is a key component in producing Solid Oxide Fuel Cells (Scandia-Stabilized-Zirconia solid electrolyte layer) or high strength Aluminum alloys used in aerospace and 3D printing applications (SCALMALLOY). Yet Scandium supply is limited due to its scarcity and the high cost of its production, which currently takes place in Asia and Russia. Europe has no production of Scandium, but is home to many Sc industrial end-users (Airbus, II-VI, KBM Affilips and others). In fact end-users like Airbus, are not deploying their Sc applications due to the lack of a secure Sc supply. The SCALE project sets about to develop and secure a European Sc supply chain through the development of technological innovations which will allow the extraction of Sc from European industrial residues. Bauxite Residues from alumina production (5 Million tons on dry basis per year in Europe) and acid wastes from TiO2 pigment production (1.4 Million tons on dry basis per year in Europe) have Sc concentrations which are considered exploitable, given a viable extraction technology. SCALE develops and demonstrates the value chain starting from residue and finishing to high tech end-product. In more detail: SCALE develops innovative technologies that can extract economically and sustainably Sc from dilute mediums (<100 mg/L) and upgrade them to pure oxides, metals and alloys at lower energy or material cost. SCALE extracts along with Sc all other REEs found in the by-products (AoGs BR on an annual base contain 10% of the European REE raw material imports) The industrially driven SCALE consortium covers the entire Sc value chain with 7 major European industries and further features 8 academic and research institutes and 4 engineering companies with track records in RTD.
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: NMBP-26-2016 | Award Amount: 10.76M | Year: 2016
An increasing number of nanomaterials (NMs) are entering the market in every day products spanning from health care and leisure to electronics, cosmetics and foodstuff. Nanotechnology is a truly enabling technology, with unlimited potential for innovation. However, the novelty in properties and forms of NMs makes the development of a well-founded and robust legislative framework to ensure safe development of nano-enabled products particularly challenging. At the heart of the challenge lies the difficulty in the reliable and reproducible characterisation of NMs given their extreme diversity and dynamic nature, particularly in complex environments, such as within different biological, environmental and technological compartments. Two key steps can resolve this: 1) the development of a holistic framework for reproducible NM characterisation, spanning from initial needs assessment through method selection to data interpretation and storage; and 2) the embedding of this framework in an operational, linked-up ontological regime to allow identification of causal relationships between NMs properties, be they intrinsic, extrinsic or calculated, and biological, (eco)toxicological and health impacts fully embedded in a mechanistic risk assessment framework. ACEnano was conceived in response to the NMBP 26 call with the aim to comprehensively address these two steps. More specifically ACEnano will introduce confidence, adaptability and clarity into NM risk assessment by developing a widely implementable and robust tiered approach to NM physico-chemical characterisation that will simplify and facilitate contextual (hazard or exposure) description and its transcription into a reliable NMs grouping framework. This will be achieved by the creation of a conceptual toolbox that will facilitate decision-making in choice of techniques and SOPs, linked to a characterisation ontology framework for grouping and risk assessment and a supporting data management system.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 2.14M | Year: 2017
The overall objective of Glyco Imaging is to develop novel assays for detection of glycans as biomarkers associated with aggressive and metastatic cancer forms. The assays will be developed for biomarker detection in blood, urine, cells and tissue. Molecularly Imprinted Polymers (MIPs), or plastic antibodies, have been developed for targeting the human glycan sialic acid (SA), or Neu5Ac. The efficiency of the Neu5Ac specific SAMIPs targeted to the biomarker SA in different solvents (methanol, water, phosphate buffer) will be exploited. The non-human Neu5Gc, which is incorporated into human glycoconjugates through dietary sources such as red meat, and shown to be involved in malignant cell transformation in humans, will also be investigated by using highly specific Neu5Gc-SAMIPs. The imaging and detection techniques used will be based on fluorescence, 3D-viewing of cancer cells by digital holographic microscopy and magnetic separation columns. The results in this research consortium will lead to major technological advances having impact on 1) health care, since it will develop more accurate and reliable diagnostics of aggressive and metastatic cancers, 2) drug discovery allowing a faster and cheaper biomarker targeting and detection; and 3) biochemistry research laboratories in resulting in improved understanding of glycan expression in cancer, with emphasis on aggressive metastatic cancer. The training of researchers will be performed by a consortium consisting of 6 partners with biomedical, imaging and particle synthesis skills (4 groups, one institution, one technology company). This forms the basis for a very competent interdisciplinary training program with high quality in both education and research. 8 early stage researchers (ESRs) working on specific tasks within 5 work packages will follow a rich training program providing a well-balanced spectrum of scientific, business and entrepreneurial skills.
