B Pharmacy College Rampura

Kakanpur, India

B Pharmacy College Rampura

Kakanpur, India
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Bhattacharya S.,Gujarat University | Bhattacharya S.,B Pharmacy College Rampura | Prajapati B.G.,Ganpat University
Asian Journal of Pharmaceutics | Year: 2016

Cryoprotectants are basically some chemical compounds which prevent cells or tissues from damage due to freezing. Mostly, verification and thawing process is used in cryopreservation. The various animal tissues, organs, lymphocytes, cartilages, bone marrow, and proteins can be stored using proper cryoprotectants. Optimization of cryoprotectants is a challenging task, as elevated concentration may cause cytotoxicity. In this article, we discussed the implication, challenges, and recent advances of cryoprotectants along with its types. The importance of cryobank system and its importance were also being emphasized in this article.


Biswal B.,B Pharmacy College Rampura | Karna N.,B Pharmacy College Rampura | Patel R.,B Pharmacy College Rampura
Der Pharmacia Lettre | Year: 2014

The present study was carried out with an aim of studying the ability of polysaccharide extracted from Abelmoschus esculentus (AE) to be used as a Binder in Drug delivery systems. Keeping in view the aim, the natural mucilaginous substances were collected from AE by Ethanol precipitation method and were undergone identification tests, quantitative determination of pectin by Carbazole tests and identification tests were carried out by FT-IR. After extraction of the mucilage these were used as a binder in various concentrations in the preparation of paracetamol tablet.


Padihar B.,B Pharmacy College Rampura | Biswal B.,B Pharmacy College Rampura
Journal of Chemical and Pharmaceutical Research | Year: 2013

Zaltoprofen is BCS Class-II drug which rapidly and completely absorbed but plasma level achieved is highly variable after oral administration. Besides it also has relatively short elimination half-life (4.83 ± 2.01 hours). A drug with a short half-life requires frequent dosing and this makes Zaltoprofen an ideal candidate for a sustainedrelease formulation. Hydrophilic and swellable polymer matrix such as Polyox WSR 303, Carbopol 934 and HPMC K15M are widely used in sustained-release delivery because of their flexibility to obtain a desirable drug release profile. To provide a sustained-release composition which releases Zaltoprofen over a time period of at least about 24 hours when exposed to gastrointestinal milieu thus facilitating a reduction in frequency of drug administration through sustain-drug delivery system. To develop a sustained-release dosage form that has desirable in vitro dissolution profile as compared to Theoretical release profile.


Karna N.,B Pharmacy College Rampura | Biswal B.,B Pharmacy College Rampura | Bhavsar B.,Emcure Pharmaceutical Ltd
International Journal of PharmTech Research | Year: 2014

Levetiracetam is an antiepileptic drug with good bioavailability, rapid achievement of steady state concentration after oral administration. Besides it also has relatively short elimination half-life (6 hours). A drug with a short half-life requires frequent dosing and this makes Levetiracetam an ideal candidate for a extended-release formulation. Hydrophilic and swellable polymer matrix such as HPMC K-15M and PEO are widely used in extended-release delivery because of their flexibility to obtain a desirable drug release profile. To provide a extended-release composition which releases Levetiracetam over a time period of at least about 12 hours when exposed to gastrointestinal milieu thus facilitating a reduction in frequency of drug administration through extended-drug delivery system. Optimization was done using 32 full factorial design at 3 levels and 2 factors. From the polynomial equation, both the two independent factors showed significant effect on dependent variables.


Shah K.H.,B Pharmacy College Rampura | Patel J.B.,B Pharmacy College Rampura | Shrma V.J.,B Pharmacy College Rampura | Shrma R.M.,B Pharmacy College Rampura | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Prunus amygdalus Batsch (Family - Rosaceae) is widely used in traditional system of medicine to treat diabetes in India. The ethanolic extract (250 & 500 mg/kg) of leaf, flower and seed were taken up undertaken to evaluate the antidiabetic activity against normal and streptozotocin induced diabetic mice. Oral administration of extract for 21 days resulted in significant reduction in blood glucose level. Chronic effect of the extract on serum biochemistry were also studied and it was found that serum cholesterol, triglyceride, creatinine, urea, alkaline phosphatase levels were decreased significantly by all the extracts and Glibenclamide but HDL levels and total proteins were found to be increased after treatment. Thus, this studies shows that P. amygdalus has antidiabetic action and the extract should further be subjected to bioactivity guided drug discovery to isolate a lead compound responsible for this activity. © 2010 RJPBCS.


Biswal B.,B Pharmacy College Rampura | Parmar H.,B Pharmacy College Rampura | Nayak J.,inVentiv Health
Asian Journal of Pharmaceutical and Clinical Research | Year: 2015

Objective: Nicorandil is a vasodilatory drug used to treat angina. Nicorandil has oral bioavailability (70%) and half-life 1 hr. It is administered through the buccal mucosa enters directly in the systemic circulation, thereby minimizing the first pass hepatic metabolism and adverse gastro-intestinal effects. Therefore, the present investigation is concerned with the development of the buccal tablets. Methods: The present work was performed to develop and evaluate buccal tablet containing anti-diabetic drug (nicorandil). Ethyl cellulose was used as backing membrane and carbopol 934p and hydroxypropyl methyl cellulose K100M was used as bucco adhesive polymer. Aspartame was used as a sweetener. Thickness, hardness, weight variation and drug uniformity were investigated. Results: The tablet formulations were also subjected to drug release in 250 ml 6.8 phosphate buffer. Ex vivo bioadhesion, retention time and permeation through porcine buccal mucosa membrane. F5 formulations showed maximum amounts of drugs release (89.24%) at the end of 10 hrs dissolution study. F5 also showed maximum bioadhesion (0.0791 N) and the resident time of F5 formulation was 9.5 hrs. It shows 49.32% drug release after 10 hrs permeation study through porcine buccal mucosa mounted in Franz cell. Conclusion: The results of the study suggested that new buccal tablet formulations of combined bucco adhesive polymers can be suitably developed as an alternate to conventional dosage forms. © 2015, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.


Biswal B.,B Pharmacy College Rampura | Karna N.,B Pharmacy College Rampura | Nayak J.,inVentiv Health | Joshi V.,B Pharmacy College Rampura
Journal of Applied Pharmaceutical Science | Year: 2014

The objective of present study was to formulate hydrogel thickened Lornoxicam transdermal formulation. Eutectic mixture of camphor and menthol was chosen as oily phase (maximum 10%), solvent for Lornoxicam and powerful penetration enhancer. Tween 80, ethanol and Carbopol 934p, HPMC K-15M and Xanthan gum were selected as surfactant, co-surfactant and hydrogel thickening agent respectively. Ternary phase diagrams were constructed to obtain the concentration range of oil phase, surfactant and co-surfactant for microemulsion formulation. Hydrogel thickened microemulsions were characterized for pH, viscosity, spreadability, in vitro drug transport study with excised rat skins and invivo anti inflammatory activity. The average drug transport rate of optimized hydrogel thickened microemulsion containing 1 % w/w Lornoxicam, 10 % w/w oily phase of camphor and menthol, 30 % w/w tween 80, ethanol (2:1), 57 % w/w water, 1.5 % w/w Carbopol 934p and 0.5 % w/w Triethanolamine through rat skin was 2.02 μg/cm2/h . The percentage in vitro drug release of optimized hydrogel thickened microemulsion was 78.91 %. pH, viscosity and spreadability of optimizes batch was 6.4, 5291 cps and 5.98 gcm/sec. © 2014 Biswajit Biswal et al.

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