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Moscow, Russia

Kovalev G.I.,Russian Academy of Medical Sciences | Kondrakhin E.A.,ul. Baltiiskaya | Salimov R.M.,ul. Baltiiskaya
Neurochemical Journal | Year: 2013

We studied spontaneous behavior in the cross-maze test and differences in neuroreceptors in inbred C57BL/6 and BALB/c mice. Correlation and factor analysis of behavioral data showed that the indices of exploratory behavior and anxiety in a novel context were rather independent from each other. The densities of NMDA receptors (B max, fmol/mg of protein) in the hippocampus and benzodiazepine receptors in the prefrontal cortex were higher in C57BL/6 mice. Our data demonstrate the opportunity for selective pharmacological regulation of cognitive behavior and anxiety using nootropic and anxiolytic drugs. © 2013 Pleiades Publishing, Ltd.

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