Bahauddin Zakariya University
Multan, Pakistan

Bahauddin Zakariya University is located in Multan, Punjab, Pakistan. It is the Largest university of South Punjab. Bahauddin Zakariya University was formerly known as Multan University. It was renamed in honor of Hazrat Baha-ud-din Zakariya. It is a degree awarding institute in more than 60 subjects, including pharmacy, medical, engineering, humanities, business administration, law, art, music, IT Agriculture and languages. The university is currently ranked at No. 3 in General Category Ranking of 2012 by Higher Education Commission of Pakistan Wikipedia.

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Qadir M.I.,Bahauddin Zakariya University
Critical Reviews in Eukaryotic Gene Expression | Year: 2017

Green tea is made from Camellia sinensis and leaves through the oxidation process. It mainly originates in China and has been used traditionally throughout Asia. In the West, black tea has been used mostly, but green tea has become the most popular beverage throughout the world. It is also used as a raw material in cosmetics, health foods, and as an added ingredient in various beverages. Different varieties of green tea are available. The main differences between the varieties are due to harvesting time, production procedures, and horticulture. Drinking green tea has many positive effects on the body. It helps to nourish our five vital organs, among which the most important is the heart. It also has many qualities to help improve our state of mind (thus possibly reducing the consumption of alcohol), it acts as a stimulant, cures blotchiness, fulfills thirst, eliminates indigestion, cures beriberi disease, prevents fatigue, and improves kidney and brain function. © 2017 by Begell House, Inc.

Ismail T.,Bahauddin Zakariya University | Sestili P.,Urbino University | Akhtar S.,Bahauddin Zakariya University
Journal of Ethnopharmacology | Year: 2012

Ethnopharmacological relevance: Punica granatum L. (Punicaceae) has been used for centuries in many cultures for the prevention and treatment of a wide number of health disorders such as inflammation, diabetes, diarrhea, dysentery, dental plaque and to combat intestinal infections and malarial parasites. Aim of the review: This review aims at providing an up-to-date overview of the chemical constituents, traditional uses, phytochemistry, pharmacology and toxicology of Punica granatum L. Moreover, the focus of this review is the possible exploitation of this species to treat different diseases and to suggest future investigations. Materials and methods: An extensive and systematic review of the extant literature was carried out, and the data under various sections were identified by using a computerized bibliographic search via PubMed, Web of Science and Google Scholar. All abstracts and full-text articles were examined. The most relevant articles were selected for screening and inclusion in this review. Key findings: A variety of pomegranate ethnomedical uses have been recorded. Additionally, over the last decade, there has been a dramatic increase of interest in pomegranate as a medicinal and nutritional product due to its n1ewly identified potential health effects, which include treatment and prevention of cancer and cardiovascular diseases. From the toxicological perspective, pomegranate fruit juice, extracts and preparations have been proven to be safe. Conclusions: The ethnopharmacological relevance of pomegranate is fully justified by the most recent findings indicating the fruit is a medicinal and nutritional agent useful for treating a wide range of human disorders and maladies. Further investigations are needed to fully understand the mode of action of the active constituents and to fully exploit pomegranate's preventive and therapeutic potential. © 2012 Elsevier Ireland Ltd.

Saqib F.,Bahauddin Zakariya University | Janbaz K.H.,Bahauddin Zakariya University
Journal of Ethnopharmacology | Year: 2016

