Ratnasekhar C.,Academy of Scientific and Innovative Research |
Sonane M.,Indian Institute of Toxicology Research |
Sonane M.,Babu Banarasi Das University |
Satish A.,Indian Institute of Toxicology Research |
Mudiam M.K.R.,Academy of Scientific and Innovative Research
Nanotoxicology | Year: 2015
The increasing use of nanotechnology in our daily life can have many unintended effects and pose adverse impact on human health, environment and ecosystems. Wider application of engineered nanoparticles, especially TiO2 nanoparticles (TiO2 NP) necessitates the understanding of toxicity and mechanism of action. Metabolomics provides a unique opportunity to find out biomarkers of nanoparticles exposure, which leads to the identification of cellular pathways and their biological mechanisms. Gas chromatography mass spectrometry (GC–MS)-based metabolomics approach was used in the present study to understand the toxicity of sub-lethal concentrations (7.7 and 38.5 µg/ml) of TiO2 NP (<25 nm) in well-known, soil nematode Caenorhabditis elegans (C. elegans). Multivariate pattern recognition analysis reflected the perturbations in the metabolism (amino acids, organic acids, sugars) of C. elegans on exposure to TiO2 NP. The biological pathways affected due to the exposure of TiO2 NP were identified, among them mainly affected pathways are tricarboxylic acid (TCA) cycle, arachidonic acid metabolism and glyoxalate dicarobxylate metabolism. The manifestation of differential metabolic profile in organism exposed to TiO2 (NP or bulk particle) was witnessed as an effect on reproduction. The present study demonstrates that metabolomics can be employed as a tool to understand the potential toxicity of nanoparticles in terms of organism–environment interactions as well as in assessing the organism function at the molecular level. © 2015 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted
Rizvi S.W.A.,Babu Banarasi Das University |
Singh V.K.,Babu Banarasi das BBD National Institute of Technology and Management |
Khan R.A.,University of Lucknow
Procedia Computer Science | Year: 2016
Today, the influence of information technology has been spreading exponentially, from high level research going on in top labs of the world to the home appliances. Such a huge demand is compelling developers to develop more software to meet the user expectations. As a result reliability has come up as a critical quality factor that cannot be compromised. Therefore, researchers are continuously making efforts to meet this challenge. With this spirit, authors of the paper have proposed a highly structured framework that guides the process of quantifying software reliability, before the coding of the software start. Before presenting the framework, to realize its need and significance, the paper has presented the state-of-the-art on software reliability quantification. The strength of fuzzy set theory has been utilized to prevail over the limitation of subjectivity of requirements stage measures. Salient features of the framework are also highlighted at the end of the paper. © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
Kaur K.,Babu Banarasi Das University |
Gupta R.,Babu Banarasi Das University |
Saraf S.A.,Babasaheb Bhimrao Ambedkar University |
Saraf S.K.,Babu Banarasi Das Northern India Institute of Technology
Comprehensive Reviews in Food Science and Food Safety | Year: 2014
The importance of zinc was 1st reported for Aspergillus niger. It took over 75 y to realize that zinc is also an essential trace element for rats, and an additional 30 y went by before it was recognized that this was also true for humans. The adult body contains about 2 to 3 g of zinc. Zinc is found in organs, tissues, bones, fluids, and cells. It is essential for many physiological functions and plays a significant role in a number of enzyme actions in the living systems. Bioinformatics estimates report that 10% of the human proteome contains zinc-binding sites. Based on its role in such a plethora of cellular components, zinc has diverse biological functions from enzymatic catalysis to playing a crucial role in cellular neuronal systems. Thus, based on the various published studies and reports, it is pertinent to state that zinc is one of the most important essential trace metals in human nutrition and lifestyle. Its deficiency may severely affect the homeostasis of a biological system. This review compiles the role of zinc in prophylaxis/therapeutics and provides current information about its effect on living beings. © 2014 Institute of Food Technologists.
Gupta S.,Babu Banarasi das Northern India Institute of Technology |
Katiyar H.,Babu Banarasi Das University
2014 20th National Conference on Communications, NCC 2014 | Year: 2014
A infrastructure based fixed relay has been employed between the source and the destination and its outage performance has been investigated. The relay decodes the message it receives in one time slot and forwards it in the next time slot. The Generalized K (KG) fading distribution has been assumed. The KG fading distribution is considered to be a generic and a versatile distribution which defines both small scale and large scale fading and is thus referred to as a composite fading distribution. The closed form expression has been derived for the outage probability, when it has been assumed that the destination performs the Selection Combining (SC). The Monte Carlo simulation has been used to verify the theoretical results. © 2014 IEEE.
Tahilyani S.,Babu Banarasi Das University |
Darbari M.,Babu Banarasi Das University
Advances in Intelligent Systems and Computing | Year: 2015
The paper highlights the use of two basic components: Cognitive Ra-dio and EMO in controlling Urban Traffic System. The coordination of the ac-tivities like: identification of route network, traffic jams and coordination of VMS for route diversion. The learning of central control system is achieved by software defined radios integrated with evolutionary Multiobjective optimiza-tion. © Springer International Publishing Switzerland 2015.
