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Tripodi S.A.,University of Siena | Rocca B.J.,University of Siena | Mourmouras V.,University of Siena | Barbanti G.,Azienda Ospedaliera Universitaria Senese | And 2 more authors.
Archives of Pathology and Laboratory Medicine | Year: 2013

Glomus tumors are rare, mesenchymal neoplasms of adulthood, which occur in both the sexes with equal frequency. Most of these tumors are benign, but some cases with atypical/malignant behavior have been reported. They most often occur in the extremities, typically in the subungual region of the fingers, and rarely involve the internal organs. We report the case of a 63-year-old man who presented with hematuria. The cystoscopy showed a polypoid lesion of the anterior wall of the bladder, which was diagnosed on biopsy as a benign glomus tumor. To the best of our knowledge, this is the first case of benign glomus tumor of the bladder described in the literature. This report widens the spectrum of the differential diagnoses of bladder neoplasms.

Da Filicaia M.G.,Azienda Ospedaliera Universitaria Senese
Recenti Progressi in Medicina | Year: 2014

The management of patients with end-stage organ failure necessitates a considerable integration between palliative care and those who care the patient in different clinical settings: the general practitioner, who is - or should be - always involved and, in relation to the steps of care, the emergency department, the hospital units, and the intensive care unit. The staff involved should have skills and competences to plan with the patient or his/her family a shared schedule, which may result in the interruption of disproportionate treatments. All this leads to many concerns discussed in the document by the Società Italiana di Anestesia Analgesia Rianimazione e Terapia Intensiva (SIAARTI); the paper provides a useful guide to where, how, and when we care, inform, and communicate. In this editorial, the author discusses these three topics, setting them in the reality of the Italian health care system. The aim is to emphasize the aspects of space, time and organization of care, focusing on the communication challenges that influence the process of defining a "shared schedule" between the patients, their families, and the health care system.

Bianciardi G.,University of Siena | Miracco C.,University of Siena | Lazzi S.,Azienda Ospedaliera Universitaria Senese | Luzi P.,University of Siena
Current Bioinformatics | Year: 2013

This paper investigates the use of computerized fractal analysis for objective characterization of the complexity of the epithelial-connective tissue interface in basal cell carcinoma and the ability of the technique to quantitatively discriminate among different diagnostic categories. Tumor boundaries were extracted by means of image analysis. The fractal dimension was calculated by using the box-counting method. The results showed that the shape of the boundaries between epithelium and stroma is significantly more complex in infiltrative high risk tumors than in circumscribed low risk ones (p<0.001), with 100% correct classifications. This study shows that the computerized fractal analysis of epithelial-connective tissue interface in basal cell carcinomas can provide an accurate, quantitative, inexpensive technique to help in tumor diagnosis. © 2013 Bentham Science Publishers.

Mazzei M.A.,University of Siena | Guerrini S.,University of Siena | Squitieri N.C.,University of Siena | Imbriaco G.,University of Siena | And 5 more authors.
World Journal of Gastroenterology | Year: 2013

AIM: To validate the utility of magnetic resonance imaging (MRI) for the clinical management of acute ischemic colitis (IC). METHODS: This is a magnetic resonance (MR) prospective evaluation of 7 patients who were proved to have acute IC on the basis of clinical, endoscopic and computed tomography (CT) findings and who were imaged in our institution between February 2011 and July 2012. The mean age of the patients was 72.28 years. Abdominal CTs were obtained using a 64-detector row configuration for all patients with un-enhanced and contrast-enhanced scans, in the late arterial phase (start delay 45-50 s) and in the portal venous phase (start delay 70-80 s). The MR examinations were performed using a 1.5T superconducting magnet, using Fast Imaging Employing Steady State Acquisition and T2-weighted fast-recovery fast-spin echo sequences in axial and coronal plane. CT and MRI examinations were analysed for the presence of colonic abnormalities and associated findings. RESULTS: Segmental involvement was seen in 6 patients (85.71%), with a mean length of involvement of 412 mm (range 145.5-1000 mm). Wall thickness varied between 6 mm and 17.5 mm (mean 10.52 mm) upon CT examinations and from 5 to 15 mm (mean 8.8 mm) upon MR examinations. The MRI appearance of the colonic wall varied over the time: Type I appearance with a 3 layer sandwich sign was seen in 5 out of 12 examinations (41.66%), patients underwent MR within a mean of 36 h (ranging from 1 to 54 h) after the CT examination. Type II and III appearance with a 2 layer sign, was seen in 4 examinations (33.33%), patients underwent MR within a mean of 420.5 h (ranging from 121 to 720 h) after the CT examination. In the remaining three MRI examinations, performed within a mean of 410 h (ranging from 99.5 to 720 h) the colonic wall appeared normal. CONCLUSION: MRI, only using precontrast images, may be used as a substitute for invasive procedures in diagnosis and follow-up of acute IC. © 2013 Baishideng. All rights reserved.

Centro Of Riferimento Oncologico Instituto Nazionale Tumori Aviano and Azienda Ospedaliera Universitaria Senese | Date: 2012-02-01

The invention relates to a method for determining prognosis, predicting or monitoring response to therapy of patients affected by melanoma through the evaluation of the methylation of different genomic DNA sequences, including the Long Interspersed Nucleotide Element-1 (LINE-1) repetitive DNA sequences and/or the concomitant methylation profile of specific groups of genes defined as methylation signature.

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