Pharmacy College

Āzamgarh, India

Pharmacy College

Āzamgarh, India
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Hossain E.,Pharmacy College | Sarkar D.,Barasat Government College | Maiti A.,Pharmacy College | Chatterjee Mitali M.,Bose Institute of India | And 2 more authors.
Journal of Ethnopharmacology | Year: 2010

Aim of study: The aim of this study was to establish the anti-inflammatory activity of the methanolic extract of Dregea volubilis leaves (MEDV) with its fractions and to delineate the possible mechanism of action for MEDV. Materials and methods: The anti-inflammatory activities of MEDV along with its petroleum ether and chloroform fractions were evaluated in a carrageenan induced model of acute inflammation. The effect of MEDV on lipopolysaccharide induced production of nitric oxide (NO) in macrophages was also studied. Results: MEDV (100, 200 and 400 mg/kg body weight) significantly reduced carrageenan induced paw edema; chloroform fraction was most potent (66%, p< 0.001). MEDV was non-toxic up to 125 μg/ml in mouse peritoneal macrophages wherein it (0-100 μg/ml) reduced lipopolysaccharide induced NO production. Conclusion: MEDV possesses significant anti-inflammatory activity. Chloroform fraction of MEDV showed best anti-inflammatory activity. © 2010 Elsevier Ireland Ltd.


Jena J.,Pharmacy College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Benzothiazole, the bicyclic ring system consists of thiazole ring fused with benzene ring. The literature study of benzothiazoles reveals that the presence of this bicyclic ring system in various amine or terrestrial natural compounds possess different biological properties. Thus benzothiazole moiety is continuously drawing interest for development of newer drug moiety due to its wide range of activities like antitumor, antimicrobial, schictosomicidal, anti-inflammatory, anticonvulsants, Antidiabetic, antipsychotic and diuretic. Benzothiazole moiety is found to be very important in the field of pharmacy as well as to develop newer anticancer agent in recent year due to the good response as an anticancer agent. In the present review our main interest is to emphasize the various synthetic molecules developed to promote the benzothiazole moiety in the modern era of anticancer agent.


Bhattacharya S.,Pharmacy College | Prajapati B.G.,Ganpat University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Objective: The main objective of this experiment was to prepare and optimized celecoxib nanoemulgel. This formulation can be used for acute rheumatoid arthritis patients. Methods: Celecoxib is a poorly water soluble drug. We prepared celecoxib nanoemulgel to improve intrinsic solubility of celecoxib and enhance deeper permeation throughout the skin. After several screening, the combination of acetonitrile, triacetin, campul 908P was considered for oil phase; acconon MC8-2EP as surfactant, and capmul MCM C-10 as a co-surfactant accordingly. As per Box-Behnken surface design model, optimization was done for all the 13 formulations. Results: Based on pseudo ternary plot, it was found that 4:1 Smix ratio was optimum and possessed maximum drug solubility. Further, screening shown, 0.25-0.75% carbopol-940 can be a stable candidate for hydrogel preparation. Prepared nanoemulsions and hydrogels were admixed to prepare nanoemulgel. Based on overlay plot, EG14* formulation was consider as optimum one, and various evaluation parameters were performed along with other formulations. Using Franz diffusion cell, in-vitro diffusion studies was performed. Almost all the formulations produces good qualitative drug release profile. The EG14* shown 95.50% drug release after 12th hrs with standard Higuchi plot (R2 value 0.9989). The optimum viscosity was found to be 521±0.81 mPas at 100 rpm. The appearance of the formulations was milky, yellowish white with expectable pH ranged from 5.8 to 6.7. The optimized formulation has good spreadability coefficient, good ex-vivo diffusion enhancement factor (3.03) as compare to marketed gel. Mostly, our formulations have less skin irritation and higher anti-inflammatory activity (92.56% of inhibition of paw edema for EG14*). Conclusion: From the thermodynamic studies, it was confirmed that EG14* maintained excellent stability profile in various heating-cooling cycle, centrifugation, and freeze-thaw cycle condition. Hence, it can be conclude that, our formulation, can be consider for pilot scale up. © 2017 The Authors.


