Lahore, Pakistan
Lahore, Pakistan

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Tauseef A.,Lahore Medical and Dental College | Sabir S.,Khawaja Muhammad Safdar Medical College | Akmal A.,Lahore Medical and Dental College | Sajjad S.,Azra Naheed Medical College | Zulfiqar S.,Shaikh Zayed PGMI
Journal of the College of Physicians and Surgeons Pakistan | Year: 2016

Objective: To evaluate the plasma interleukin-10 (IL-10) levels in patients suffering from dengue hemorrhagic fever between 4 to 7 days of onset of disease and 24 hours after the first sample, to find out the association of plasma IL-10 levels with the outcome. Study Design: Analytical study. Place and Duration of Study: All major hospitals of Lahore, Pakistan, from August to November 2012. Methodology: Participants included 50 registered patients of dengue hemorrhagic fever (DHF) aged between 15 - 50 years. Plasma IL-10 concentrations were measured on above stated day. Outcome was described as recovery and shock. Platelet count and hematocrit percentages were also recorded. Statistical analyses were done using SPSS version 19. A p-value ≤ 0.05 was considered significant. Results: Plasma IL-10 levels were found to be raised in DHF patients and were associated with fatal outcome (p=0.004). In recovered DHF patients, plasma IL-10 levels decreased after 24 hours (mean 26.54 ±16.03 pg/ml) as compared to admission time (mean 74.39 ±61.69 pg/ml) but in case of DHF patients suffering from shock, plasma IL-10 was found to be higher after 24 hours (mean 87.69 ±7.77 pg/ml) as compared to levels at admission time (mean 42.56 ±28.09 pg/ml). ROC curve analysis revealed a change (30 units pg/ml) of plasma IL-10 concentration, within 24 hours of admission, raised from the base line to be 105 times more critical for shock in DHF patients (100% sensitivity and 71.4% specificity, p < 0.001). Conclusion: Elevated plasma IL-10 is a potential predictor of disease severity and fatal outcome in DHF patients.


PubMed | Shaikh Zayed PGMI, Khawaja Muhammad Safdar Medical College, Azra Naheed Medical College and Lahore Medical and Dental College
Type: Journal Article | Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP | Year: 2016

To evaluate the plasma interleukin-10 (IL-10) levels in patients suffering from dengue hemorrhagic fever between 4 to 7 days of onset of disease and 24 hours after the first sample, to find out the association of plasma IL-10 levels with the outcome.Analytical study.All major hospitals of Lahore, Pakistan, from August to November 2012.Participants included 50 registered patients of dengue hemorrhagic fever (DHF) aged between 15 - 50 years. Plasma IL-10 concentrations were measured on above stated day. Outcome was described as recovery and shock. Platelet count and hematocrit percentages were also recorded. Statistical analyses were done using SPSS version 19. Ap-value 0.05 was considered significant.Plasma IL-10 levels were found to be raised in DHF patients and were associated with fatal outcome (p=0.004). In recovered DHF patients, plasma IL-10 levels decreased after 24 hours (mean 26.54 16.03 pg/ml) as compared to admission time (mean 74.39 61.69 pg/ml) but in case of DHF patients suffering from shock, plasma IL-10 was found to be higher after 24 hours (mean 87.69 7.77 pg/ml) as compared to levels at admission time (mean 42.56 28.09 pg/ml). ROC curve analysis revealed a change (30 units pg/ml) of plasma IL-10 concentration, within 24 hours of admission, raised from the base line to be 105 times more critical for shock in DHF patients (100% sensitivity and 71.4% specificity, p < 0.001).Elevated plasma IL-10 is a potential predictor of disease severity and fatal outcome in DHF patients.


Sheikh R.M.,Azra Naheed Medical College | Butt K.,Institute of Molecular Biology and Biotechnology | Khan H.M.,Masood Hospital | Arslan M.,The University of Lahore
Pakistan Journal of Medical and Health Sciences | Year: 2013

Objective: To evaluate the status of pro inflammatory markers in children with extreme obesity. Subjects and methods: 37 children were recruited for the study (20 non obese and 17 obese). Serum concentration of C reactive protein (CRP), α-2 macroglobulin (A2M) and hepatoglobin were measured. Anthropometric findings were correlated with biochemical parameters. Results: Mean serum CRP, A2M and hepatoglobin were several fold higher in obese group as compared to the controls (p value < 0.05). CRP was significantly correlated with body weight (BW), body mass index (BMI) and A2M (p value <0.05). Conclusion: Childhood obesity is associated with a pro-inflammatory state before the appearance of comorbidities of metabolic syndrome, where as CRP, A2M and hepatoglobin are the most likely indicator of development of inflammation.