Ethnopharmacological relevance Tribal herbal practitioners of Pakistan use Alternanthera sessilis (Amaranthaceae) to treat diarrhea, asthma and hypertension. Objective The current study was conducted to provide mechanistic basis for anti-spasmodic, anti- asthmatic and anti-hypertensive use of Alternanthera sessilis. Materials and methods The crude ethanolic extract of Alternanthera sessilis (As.Cr) and its fractions were tested in- vitro on isolated rabbit tissue preparations (i.e., jejunum, trachea, and aorta) and in-vivo in ketamin-diazepam anaesthetized normotensive rats.The responses were recorded using isotonic and isometric transducers coupled with Power Lab data acquisition system. Results On isolated rabbit jejunum preparations, As.Cr exerted concentration-dependent (0.01-1.0 mg/ml) spasmolytic effect and caused relaxation of K+(80 mM)-induced spastic contractions. Furthermore, there was non-parallel shift in Ca++concentration response curves (CRCs) towards right at tissue bath concentrations of 0.1 and 0.3 mg/ml. On isolated rabbit trachea, it relaxed carbachol (1 μM)- and K+(80 mM)-induced contractions at respective tissue bath concentrations of 5.0 and 1.0 mg/ml. On isolated rabbit aorta, it also demonstrated relaxant effect on phenylephrine (1 μM)- and K+(80 mM)-induced contractions at tissue bath concentrations of 5.0 and 3.0 mg/ml respectively. These findings were found to be comparable with verapamil, a reference Ca++channel blocker (CCB). The solvent-solvents fractionation revealed domination of spasmolytic effects in dichloromethane fraction as compared to aqueous fraction. Intravenous administration of As.Cr decreased mean arterial blood pressure, systolic blood pressure and diastolic blood pressure of ketamine-diazepam anaesthetized normotensive albino rats dose-dependently, at dose range of 1-10 mg/kg. Conclusion Our results reflected presence of Ca++ channel blocking (CCB) activity in As.Cr, thus rationalizing medicinal use of Alternanthera sessilis in diarrhea, asthma and hypertension. © 2016 Elsevier Ireland Ltd. All rights reserved.

Butt M.S.,National University of Sciences and Technology | Sultan M.T.,Bahauddin Zakariya University
Critical Reviews in Food Science and Nutrition | Year: 2011

Recent research has rejuvenated centuries-old traditional herbs to cure various ailments by usingmodern tools like diet-based therapy and other regimens. Ginger is one of the classic examples of an herb used for not only culinary preparations but also for unique therapeutic significance owing to its antioxidant, antimicrobial, and anti-inflammatory potential. The pungent fractions of ginger, namely gingerols, shogaols, paradols, and volatile constituents like sesquiterpenes and monoterpenes, are mainly attributed to the health-enhancing perspectives of ginger. This review elucidates the health claims of ginger and the molecular aspects and targets, with special reference to anticancer perspectives, immunonutrition, antioxidant potential, and cardiovascular cure. The molecular targets involved in chemoprevention like the inhibition of NF-κB activation via impairing nuclear translocation, suppresses cIAP1 expression, increases caspase-3/7 activation, arrests cell cycle in G2 + M phases, up-regulates Cytochrome-c, Apaf-1, activates PI3K/Akt/I kappaB kinases IKK, suppresses cell proliferation, and inducts apoptosis and chromatin condensation. Similarly, facts are presented regarding the anti-inflammatory response of ginger components and molecular targets including inhibition of prostaglandin and leukotriene biosynthesis and suppression of 5- lipoxygenase. Furthermore, inhibition of phosphorylation of three mitogen-activated protein kinases (MAPKs), extracellular signal-regulated kinases 1 and 2 (ERK1/2), and c-Jun N-terminal kinase (JNK) are also discussed. The role of ginger in reducing the extent of cardiovascular disorders, diabetes mellitus, and digestive problems has also been described in detail. Although, current review articles summarized the literature pertaining to ginger and its components. However, authors are still of the view that further research should be immediately carried out for meticulousness. © Taylor and Francis Group, LLC.