Vishwakarma A.G.,Sandip Foundation | Mogal R.T.,Sandip Foundation | Pawar A.Y.,Pharmacy college
International Journal of PharmTech Research | Year: 2014

Over the past 30 years, the expenses and complications involved in marketing new drug entities have increased with concomitant recognition of therapeutic advantages of controlled drug delivery. Now a days greater attention has been focused on development of controlled & immediate release drug delivery systems. Several pharmaceutical companies are currently developing bi-layer tablets, for a variety of reasons: patent extension, efficient pharmacological effect, better patient compliance etc. Bilayer tablet is becoming new approach for the successful development of controlled & immediate release formulation along with various features to provide a way of successful drug delivery system. Bi-layer tablet is suitable for sequential release of two drugs in combination and/or to incorporate two incompatible substances in same tablet. This approach can be utilized for fabrication of sustained release dosage form (tablet) consisting of outer immediate and inner layer as a maintenance dose. To overcome the short comings of single layered tablet approach like bilayered tablet (immediate and sustained release) can be satisfactorily used. This review explains fundamentals of bilayer tablet system along with its fabrication techniques, different approaches, characterization, challenges in Bilayer tablet manufacturing, Quality & GMP requirements, for their production and recent developments in the field of bilayer technology. Present review mainly focuses on fundamentals of bilayer tablets and it’s applications in Pharmaceutical industries. © 2014, Sphinx Knowledge House. All rights reserved.


Hossain E.,Pharmacy College | Chandra G.,University of Burdwan | Nandy A.P.,University of Burdwan | Mandal S.C.,Jadavpur University | Gupta J.K.,Jadavpur University
Parasitology Research | Year: 2012

Bombax malabaricum (family Bombacaceae) is used as anthelmintic in traditional system of medicine in Southern Punjab of Pakistan. The objective of this study was to evaluate the anthelmintic activity of the methanol extract of B. malabaricum leaves (MEBM). Live parasites (trematode: Paramphistomum explanatum) were collected from buffalo in 0.9% phosphate-buffered saline. It was incubated in Petri dishes at 37±1°C in media containing either no extract (control) or MEBM, the test drug at 10, 25, 50, and 100 mg/ml dose level or albendazole, the standard drug at 10 mg/ml. The efficacy of the extract or albendazole was measured on the basis of the loss of spontaneous movement and/or death of the trematodes. Paralysis was considered when there is no movement unless shaken vigorously. Death was confirmed when the trematodes completely lost their motility, even when vigorously shaken or dipped in warm water (50°C), followed by fading away of their body color. The trematodes, both drug treated and others, were further processed for SEM study using the standard method. All trematodes died with all the abovementioned doses of MEBM within a short period of time (less than 45 min) which was statistically highly significant (p<0.001). MEBM at 100 mg/ml showed maximum efficacy. It paralyzed and killed trematodes in 18.50±0.62 and 22.17±0.48 min, respectively. SEM study showed that MEBM-treated trematodes were stretched. The study established the anthelmintic activity of MEBM. © Springer-Verlag 2011.


Hossain E.,Pharmacy College | Chandra G.,University of Burdwan | Nandy A.P.,University of Burdwan | Mandal S.C.,Jadavpur University | Gupta J.K.,Jadavpur University
Parasitology Research | Year: 2012

Dregea volubilis (family Asclepediaceae) is widely used as anthelmintic in traditional system of medicine in eastern and southern part of India. The aim of this study was to evaluate the anthelmintic activity of the methanol extract of D. volubilis leaves (MEDV) and to observe its effect through SEM study. Live parasites (trematode Paramphistomum explanatum) were collected from buffalo in 0.9% phosphate-buffered saline (PBS). It was incubated at 37±1°C in media containing either no extract (control), the test drug, MEDV at four dose levels (10, 25, 50, and 100 mg/ml) or the standard drug, albendazole, at a dose of 10 mg/ml. The effectiveness of the extract was judged on the basis of the loss of spontaneous movement and/or complete destruction or death of the trematodes. After being removed from the experimental medium, trematodes were dipped in PBS at 37±1°C and on gentle stimulation, the paralyzed parasite showed immobility. Death was confirmed when it completely lost its motility even when vigorously shaken or dipped in warm water (50°C). The trematodes, both drug treated and others, were further processed for SEM study using standard method. The anthelmintic activity was found with all the doses through paralysis and death of the organisms (p<0.001). Maximum anthelmintic activity was found with a dose of 100 mg/ ml. Minor damage was observed with both suckers, but severe distortion was found with tegumental surface of the treated trematodes. The present SEM-based study established the anthelmintic activity of MEDV. © Springer-Verlag 2011.


