Balaji Institute of Pharmaceutical science

Warangal, India

Balaji Institute of Pharmaceutical science

Warangal, India

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Othayoth R.,Koneru Lakshmaiah College of Engineering | Mathi P.,Koneru Lakshmaiah College of Engineering | Bheemanapally K.,Balaji Institute of Pharmaceutical science | Kakarla L.,Koneru Lakshmaiah College of Engineering | And 2 more authors.
Journal of Microencapsulation | Year: 2015

Context: Vitamins have been shown to reduce chemotherapy-related fatigue (CRF) by conserving energy loss both during and after cancer treatment. However, it remains unknown whether this reduction of fatigue interferes with the cancer drugs or alters the effectiveness of these agents. Objectives: The objective was to synthesize vitamin-cisplatin-loaded chitosan nano-particles for chemoprevention and cancer fatigue. Materials and methods: Multi-vitamin (C, D3, and B12)-cisplatin composite nano-formulation called NanoCisVital (NCV) to overcome CRF. The interactions between vitamins and NCV were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, and a particle size analyser. The chemo-preventive activity was performed by in vitro bio assays. Results: SEM analysis showed spherical shape and the size is < 225 nm. NCV inhibited the proliferating yeast cells as well as denaturation of bovine serum albumin, and it also reduced the sprouting of new blood vessels in dose-dependent manner. Conclusion: Collectively, these results demonstrate that the NCV particles can be used to reduce CRF without much affecting the anti-cancer properties of cisplatin. © 2015 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.

Krishnakumar E.,Balaji Institute of Pharmaceutical science
Avicenna Journal of Medical Biotechnology | Year: 2010

Adjuvant induced arthritis is a chronic crippling, skeleton-muscular disorder having nearest approximation to human rheumatoid arthritis for which there is currently no medicine available effecting a permanent cure. Even modern drugs used for the amelioration of the symptoms, offer only temporary relief and also produce severe side effects. In the indigenous system of medicine, wood of Premna serratifolia Linn., is reported to be useful in the treatment of arthritis. It is a large shrub, distributed throughout Asia, used against a wide variety of diseases. However, no systematic study has been reported regarding its anti-arthritic activity. This work was aimed at the scientific validation of the ethno-pharmacological claim about its anti-arthritic property. In the present study, anti-arthritic activity of ethanol extract of Premna serratifolia Linn., wood is done by Freund's adjuvant induced arthritis model. Loss in body weight during arthritis condition was corrected on treatment with ethanol extract and standard drug, indomethacin. Biochemical parameters such as hemoglobin content, total WBC, RBC, erythrocyte and sedimentation rate were also estimated. The ethanol extract at the dose of 300 mg/kg body weight inhibited the rat paw edema by 68.32% which is comparable with standard drug indomethacin 74.87% inhibition of rat paw edema after 21 days. The results of the current investigation concluded, ethanol extract of Premna serratifolia Linn., wood possess a significant anti-arthritic activity against adjuvant induced arthritis and justifying its therapeutic role in arthritic condition. The observed antiarthritic activity may be due to the presence of phytoconstituents such as irridiod glycosides, alkaloids, phenolic compounds and flavonoids. Copyright © 2010, Avicenna Journal of Medical Biotechnology. All rights reserved.

Srikanth L.,Prasad Institute of Pharmaceutical science | Raghunandan N.,Balaji Institute of Pharmaceutical science
Der Pharma Chemica | Year: 2011

Benzimidazoles display a broad spectrum of potential pharmacological activities and are present in a number of pharmacologically active molecules such as Albendazole/ Mebendazole/ Thiabendazole (antihelmentic), Omeprazole (anti-ulcer). These compounds carrying different substituents in the benzimidazole structure are associated with a wide range of biological activities. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new therapeutic agents having improved potency and lesser toxicity. In this context, the recently synthesized 2-Substituted benzimidazole derivatives possessing important pharmacological activities have been highlighted.

