Babu Banarasi das Northern India Institute of Technology BBD City

Lucknow, India

Babu Banarasi das Northern India Institute of Technology BBD City

Lucknow, India
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Bhandari S.,Babu Banarasi das Northern India Institute of Technology BBD City | Tripathi A.C.,Babu Banarasi das Northern India Institute of Technology BBD City | Saraf S.K.,Babu Banarasi das Northern India Institute of Technology BBD City
Medicinal Chemistry Research | Year: 2013

A series of new 2-pyrazoline derivatives has been synthesized by reacting 3-(substituted-phenyl)-1-pyridin-2-yl-propenones using two routes one using thiosemicarbazide and the other by hydrazine hydrate. The chemical structures were established by IR, Mass, 1H-NMR, 13C-NMR spectroscopic data, and elemental analysis. The anticonvulsant activity of the synthesized compounds was evaluated by the "maximal electroshock seizure" (MES) test and pentylenetetrazole (PTZ) test using male albino mice. Compounds 2e, 5-(naphthalene-1-yl)-3-(pyridine-2-yl)-4,5-dihydro-1H- pyrazole-1-carbothioic acid amide, and 3c, N-ethyl-5-(naphthalene-1-yl)-3- (pyridine-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide showed appreciable activity in the MES as well as PTZ test at all the evaluated doses. © 2013 Springer Science+Business Media New York.


Sahu S.K.,Babu Banarasi das Northern India Institute of Technology BBD City | Tripathi A.C.,Babu Banarasi das Northern India Institute of Technology BBD City | Koshy M.,Babu Banarasi das Northern India Institute of Technology BBD City | Saraf S.K.,Babu Banarasi das Northern India Institute of Technology BBD City
Medicinal Chemistry Research | Year: 2014

The study was aimed at the syntheses and evaluation of a series of novel 3-benzyl-2,6-diarylpiperidine-4-ones. The newly synthesized compounds were characterized by elemental analysis, infrared, 1H NMR, 13C NMR, and mass spectral analyses. These compounds were screened for their inhibiting potential against various bacterial and fungal strains. The antimicrobial activity was performed against four Gram positive bacteria (S. aureus, B. subtilis, B. pumilus, and M. luteus), three Gram negative bacteria (P. aeruginosa, P. fluorescens, and E. coli), and two fungal strains (A. niger and P. chrysogenum) by cup-plate method and tube assay method. The results reveal that some of these compounds exhibited remarkable activity against the selected bacterial and fungal strains, with MIC values as low as 50 μg/mL. Interestingly, all the compounds exhibited better antifungal activity than antibacterial activity. Thus, it can be concluded that 3-benzyl-2,6- diarylpiperidine-4-ones may exhibit potent antifungal activity. © 2013 Springer Science+Business Media New York.

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