Hossain E.,Pharmacy College | Rawani A.,University of Burdwan | Chandra G.,University of Burdwan | Mandal S.C.,Jadavpur University | Gupta J.K.,Jadavpur University
Asian Pacific Journal of Tropical Medicine | Year: 2011

Objective: To analyze the larvicidal activity of two plant leaf powder and leaf-extracts, Dregea volubilis and Bombax malabaricum against Culex quinquefasciatus. Methods: The larvicidal bioassay was done for powdered leaves of Dregea volubilis and Bombax malabaricum individually and their methanol extracts against first-, second-, third- and fourth-instar larval forms of Culex quinquefasciatus. Mortality rate was recorded after 24, 48 and 72 h of post-exposure. LC 50 and LC 90 values were calculated at different time intervals for third instar larvae. Results: All the graded concentration (0.1%, 0.2%, 0.3%, 0.4%, 0.5%) of powdered leaves showed significant (P <0.05) larval mortality. The mortality rate was higher in 50 ppm doses of methanolic extracts of both the plants against Culex quinquefaciatus. The corresponding LC 50 values were 56.97 ppm and 48.85 ppm, respectively after 24 h of exposure. There is no mortality of non-target organism such as Chironomous circumdatus, Oreochromis niloticus niloticus and Diplonichus annulatum within 72 h of post exposure to 0.1%, 0.2%, 0.3% crude powdered leaves and methanolic extracts of both the two individual plants under the laboratory condition. The results of preliminary qualitative phytochemical analysis of both the plants revealed the presence of many bioactive principles such as steroids, tannins, flavonoids, triterpenoids, saponins, etc. that may be responsible for their bio-control potentiality. Conclusions: The results have shown potential and eco-friendly use of both plant extracts against larva of Culex quinquefasciatus for the first time. © 2011 Hainan Medical College.


Hossain E.,Pharmacy College | Mandal S.C.,Jadavpur University | Gupta J.K.,Jadavpur University
Tropical Journal of Pharmaceutical Research | Year: 2011

Purpose: To investigate the antipyretic activity of the methanol extract of Bombax malabaricum leaves (MEBM) in rats. Methods: Baker's yeast was used to induce fever in Wistar rats which were divided into four groups. The animal groups were thereafter administered MEBM (200 mg/kg), MEBM (400 mg/kg), paracetamol (reference standard, 150 mg/kg) and 1% Tween 80 (control), respectively. The body temperature of the rats was measured rectally over a period of 8 h. MEBM was also phytochemically screened for alkaloids, steroids, carbohydrates, tannins, fixed oils, proteins, triterpenoids, deoxy-sugar, flavonoid, cyanogenetic and coumarin glycosides. Results: MEBM (200 mg/kg and 400 mg/kg) significantly reduced yeast-induced pyrexia (p < 0.05, p < 0.01, respectively). Phytochemical tests showed the presence of steroids, carbohydrates, tannins, triterpenoids, deoxy-sugars, flavonoids and coumarin glycosides. Conclusion: The methanol extract of Bombax malabaricum leaves possesses significant antipyretic activity. © Pharmacotherapy Group.


Samanta K.,Pharmacy College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Hygrophila difformis Blume (Family-Acanthaceae) and has great medicinal importance like An antibacterial activity, high insecticide activity and Tribal's are also used as anticoagulants. It is very useful in tropical fresh water aquarium plant and Environmental importance Ornamentals plants. In present study deals with the characterization of morphological features, determination of physical constant such as the total ash value, acid insoluble ash value and water soluble ash value were 1.97%, 0.59%, 1.37% respectively. Loss of weight drying was 4.5%, the percent yield for ethanol 9.12% and aqueous 5.45%.


Lei G.M.,Pharmacy College
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2011

To improve the quality standard of stewed Rhizoma Polygonati with yellow wine. On the basis of Chinese Pharmacopoeia 2010, some items were added, which included assay of reducing sugars, water-soluble extracts, acid insoluble ash content and 5-hydroxymethylfurfural. Reducing sugars was no less than 34.0%, water-soluble extracts no less than 19.0%, acid insoluble ash content no more than 0.2%, 5-hydroxymethylfurfural no more than 0.02%. The quality standard of stewed Rhizoma Polygonati with yellow wine is improved on the basis of Chinese Pharmacopoeia.

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