Raghunandan N.,Balaji Institute of Pharmaceutical science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2016

Objective: The objective of the study was to evaluate the antihyperglycemic activity and in vivo antioxidant effect of Artocarpus hirsutus seeds in both normal and diabetic rats. Methods: Male Wistar rats weighing about 180-250 g were divided into six groups, of six rats each. Diabetes was induced by giving streptozotocin (30-50 mg/kg) intraperitoneally. Rats, which showed blood glucose levels ≥250 mg/dl, were selected for the study. Metformin (50 mg/kg) was used as a standard oral hypoglycemic agent. Oral glucose tolerance test was performed in all groups of rats. In the estimation of in vivo antioxidant activity, the levels of liver enzymes superoxide dismutase (SOD), lipid peroxidation, and CAT (catalase) were measured using standard methods. Results: The ethyl acetate seed extract of A. hirsutus at different doses was selected and administered orally. The blood glucose levels were estimated by the glucose oxidase method, and insulin levels were measured by chemiluminescence assay method. Antihyperglycemic activity of the test drug in diabetic rats showed a significant reduction in blood glucose levels (p<0.001) at 2, 4, 6, and 8 hrs, respectively, as compared to diabetic groups. The antioxidant enzymes SOD and CAT levels were significantly raised, whereas malondialdehyde-thiobarbituric acid residue substances levels have decreased (p<0.001). Conclusion: The results suggested that A. hirsutus seed extract showed a potential antidiabetic activity and antioxidant effect justifying the use of the drug for the treatment of diabetes mellitus and its associated oxidative damage. © 2016, Innovare Academics Sciences Pvt. Ltd. All rights reserved.

Kumar V.A.,Pathfinder institute of Pharmacy Education and Research | Satla S.R.,JNTUH College of Engineering | Thimmaraju M.K.,Balaji Institute of Pharmaceutical science
Journal of Applied Pharmaceutical Science | Year: 2016

A stability indicating simple, selective, accurate high Performance Liquid Chromatographic (HPLC) method was developed and validated for the combined tablet formulation of pyrimethamine & sulphadoxine. Chromatographic separation was optimized by gradient HPLC on a C18 column [Inertsil Silica, 250 × 4.6 mm, 5μ] utilizing a mobile phase of potassium dihydrogen phosphate and acetonitrile taken in the ratio 70:30 at a flow rate of 1.0 ml/min with UV detection at 221nm. The retention time of pyrimethamine and sulphadoxine was 2.77 and 6.57 min respectively. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantitation, robustness and stress degradation studies. Validation of the method was done in accordance with ICH guidelines for the assay of active ingredients. Thus validated method can be recommended for the routine laboratory analysis. © 2016 Veeragoni Anil Kumar et al.

Jagadeeswaran M.,Balaji Institute of Pharmaceutical science | Gopal N.,Balaji Institute of Pharmaceutical science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

A simple reverse phase high-performance liquid chromatographic method has been developed for the simultaneous determination of diacerein and aceclofenac in tablets. Chromatographic separations of the two drugs were analyzed on a Phenomenex C18 column (250 × 4.60 mm, 5 μ). The mobile phase constituted of 0.01 M potassium dihydrogen phosphate and acetonitrile 60:40 (v/v) and pH adjusted to 4.5 using glacial acetic acid was delivered at the flow rate 2.0 mL min-1. Detection was performed at 280 nm. The retention time of diacerein and aceclofenac was 3.61 and 6.28 min, respectively. Calibration curves were linear with coefficient correlation between 0.99 to 1.0 over a concentration range of 80-120 μg mL-1 of diacerein and aceclofenac. The relative standard deviation (R.S.D) was found to be < 2.0 %.

PubMed | Balaji Institute of Pharmaceutical science and Averinbiotech
Type: | Journal: Interdisciplinary sciences, computational life sciences | Year: 2016

Aurora kinases are the cell cycle mitotic regulators processing multiple functions during cell division. Altered mechanism of these mitotic kinases may contribute to genomic instability that is most often correlated with tumorigenesis, which has been reported in many human cancers. Selective blockage of the aberrantly expressed Aurora kinases has the potential therapeutic assessment to control the deregulated cell cycle machinery and their associated risks of cancer. Using a combination of docking-, ligand- and structure-based pharmacophore strategies, in the present study, we have tried to predict the anticancer potentiality of our synthesized compounds (A1 to A5 and B1 to B9) against human Aurora B kinase. The results revealed that among all the compounds, compound B7 may act as a best candidate to be an agent of the high binding affinity with a score of 113.464kcal/mol and good pharmacophoric features with acceptable fit values of both ligand- and structure-based pharmacophore models. Consequently, ADMET properties are also calculated to predict the safer efficacy of the compounds.

