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Wang Y.,Baicheng Medical College | Shi S.,Beijing University of Chemical Technology
Chemistry Bulletin / Huaxue Tongbao | Year: 2012

Halogen bond is defined as a new type of weak interaction between halogen atoms (Lewis acid) and objects with lone-pairs or iT-electron systems (Lewis base). It plays an important role in multi-dimensional supramolecular self-assembly, supramolecular recognition, such as supramolecular catalysis, supramolecular chiral resolution,supramolecular sensing and transmission, and some other fields. The properties of halogen bond, such as type,characteristics and functions,as well as applications in supramolecular chemistry were introduced.


Cui Z.-H.,Northeastern University China | Zhang P.,Anshan Normal University | Li H.-J.,Baicheng Medical College | Gao L.-Q.,Northeastern University China
Dongbei Daxue Xuebao/Journal of Northeastern University | Year: 2013

To improve the ability of fuzzy C-means clustering algorithm (FCM) for complex texture structure images, a new fuzzy C-means clustering algorithm (En-FCM) was proposed by combining image structure features. Firstly, the input image was mean-filtered, and the filtered image was added to the original image to form the new image for the subsequent operations. Secondly, the 2-D Gabor filtering function was adopted to extract texture structure feature for the new images to replace the gray level similarity measurement in the traditional FCM algorithm. Finally, a new distance measure function was proposed to calculate the distance between the nodes and the clusters. The simulation results showed that more precise segmentation results could be obtained from complicated texture structure images using the presented algorithm.


Zhang Q.,Changchun University | Zhuang L.,Baicheng Medical College | Thomsen A.B.,National Laboratory for Sustainable Energy
Nongye Jixie Xuebao/Transactions of the Chinese Society of Agricultural Machinery | Year: 2012

After hydrothermal pretreatment of corn stover, solid fraction and hydrolysate were collected separately. To find out the appropriate process for ethanol production from corn stover, ethanol production was evaluated from dried solid fraction and the hydrolysate employed as liquid fraction by baker' yeast. The effects of different pH value and detoxification on ethanol production were investigated. Firstly, prehydrolysis was performed at 50°C for 24 h. When 100% hydrolysate was added, ethanol content of 0.31 g/L (9.48% of theoretical ethanol yield) was obtained based on the cellulose available in the pretreated corn stover due to the existence of acetic acid and furans which are important inhibitors of the fermentation to microorganisms. After prehydrolysis, the initial pH value was adjusted to 5.5, 6.0 and 6.5, respectively. The best value obtained was ethanol content of 10.67 g/L with addition of 100% hydrolysate at pH value of 5.5. The hydrolysate was overlimed, then prehydrolysized for 24 h at 50°C. After prehydrolysis, the initial pH value was adjusted again to 5.5. Ethanol content of 10.96 g/L (57.9% of theoretical ethanol yield) was obtained. Ethanol yield increased almost 6 times compared to that at pH value of 4.8.


Polyphosphate is a biocompatible, modified and functionalized biodegradable polymer. It has a broad application prospects in the field of medical biomaterials. It is an excellent drug carrier material. In this essay, through the open-loop and ATRP polymerization, it synthesizes biodegradable amphiphilic triblock copolymer PEG-PCL-PDMAEMA. Composition and structure of the polymer is Characterized by 1H NMR and IR In this essay. This essay also studies that the polymer in water can be self-assembled to form a stable nanoparticles; The polymer micelle can form composite particles with siRNA,. This essay also studies the load and transfection of the polymer micelles on siRNA. © (2014) Trans Tech Publications, Switzerland.


Chen Y.,Northeast Normal University | Chen Y.,Baicheng Medical College | Li S.,Jilin Agricultural University | Sun F.,Northeast Normal University | And 5 more authors.
Pharmaceutical Biology | Year: 2010

