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Deveci C.D.,Ankara Nuclear Research And Training Center | Demir B.,Etlik Zubeyde Hanm Womens Health Teaching and Research Hospital | Sengul O.,Etlik Zubeyde Hanm Womens Health Teaching and Research Hospital | Dilbaz B.,Etlik Zubeyde Hanm Womens Health Teaching and Research Hospital | Goktolga U.,Bahceci Fulya Center
Archives of Gynecology and Obstetrics | Year: 2015

Purpose: To evaluate the efficacy of the stair-step protocol using clomiphene citrate (CC) and to assess the uterine and systemic side effects in patients with polycystic ovary syndrome (PCOS). Methods: A total of 60 PCOS patients who failed to respond to 50 mg/day for 5 days of CC treatment within the cycle were randomly allocated to the control (traditional protocol) and study (stair-step protocol) groups. In the stair-step protocol,patients were treated with CC 50 mg/day for 5 days and then in nonresponsive patients, the dosage was increased to 100 mg/day for 5 days in the same cycle. Patients who failed the 50 mg/day CC treatment in the previous cycle were stimulated with 100 mg/day CC and were accepted as the control group. Ovulation and pregnancy rates, duration of treatment and uterine and systemic side effects were evaluated. Results: Ovulation and pregnancy rates were similar between the stair-step and the control group (43.3 vs. 33.3 %, respectively) (16.7 vs. 10 %, respectively). The duration of treatment was significantly shorter in stair-step compared to traditional protocol (20.5 ± 2.0 vs. 48.6 ± 2.4 days, respectively). There were no significant differences in the systemic side effects between the groups. Uterine side effects were evaluated with endometrial thickness and uterine artery Doppler ultrasound; no significant differences were observed in stair-step compared to traditional protocol. Conclusions: The stair-step protocol was determined to have a significantly shorter treatment period without any detrimental effect on the ovulation and pregnancy rates. © 2014, Springer-Verlag Berlin Heidelberg. Source

Serdarogullari M.,Bahceci Umut Center | Findikli N.,Bahceci Fulya Center | Goktas C.,Bahceci Fulya Center | Sahin O.,Bahceci Umut Center | And 3 more authors.
Reproductive BioMedicine Online | Year: 2014

Numerous studies indicate that there might be differences in embryo growth dynamics between male and female embryos. However, current data in humans are scarce and the results are inconclusive or conflicting. This study asks whether there exist gender-specific embryo development kinetics or parameters between human male and female embryos that can be observed by time-lapse technology. Study included data from 139 consecutive cycles (177 embryos transferred, 179 sacs analysed) with positive pregnancy that resulted in 100% implantation. Single- or double-embryo transfers were performed. Cases were analysed for parameters including cleavage time points and duration in each cleavage from two cells to hatching blastocyst stages and time interval between cleavages. Morphokinetic parameters of 78 female and 60 male embryos from a total of 119 cycles (139 sacs were examined after transfer of 138 embryos) were processed for data analysis according to the gender group. A detailed analysis of the data regarding each time point or interval between consecutive events according to these groups showed them to be similar in cell division kinetics, from the early cleavage through their development to blastocyst stage. However, female embryos showed earlier cavitation than male embryos, but the results did not reach statistical significance. © 2014 Reproductive Healthcare Ltd. © 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. Source

Bakircioglu M.E.,Bahceci Umut Center | Bakircioglu M.E.,Bahceci Fulya Center | Ulug U.,Bahceci Umut Center | Erden H.F.,Bahceci Fulya Center | And 4 more authors.
Fertility and Sterility | Year: 2011

Objective: To determine the effectiveness of microsurgical testicular sperm extraction (micro-TESE) and intracytoplasmic sperm injection (ICSI) for men with Klinefelter syndrome (KS). Design: Retrospective clinical study. Setting: Private IVF center. Patient(s): Men with nonmosaic KS (n = 106), and men with nonobstructive azoospermia (NOA) and normal karyotypes (n = 379). Intervention(s): Micro-TESE on the day of oocyte retrieval. Main Outcome Measure(s): Sperm recovery, fertilization, pregnancy, and spontaneous abortion rates. Result(s): Sperm was successfully recovered in 50 of 106 (47%) men in the KS group and 188 of 379 (50%) in the NOA group. The fertilization rate was higher in the NOA group than the KS group (65% vs. 57%, respectively); however, pregnancy (55% vs. 53%) and abortion rates (12% vs. 11.5%) did not differ statistically significantly between groups. In the KS group, 23 pregnancies resulted in 29 live births; the 21 children who underwent genetic evaluation had normal karyotypes. Conclusion(s): Sperm recovery rates in men with KS were similar to those of men with NOA and normal karyotypes. The fertilization rate was statistically significantly lower for men with KS than men with NOA, but pregnancy and abortion rates were similar. We observed good sperm recovery and ICSI outcomes for patients with KS. Copyright © 2011 American Society for Reproductive Medicine, Published by Elsevier Inc. Source

Tulay P.,Bahceci Fulya Center | Gultomruk M.,Bahceci Fulya Center | Findikli N.,Bahceci Fulya Center | Bahceci M.,Bahceci Fulya Center
Zygote | Year: 2015

Balanced reciprocal translocation carriers are usually phenotypically normal. Although the reproductive risk of these carriers varies, they generally have a lower chance to produce normal or balanced gametes. Preimplantation genetic diagnosis (PGD) is offered to these patients to increase their chances of becoming pregnant by selecting a balanced embryo for transfer. This study aimed to analyse the development and the PGD outcome of the embryos obtained from reciprocal translocation carriers focusing on ones with chromosome 10 rearrangements. In total, 27 reciprocal translocation carriers underwent 31 cycles of PGD. PGD was performed using multicolour fluorescence in situ hybridisation for 298 embryos and of these 136 were obtained from couples carrying translocations involving chromosome 10 rearrangements. Carriers of translocations involving chromosome 10 rearrangements have a lower chance of producing normal or balanced embryos compared with the carriers with other rearrangements. The development of embryos obtained from the patients with chromosome 10 rearrangements was impaired and only a limited number of embryos developed to the blastocyst stage. © 2014 Cambridge University Press. Source

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