Khan H.A.A.,University of Punjab | Akram W.,University of Agriculture at Faisalabad | Shad S.A.,Bahauddin Zakariya University
Acta Tropica | Year: 2014

The house fly, Musca domestica L., is a cosmopolitan insect with the ability to develop resistance to insecticides used for their management. In the present study, we investigated the genetics of spinosad resistance, and cross-resistance potential to other insecticides by selecting a field strain with a commercial spinosad formulation. Bioassays with the field strain, before selection with spinosad, gave resistance ratios (RRs) of 4, 5, 66, 21 and 5 fold for spinosad, indoxacarb, abamectin, imidacloprid and deltamethrin, respectively, in comparison to a laboratory susceptible (Lab-susceptible) strain. After continuous selection of the field strain (Spin-SEL) with spinosad, the RR was increased up to 155 fold; however, the resistance was unstable (RR decreased 1.43 fold) when this strain was not exposed to spinosad for five generations. The Spin-SEL strain did not show cross-resistance to abamectin, indoxacarb or deltamethrin, but showed negative cross-resistance to imidacloprid. Crosses between the Spin-SEL and Lab-susceptible strains revealed an autosomal and incomplete dominant mode of resistance to spinosad. A direct test using a monogenic inheritance model based on Chi-square analysis revealed that the resistance was governed by more than one gene. Moreover, the resistance was neither overcome with the insecticide synergist piperonyl butoxide nor with S,. S,. S-tributylphosphorotrithioate. Lack of cross-resistance and instability of resistance suggest that rotation with spinosad could be an effective resistance management strategy. © 2013 Elsevier B.V.

Qadir M.I.,Bahauddin Zakariya University
Pakistan Journal of Pharmaceutical Sciences | Year: 2015

The evolution of antibiotic-resistant in bacteria has aggravated curiosity in development of alternative therapy to conventional drugs. One of the emerging drugs that can be used alternative to antibiotics is bacteriophage therapy. The use of living phages in the cure of lethal infectious life threatening diseases caused by Gram positive and Gram negative bacteria has been reported. Another development in the field of bacteriophage therapy is the use of genetically modified and non replicating phages in the treatment of bacterial infection. Genetically engineered bacteriophages can be used as adjuvant along with antibiotic therapy. Phages encoded with lysosomal enzymes are also effectual in the treatment of infectious diseases.

Akhtar S.,Bahauddin Zakariya University
Journal of Health, Population and Nutrition | Year: 2013

This article attempts to highlight the prevalence of zinc deficiency and its health and economic consequences in South Asian developing countries and to shed light on possible approaches to combating zinc deficiency. A computer-based search was performed on PubMed, Google, and to retrieve relevant scientific literature published between 2000 and 2012. The search yielded 194 articles, of which 71 were culled. Studies were further screened on the basis of population groups, age and sex, pregnancy, and lactation. The most relevant articles were included in the review. Cutoffs for serum zinc concentration defined for zinc deficiency were 65μg/dL for males and females aged <10 years, 66μg/dL for non-pregnant females, and 70μg/dL for males aged ≥10 years. Population segments from rural and urban areas of South Asian developing countries were included in the analysis. They comprised pregnant and lactating women, preschool and school children. The analysis reveals that zinc deficiency is high among children, pregnant and lactating women in India, Pakistan, Bangladesh, Sri Lanka, and Nepal. Diarrhoea has been established as a leading cause to intensify zinc deficiency in Bangladesh. Little has been done in Sri Lanka and Nepal to estimate the prevalence of zinc deficiency precisely. A substantial population segment of the South Asian developing countries is predisposed to zinc deficiency which is further provoked by increased requirements for zinc under certain physiological conditions. Supplementation, fortification, and dietary diversification are the most viable strategies to enhancing zinc status among various population groups. © International Centre for Diarrhoeal Disease Research, Bangladesh.