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: NMBP-27-2016 | Award Amount: 2.00M | Year: 2016
A significant challenge to ensuring sustainable production and use of nanotechnologies is to understand safety and health risks of the technology and its end-products, and to implement practical strategies to manage these risks. Knowledge is growing rapidly, but effective use of this knowledge for risk management is lagging behind. We therefore need to bridge the gap between knowledge on hazard and risk, and fit-for-purpose risk management tools and strategies supported by measurement and control methods. EC4SafeNano will bridge this gap in an efficient and sustainable way by setting up an independent, science-based, managed Centre (hub) linked with several networks (spokes) to act at the interface between research organisations, industry, regulatory bodies, and civil society. The objectives are to: 1) understand the needs of all stakeholders along the innovation value chain for nanotechnologies, ensuring safer, marketable, regulated and accepted long-lived products; 2) identify the resources and capabilities available to address these needs, and evaluate the capacity to provide technical solutions and actions; 3) build, test and benchmark a range of services, based on selected resources that answer stakeholder needs across the innovation value chain; 4) develop mechanisms and operating procedures to facilitate periodic updating of the needs and resources mapping and of the service provision; 5) develop networking activities aiming to share, benchmark and promote the EC4SafeNano services thereby enhancing and harmonizing the overall expertise, at EU level and beyond; and 6) develop governance rules and a strategic plan to prepare for self-sufficient operation beyond the project lifetime. The main outcome is the definition of a legal entity with operating procedures, gathering, integrating and sharing available technology, tools, skills and processes and promoting services and capabilities to support stakeholder needs in risk management and safe innovation.
Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 3.37M | Year: 2016
Limiting the climate change-induced temperature increase to less than 2C will require strong reductions in greenhouse gas emissions. Lightweight materials and fibre-reinforced composites in particular, are a key enabling technology to achieve this goal. Current composite applications are however strongly overdesigned due to a lack of reliable design tools and predictive models for their mechanical properties. Developing, using and applying these models requires interdisciplinary researchers with a strong background in both modelling and experiments, but such researchers are scarce. The 9 beneficiaries and 3 partner organisations in FiBreMoD aim to train 13 such researchers to become multi-talented and interdisciplinary researchers that will be highly coveted in the field of composites. They will be intensively trained by leading experts with world-class facilities and will be supported by a strong industry participation and an extensive international network. The training programme places a strong emphasis on entrepreneurship and innovation skills not only by dedicated workshops but also by the involvement of the researchers in potential commercialisation. This approach will be key to improving the EUs innovation capacity. Simultaneously, the researchers will advance state-of-the-art composite failure models to reach the required levels of accuracy and develop advanced and industry-friendly characterisation techniques for measuring the required input data. The goal will be to enable blind predictions, which means that parameter fitting or tuning of the models is no longer required. These new and unprecedented levels of understanding coupled with improved prediction accuracy will be exploited to (1) design novel microstructures for hybrid, hierarchical and discontinuous fibre composites and (2) increase the usefulness of models in practical composite applications. The developed models will be validated and used to design composite cylinders and automotive parts.
Wurth C.,BAM Federal Institute of Materials Research and Testing
Nature protocols | Year: 2013
Luminescence techniques are among the most widely used detection methods in the life and material sciences. At the core of these methods is an ever-increasing variety of fluorescent reporters (i.e., simple dyes, fluorescent labels, probes, sensors and switches) from different fluorophore classes ranging from small organic dyes and metal ion complexes, quantum dots and upconversion nanocrystals to differently sized fluorophore-doped or fluorophore-labeled polymeric particles. A key parameter for fluorophore comparison is the fluorescence quantum yield (Φf), which is the direct measure for the efficiency of the conversion of absorbed light into emitted light. In this protocol, we describe procedures for relative and absolute determinations of Φf values of fluorophores in transparent solution using optical methods, and we address typical sources of uncertainty and fluorophore class-specific challenges. For relative determinations of Φf, the sample is analyzed using a conventional fluorescence spectrometer. For absolute determinations of Φf, a calibrated stand-alone integrating sphere setup is used. To reduce standard-related uncertainties for relative measurements, we introduce a series of eight candidate quantum yield standards for the wavelength region of ∼350-950 nm, which we have assessed with commercial and custom-designed instrumentation. With these protocols and standards, uncertainties of 5-10% can be achieved within 2 h.