Anand V.,Babu Banarasi Das University |
Gulati M.,Babu Banarasi Das University |
Govila V.,Babu Banarasi Das University |
Anand B.,Sardar Patel Post Graduate Institute of Medical and Dental Science
Indian Journal of Dental Research | Year: 2013
Recurrent aphthous stomatitis (RAS) is one of the most common and painful ulcerative lesions of the oral cavity, but until now no cure has been recognized for it. Two patients diagnosed with minor RAS were treated in a single sitting with low level laser therapy using 940-nm diode laser. The lesions healed completely within 3-4 days and a follow-up for 1 showed no recurrence in these patients. According to the results of this study, low level laser therapy can decrease the healing time, pain intensity, size, and recurrence of the lesion in patients with minor RAS, and hence can be considered the most appropriate treatment modality for minor RAS, with greatest clinical effectiveness.
Rathaur A.K.,Babu Banarasi Das University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013
Some of the medicinal plants valued in Ayurvedic Rasayana for their therapeutic potential have been scientifically investigated with promising results. A number of plant-based principles have been isolated with potential immunomodulatory activity that can explain and justify their use in traditional medicine in the past and can form the basis for further research in the future as well. The aim of this review is to highlight results of research done on immunomodulators of plant origin. The selection of papers was made using the most relevant databases for the biomedical sciences on the basis of their ethnopharmacological use. Many plants and some phytoconstituents responsible for immunomodulation have been explained. The review also discusses biological screening methods for various plant drugs that focus on revealing the mechanism involved in immunomodulation.
Gupta S.,Babu Banarasi Das University |
Gupta R.,Babu Banarasi Das University
Asian Pacific Journal of Tropical Disease | Year: 2012
Objective: To detect and quantify the concentrations of Quercetin in the root, leaves and flower test sample of Clerodendrum infortunatum L. Method: In the present study High Performance Thin Layer Chromatography has been developed for detection and quantification of Quercetin in Clerodendrum infortunatum L. Increasing serial dilutions of reference standard Quercetin (20 to 100 μg/ml) were scanned at 366 nm to detect and quantify the concentrations of Quercetin in the test sample. Result: The estimated values obtained from the same were 0.05mg/g, 0.111mg/g and 0.199mg/g of Quercetin in powdered root, leaves and flower sample respectively. Conclusion: The method provided a rapid and easy approach for detection and the quantitation of the bio-marker Quercetin. In the present study we established the HPTLC profile for the vegetative and reproductive parts of Clerodendrum infortunatum L. to detect and quantify the Quercetin. © 2012 Asian Pacific Tropical Medicine Press.
Katiyar H.,Babu Banarasi Das University
Wireless Personal Communications | Year: 2013
Performance of cooperative relay schemes employing infrastructure based fixed relays having multiple antennas, has been investigated. Closed form expressions of outage probability, bit error rate and throughput for such system have been derived for Nakagami-m fading channels, with integer values of m. Here, relay and destination may perform either maximum ratio combining or selection combining of the signals. Comparative performance analysis of all four possible combinations has been analyzed for various relay locations, different number of antennas on the relay, various transmission rate and different fading conditions. © 2012 Springer Science+Business Media, LLC.
Dixit S.,Babu Banarasi Das University |
Katiyar H.,Babu Banarasi Das University
Proceedings - 2015 5th International Conference on Communication Systems and Network Technologies, CSNT 2015 | Year: 2015
With the growing demand for higher data rate networks, OFDM has emerged as a key technology for 4G standards like 3GPP LTE, IEEE 802.16m WiMAX and IEEE 802.11n WLAN. With its robustness to frequency selective fading, high spectral efficiency and ease of implementation by means of Discrete Fourier Transform(DFT), OFDM is a cutting edge technology for Broadband mobile wireless. Along with its compatibility with MIMO, OFDM is an attractive air-interface solution to meet the demands of 4G networks. In mobile environment, channel is subject to both time and frequency selective fading. Although OFDM is resistant to ISI resulting from frequency selective fades, but it is quite sensitive to time selective multipath fading. This time selective fading causes ICI thus degrading system performance. For a satisfactory performance of OFDM, it is imperative that the sub-carriers remain orthogonal to each other. The orthogonal behaviour of sub-carriers can be jeopardised due to two effects namely Carrier frequency offset, and Doppler spread. In the case of high Doppler spread owing to high mobility, maintaining orthogonality between sub-carriers is a challenging task. To keep a SIR of 20 dB, OFDM symbol duration must not exceed 8% of the Coherence time of the channel. In the case of Carrier frequency offset, which is caused by the use of Local Oscillators, there is a frequency shift of the received signal spectrum. This frequency shift of the received signal spectrum compromises the orthogonality between the sub-carriers. This paper reviews the methods to mitigate the deleterious effect of time selective fading and compares the simulation result of high Doppler spread with that of small Doppler spread. © 2015 IEEE.