Besiroglu H.,Catalca Ilyas Cokay State Hospital |
Dursun M.,Bahcelievler State Hospital |
Otunctemur A.,Okmeydani Training and Research Hospital |
Ozbek E.,Istanbul Training and Research Hospital
Aging Male | Year: 2017
Objectives: To assess the association between triglyceride (TG)/high density lipoprotein (HDL) ratio and benign prostate hyperplasia/lower urinary tract symptoms (BPH/LUTS). Methods: Four hundred patients who were admitted to the Urology Clinic between January and December 2014 with complaints of BPH/LUTS were enrolled in this cross-sectional study. Patients were divided into two groups according to their International Prostate Symptom Score and prostate volume (PV). They were compared in terms of age, body mass index (BMI), PV, PSA, post micturional residual volume, uroflowmetry Q max value, fasting blood sugar, TG and high density lipoprotein-cholesterol (HDL-C) level and TG/HDL ratio. Results: Although univariate analyses reveal that age, BMI, waist circumference (WC), FBS, TG, HDL-C level, and TG/HDL ratio were correlated with PV, only age [1.125 OR (1.088–1.164), p = .00001], BMI [1.119 OR (1.040–1.204), p = .003], TG [(1.043 OR (1.016–1.071), p = .002], HDL-C [(0.923 OR (0.860–0.990), p = .025], and TG/HDL ratio [(1.224 OR (1.130–1.315), p = .014] were statistically significant in multivariate analysis. The calculated area under the curve (AUC) for PV of 30 ml, 40 ml, and 50 ml was 0.668 (0.608–0.727), 0.617 (0.561–0.673), and 0.592 (0.530–0.654), respectively. Conclusions: Our results indicate that the TG/HDL ratio correlates with enhancement in PV. Further studies are warranted to better evaluate this relationship. © 2017 Informa UK Limited, trading as Taylor & Francis Group
PubMed | Bilge Hospital and Bahcelievler State Hospital
Type: | Journal: International journal of surgery case reports | Year: 2016
Acute renal failure is characterized by rapidly disruption in kidney function and postrenal causes typically result from obstruction of urinary flow. Multiple etiologies were described for acute renal failure, but labial fusion in postmenopausal female is a quite rarely encountered pathology among postrenal causes. Only a few cases have been presented in postmenopausal women presenting with urinary retention. We present a case with acute renal failure due to complete labial fusion in a postmenopausal woman and its treatment.
PubMed | Marmara University, Prof Dr Celal Ertug Etimesgut State Hospital, Bahcelievler State Hospital and Tuzla State Hospital
Type: Journal Article | Journal: Cancer chemotherapy and pharmacology | Year: 2016
Cisplatin is a potent chemotherapeutic drug with serious side effects such as ototoxicity which is characterized by irreversible, bilateral, progressive sensorineural hearing loss. Oxytocin, which is a well-known hormone secreting during pregnancy, has antioxidant and antiinflammatory effect. Our study aims to test and compare the effect of intratympanic (IT) and intraperitoneal (IP) oxytocin on cisplatin ototoxicity with DPOAE.A total of 24 Wistar albino rats were randomly divided into four groups: Group 1 received 0.1-0.3ml IT saline+IP saline solutions for 4days (n=6), Group 2 received cumulative dose of 20mg/kg IP cisplatin divided into two equal doses in first and second days of experiment+0.1-0.3ml IT saline for 4days, Group 3 received same dose of cisplatin as Group 2+0.1-0.3ml IT oxytocin for 4days, and Group 4 received same dose of cisplatin as Groups 2 and 3+IP oxytocin with dose of 1mg/kg. DPOAE was performed prior to procedure and at the end of the experiment on day 5.Group 2 showed severe ototoxic effect of cisplatin according to DPOAE result (p<0.05). When compared with Group 2, DPOAE amplitude reductions were smaller in Group 3 (3.2, 3.8, 4.5, 6.3 and 7.6kHz) (p<0.05) and Group 4 which is statistically significant in 5.4, 6.3 and 7.6kHz (p<0.05). When Group 3 and Group 4 were compared, reductions were smaller in 2.7 and 3.2kHz in Group 3 (p<0.05).In this study, we showed the protective effect of IT and IP oxytocin on cisplatin ototoxicity. We suggest oxytocin in cisplatin ototoxicity, especially via IT route even with high-dose cisplatin.
PubMed | Derince Training and Research Hospital, Okmeydani Training and Research Hospital, Bahcelievler State Hospital, Istanbul Medeniyet University and 2 more.
