Azeezia Institute of Medical Science

Kollam, India

Azeezia Institute of Medical Science

Kollam, India
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Viveka S.,Azeezia Institute of Medical science | Sagar T.V.,Sri Ramachandra University | Kumar A J.,Azeezia Institute of Medical science
Journal of the Anatomical Society of India | Year: 2017

Introduction: Coronary artery disease (CAD) is increasing in prevalence worldwide. In this regard, the extravascular markers in evaluating atherosclerosis is of importance in clinical evaluation. Methodology: After informed consent from fifty CAD patients (confirmed from coronary angiographic studies) were recruited into the study. Similar number of age and sex matched controls without CAD were selected. We evaluated digit ratio (2D:4D) and diagonal ear lobe crease (DELC) in patients and compared with healthy individuals. Measurement of digit ratio was by photographic method. Ear lobe of all patients were photographed and evaluated for presence of diagonal ear lobe crease. Results: We found that 2D:4D ratios in males with CAD are higher than the control group. There were no such differences in females. 2D:4D ratios as usual sexually dimorphic. Coden's d calculation revealed that 84% of the males with CAD will be having digit ratios above mean of the control group, and there is a 76% chance that a person picked at random from the CAD group will have a digit ratio more than the mean of control group. Diagonal ear lobe crease was found in 74% of CAD patients out of which 40% creases were unilateral and 34% were bilateral. Discussion: It is concluded that 2D:4D ration and Diagonal ear lobe crease are the two extravascular atherosclerotic markers are invaluable in clinical evaluation of CAD patients. © 2017 Anatomical Society of India.

Prashanth Y.S.,Azeezia Institute of Medical science | Niranjan M.,Bangalore Baptist Hospital
Journal of Clinical and Diagnostic Research | Year: 2017

Introduction: There is evidence for use of cemented hemiarthroplasty resulting in greater anchoring and lesser peri prosthetic fracture. However, this procedure results in more haemodynamic instability and cardiopulmonary complications termed as ‘cement reaction’ or bone cement implantation syndrome. There has been a heightened interest among surgeons to compare cemented and uncemented hemiarthroplasty for fracture neck of femur. Aim: To compare cemented and uncemented hemiarthroplasty in terms of blood loss during the procedure, post-operative complications, mortality, functional recovery and long term clinical outcome. Materials and Methods: In a prospective study spanning 8 years from January 2006 to January 2014 in a tertiary care hospital, 52 cases of fracture of neck were selected. Twenty four patients underwent cemented and 28 patients underwent uncemented hemiarthroplasty. Mean follow-up duration was 59.3 months. Harris Hip Score evaluation was done at each follow up. Radiological evaluation was done at each follow up for calcar length and periprosthetic fractures. Results: Mean age of patients was 70 years. Harris Hip scores at 3, 6 and 12 months did not show statistically significant differences. Periprosthetic osteolysis or loosening was not seen in the present study. No complications noted in uncemented hemiarthroplasty. Four patients who had cemented hemiarthroplasty had infections. No mortality occurred during admission and within 12 months after surgery. Conclusion: No significant difference was noted between the cemented and uncemented hemiarthroplasty procedures on long term follow-up in terms of functionality. No re-operations and no mortality reported. Cemented hemiarthroplasty had more blood loss and minimal post-operative complications. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.

Ballur M.S.,Azeezia Institute of Medical science | Dayananda R.,Mysore Medical College | Karthik S.K.,Dr B R Ambedkar Medical College | Murgod P.,S Nijalingappa Medical College | Sujathan G.,Azeezia Institute of Medical science
Journal of Indian Academy of Forensic Medicine | Year: 2016

Hanging is the commonest method of committing suicide and is considered as a painless form of death. In hanging the appreciation of external signs particularly ligature mark plays a vital role. Hence a proper observation and study of ligature mark which the characteristic hallmark of hanging, needs greater emphasis. The ligature mark is a pressure abrasion on the neck at the site of the ligature which appears as a groove. This prospective study was conducted among victims of hanging brought to Dr. B. R. Ambedkar Medical College morgue, Bangalore during the period November 2010 to October 2012. A sum total of 232 cases brought with a history of hanging were selected for this prospective study. Atypical ligature marks with partial hanging outnumbered typical ligature mark with complete hanging. Single ligature mark above the level of thyroid cartilage with a breadth of 1to2cms is observed in the maximum number of cases. Majority of the ligature marks were prominent in their appearance. The colour of ligature mark was dark brown in one third of cases.

Saniya K.,Azeezia Institute of Medical science | Patil B.G.,Shri B M Patil Medical College | Chavan M.D.,Azeezia Institute of Medical science | Prakash K.G.,Azeezia Institute of Medical science | And 3 more authors.
Journal of Natural Science, Biology and Medicine | Year: 2017

Understanding the microanatomical changes in brain structures is necessary for developing innovative therapeutic approaches to prevent/delay the cognitive impairment in epilepsy. We review here the microanatomical changes in the brain structures related to cognition in epilepsy. Here, we have presented the changes in major brain structures related to cognition, which helps the clinicians understand epilepsy more clearly and also helps researchers develop new treatment procedures. © 2017 Journal of Natural Science, Biology and Medicine. Published by Wolters Kluwer - Medknow.

