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Gammeri E.,Azienda Sanitaria Provinciale Messina | Dell'Albani I.,Stallergenes | Incorvaia C.,ICP Hospital | di Cara G.,Institute of Pediatrics | And 3 more authors.
Revue Francaise d'Allergologie | Year: 2014

Background: Sublingual immunotherapy (SLIT) is clinically effective, but, as any other long-term treatment, faces the problem of adherence. Measurement of fractional exhaled nitric oxide (FeNO) is a non-invasive exam for assessing inflammation in asthma. The aim of our study was to evaluate whether repeated FeNO measurements could increase adherence to SLIT. Methods: Forty-four patients (23 males and 21 females, mean age 25.5. years. ±. 12.9) with allergic rhinitis undergoing SLIT for house dust mites (HDM), were included in the study. They were divided in 2 groups: patients performing at least 2 FeNO measurements (FeNO-group) vs. patients who had never measured FeNO or had only one measurement (noFeNO-group). To evaluate adherence to therapy, we considered allergen immunotherapy renewal rate (number of vials) as a parameter. Results: The FeNO-group showed a significant higher renewal rate compared to the noFeNO-group, both in the first year and for all the duration of SLIT. Conclusion: We found a correlation between FeNO measurement and adherence to SLIT in terms of product reorders. These findings suggest that monitoring the disease with a clear numeric parameter, as FeNO, may help patients to understand their disease state and motivate their continuation of immunotherapy. © 2014 Elsevier Masson SAS.

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