Type: Journal Article | Journal: International braz j urol : official journal of the Brazilian Society of Urology | Year: 2016
SUI, involuntary loss of urine, occurs when intra abdominal pressure exceeds urethral pressure in women. Recent animal study has shown that there are therapeutic effects of Insulin-like growth factors (IGF-1) on stress urinary incontinence in rats with simulated childbirth trauma. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues and stimulates fibroblast proliferation and enhances collagen synthesis. The purpose of the current study was to determine the association between IGF-1 levels and SUI.All patients were evaluated for SUI and divided into two groups: 116 women with SUI and 76 women without SUI. Diagnosis of SUI was based on the International Consultation on Incontinence Questionnaire-Short Form (ICIQSF). Levels of IGF-1 were measured in serum by enzyme-linked immunosorbent assay. The relationship between IGF-1 levels and SUI in patients was evaluated statisticaly.The mean age of patients wiyh SUI was 49.98.6 and 48.77.8 in control group. Plasma IGF-1 levels were significantly lower in SUI than in control group (106.526.4 and 133.337.1ng/mL, respectively, P <0.001). Body mass indexes were higher in women with SUI than women without SUI.In this study lower serum IGF-1 levels were found to be associated with SUI. Serum IGF-1 level appears to be a specific predictor of SUI, and it may be used in early prediction of SUI in female population.
PubMed | Taksim Training and Research Hospital, Istanbul University, Baltaliman Training and Research Hospital, Haseki Training and Research Hospital and Bahcelievler State Hospital
Type: Journal Article | Journal: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine | Year: 2016
The purpose of this study was to investigate the interobserver, intraobserver, and intermethod reliability of computer-assisted digital and manual measurements of hip sonograms.Seventy-four hip sonograms were evaluated in this retrospective study. Five evaluators measured digital images and manual paper printouts according to the Graf method (Arch Orthop Trauma Surg 1984; 102:248-255). Interobserver and intraobserver reliability rates were calculated. Reliability criteria were graded on a numeric scale.The interobserver reliability of both computer-based and manual methods for alpha angle measurements was good to excellent, but the interobserver reliability was fair to poor for beta angle measurements. Intraobserver reliability was varied. Alpha angle measurements by both manual and computer-based methods had high concordance with each other, whereas beta angle measurements had low concordance. The intermethod variability did not differ between observers.The alpha angle measurements had high concordance with each other for both manual and computer-based methods, whereas the beta angle measurements had low concordance. This information should be taken into account in clinical practice. Overall, the two measurement methods were reliable and consistent with each other.
Otunctemur A.,Okmeydani Training and Research Hospital |
Ozbek E.,Atatürk University |
Besiroglu H.,Okmeydani Training and Research Hospital |
Dursun M.,Bahcelievler State Hospital |
And 6 more authors.
International Journal of Urology | Year: 2014
Objectives: To evaluate the relationship between varicocele and benign prostatic hyperplasia/lower urinary tract symptoms in patients over the age of 40 years. Methods: A total of 1040 patients with benign prostatic hyperplasia/lower urinary tract symptoms were evaluated for prostate volume, testicular volume, testicular consistency, total testosterone, total prostate-specific antigen and body mass index. A questionnaire including International Prostate Symptom Score and a uroflow test were also carried out. The presence and grade of varicocele was determined in each patient by physical examination. Results: Varicocele was found bilaterally in 22.3% and unilaterally in 25.7% of the patients. There was no difference in terms of age and body mass index distribution between subgroups. When grouping patients for varicocele laterality, total testosterone (P=0.04), prostate volume (P=0.009) and total prostate-specific antigen (P=0.02) level were significantly different. Similarly, these parameters were significant between patients with grade 1, 2 and 3 varicocele. Total testosterone level (P=0.02) and prostate volume (P=0.035) were found to be significantly different when patients were grouped according to testicular size. A positive correlation was found between testosterone level and prostate volume (P=0.004; r2=0.084). Conclusions: Bilateral and/or higher-grade varicocele is associated with lower prostate volume and testosterone levels, as well as lower prostate-specific antigen levels. However, it is not associated with dynamic components of benign prostatic hyperplasia/lower urinary tract symptoms in patients over the age of 40 years. © 2014 The Japanese Urological Association.
PubMed | Bakirkoy Research and Training Hospital for Psychiatry Neurology and Neurosurgery, Kanuni Sultan Suleyman Research and Training Hospital and Bahcelievler State Hospital
Type: Journal Article | Journal: International journal of psychiatry in clinical practice | Year: 2016
Impulsivity is an important aspect of obsessive-compulsive disorder (OCD) which is classified under a new heading in DSM-5 with other impulsivity related disorders like trichotillomania. Due to its heterogeneous nature, different obsessions may be linked to varying impulsivity profiles. Aim of this study was to investigate the impulsivity traits and their relationship with obsession types by comparing OCD subjects who display sexual, religious and aggressive obsessions or other obsessions to healthy controls.Outpatients with OCD (n=146) and healthy controls (n=80) were evaluated with Sociodemographic Data Form, SCID-I, SCID non-patient version, Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Barratt Impulsiveness Scale (BIS-11).BIS-11 attention scores of the OCD group were significantly higher than healthy subjects. In patients with sexual, aggressive, religious obsessions, BIS-11 attention scores were significantly higher than those who have other obsession types and that of controls.Higher levels of attentional impulsivity, particularly in patients suffering from sexual, aggressive or religious obsessions suggest a common diathesis for a dysfunction in neural correlates corresponding to these symptoms. The results of our study may promote further studies conducted with more advanced and objective neuropsychometric tests evaluating features of the clinical course, neurobiology and the response to OCD treatment.