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Othayoth R.,Koneru Lakshmaiah College of Engineering | Mathi P.,Koneru Lakshmaiah College of Engineering | Bheemanapally K.,Balaji Institute of Pharmaceutical science | Kakarla L.,Koneru Lakshmaiah College of Engineering | And 2 more authors.
Journal of Microencapsulation | Year: 2015

Context: Vitamins have been shown to reduce chemotherapy-related fatigue (CRF) by conserving energy loss both during and after cancer treatment. However, it remains unknown whether this reduction of fatigue interferes with the cancer drugs or alters the effectiveness of these agents. Objectives: The objective was to synthesize vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue. Materials and methods: Multi-vitamin (C, D3, and B12)-cisplatin composite nano-formulation called NanoCisVital (NCV) to overcome CRF. The interactions between vitamins and NCV were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, and a particle size analyser. The chemo-preventive activity was performed by in vitro bio assays. Results: SEM analysis showed spherical shape and the size is < 225 nm. NCV inhibited the proliferating yeast cells as well as denaturation of bovine serum albumin, and it also reduced the sprouting of new blood vessels in dose-dependent manner. Conclusion: Collectively, these results demonstrate that the NCV particles can be used to reduce CRF without much affecting the anti-cancer properties of cisplatin. © 2015 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted. Source

Krishnakumar E.,Balaji Institute of Pharmaceutical science
Avicenna Journal of Medical Biotechnology | Year: 2010

Adjuvant induced arthritis is a chronic crippling, skeleton-muscular disorder having nearest approximation to human rheumatoid arthritis for which there is currently no medicine available effecting a permanent cure. Even modern drugs used for the amelioration of the symptoms, offer only temporary relief and also produce severe side effects. In the indigenous system of medicine, wood of Premna serratifolia Linn., is reported to be useful in the treatment of arthritis. It is a large shrub, distributed throughout Asia, used against a wide variety of diseases. However, no systematic study has been reported regarding its anti-arthritic activity. This work was aimed at the scientific validation of the ethno-pharmacological claim about its anti-arthritic property. In the present study, anti-arthritic activity of ethanol extract of Premna serratifolia Linn., wood is done by Freund's adjuvant induced arthritis model. Loss in body weight during arthritis condition was corrected on treatment with ethanol extract and standard drug, indomethacin. Biochemical parameters such as hemoglobin content, total WBC, RBC, erythrocyte and sedimentation rate were also estimated. The ethanol extract at the dose of 300 mg/kg body weight inhibited the rat paw edema by 68.32% which is comparable with standard drug indomethacin 74.87% inhibition of rat paw edema after 21 days. The results of the current investigation concluded, ethanol extract of Premna serratifolia Linn., wood possess a significant anti-arthritic activity against adjuvant induced arthritis and justifying its therapeutic role in arthritic condition. The observed antiarthritic activity may be due to the presence of phytoconstituents such as irridiod glycosides, alkaloids, phenolic compounds and flavonoids. Copyright © 2010, Avicenna Journal of Medical Biotechnology. All rights reserved. Source

Lingala S.,Acharya Nagarjuna University | Nerella R.,Balaji Institute of Pharmaceutical science | Sambasiva Rao K.R.S.,Acharya Nagarjuna University
Der Pharma Chemica | Year: 2011

New benzimidazole derivatives containing 4-chloropyridine-2-carbonyl and N-methyl picolinamide moieties in one side chain at 1H position of benzimidazoles (2-((benzylthio)methyl)-1H-benzo[d]imidazol-1-yl)(4-chloropyridin-2-yl)methanones(3) have been synthesized as depicted in scheme-1. The intermediates and final compounds were purified and their chemical structures have been confirmed by IR, 1H NMR, and Mass spectral data. All the derivatives were examined for their anthelmintic activity against Indian adult earthworms (pheretima posthuma) at various concentrations (0.2% and 0.5%), antibacterial activity against B.subtilis, B.cereus, S.epidermidis, S.typhi, P.aeruginosa and K.pneumoniae and antifungal activity against A.flavus, F.oxysporium and P.notatum at a concentration of 2mg/ml. Most of the compounds tested have shown promising activities when compared with the standard drugs. Source

Gopal N.,Balaji Institute of Pharmaceutical science | Gandhimathi M.,JKK Nataraja Dental College and Hospital
Eurasian Journal of Analytical Chemistry | Year: 2011

A simple, rapid, reliable and accurate HPTLC method has been developed for the quantitative determination of Donepezil HCl in bulk and tablets. Various aliquots of the sample solution were spotted automatically by means of camag Linomat 5 applicator on precoated silica gel 60 F 254 on aluminium sheet as stationary phase pre washed with methanol using Methanol: Chloroform (8:2 v/v) as mobile phase. The spots were scanned at 254 nm. The R f value of Donepezil HCl was 0.54 ± 0.02. Calibration curves were linear in the range of 200-1000 ng spot -1. The limit of detection and limit of quantification were found to be 120 ng spot -1 and 165 ng spot -1 respectively. The suitability of this method for the quantitative determination of compound was proved by validation in accordance with requirements of pharmaceutical regulatory standards. © 2011. Source

Srikanth L.,Prasad Institute of Pharmaceutical science | Raghunandan N.,Balaji Institute of Pharmaceutical science
Der Pharma Chemica | Year: 2011

Benzimidazoles display a broad spectrum of potential pharmacological activities and are present in a number of pharmacologically active molecules such as Albendazole/ Mebendazole/ Thiabendazole (antihelmentic), Omeprazole (anti-ulcer). These compounds carrying different substituents in the benzimidazole structure are associated with a wide range of biological activities. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new therapeutic agents having improved potency and lesser toxicity. In this context, the recently synthesized 2-Substituted benzimidazole derivatives possessing important pharmacological activities have been highlighted. Source

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