Lingala S.,Balaji Institute of Pharmaceutical science | Samudrala K.,Balaji Institute of Pharmaceutical science | Nerella R.,Balaji Institute of Pharmaceutical science
Journal of Applied Pharmaceutical Science | Year: 2013

In view of various biological activities and enormous importance of indoles, isatins and their derivatives, it was our interest to synthesize and characterize some new 5-Sulfamoyl Isatin derivatives and evaluate them for antimicrobial and anti-inflammatory activity. An appropriate quantity of isatin hydrazone was heated under reflux with ethylchloroformate to give ethyl n-[(z)-(2-oxo-5-sulfamoyl-indolin-3-ylidene)amino]carbamate which was then heated under reflux with various primary amines to give ethyl n-[(z)-(2-oxo-5-sulfamoyl-indolin-3- ylidene) amino]carbamate derivatives. The intermediates and final compounds were purified and their chemical structures have been confirmed by IR, 1H NMR, and Mass spectral data. All the synthesized compounds were screened for antibacterial activity against B. subtilis, B.cereus, S. epidermidis, S. typhi, P. aeruginosa and K. pneumoniae, antifungal activity against A. flavus, F. oxysporium and P. notatum and anti-inflammatory activity using carrageenan induced rat paw edema model. Most of the compounds tested have shown promising activities when compared with the standard drugs. © 2013 Srikanth Lingala et al.

Lingala S.,Acharya Nagarjuna University | Nerella R.,Balaji Institute of Pharmaceutical science | Sambasiva Rao K.R.S.,Acharya Nagarjuna University
Der Pharma Chemica | Year: 2011

New benzimidazole derivatives containing 4-chloropyridine-2-carbonyl and N-methyl picolinamide moieties in one side chain at 1H position of benzimidazoles (2-((benzylthio)methyl)-1H-benzo[d]imidazol-1-yl)(4-chloropyridin-2-yl)methanones(3) have been synthesized as depicted in scheme-1. The intermediates and final compounds were purified and their chemical structures have been confirmed by IR, 1H NMR, and Mass spectral data. All the derivatives were examined for their anthelmintic activity against Indian adult earthworms (pheretima posthuma) at various concentrations (0.2% and 0.5%), antibacterial activity against B.subtilis, B.cereus, S.epidermidis, S.typhi, P.aeruginosa and K.pneumoniae and antifungal activity against A.flavus, F.oxysporium and P.notatum at a concentration of 2mg/ml. Most of the compounds tested have shown promising activities when compared with the standard drugs.

Srikanth L.,Prasad Institute of Pharmaceutical science | Raghunandan N.,Balaji Institute of Pharmaceutical science | Srinivas P.,Prasad Institute of Pharmaceutical science | Reddy G.A.,Prasad Institute of Pharmaceutical science
International Journal of Pharma and Bio Sciences | Year: 2010

In view of various biological activities of both thiazolidinediones and quinoline derivatives like antidiabetic, antifungal, antitumoral, anti-inflammatory, retinoidal, anti atherosclerotic activities, it was our interest to prepare various thiazolidinedione derivatives with a quinoline ring moiety and to evaluate them for antidiabetic activity. 5-(4-fluorobenzyl)-2,4-thiazolidinedione was synthesized by reaction of 4-fluoroaniline with methyl acrylate to give crude 2-Bromo-3-(4-fluoro-phenyl)-propionic acid methyl ester as an oil which was treated with thiourea in presence of sodium acetate and ethanol to give 5-(4-fluoro-benzyl)-2-imino-thiazolidine-4-one which on oxidation gave 5-(4-fluoro-benzyl)-thiazolidine-2,4-dione. This was condensed with the quinoline derivatives in presence of Tetrahydrofuran. Among the synthesized derivatives five of them were screened for oral hypoglycemic activity, the compounds SK, SK-3 were showing significant activity and compound SK-2 was showing moderate activity and compounds SK-4 and SK-5 were active. The structures of newly synthesized compounds were established on the basis of elemental analysis, TLC, IR and 1H NMR spectral studies.

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