Bayazit H.,Siverek State Hospital |
Cicek E.,Cumra State Hospital |
Selek S.,University of Texas Health Science Center at Houston |
Aksoy N.,Harran University |
And 3 more authors.
European Addiction Research | Year: 2016
Background: It has been determined that cannabis has adverse effects on brain tissue, and that increased S100 calcium binding protein B (S100B) blood levels are markers of neuronal damage. Therefore, the aim of this study was to evaluate the S100B levels in cannabis use disorder. Method: Thirty-two patients with cannabis use disorder and 31 matched healthy controls were enrolled in this study. Appropriate blood samples were taken from the enrolled subjects, and the serum S100B protein levels were measured with an electrochemiluminescence immunoassay for the quantification of the protein. Findings: We found significantly increased S100B protein levels in patients with cannabis use disorder. The mean serum concentration of S100B was 0.081 ± 0.018 μg/l in patients with cannabis use disorder, and 0.069 ± 0.018 μg/l in the control group (p = 0.008). Interpretation: Our data suggest that elevated S100B protein levels might indicate neuronal damage in the brains of people with cannabis use disorder. © 2015 S. Karger AG, Basel.
Kul M.,Mersin Children Hospital |
Unal F.,Hacettepe University |
Kandemir H.,Harran University |
Sarkarati B.,Hacettepe University |
And 2 more authors.
Psychiatry Investigation | Year: 2015
Objective Oxidative metabolism is impaired in several medical conditions including psychiatric disorders, and this imbalance may be involved in the etiology of these diseases. The present study evaluated oxidative balance in pediatric and adolescent patients with attention deficit hyperactivity disorder (ADHD). Methods The study included 48 children and adolescents (34 male, 14 female) with ADHD who had no neurological, systemic, or comorbid psychiatric disorders, with the exception of oppositional defiant disorder (ODD), and 24 sex- and age-matched healthy controls (17 male and seven female). Results TAS was significantly lower, and TOS and OSI were significantly higher in patients with ADHD than in healthy controls. Total antioxidant levels were lower in patients with comorbid ODD than in those with no comorbidity. No difference was found in TOS or OSI among the ADHD subtypes; however, TAS was higher in the attention-deficient subtype. Conclusion Our findings demonstrated that oxidative balance is impaired and oxidative stress is increased in children and adolescents with ADHD. This results are consistent with those of previous studies. © 2015 Korean Neuropsychiatric Association.
Yemisen M.,Balikligol State Hospital |
Karakas E.,Sanliurfa State Hospital |
Ozdemir I.,Sanliurfa State Hospital |
Karakas O.,Sanliurfa State Hospital
Journal of Infection and Chemotherapy | Year: 2012
Brucellosis is an endemic disease in Turkey, and testicular abscess is a rare and frequently misdiagnosed complication of brucellosis. In the literature there are only seven reported cases, and all were treated with both medical and surgical therapy. We report a case of brucellar testicular abscess treated with medical therapy only. Although the patient recovered clinically at the end of 6 weeks, the regression of the testicular lesion could not be observed until after 5 months. © Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2012.
Dursun M.,Okmeydani Training and Research Hospital |
Otunctemur A.,Okmeydani Training and Research Hospital |
Ozbek E.,Okmeydani Training and Research Hospital |
Cakir S.S.,Okmeydani Training and Research Hospital |
Polat E.C.,Balikligol State Hospital
Journal of Obstetrics and Gynaecology Research | Year: 2013
Aim: Stress urinary incontinence (SUI) is a serious problem in women who have delivered vaginally, and causes some sexual dysfunction. The transobturator tape (TOT) procedure is one of the most common methods for the treatment of SUI. In the present study, we investigated the effect of the TOT procedure on sexual function in women. Material and Methods: From June 2008 to March 2011, 117 patients underwent the TOT procedure for SUI in our clinic. Ninety-six sexually active women participated in the study and the mean age was 49.2 (29-61) years. Before and 6 months after surgery, the patients' sexual desire, arousal, lubrication, orgasm, satisfaction and pain during sexual intercourse and sexual functions were all evaluated with the Female Sexual Function Index questionnaire. The results were compared statistically using the Wilcoxon test. Results: The cure rate of the TOT procedure for SUI was 87%. Of the 96 women who were sexually active, 35 (36%) experienced urinary loss during sexual activity. Thirty-three (95%) of these patients were cured after surgery completely. Female Sexual Function Index scores for desire, arousal, lubrication, orgasm and in total increased slightly after surgery but none of these improvements reached a statistically significant level. However, statistically significant improvement was determined for satisfaction and pain after surgery (P < 0.05). Conclusion: SUI causes some problems affecting quality of life, including sexual dysfunction. After the TOT procedure, significant improvement was determined in sexual function affected by SUI. © 2012 Japan Society of Obstetrics and Gynecology.
