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Gohel M.G.,B J Medical College And Civil Hospital | Chacko A.N.,GDERS Dental College
Journal of Diabetes and Metabolic Disorders | Year: 2013

Background: Diabetes is undoubtedly one of the most challenging health problems in 21st century. Understanding the pathogenesis and preventing long term complications have been major goals of research in diabetes mellitus (DM). Research in the past few years has linked oxidative stress and inflammation to beta cell dysfunction. Aim of this study is to evaluate serum gamma-glutamyl transferase (GGT) activity (marker of oxidative stress) and high sensitivity C reactive protein (hsCRP) level (an inflammatory marker) in type 2 DM subjects with good and poor glycemic control. Further, we investigated correlation between serum GGT and hsCRP level with glycemic control (FBS, PP2BS, HbA1c) in subjects.Methods: A cross sectional study consists of 150 patients out of them 50 patients having type 2 DM with good control (Group II), 50 patients with type 2 DM with poor control (Group III) and 50 normal healthy control (Group I) were selected. Serum GGT, serum hsCRP, FBS, PP2BS, HbA1c, and other biochemical investigations include serum liver enzymes and lipids were measured.Results: Mean serum GGT and hsCRP concentration were statistically significantly higher in group III patients compared to group I and group II subjects as well as increased in group II compared to group I (p < 0.001). Further significant positive correlation was observed between GGT and hsCRP concentration as well as both with HbA1c, FBS, and PP2BS.Conclusions: Oxidative stress and inflammation appears to be a key component and also associated with poor glycemic control and further pathogenesis of diabetes and its complications. All our finding suggesting a link between oxidative stress, inflammation and glycemic control in patient with type 2 diabetes mellitus. © 2013 Gohel and Chacko; licensee BioMed Central Ltd. Source


Shah D.V.,Intas Pharmaceuticals Ltd. | Desai C.K.,B J Medical College And Civil Hospital | Dikshit R.K.,B J Medical College And Civil Hospital | Dave D.J.,GMERS Medical College and Civil Hospital
Drugs and Therapy Perspectives | Year: 2013

Background: Cognitive and psychomotor impairment are important considerations in the management of depression. Antidepressant agents show differential effects on psychomotor performance. These are usually reversible with effective antidepressant treatment. Objective: To evaluate the effects the commonly prescribed antidepressant agents imipramine, fluoxetine and citalopram on psychomotor function in patients with depression using a battery of three simple tests. Study design: 60 adult patients with depression who had no history of taking antidepressant drugs were randomly selected from the psychiatry outpatient department of a hospital. The clinical status and psychomotor performance of patients were assessed at the beginning of treatment, and at the end of 1, 4 and 12 weeks after the initiation of treatment with imipramine, fluoxetine or citalopram. Results: Fluoxetine and citalopram showed significant improvement on psychomotor function tests relative to imipramine, and clinical condition improved to a similar extent with all the three drugs. Conclusion: In depressive patients in whom psychomotor function impairment is significantly troublesome, treatment with antidepressants with relatively non-sedating and non-impairing profiles may be preferred. © 2013 Springer International Publishing Switzerland. Source


Joshi M.,B J Medical College And Civil Hospital | Vankar G.K.,B J Medical College And Civil Hospital
Substance Abuse: Research and Treatment | Year: 2015

Inahalant abuse is of increasing interest in India. Te age of onset is typically during adolescence. Gasoline inhalant use is rarely reported in adolescents with intellectual deficit. We report a case of petrol dependence in a 10-year-old child with mental retardation. Possible effect of petrol huffing on behavior and cognition is discussed. © the authors, publisher and licensee Libertas academica Limited. Source


Patel S.,B J Medical College And Civil Hospital | Kinariwala D.,B J Medical College And Civil Hospital | Javadekar T.,Baroda Medical College
Indian Journal of Sexually Transmitted Diseases | Year: 2011

Objectives: The present study was undertaken to determine the prevalence of respiratory, gastrointestinal and other pathogens in 100 Human Immunodeficiency Virus (HIV) seropositive patients. Settings: This study was carried out on randomly selected 100 HIV seropositive patients from S. S. G. Hospital during the period from Jan 2006 to Jan 2007. Materials and Methods: Sputum samples, stool samples and oral swabs were collected from all the patients and cerebrospinal fluid (CSF) was collected from symptomatic patients and processed as per the standard protocol. Sputum samples were examined by microscopy and cultured for bacterial respiratory pathogens. Stool samples were concentrated and examined by microscopy for enteric parasites. Oral swabs and CSF were also examined microscopically and cultured for fungal pathogens. CSF was also examined for bacterial pathogens. Results: A total of 101 pathogens were detected in 60 patients. More than one pathogen was observed in 30 patients. Candida was the commonest isolate (32.67%), followed by Mycobacterium tuberculosis (22.71%) and Cryptosporidium parvum (19.8%). Conclusions: Since opportunistic infections are a major cause of mortality and morbidity in HIV seropositive patients, an early diagnosis and effective treatment are required to tackle them. The type of pathogens infecting HIV patients varies from region to region, and therefore such patients should be constantly screened for these pathogens. Source


Shah D.V.,Intas Pharmaceuticals Ltd. | Desai C.K.,B J Medical College And Civil Hospital | Dikshit R.K.,B J Medical College And Civil Hospital
Drugs and Therapy Perspectives | Year: 2014

Background: Accumulating evidence suggests that noradrenergic and serotonergic drugs are equally effective in ameliorating the depressive symptoms of major depression. Major depression is associated also with memory impairment, but the comparative effects of the antidepressant drugs on memory are not clear. Objective: To evaluate the effects the commonly prescribed antidepressant agents imipramine, fluoxetine and citalopram on memory function in patients with depression. Study design: 60 adult patients with depression who had no history of taking antidepressant drugs were randomly selected from the psychiatry outpatient department of a hospital. The clinical status and memory performance of patients were assessed at the beginning of treatment, and at the end of 1, 4 and 12 weeks after the initiation of treatment with imipramine 150 mg/day, fluoxetine 20 mg/day or citalopram 20 mg/day. Results: Although all the three drugs were equally effective with regard to the remission of depressive symptoms, fluoxetine and citalopram recipients had significantly greater improvements in memory performance than imipramine recipients. Conclusion: In depressive patients in whom memory impairment is significantly troublesome, treatment with serotonergic antidepressants may be preferred. © 2013 Springer International Publishing Switzerland. Source

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