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Le Touquet – Paris-Plage, France

Diamantis S.,Antibiotic Management Team | Rioux C.,University Paris Diderot | Bonnal C.,University Paris Diderot | Farfour E.,University Paris Diderot | And 5 more authors.
European Journal of Clinical Microbiology and Infectious Diseases | Year: 2012

Hospital antibiotic management teams (AMTs) have been recommended, but, in France, their concrete implementation remains scarce and their effectiveness largely unevaluated. The objective of this investigation was to evaluate the appropriateness of antibiotic therapy (AT) for bloodstream infections (BSIs) at a 950-bed university teaching hospital, and assess the role of an AMT in improving it. A prospective analysis of all significant BSIs occurring outside of the intensive care unit (ICU) during an 18-month period was carried out. AT was deemed effective if at least one prescribed antibiotic was effective in vitro, and appropriate if it was consistent with local recommendations. Out of 574 BSIs, 512 were evaluated: 231 community-acquired, 206 nosocomial, and 75 healthcare-associated. For 219 (42.8%) BSIs, the AT initiated prior to AMT intervention proved to be effective and appropriate, inappropriate but effective in 136 (26.5%), and ineffective or absent in 157 (30.7%). In the multivariate analysis, hospital-acquired and other healthcare-associated BSIs, as well as catheter-borne (CB) infections, were associated with inappropriate or absent AT. A recommendation from the AMT was given and followed in 233 (94%) out of 249 BSIs requiring intervention. Initially, two-thirds of BSIs outside the ICU did not receive appropriate AT. Healthcare-associated BSIs should, therefore, be the priority target of AMTs. © Springer-Verlag 2011. Source

Farooq S.,Sher-e-Kashmir University of Agricultural Sciences and Technology | Wani S.A.,Sher-e-Kashmir University of Agricultural Sciences and Technology | Hussain I.,Sher-e-Kashmir University of Agricultural Sciences and Technology | Bhat M.A.,Sher-e-Kashmir University of Agricultural Sciences and Technology | Bhat M.A.,Bacteriology Laboratory
Indian Journal of Animal Sciences | Year: 2010

In a study conducted in 4 districts of south Kashmir the prevalence of ovine footrot was found to be 16.41 %, with the highest prevalence of 19.43% in district Kulgam and lowest of 12.21% in district Pulwama. While 18.65 and 17.45% prevalence of footrot was observed in districts Anantnag and Shopian respectively. Overall economic impact of footrot was estimated to the tune of Rs 36.79 million annually to the sheep production in south Kashmir. Out of 400 samples collected from footrot lesions of naturally infected, sheep, 224 (56%) samples were detected D. nodosus positive. Out of these, 185 (82.58%) isolates were belonging to serogroup B of D. nodosus, 3 (1.33%) serogroup C, 21 (9.37%) serogroup E, 5 (2.23%) serogroup I and. 10 (4.46%) had mixed infection of 2 serogroups B and E. Serogroup C was detected for the first time in India. Out of 224 D. nodosus isolates, 138 (61.60%) possessed. intA gene, thus were considered, as virulent strains. Serogroup-wise, intA. gene was found, in 123 (66.48%) isolates of serogroup B, 11 (52.38%) of E and 4 (80.0%) of I. It was interesting to note that none of the sample from serogroup C was positive for intA. gene, indicating benign status of disease. Source

Mallet M.,Dron Hospital | Loiez C.,Bacteriology Laboratory | Melliez H.,Dron Hospital | Yazdanpanah Y.,Dron Hospital | And 2 more authors.
Infection | Year: 2011

Objectives: To evaluate the role of Staphylococcus simulans in bone and joint infections (BJI) and determine their main characteristics. Methods: A search of the database of the microbiology laboratories of Lille hospital and Tourcoing hospital was performed. Only results from blood, bone, and orthopedic device cultures were taken into account for hospitalized patients between January 2004 and January 2009. We considered cases in which S. simulans was the only bacteria isolated in all of the patients' biological samples with clinical and laboratory signs of infection. For patients with complete medical records, we recorded the clinical and epidemiological data. Results: Six cases of BJI due to S. simulans were recorded, with five cases related to orthopedic devices infections. Three patients lived in rural areas. In four out of six patients, S. simulans was isolated in intraoperative biopsy material. In one patient, S. simulans grew in synovial fluid and in another in blood cultures only. The latter patient had a spondylodiscitis, and chronic foot ulcers due to gout disease were suspected to be the origin of the infection. All patients were healed after a mean follow up of 9 ± 3 months. Orthopedic devices were removed in four of the five patients concerned. The combination of rifampicin plus levofloxacin was used in four patients. Conclusion: The present data suggest that, even though S. simulans remains rarely observed in clinical pathology, its role in osteoarticular infections, especially in the case of infected orthopedic devices, is not exceptional. As for the antibiotic treatment, the combination of rifampicin and levofloxacin seems to be an effective strategy according to our clinical results. © 2011 Springer-Verlag. Source

Denes E.,Limoges Teaching Hospital | Camilleri Y.,Limoges Teaching Hospital | Fiorenza F.,Limoges Teaching Hospital | Martin C.,Bacteriology Laboratory
International Journal of Infectious Diseases | Year: 2015

We report the first proven case of osteomyelitis due to Erysipelothrix rhusiopathiae. This infection occurred almost 20 years after traumatic inoculation of the bacterium, when the patient was gored by one of his cows. Diagnosis was made by bone biopsies, and treatment included rifampicin and levofloxacin for 3 months. © 2014 The Authors. Source

Allyn J.,Intensive Care Unit | Angue M.,Intensive Care Unit | Belmonte O.,Bacteriology Laboratory | Lugagne N.,Infection Control Unit | And 4 more authors.
Journal of Travel Medicine | Year: 2015

We report three cases of high drug-resistant microorganisms (HDRMO) carriage by patients repatriated from a foreign country. National recommendations suggest systematic screening and contact isolation pending results of admission screening of all patients recently hospitalized abroad. HDRMO carriage (carbapenem-resistant Acinetobacter baumanii and carbapenemase-producing Enterobacteriaceae) was not isolated on admission screening swabs, but later between 3 and 8-days after admission. In absence of cross-transmission, two hypotheses seem possible: a false-negative test on admission, or a late onset favored by antibiotic pressure. Prolonged isolation may be discussed even in case of negative screening on admission from high-risk patients. © 2015 International Society of Travel Medicine. Source

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