Butt M.S.,National University of Sciences and Technology | Sultan M.T.,Bahauddin Zakariya University
Critical Reviews in Food Science and Nutrition | Year: 2011

Coffee is the leading worldwide beverage after water and its trade exceedsUS $10 billion worldwide. Controversies regarding its benefits and risks still exist as reliable evidence is becoming available supporting its health promoting potential; however, some researchers have argued about the association of coffee consumption with cardiovascular complications and cancer insurgence. The health-promoting properties of coffee are often attributed to its rich phytochemistry, including caffeine, chlorogenic acid, caffeic acid, hydroxyhydroquinone (HHQ), etc.Many research investigations, epidemiological studies, and meta-analyses regarding coffee consumption revealed its inverse correlation with that of diabetes mellitus, various cancer lines, Parkinsonism, and Alzheimer's disease. Moreover, it ameliorates oxidative stress because of its ability to induce mRNA and protein expression, and mediates Nrf2-ARE pathway stimulation. Furthermore, caffeine and its metabolites help in proper cognitive functionality. Coffee lipid fraction containing cafestol and kahweol act as a safeguard against some malignant cells by modulating the detoxifying enzymes. On the other hand, their higher levels raise serum cholesterol, posing a possible threat to coronary health, for example, myocardial and cerebral infarction, insomnia, and cardiovascular complications. Caffeine also affects adenosine receptors and its withdrawal is accompanied with muscle fatigue and allied problems in those addicted to coffee. An array of evidence showed that pregnant women or those with postmenopausal problems should avoid excessive consumption of coffee because of its interference with oral contraceptives or postmenopausal hormones. This review article is an attempt to disseminate general information, health claims, and obviously the risk factors associated with coffee consumption to scientists, allied stakeholders, and certainly readers. © Taylor and Francis Group, LLC.

Khan M.A.,Bahauddin Zakariya University
Parallel Computing | Year: 2012

A complex computing problem may be efficiently solved on a system with multiple processing elements by dividing its implementation code into several tasks or modules that execute in parallel. The modules may then be assigned to and scheduled on the processing elements so that the total execution time is minimum. Finding an optimal schedule for parallel programs is a non-trivial task and is considered to be NP-complete. For heterogeneous systems having processors with different characteristics, most of the scheduling algorithms use greedy approach to assign processors to the modules. This paper suggests a novel approach called constrained earliest finish time (CEFT) to provide better schedules for heterogeneous systems using the concept of the constrained critical paths (CCPs). In contrast to other approaches used for heterogeneous systems, the CEFT strategy takes into account a broader view of the input task graph. Furthermore, the statically generated CCPs may be efficiently scheduled in comparison with other approaches. The experimentation results show that the CEFT scheduling strategy outperforms the well-known HEFT, DLS and LMT strategies by producing shorter schedules for a diverse collection of task graphs. © 2012 Elsevier B.V. All rights reserved.

The International Association of HealthCare Professionals is pleased to welcome Muhammad Siddique, MD, Internist, to their prestigious organization with his upcoming publication in The Leading Physicians of the World. He is a highly trained and qualified internist with a vast expertise in all facets of his work, especially hematology, oncology, and internal medicine. Dr. Siddique has been in practice for more than 20 years and is currently serving patients at 21st Century Oncology in Seaford, Delaware. Dr. Muhammad Siddique received his Medical Degree from the Nishtar Medical College of Bahauddin Zakariya University in Multan in Pakistan. After moving to the United States, he completed an internship and residency in 2004 and 2005. Dr. Siddique is certified by the American Board of Internal Medicine in both Internal Medicine and in Hematology and Oncology. He maintains a professional membership with the American Society of Hematology, and attributes his success to the support of his parents, along with his determination and love for helping people. When he is not working, Dr. Siddique enjoys dining out, spending time with his family, and being outdoors. Learn more about Dr. Siddique by reading his upcoming publication in The Leading Physicians of the World. is a hub for all things medicine, featuring detailed descriptions of medical professionals across all areas of expertise, and information on thousands of healthcare topics.  Each month, millions of patients use FindaTopDoc to find a doctor nearby and instantly book an appointment online or create a review. features each doctor’s full professional biography highlighting their achievements, experience, patient reviews and areas of expertise.  A leading provider of valuable health information that helps empower patient and doctor alike, FindaTopDoc enables readers to live a happier and healthier life.  For more information about FindaTopDoc, visit

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