Bakirkoy Dr Sadi Konuk Education And Research Hospital
Bakirkoy Dr Sadi Konuk Education And Research Hospital
Gunaldi M.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
Okuturlar Y.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
Gedikbasi A.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
Akarsu C.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
And 2 more authors.
Biomedicine and Pharmacotherapy | Year: 2015
Background: The most frequent cause of cancer deaths throughout the world is breast cancer (BC). Therefore, preventing, diagnosing and treating BC has gained importance. S100 protein probably plays an important role in carcinogenesis, cancer development, and metastasis. In this study, we aimed at diagnostic and clinic-pathological importance of serum levels of S100A9 and S100A12 with known cytokine-like pro-inflammatory effects in BC. Material and method: Serum samples were collected with BC and the control group consisting of healthy individuals. All the samples were analyzed with enzyme-linked immunosorbent assay for serum S100A9 and S100A12 levels before starting the systemic chemotherapy. Clinicopathological characteristics of BC and other blood parameters were compared in relation with serum S100A9 and S100A12 levels. Results: While the serum S100A9 levels were found significantly higher as compared to healthy individuals (190.85. ±. 32.29 and 92.72. ±. 54, respectively) (p= 0.001), it was observed that there were no differences in S100A12 (120.50. ±. 15.78 and 112.21. ±. 10.46, respectively) (p= 0.056) levels. As regards the subgroup analysis in BC patients, no statistically significant results were found in body mass index (BMI), smoking, menopause status, histopathologic type, grade, and biological subtype of BC, tumor size, presence of lymph node metastases, lymphovascular invasion (LVI), perineural invasion (PNI) and stage. As regards the blood parameters and serum S100 A9, while only statistically significant results were found with anemia (209.05. ±. 33.12 and 181.75. ±. 28.21, respectively) (p= 0.005), no statistically significant results were found with leukocytosis, thrombocytosis and tumor markers. Conclusion: In this study, while we found the level of S100A9, which has a potential cytokine-like function in inflammation, significantly higher, we could not find any increase in S100A12 level. Therefore, it is possible that S100A9 can play a key role in inflammation-related BC. Despite of there are no significance relationship between S100A9 and S100A12 clinicopathological features of BC, the determination of S100A9 levels contributes to diagnosis the of BC patients. In future, we suggest that serum S100A9 is investigated as a diagnostic tool even the target marker in BC to suppress inflammation in treatment. © 2015 .
Erdim I.,Erbaa Government Hospital |
Akcay T.,Kanuni Sultan Suleyman Education and Research Hospital |
Yilmazer R.,Istanbul University |
Yilmazer R.,University of Miami |
And 2 more authors.
Journal of Clinical Sleep Medicine | Year: 2015
Objective: To investigate whether there is an association between metabolic syndrome and obstructive sleep apnea syndrome (OSAS) in obese adolescents. Methods: In total, 240 pubertal children or prepubertal children older than 11 y recruited consecutively from the pediatric endocrinology unit, obesity clinic. Patients with tonsillar and adenoid hypertrophy (grade 3/4), systemic illnesses, or chronic drug usage were excluded. After anthropometric measurement and laboratory study, patients were divided into two groups according to metabolic syndrome (MS): MS and non-MS. Overnight polysomnographic evaluation was performed and 104 subjects were included for statistical analysis. The two groups were compared in terms of sleep efficiency, number of awakenings per night, oxygen desaturation index, snoring time, and obstructive/central/mixed apnea-hypopnea index (AHI). Results: Of the obese adolescents, 51 had MS and 53 did not. The AHI was ≥ 1 in 25 of the 53 non-MS children (47.2%) and in 25 of the 51 MS children (49%). The median obstructive AHI value was 0.9 (0.2-2.4) and total AHI was 0.9 (0.2-2.5) in the MS group; these values were 0.9 (0.25-3.55) and 0.9 (0.3-3.55), respectively, in the non-MS group. Obstructive, central, mixed, and total AHI values in the MS and non-MS groups were not statistically significantly different (p > 0.05). Conclusions: In our study, we did not find an association between MS and sleep apnea in obese adolescents.
Tugcu B.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
Araz-Ersan B.,Kanuni Sultan Suleyman Education and Research Hospital |
Erdogan E.T.,Istanbul University |
Tarakcioglu H.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
And 3 more authors.