Kocarslan S.,Harran University |
Turan E.,Harran University |
Ekinci T.,Balikligol State Hospital |
Yesilova Y.,Harran University |
Apari R.,Harran University
Indian Journal of Pathology and Microbiology | Year: 2013
Background: The aim of our study was to investigate the clinical and histopathological characteristics of cutaneous leishmaniasis (CL) in the city of Sanliurfa in Turkey, where Syrian refugees also reside. Materials and Methods: At the Harran University Hospital outpatient clinics between 2012 and 2013, 54 CL cases, including 24 Syrian patients, underwent punch biopsy of the skin and/or a touch imprint. Patients in whom leishmania parasites were detected were included in the study. The clinical and histopathological data of the patients were obtained by a review of the patients' medical records. All the slides of each patient were re-evaluated histopathologically. Results: Fifty-four cases (mean age; 17 ± 12 years), consisting of 32 males (59.3%) and 22 females (40.7%), were examined. The most common site of involvement was the face (63%). The most common presentation was noduloulcerative lesions (57.4%). Histopathologically, the majority of the cases exhibited hyperkeratosis, follicular plugging of the epidermis, chronic inflammatory infiltration, leishmania amastigotes and non-caseating granulomatous inflammation in the dermis. Conclusion: CL presents with a wide spectrum of expression, both clinically and histologically, and may mimic other inflammatory and neoplastic diseases. The diagnosis of CL relies on the identification of leishmania amastigotes in either a direct smear of the lesion or in a tissue section.
Kaya D.,Dokuz Eylül University |
Tanriverdi Z.,Balikligol State Hospital |
Dursun H.,Dokuz Eylül University |
Colluoglu T.,Dokuz Eylül University
International Journal of Cardiovascular Imaging | Year: 2016
Transcatheter aortic valve implantation (TAVI) with self-expandable Medtronic CoreValve (MCV; Medtronic, Minneapolis, MN) or balloon-expandable Edwards SAPIEN XT valve (ESV; Edwards Lifesciences, Irvine, CA) has been widely used for treatment of high-risk patients with severe aortic stenosis (AS). There is limited data comparing the long-term hemodynamic performance of these two valves. Therefore, this study aimed to compare the short and long-term hemodynamic performance of TAVI with either MCV or ESV. A total of 78 patients who underwent TAVI in our center between June 01, 2012 and January 01, 2014 were enrolled in this retrospective study. For each of the patients we recorded the preprocedural echocardiographic data as well as the post-TAVI echocardiographic outcomes at day one, 6 months and 1 year. The MCV group had lower transaortic gradients than the ESV group, with respect to both maximum (13.4 ± 5.8 vs 18.7 ± 8.1 mmHg, p = 0.001) and mean values (6.5 ± 3.2 vs 9.4 ± 4.3 mmHg, p < 0.001) at post-TAVI day one. These values continued to be significantly lower in the MCV group during post-TAVI 6 months (p < 0.001) and post-TAVI 1 year follow-up (p < 0.05). A paravalvular leak (PVL, grade ≥2) was observed in 6.4 % of patients after TAVI; however, this value decreased over time, and there was no significant difference between the MVC and ESV groups (8.2 vs 3.4 %, p = 0.646). The MCV bioprosthesis was associated with lower transaortic gradients than those of the ESV throughout 1 year of follow-up. The incidence of PVL grade ≥2 in MCV and ESV was comparable. © 2016 Springer Science+Business Media Dordrecht
Akcal M.A.,Antalya Ataturk State Hospital |
Poyanli O.,Istanbul Medeniyet University |
Unay K.,Istanbul Medeniyet University |
Esenkaya I.,Istanbul Medeniyet University |
And 2 more authors.