Latif M.Z.,Azra Naheed Medical College | Hussain I.,Services Institute of Medical science | Nizami R.,University of Management and Technology | Farooq U.,Institute of Public Health | Riaz H.,Health Care Diagnostics and Research Center
Pakistan Journal of Medical and Health Sciences | Year: 2013

Aim: To find out the benefits of Private Public Mix Working Model of a Teaching Hospital for the organizations and end users. Study design: Cross sectional Survey Methods: The study was conducted at Islamic International Medical College (IIMC) and Pakistan Railway Hospital (PRH) Rawalpindi. Retrospective data was collected on a semi structured, pre tested questionnaire from the records of PRH. The benefits of PPM working model were assessed using variables like training of students, hiring of academic staff, availability and utilization of different services. Results: 600 undergraduate, 7 postgraduate and 26 nursing students were being trained after implementation of model. Academic staff increased from 17 to 127 doctors. Number of departments increased from 4 to 15 and range of laboratory test increased from 16 to 92. Outpatient and indoor flow of patients increased up to 500% after the intervention. There are evident benefits for both the organizations and end users through this private public mix working model.


Fahim A.,Post Graduate Medical Institute | Ilyas M.S.,Post Graduate Medical Institute | Jafari F.H.,Azra Naheed Medical College | Farzana F.,Post Graduate Medical Institute
Journal of Oral Biology and Craniofacial Research | Year: 2016

Background: Carbonated drinks are the second most consumed non-alcoholic beverages in the world after tea. The effects of these drinks on hard tissues and vital organs of the body have been proved beyond doubt. This study, however, explains the effect of these drinks on wound healing of oral epithelium. Methods: Thirty-six male Wistar rats were considered for the study. A circular wound of 3.0 mm was created on the buccal mucosa of all animals and they were divided into two groups. Animals in group 1 were fed with chow pellet and water, while those in group 2 were fed with a commercially available carbonated drink instead of water. Six animals from each group were euthanized at 0, 7, and 21 days. Wound site was histologically assessed for differences in thickness and characteristics of the regenerating epithelium between two groups. Results: There was a marked difference in the healing pattern between the two groups. Animals in group 1 showed a normal healing pattern at the end of day 21. In the group 2, the regenerated epithelium showed hyperplasia and hyperkeratosis along with acanthosis at the end of the experiment with a subsequent delayed inflammatory reaction at day 21. Conclusion: Consumption of carbonated drinks can disrupt oral wound healing. The contents in carbonated drinks have a proinflammatory action on the soft tissue. Results suggest that epithelial changes seen in experimental group 2 could be a result of constant irritation by the acidic and fizzy nature of carbonated drinks. © 2015 Craniofacial Research Foundation.


Sheikh R.M.,Azra Naheed Medical College | Shoaib N.,Azra Naheed Medical College | Deeba F.,Azra Naheed Medical College
Pakistan Journal of Medical and Health Sciences | Year: 2012

Aims: To evaluate the association between breakfast taking practices and weight among female students of medical colleges of Lahore. Methods: This study was a randomized cross sectional survey. A sample of 800 female students, aged 19-24 years were included in this study. A structured questionnaire was used to get information on breakfast taking practices; type of food consumed in breakfast. Height and weight of students were taken to calculate Body Mass Index. Results The percentage and frequencies of breakfast taking practices and Body Mass Index showed that 370(46%) students consumed breakfast regularly, 220(27.5%) students consumed breakfast irregularly, and 210(26.3%) students skipped or omitted breakfast. Out of 800 students, 439(54.9%) were of normal weight according to Body Mass Index, 185(23.1%) were under weight and 176(22%) were overweight. Association between breakfast taking practices and body Mass Index was found significant with p value of 0.04. Maximum numbers of normal weight students were taking breakfast regularly. The students with irregular breakfast practices showed highest percentage (25.9%) of overweight/obesity while a percentage (22.4%) of overweight/obesity was observed in students skipping breakfast. Association between breakfasts taking practices and weight gain over last two years was checked and was found significant with a p value 0.000. Those skipping breakfast were having maximum percentage (52.4%) of those who gained weight over the last two years. Conclusion: Skipping breakfast does have association with gain in weight. Though weight gain is not necessarily obesity but this gain in weight may become obesity in future.