Documenta Ophthalmologica | Year: 2014
Purpose: To assess structural or functional differences of the retina among subjects with persistent and resolved amblyopia. Methods: Fourteen eyes with persistent amblyopia that did not reach normal visual acuity (VA) levels (≤0.1 LogMAR) despite amblyopia treatment, 18 eyes with resolved amblyopia, and 16 eyes of 16 normal subjects were included. All subjects underwent optical coherence tomography (OCT), pattern visual evoked potential (PVEP), and pattern electroretinography (PERG) evaluation. Results: There was no significant difference in foveal thickness, foveal volume, macular volume, ganglion cell layer thickness, and total and sectorial retinal nerve fiber layer measurements among three groups (p > 0.05). Foveolar thickness was significantly increased in both resolved and persistent amblyopia groups compared with the control group (p = 0.031). However, there was no difference between amblyopic groups (p = 0.98). Although, in the PVEP study, N75 implicit time was found significantly prolonged in both amblyopia groups (p = 0.046), there were no significant differences in P100 implicit time and amplitude among the groups (p > 0.05). PERG amplitude of the persistent group was significantly lower than that of the control group (p = 0.003). There were no significant differences in P50, N95 implicit times among groups (p > 0.05). Conclusions: In our study, the only significant difference between persistent and resolved amblyopia groups was the initial VA. Neither OCT nor electrophysiological examinations were found to be useful in order to explain why some cases were resistant to the treatment for amblyopia. © 2013 Springer-Verlag.
Usta M.,Sisli Etfal Education and Research Hospital |
Erkan T.,Istanbul University |
Cokugras F.C.,Istanbul University |
Urganci N.,Sisli Etfal Education and Research Hospital |
And 3 more authors.
Pediatrics | Year: 2014
OBJECTIVE: Caustic substance ingestion in childhood is a public health issue in developing countries, and several management protocols have been proposed to prevent the resulting esophageal strictures. The role of corticosteroids in preventing corrosive-induced strictures is controversial. Our aim was to study the influence of high doses of corticosteroids in preventing esophageal strictures. METHODS: Eighty-three children with a mean age of 4.10 ± 2.63 years and with grade IIb esophageal burns (an esophagogastroscopy was performed within 24-48 hours of injury) due to corrosive substance ingestion were enrolled in our study between 2005 and 2008. Forty-two children (study group) received methylprednisolone (1 g/1.73 m2 per day for 3 days), ranitidine, ceftriaxone, and total parenteral nutrition. Forty-one children (control group) were administered the same regimen excluding methylprednisolone. Stricture development was compared between groups based on endoscopic and radiologic findings. RESULTS: During the endoscopic examination, stricture development was observed in 4 patients (10.8%) in the study group and in 12 patients (30%) in the control group. The difference was statistically significant (P = .038). The stricture development rate in the upper gastrointestinal system with barium meal was 14.3% and 45.0% in the study and control groups, respectively. The difference was statistically significant (P = .004). The duration of total parenteral nutrition was shorter in the study group compared with the control group (P = .001). High doses of methylprednisolone were well tolerated in the study group without any side effects. CONCLUSIONS: High doses of methylprednisolone used for the management of grade IIb esophageal burns may reduce stricture development. Copyright © 2014 by the American Academy of Pediatrics.
Bulbul A.,Sisli Children Hospital |
Okan F.,Sisli Children Hospital |
Bulbul L.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
Nuhoglu A.,Sisli Children Hospital
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2012
Objective: To study the efficacy of early high doses parenteral nutrition (PN) versus early low dose with progressive increments PN regimens, we performed a prospective randomized study in very low birth-weight infants. Study design: Forty-one appropriate gestational age preterm infants with birth weights ranging from 7501500g were randomly assigned into two groups. In Group 1, infants started on 3.0g/kg/day amino acids (AA) and 3g/kg/day of 20% lipid; in Group 2, AA and lipid were started on 1g/kg/day, and advanced over 3 days to a maximum 3g/kg/day. Blood samples were obtained for AA concentrations before starting of the PN, and at the 7th and 14th days. Results: The mean (±SD) birth weight was 1335g (240), gestational age was 29.7 weeks (1.7) of the study group. The mean body weight and head circumference was similar in the Group 1 and Group 2 at the 14th postnatal days. There was no difference in the blood levels of triglyceride, blood urea nitrogen, creatinine, ammonia, lactat and bicarbonate in the two groups. There was no significant difference in the concentrations of AA except for arginine and asparagine. On day 14, the mean arginine concentrations were significantly higher and asparagine concentrations were lower in Group 2. Conclusion: Although earlier more aggressive administration of AA and fat is not associated with any significant metabolic abnormalities, growth rates and plasma AA concentrations of the infants were similar to infants who AA and lipid given lower in the first day of life. © 2012 Informa UK, Ltd.