Journal of Orthopaedic Surgery and Research | Year: 2014
Background: Comminuted fractures can occur due to severe traumas. The treatment of these fractures that may cause serious morbidity and sometimes mortality is N-butyl cyanoacrylate. It has been reported that this adhesive provides sufficient rigid fixation for bone healing. This study aims to examine cyanoacrylate radiologically and histologically to determine whether it provides adequate recovery in segmental fractures. The secondary objective is to evaluate N-butyl cyanoacrylate, an adhesive material that can hold the fragments on the fracture line together following reduction.Methods: Sixteen Sprague-Dawley rats were divided in two groups as control (n = 8) and experimental (n = 8) groups. In the control group, segmental fractures were made and fixated with K-wire. In the experimental group, the same surgical procedure was applied and also fragments were stabilized with N-butyl cyanoacrylate.Results: On the sixth week, we did not see any statistically significant difference in the radiological scoring between groups. However, the pathological scores of the control group were statistically higher than the cyanoacrylate group.Conclusions: We found that cyanoacrylate was rapidly and easily applied in the segmental fractures but did not cause any superior radiological and clinical results compared to the control group. The cyanoacrylate had low viscosity, and it was not capable enough to fill the defects formed between osteotomy surfaces. However, it did not adversely affect fracture healing as seen in biopsies taken as a result of follow-ups. © 2014 Akcal et al.; licensee BioMed Central Ltd.
PubMed | Balikligol State Hospital and Harran University
Type: Journal Article | Journal: Redox report : communications in free radical research | Year: 2016
The purpose of this study was to investigate oxidative stress in children with attention deficit hyperactivity disorder (ADHD).Total oxidant status (TOS), total antioxidant status (TAS), paraxonase-1 (PON-1) and arylesterase (ARE) activity were measured in 76 children (44 boys, 32 girls) diagnosed with ADHD according to the DSM-IV and 78 healthy children (46 boys, 32 girls).Age and sex were similar between the groups (P>0.05). TOS and the oxidative stress index (OSI) were higher in the patient group than the control group (P<0.001). PON-1 (P=0.002), ARE (P=0.010) activity and TAS (P<0.001) were lower in the patient group than the control group.We found decreased PON-1, ARE activity and TAS, and increased TOS and OSI in children with ADHD. Our study showed that there is significantly increased oxidative stress in children with ADHD.
PubMed | Balikligol State Hospital and Dokuz Eylül University
Type: Journal Article | Journal: The international journal of cardiovascular imaging | Year: 2016
Transcatheter aortic valve implantation (TAVI) with self-expandable Medtronic CoreValve (MCV; Medtronic, Minneapolis, MN) or balloon-expandable Edwards SAPIEN XT valve (ESV; Edwards Lifesciences, Irvine, CA) has been widely used for treatment of high-risk patients with severe aortic stenosis (AS). There is limited data comparing the long-term hemodynamic performance of these two valves. Therefore, this study aimed to compare the short and long-term hemodynamic performance of TAVI with either MCV or ESV. A total of 78 patients who underwent TAVI in our center between June 01, 2012 and January 01, 2014 were enrolled in this retrospective study. For each of the patients we recorded the preprocedural echocardiographic data as well as the post-TAVI echocardiographic outcomes at day one, 6months and 1year. The MCV group had lower transaortic gradients than the ESV group, with respect to both maximum (13.45.8 vs 18.78.1mmHg, p=0.001) and mean values (6.53.2 vs 9.44.3mmHg, p<0.001) at post-TAVI day one. These values continued to be significantly lower in the MCV group during post-TAVI 6months (p<0.001) and post-TAVI 1year follow-up (p<0.05). A paravalvular leak (PVL, grade 2) was observed in 6.4% of patients after TAVI; however, this value decreased over time, and there was no significant difference between the MVC and ESV groups (8.2 vs 3.4%, p=0.646). The MCV bioprosthesis was associated with lower transaortic gradients than those of the ESV throughout 1year of follow-up. The incidence of PVL grade 2 in MCV and ESV was comparable.
PubMed | Balikligol State Hospital, Siverek State Hospital, University of Texas Health Science Center at Houston, Makif Inan Training And Education Hospital and Harran University
Type: Journal Article | Journal: Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD) | Year: 2016
Preclinical studies indicate that stress early in life can cause long-term alterations in brain development. Studies have shown alterations in the brain functions of patients after experiencing trauma. Our aim is to examine whether the integrity of white matter tracts might be affected in dissociative disorder (DD) patients. A total of 15 DD patients and 15 healthy controls were studied, with the groups matched by age and gender. Diffusion-weighted echoplanar brain images were obtained using a 1.5 Tesla magnetic resonance imaging scanner. Regions of interest were manually placed on directional maps based on principal anisotropy. Apparent diffusion coefficient and fractional anisotropy (FA) values of white matter were measured bilaterally in the anterior corona radiata (ACR) and by diffusion tensor imaging in the genu and splenium of the corpus callosum. Significantly lower FA values were observed in the right ACR of DD patients versus healthy individuals. We also found an association between bad paternal relationships and lower FA in the genu of the corpus callosum in female patients. Alterations in the right ACR suggest that diffusion anisotropy measurement can be used as a quantitative biomarker for DD. Paternal relationships may also affect the brains microstructure in women with DD.