Ahmad M.,Children Hospital and Institute of Child Health Lahore | Butt M.S.,Riphah International University | Umar B.,Riphah International University | Arshad H.S.,Azra Naheed Medical College | And 2 more authors.
Biomedical Research (India) | Year: 2015

Women undergo various physical and mental changes during their postpartum period and are in a vulnerable state of mind. Some women may not cope with these situations as better than others and consequently they undergo a depressive state known as postpartum depression. It is a debilitating disorder and should be screened at an early stage to avoid long term adverse effects. The objectives of this study were to quantify the prevalence of postpartum depression in an urban setting where literacy rate is higher and medical facilities are readily available. This observational cross sectional study was performed in National Hospital, Lahore and Fatima Memorial Hospital, Lahore and was accumulated at RCRS Lahore. Study was accomplished in 4 months after the ratification of synopsis. Non-probability, purposive sampling was used. Sample size was calculated to be of 88 women. Self-administered questionnaire consisting of validated 10 items, Edinburgh postnatal depression scale (EPDS) [1] was employed to detect depression among women living in an urban setting. The grand mean of all the 10 items of Edinburgh postnatal scale was 6.7 ± 2.6 SD. The grand mean of question number 10 was calculated to be 2.37 ± 3.48 SD which shows that most women hardly ever thought about committing suicide. The results depicts that prevalence of postpartum depression in an urban setting is very low. The association between age, postnatal week, educational level and socioeconomic status states that depression most commonly occurs in undergraduate adolescents belonging to lower class families and peeks in their third postnatal week. The prevalence of postpartum depression is quite low in urban settings. This shows that the depressive states are avoided in better literate and socioeconomic statuses. Women are more capable of coping with new challenges and their families are better apt of supporting them through this period. © 2015, Scientific Publishers of India. All rights reserved.


Bashir T.,Azra Naheed Medical College | Sharif M.,KFH | Ahmad M.,Azra Naheed Medical College
Medical Forum Monthly | Year: 2015

Objectives: To study the pattern and severity of abdominal injuries due to road traffic accidents (RTA) in KSA. Study Design: Retrospective descriptive. Place and Duration of Study: This study was conducted in the Department of Surgery, King Fahad Hospital Albaha, Kingdom of Saudi Arabia during one year from 2012 to 2013. Materials and Methods: This is retrospective study of all patients admitted with torso-trauma in Department of Surgery KFH Al-Baha from the period of Aug. 2012 to Aug. 2013. Results: In the 01 year period, 2520 patients were admitted following an RTA. Out of these, 537 were admitted due to torso trauma. 120 patients were admitted in SICU, 280 in intermediate dependency unit while remaining 137 admitted in surgical ward. 27 patient died due to torso trauma with multiple injuries. 3 patients died of pure liver trauma while 2 patients died of splenic injury. Conclusion: Lot of burden over the hospital because of RTA related injuries. There was very severe and fatal injuries faced because of accidents happened in youth and male preponderance.


Nayyar U.,Institute of Public Health | Dar U.F.,Institute of Public Health | Latif M.Z.,Azra Naheed Medical College | Haider R.,Institute of Public Health | And 2 more authors.
Pakistan Journal of Medical and Health Sciences | Year: 2013

Aim: To find out knowledge of Dengue fever among university students, studying different courses. Duration: Study was conducted during month of June, July and August, 2011. Methods: It was ac cross-sectional study conducted on 374 students studying at intermediate bachelors and master level in University of Gujrat. Pretested questioners were used to collect primary data. Composite cumulative scores were used to determine knowledge about dengue fever. Students enrolled in engineering, medical, basic sciences, It & business administration and social sciences were major groups of study. Data was entered and analysed in SPSS 17. Results: Response was collected from 374(53.5% females & 36.5% males participants. Mean age with SD was 21.3±1.72. IT & business administration students scored the highest in knowledge. No considerable difference seen among high and low socio-economic groups (p=0.06) Conclusion: Good knowledge in IT students among different groups (p=0.000), support the fact that internet is strong source of information and helpful tool for raising awareness amongst general public. High knowledge of preventive measures is not depicted in practice and needs awareness strategies towards ensuring implementation of preventive measures.


Dar U.F.,Institute of Public Health | Iqbal M.S.,Institute of Public Health | Latif M.Z.,Azra Naheed Medical College | Javaid M.S.,Institute of Public Health | And 2 more authors.
Pakistan Journal of Medical and Health Sciences | Year: 2013

Aim: To determine the frequency of worm infestation among the children of Union Council Mangri, Tehsil Shakargarh, District Narowal. Methodology: It was cross-sectional descriptive study conducted on 97 children living in Union Council Mangri, Tehsil Shakargarh, District Narowal using non-probability convenient sampling. Pretested questionnaire was used to collect demographic data and microscopic examination of stool for ova and parasite for was done. Study was conducted during months of August-September 2011. Results: Response was collected from 97 mothers of children under 12 years of age among whom 58 (59.8%) were male and 39(40.2%) children were female. Stool microscopic examination revealed 12(12.4%) having worm infestation while no parasite or ova found in 85(87.6%) children. Among 12 infested children, hookworm ova were found in 5(41.7%), roundworms 4(33.3%), tapeworms 3(25%). Conclusion: Despite the regular program of deworming the children during mother child week in Punjab, worm infestation still needs response and effective interventions.

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