Ercin E.,Bakirkoy Dr Sadi Konuk Education and Research Hospital |
Gamsizkan M.,Gulhane Military Medical Academy |
Avsar S.,Izmir Military Hospital
Orthopedics | Year: 2012
High levels of uric acid cause accumulation of monosodium urate crystals. This formation of masses is called tophus. Intraosseous tophus deposits are rare, even for patients with gout. We report an unusual case of intraosseous tophus deposits in the os trigonum. The patient presented with ankle pain with no previous history of gout. On examination, tenderness on the posterior aspect of his ankle and limitation of plantarflexion was noted. Laboratory values were normal, except for an elevated serum uric acid value. Radiographs of the right ankle showed the presence of a large os trigonum with osteosclerotic changes, whereas magnetic resonance imaging showed intraosseous tophus deposits in the os trigonum. Conservative therapy failed, and the patient was admitted for an endoscopic resection of the os trigonum. Intraosseous chalky crystals were detected during endoscopic resection of the os trigonum. The histological diagnosis was tophaceous gout. The underlying pathological mechanism of intraosseous tophi is uncertain. Penetration of urate crystals from the joint due to hyperuricemia may be the mechanism of deposition in this patient. When a patient with hyperuricemia presents with posterior ankle impingement symptoms, intraosseous tophus deposits should be included in the differential diagnosis. Posterior endoscopic excision may be an option for treating intraosseous lesions of the os trigonum because of good visualization, satisfactory excision, and rapid recovery time.
Bes C.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
Yazici A.,Sakarya Education and Research Hospital |
Soy M.,Hisar Intercontinental Hospital
Rheumatology International | Year: 2013
Anemia is one of the extra-articular findings of ankylosing spondylitis (AS), and anti-TNF therapy has been shown benefit in patients with anemia associated AS. In this study, we aimed to evaluate and compare the effects of biological and non-biological agents on hemoglobin levels in AS patients. One hundred consecutive patients who fulfilled ASAS criteria for AS were included in the study. Fifty-four of the patients treated with anti-TNF agents (20 patients treated with infliximab, 20 patients with adalimumab, and 14 patients with etanercept), and 46 patients treated with non-steroidal anti-inflammatory drugs and/or other disease modifying anti-rheumatic drugs. The C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), hemoglobin (HGB), hematocrit (HCT) counts, and BASDAI scores were compared before starting therapy and at 52 weeks. There was no statistically significant difference between patients about demographical data (age, sex) and disease age (p > 0.05 for all). Significant difference was determined between HGB, HCT, CRP, ESR, and BASDAI values before and after therapy (for infliximab p: 0.001; 0.000; 0.000; 0.000; 0.000, respectively, and for adalimumab p: 0.017; 0.03; 0.001; 0.002; 0.000, respectively). In etanercept group, there was no significant difference in HGB values, when compared with before starting therapy and at 52 weeks (p > 0.05). In the group of treated with non-biological agents, ESR values and BASDAI scores showed distinctive improvement after 52 weeks of therapy, but was not a significant difference in hemoglobin and hematocrit values. Conclusion: Anti-TNF-alpha therapy with monoclonal antibodies (adalimumab and infliximab) did not only suppress disease activity but also provided a significant improvement in HGB levels. In the groups of treated with a TNF-alpha receptor antagonist (ETA) and non-biological agents, disease activity was suppressed, but there was not founded significant improvement in HGB levels after 52 weeks. Different outcomes of anti-TNF agents may be associated with their different effect mechanisms. © 2012 Springer-Verlag Berlin Heidelberg.
Kara N.,Sehitkamil State Hospital |
Evcimen Y.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
Kirik F.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
Agachan A.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
Yigit F.U.,Bakirkoy Dr Sadi Konuk Education And Research Hospital
Seminars in Ophthalmology | Year: 2014
Purpose: To compare the safety and efficacy of two Nd: YAG laser capsulotomy techniques. Methods: In this prospective comparative interventional case series, 60 eyes of 57 patients with posterior capsular opacification were enrolled. Thirty eyes were selected to undergo a cruciate capsulotomy (Cross group) and the other 30 eyes were selected to undergo a circular capsulotomy (Circular group). Main outcome measures were best-corrected visual acuity (BCVA), intraocular pressure (IOP), amount of energy used, mean macular thickness (MMT), and floater symptoms. Results: The amount of energy used was significantly higher in the Circular group than in the Cross group (p < 0.001). BCVA and IOP were not significantly different between the two groups at baseline or follow-up. MMT was significantly higher in the Circular group than in the Cross group at one day after the laser procedure (p = 0.032). MMT was not significantly different between groups at one week, one month, and three months (p > 0.05). The number of patients with floater symptoms was significantly higher in the Circular group than in the Cross group at one week and one month (p < 0.05). Conclusion: Both the cross-like and circular Nd:YAG laser capsulotomy techniques induce similar visual and IOP changes. The circular technique is associated with a higher amount of energy used, more floater symptoms, and has a greater effect on macular thickness at one day after laser capsulotomy. © 2014 Informa Healthcare USA, Inc. All rights reserved.