Context: Malaria is one of the most common and serious protozoan tropical diseases. Multi-drug resistance remains pervasive, necessitating the continuous development of new antimalarial agents. Objective: Many glycosides, such as triterpenoid saponins, were shown to have antimalarial activity against Plasmodium falciparum in vitro. This study was to elucidate the ability of five glycoalkaloids against Plasmodium yoelii and develop new antimalarial lead compounds. Materials and methods: Glycoalkaloids were isolated from three kinds of Solanaceae plants: chaconine and solanine were isolated from Solanum tuberosum L. sprouts, solamargine and solasonine from Solanum nigrum L. fruit, tomatine from Lycopersicon esculentum Mill. fruit. The five isolated glycoalkaloids were evaluated against Plasmodium yoelii 17XL in mice with 4-day parasitemia suppression test in different concentrations. Results: Chaconine showed a dose-dependent suppression of malaria infection, ED50, 4.49mg/kg; therapeutic index (TI), ≈9. At a dose of 7.50mg/kg, the parasitemia suppressions of chaconine, tomatine, solamargine, solasonine and solanine were 71.38, 65.25, 64.89, 57.47 and 41.30%, respectively. At 3.75mg/kg, the parasitemia suppression of chaconine was 42.66%, but the derivative, chaconine-6-O-sulfate, appeared to show no antimalarial activity. Simultaneous administration of chaconine and solanine in 1:1 did not show any synergistic effects. Discussion and conclusion: The results showed that the glycoalkaloids with chacotriose (chaconine and solamargine) were more active than those with solatriose (solanine and solasonine). Chaconine was the most active among the five glycoalkaloids. We propose that the activity is dependent upon non-specific carbohydrate interactions. The 6-OH of chaconine is important for antimalarial activity. © 2010 Informa Healthcare USA, Inc.


Cui Z.-H.,Northeastern University China | Li H.-J.,Baicheng Medical College | Li W.-N.,Northeastern University China | Gao L.-Q.,Northeastern University China
Dongbei Daxue Xuebao/Journal of Northeastern University | Year: 2013

The traditional FCM algorithm has the shortcomings of simple image feature description, and it can be easily disturbed by complex texture in wrong segmenting. An adaptive filtered structure tensor based FCM algorithm for image segmentation was proposed to solve the problems. Firstly, a new anisotropy filtering based structure tensor was proposed to break the constraints of filtering direction and rotation of traditional filtering. Secondly, the image edge density function for adaptively calculating anisotropy filtering proportion was introduced into FCM algorithm to accurately measure image node gliding property. Then, an adaptive filter structure tensor similarity measurement was defined to replace the gray level similarity measurement in the traditional FCM algorithm. Finally, a new distance measure function was adopted to calculate the distance between a node and the clusteringcenter. The simulation results showed that more precise segmentation results could be obtained from complicated texture structure images by the presented algorithm.


Cao X.,BaiCheng Medical College | Cao X.,Beihua University | Gao L.,BaiCheng Medical College | Zhang M.,BaiCheng Medical College
WIT Transactions on Biomedicine and Health | Year: 2014

Objective: To study the physical and mental health of the empty nest elderly and analyze the related factors. To find the corresponding solution and improve the quality of old age. Methods: 154 empty nest elderly were used selected through stratified random cluster sampling and analyzed by SDS scale and the Health Status Questionnaire of Nationwide Elderly Population. Results: There are 79 cases (51.30%) of empty nest elderly in varying degrees of depression and 45 cases (29.22%) of empty nest elderly in daily life need help from others. In the top three diseases were hypertension (91 cases, 59.23%), cerebral vascular disease (54 cases, 35.27%), and heart disease (49 cases, 31.83%). Conclusions: Empty nest elderly generally exist the different degree of depression, self-care ability, high incidence of chronic diseases. © 2014 WIT Press.


Zhou Y.,Northeast Normal University | Bi H.,Northeast Normal University | Han H.,Northeast Normal University | Li Z.,Northeast Normal University | And 6 more authors.
Evidence-based Complementary and Alternative Medicine | Year: 2011

A water-soluble polysaccharide (BIWS-4b) was purified from the fruit bodies of Bulgaria inquinans (Fries). It is composed of mannose (27.2), glucose (15.5) and galactose (57.3). Its molecular weight was estimated to be 7.4kDa (polydispersity index, Mw/Mn: 1.35). Structural analyses indicated that BIWS-4b mainly contains (1 → 6)-linked, (1 → 5)-linked and (1 → 5,6)-linked -Galf units; (1 → 4)-linked and non-reducing terminal -Glcp units; and (1 → 2)-linked, (1 → 6)-linked, (1 → 2,6)-linked and non-reducing terminal -Manp units. When examined by the 4-day method and in a prophylactic assay in mice, BIWS-4b exhibited markedly suppressive activity against malaria while enhancing the activity of artesunate. Immunological tests indicated that BIWS-4b significantly enhanced macrophage phagocytosis and splenic lymphocyte proliferation in malaria-bearing mice and normal mice. The anti-malarial activity of BIWS-4b might be intermediated by enhancing immune competence and restoring artesunate-suppressed immune function. Thus, BIWS-4b is a potential adjuvant of anti-malaria drugs. Copyright © 2011 Hongtao Bi et al.

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