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Popescu M.,Emergency County Hospital | Grigorean V.T.,Emergency Clinical Hospital Bagdasar Arseni | Sinescu C.J.,Emergency Clinical Hospital Bagdasar Arseni | Lupascu C.D.,Grigore T. Popa University of Medicine and Pharmacy | And 3 more authors.
Neurologia Medico-Chirurgica | Year: 2013

Cavernous haemangioma (cavernoma) is a benign vascular lesion, exceptionally located in cauda equina. We report a case, diagnosed and operated in the Department of Neurosurgery from Pitesti County Emergency Hospital, of a 60-year-old woman with history of lumbar region distress, who presented with low back pain, paravertebral muscle contracture, and bilateral lumbar radiculopathy, with sudden onset after lifting effort. The preoperative diagnosis was done using computed tomography (CT) and magnetic resonance imaging (MRI), and the patient underwent surgery-two level laminectomy, dural incision, and tumor dissection from the cauda equina nerve roots under operatory microscope. Histopathological examination confirmed the positive diagnosis of cavernoma of cauda equina. The patient's outcome was favorable, without postoperative neurological deficits. © 2013 by The Japan Neurosurgical Society. Source

Brehar F.M.,Emergency Clinical Hospital Bagdasar Arseni | Ciurea A.V.,Emergency Clinical Hospital Bagdasar Arseni | Zarnescu O.,University of Bucharest | Bleotu C.,Stefan S Nicolau Institute Of Virology | And 3 more authors.
Chirurgia (Romania) | Year: 2010

Objective: The number of evidences regarding the role of tumor stem cells (TSC) in the initiation and progression of highgrade astrocytomas became more and more numerous in the last years. This issue has been intensively tested in glioblastoma, but little attention has been paid for anaplastic astrocytoma. The main objective of this paper was to study the morphological characteristics of the xenografts developed from glioblastoma and anaplastic astrocytoma derived cancer stem cells. Methods: The authors of this study successfully isolated and partial characterized primary cultures of glioblastoma and anaplastic astrocytoma derived TSC. Tumors stem cells have been stereotactically inoculated in nude mice brains and the xenografts have been studied using morphological and imunohistochemistry techniques. Results: The tumor xenografts which have been established in nude mice using TSC had different characteristics when compared with U87 xenografts previously developed by our group, and depend of the origin type of the tumors (glioblastoma versus anaplastic astrocytoma). The diffuse growing pattern and cells infiltration have been more pronounced in both anaplastic astrocytoma and glioblastoma derived TSC xenografts compared with U87 line xenografts. Conclusion: Our results support the hypothesis regarding the role of TSC in the infiltration process of glioblastoma and anaplastic astrocytoma. The extensive infiltration growing patterns of these types of xenografts make them useful models for studying the invasion mechanisms in gliomas. Abbreviations: TSC - tumor stem cells. Copyright © Celsius. Source

Mihai R.,Emergency Clinical Hospital Bagdasar Arseni | Florescu I.P.,Emergency Clinical Hospital Bagdasar Arseni | Moldovan L.,Romanian National Institute for Research and Development for Biological Sciences | Oancea A.,Romanian National Institute for Research and Development for Biological Sciences | Giuglea C.,Emergency Clinical Hospital Bagdasar Arseni
Therapeutics, Pharmacology and Clinical Toxicology | Year: 2011

Nowadays it is unanimously accepted in the specialty scientific medical world that an axon physical guidance is vital for the repair of injured peripheral nerves. Nerve guidance channels represent a diffusion pathway for growth factors secreted by the injured nerves and they also decrease the development of scar tissue. The researches in this domain were axed on the use of natural and synthetic materials for nervous conduits (NC) manufacture. Lately, the studies have been centered on the combination of more materials and bio-molecules in order to develop new composite materials that can stimulate nervous regeneration. Also demonstrated was the importance of neurotrophic factors (neurotrophins, neuronal growth factor, fibroblastic growth factor, etc) and cell adhesion molecules presence. To enhance the performances of the biomaterials used for the manufacture of NC, the effect of Schwann and other cell introduction in these structures was also tested. The biocompatible biomaterial domain is very dynamic, the researches leading to the achievement of new more efficient types. These will improve the prognosis of nerve sections with loss of motor, sensory, or both functions. Peripheral nerve regeneration by mean of efficient NC became a priority for plastic surgeons, neurologists and neurosurgeons. NC achievement in a shape that will ensure patients' rapid and precise healing is a challenge for the biomaterial research domain. Source

Ciurea A.V.,Emergency Clinical Hospital Bagdasar Arseni | Iencean S.M.,Emergency Clinical Hospital Bagdasar Arseni | Rizea R.E.,Emergency Clinical Hospital Bagdasar Arseni | Brehar F.M.,Emergency Clinical Hospital Bagdasar Arseni
Neurosurgical Review | Year: 2012

We report here a retrospective study of 59 consecutive patients with olfactory groove meningiomas admitted and operated on between 1991 and 2008. Our goal was to characterize clinical features, treatment strategies, and outcome of these lesions. The surgical resection grade, the histological type and the presence of recurrences in the follow-up period were analyzed. Maximum tumor diameter determined by preoperative magnetic resonance imaging (MRI) examinations was between 2 and 11 cm. In 38 surgical procedures (64.4%), the tumor was removed through a bilateral subfrontal approach, in 12 (20.3%) a unilateral subfrontal approach was used, and in nine procedures (15.3%) a pterional approach was performed. The average age at presentation was 52 years (age: 20- 76 years) and the sex ratio was 1.45:1 (females/males). According to Simpson's grading system, the degree of tumor removal was: grade I in 14 cases (23.8%), grade II in 38 cases (64.4%), grade III in four cases (6.8%) and grade IV in three cases (5%). Fifty-six patients had benign meningiomas (94.9%) and three patients had atypical meningiomas (5.1%). Two patients (3.4%) died from pulmonary embolism and bronchopneumonia. There were recurrences in six patients (10.1%), between 9 months and 12 years (mean 7.2 years) after surgery. The olfactory groove is a relatively frequent location for intracranial meningiomas, accounting for 9.1% of all intracranial meningiomas in our experience. Olfactory groove meningiomas tend to be clinically silent tumors until they are very large when symptoms or other abnormalities become evident. A surgical procedure adapted to the size and the extension of the tumor combined with microsurgical techniques allows total meningioma removal with good neurological outcome. © Springer-Verlag 2011. Source

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