Ulviye Y.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
Betul T.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
Nur T.,Bakirkoy Dr Sadi Konuk Education And Research Hospital |
Selda C.,Bakirkoy Dr Sadi Konuk Education And Research Hospital
Indian Journal of Ophthalmology | Year: 2013
Objective: To determine whether early toxic effects from hydroxychloroquine (HCQ) could be detected by spectral-domain optical coherence tomography (SD-OCT) before symtomatic visual loss occured. Materials and Methods: Fifteen subjects with a history of the chronic use of hydroxychloroquine monotherapy for less than five years without fundus changes (group 1) and 15 visually normal healthy subjects (group 2) were enrolled in this study. All participants underwent systemic and ocular examination, visual field testing, and macular scan imaging using SD-OCT. Results: There were no significant differences in sex and ages between the groups (P > 0.05). Mean duration of HCQ usage in group 1 was 2.5 ± 1.34 (range:1-5) years. Visual field testing with central 10-2 threshold program was normal in all subjects. Inner retinal thickness in parafoveal and perifoveal area were found to be significantly lower in group 1 compared to group 2 (P < 0.01 for perifoveal, P < 0.05 for parafoveal retinal measurements). However, significant thinning was demonstrated only in full retinal thickness of perifoveal area in group 1 compared to group 2 (P: 0.013). Parafoveal and perifoveal inner retinal thickness measurements of inferior quadrants were significantly reduced in group 1 compared to group 2 (P < 0.01). Conclusion: Significant thinning of inner retinal layer especially in parafoveal and perifoveal areas in the absence of clinical fundus changes was observed in our study. We consider that SD-OCT may determine when inner retinal thinning starts in these patients and may contribute a quantitative approach to the early diagnosis and progression of retinal changes.
Tugcu B.,Bakirkoy Dr Sadi Konuk Education and Research Hospital |
Araz-Ersan B.,Bakirkoy Dr Sadi Konuk Education and Research Hospital |
Kilic M.,Bakirkoy Dr Sadi Konuk Education and Research Hospital |
Erdogan E.T.,Istanbul University |
And 2 more authors.
Current Eye Research | Year: 2013
Purpose: To investigate the morphological or functional differences of retina in amblyopia. Materials and methods: Forty-one patients with unilateral strabismic, anisometropic or combined amblyopia were included in the study. A control group was composed of 16 normal children. All participants were tested with optical coherence tomography (OCT) and pattern electroretinography (PERG). The findings from amblyopic and nonamblyopic eyes were compared among the amblyopic groups. Also, amblyopic and nonamblyopic eyes were compared with the healthy control eyes. Results: No significant difference was found in OCT parameters for amblyopic and nonamblyopic eyes among the amblyopic groups (p > 0.05). In the combined and anisometropic groups, ganglion cell complex (GCC) was found to be significantly increased in both amblyopic and nonamblyopic eyes compared to the control group (p < 0.05). In strabismic amblyopia, significant reduction in GCC thickness and increase in foveal thickness were found, compared to nonamblyopic eyes (p = 0.019, p = 0.08). There were no significant differences in PERG amplitude and latency between the amblyopic and the nonamblyopic eyes in amblyopic groups (p > 0.05). PERG amplitude in amblyopic eyes was found to be significantly decreased compared with that in normal eyes (p < 0.05). When the nonamblyopic eyes were compared with the control group, only the anisometropic amblyopia group demonstrated significant reduction in amplitude and prolongation in latency (p = 0.002, p = 0.026). Conclusion: We found no significant differences in morphological and functional measures among amblyopic groups. However, we detected significant differences in the retinal function and morphology of both amblyopic and nonamblyopic eyes compared with healthy control eyes. © Informa Healthcare USA, Inc.