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Lucknow, India

Babu Banarasi Das University is a state private university in Lucknow, Uttar Pradesh, India. In 2013, it organized a management festival, "UTKARSH 2013". Wikipedia.

Ratnasekhar C.,Academy of Scientific and Innovative Research | Sonane M.,Indian Institute of Toxicology Research | Sonane M.,Babu Banarasi Das University | Satish A.,Indian Institute of Toxicology Research | Mudiam M.K.R.,Academy of Scientific and Innovative Research
Nanotoxicology | Year: 2015

The increasing use of nanotechnology in our daily life can have many unintended effects and pose adverse impact on human health, environment and ecosystems. Wider application of engineered nanoparticles, especially TiO2 nanoparticles (TiO2 NP) necessitates the understanding of toxicity and mechanism of action. Metabolomics provides a unique opportunity to find out biomarkers of nanoparticles exposure, which leads to the identification of cellular pathways and their biological mechanisms. Gas chromatography mass spectrometry (GC–MS)-based metabolomics approach was used in the present study to understand the toxicity of sub-lethal concentrations (7.7 and 38.5 µg/ml) of TiO2 NP (<25 nm) in well-known, soil nematode Caenorhabditis elegans (C. elegans). Multivariate pattern recognition analysis reflected the perturbations in the metabolism (amino acids, organic acids, sugars) of C. elegans on exposure to TiO2 NP. The biological pathways affected due to the exposure of TiO2 NP were identified, among them mainly affected pathways are tricarboxylic acid (TCA) cycle, arachidonic acid metabolism and glyoxalate dicarobxylate metabolism. The manifestation of differential metabolic profile in organism exposed to TiO2 (NP or bulk particle) was witnessed as an effect on reproduction. The present study demonstrates that metabolomics can be employed as a tool to understand the potential toxicity of nanoparticles in terms of organism–environment interactions as well as in assessing the organism function at the molecular level. © 2015 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted Source

Kaur K.,Babu Banarasi Das University | Gupta R.,Babu Banarasi Das University | Saraf S.A.,Babasaheb Bhimrao Ambedkar University | Saraf S.K.,Babu Banarasi Das Northern India Institute of Technology
Comprehensive Reviews in Food Science and Food Safety | Year: 2014

The importance of zinc was 1st reported for Aspergillus niger. It took over 75 y to realize that zinc is also an essential trace element for rats, and an additional 30 y went by before it was recognized that this was also true for humans. The adult body contains about 2 to 3 g of zinc. Zinc is found in organs, tissues, bones, fluids, and cells. It is essential for many physiological functions and plays a significant role in a number of enzyme actions in the living systems. Bioinformatics estimates report that 10% of the human proteome contains zinc-binding sites. Based on its role in such a plethora of cellular components, zinc has diverse biological functions from enzymatic catalysis to playing a crucial role in cellular neuronal systems. Thus, based on the various published studies and reports, it is pertinent to state that zinc is one of the most important essential trace metals in human nutrition and lifestyle. Its deficiency may severely affect the homeostasis of a biological system. This review compiles the role of zinc in prophylaxis/therapeutics and provides current information about its effect on living beings. © 2014 Institute of Food Technologists. Source

Pant V.A.,Babu Banarasi Das University | Pant A.B.,Indian Institute of Toxicological Research | Pant A.B.,Council of Scientific and Industrial Research
Dental Traumatology | Year: 2013

Aim: The resin ionomer Geristore, originally designed for restorative procedures, has been used extensively in treating subgingival defects (such as root resorption and perforations) and as a retrofilling material. The purpose of this study was to evaluate the cell adhesion as well as in vitro biocompatibility of human periodontal fibroblast cells with resin ionomer Geristore in comparison with mineral trioxide aggregate (MTA) and glass ionomer cement (GIC). Material and method: Adhesion, growth, and morphology of human periodontal fibroblasts over test materials were evaluated by scanning electron microscopy (SEM). Biocompatibility was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide salt (MTT) assay. Results: Compared to glass coverslips, cells grew and spread qualitatively better over the surface of Geristore in comparison with the other test materials. In vitro interpretation indicates that Geristore is significantly less cytotoxic to human periodontal ligament cells. Results of statistical analysis revealed that material extracts had significant effect on cell proliferation at both 24 h (F = 547.62, P < 0.05) and at 48 h (F = 6048.18, P < 0.05). Conclusion: Our study supports that Geristore has enhanced biologic behavior to human periodontal ligament cells and superior biocompatibility in comparison with MTA and GIC, so it can be suggested as a material of choice in root resorption, perforations, and root-end filling. © 2012 John Wiley & Sons A/S. Source

Asthana R.,Babu Banarasi Das University | Ahuja N.J.,University of Petroleum and Energy Studies | Darbari M.,Bbdnitm Babu Banarasi Das National Institute Of Technology And Management
International Review on Computers and Software | Year: 2011

The development of control systems to handle the congestion at intersection in urban traffic is a critical research issue. Petri Nets and Fuzzy Logic have played vital role in the development of such systems. Petri nets, a mathematical modeling tool, makes graphical modeling, simulation and real time control modeling, more functional. Fuzzy logic deals with uncertainties in the environment to make the systems more realistic. In this paper, a real time traffic control model has proposed and implemented in MATLAB. Several results have been discussed and found satisfactory. © 2011 Praise Worthy Prize S.r.l. - All rights reserved. Source

Rathaur A.K.,Babu Banarasi Das University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2013

Some of the medicinal plants valued in Ayurvedic Rasayana for their therapeutic potential have been scientifically investigated with promising results. A number of plant-based principles have been isolated with potential immunomodulatory activity that can explain and justify their use in traditional medicine in the past and can form the basis for further research in the future as well. The aim of this review is to highlight results of research done on immunomodulators of plant origin. The selection of papers was made using the most relevant databases for the biomedical sciences on the basis of their ethnopharmacological use. Many plants and some phytoconstituents responsible for immunomodulation have been explained. The review also discusses biological screening methods for various plant drugs that focus on revealing the mechanism involved in immunomodulation. Source

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