PubMed | Azeezia Institute of Medical science, Amala Institute of Medical science and Aj Institute Of Medical Science
Type: | Journal: Advanced biomedical research | Year: 2015

Spermatogenesis is a highly conserved and regulated process and it is sensitive to fluctuations in the physical and chemical environment. Gemcitabine is a novel antimetabolic anticancer drug used frequently in the treatment of many cancers. This study aimed to investigate the histomorphometric effects of gemcitabine on spermatogenesis in Swiss albino mice.Gemcitabine in high and low doses (80 and 40 mg/kg) injected intraperitoneally to inbred Swiss albino mice. Gross testicular features and seminiferous tubular histomorphometry was studies at the end of 7(th), 14(th) day and at 2 months sperm shape abnormalities were studied.Seminiferous tubular morphology was altered significantly, showing a reduction in height, perimeter and area in a dose dependent manner. Sertoli cell number decreased. Basement membrane thickness was reduced and it appeared to be permanent, with statistically insignificant changes even after 2 months. There was a reduction of intertubular spaces. Sperms have shown banana heading, decapitation and loss of normal hook of head. The effects were partially reversible at the end of 2 months.It was concluded that gemcitabine affects the process of spermatogenesis adversely in a dose and time dependent manner and the effects are partially reversible.

Ballur M.S.,Azeezia Institute of Medical science | Murgod P.,S Nijalingappa Medical College | Dayananda R.,Mysore Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2016

Background and objectives: Human identification is based on scientific principles, mainly involving estimation of age, sex, fingerprints, measurement of height, dental records. Just like these methods, lip prints can also be instrumental in identifying the sex which is vital for establishing the identity of an individual. The study of lip prints is known as cheiloscopy. The main objective of study was to find out accuracy of sex determination through lip prints. Method: The study was conducted on 2nd, 3rd and 4th year students of Azeezia medical college, Kollam. Subjects were 100 males and 100 females of the state of Kerala, aged between 18 and 25years. Details of the study were explained to the subjects and lip prints taken and analysed as per the Classification given by Tsuchihashi. Results: Type I was the most common lip print in total subjects and males. Type III predominated in females. Type I, I’, II constituted majority of females. Type III, IV,V predominated in males. Conclusion: The results obtained in our study do not prove it to be an infallible method. But it still seems to open a small window to a vast unventured field. The need of the hour is to develop a standardized method to assess and accurately record the cheiloscopic patterns. © 2015, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.

Dayananda R.,Mysore Medical College | Ballur M.S.,Azeezia Institute of Medical Science
Journal of South India Medicolegal Association | Year: 2014

Background - Myocardial bridging (MB) refers to a congenital condition where a segment of a major coronary artery courses within the myocardium for a variable distance, and has been reported as an incidental finding in many cases Systolic compression of a coronary artery by overlying myocardial tissue is termed myocardial bridging. Myocardial bridging usually has a benign prognosis. Although its involvement in the development of severe cardiovascular pathologies is disputed there are many proofs that it may possibly be associated, in particular circumstances, with sudden cardiac death, the development of malignant arrhythmias, atherosclerosis, myocardial infarction, hibernation or stunning, etc. The development of cardiovascular complications is mainly dependent upon the presence of a significant hemodynamic obstruction.Conclusion – Myocardial bridging can be a cause of sudden death, if it is associated with significant obstructive atherosclerosis in the intramyocardial part. © 2014 South India Medico-Legal Association. All rights reserved.

Sudha M.J.,Azeezia Institute of Medical science | Viveka S.,Azeezia Institute of Medical science | Rai M.,Azeezia Institute of Medical science
International Journal of Pharmacy and Technology | Year: 2013

Objectives: This study was done to investigate the antioxidant status in streptozotocin induced diabetic rats and effect of aqueous extract of Murrayakoenigii leaves on it. Materials and Methods: Albino Wistar rats weighing 200-250 g were induced diabetes with intraperitoneal streptozotocin and fed with aqueous extract of MK leaves for 30 days. Their blood glucose levels were measured and compared with controls. Erythrocyte malondealdehyde, catalase activity and total antioxidant capacity was measured after sacrificing the rats and compared with control. Results: It was noted that blood glucose levels in diabetic control rats were 2 fold than the control and MK leaves fed group. Erythrocyte malondealdehyde levels, catalase activities were significantly higher in diabetic group in comparison with normal and MK groups. Total antioxidant capacity was significantly higher in MK leaves fed group in comparison with diabetic group. Interpretation and conclusion: Diabetes induced in rats by streptozotocin is indeed a high oxidative stress state. Aqueous extract of MK leaves has resulted in lower blood glucose levels. Also MK leaves are beneficial in diabetes as it has antioxidant effects as shown by the parameters in the present study.

Viveka S.,Azeezia Institute of Medical science | Sudha M.J.,Azeezia Institute of Medical science
Biomedicine (India) | Year: 2013

Introduction: Atlanto-occipital fusion or occipitalization of atlas or assimilation of atlas is an important congenital malformation of the craniovertebral region because of the proximity to the spinomedullary region. Aim: In this study a detailed analysis of such fusion of atlas with occipital bone is attempted and classification of fusion, its embryological basis, paleopathological aspects and clinical aspects of occipitalization are delt. Materials and Methods: 100 skulls were collected from the department of Anatomy of 4 medical colleges in south Kerala and examined for vertebrobasal skeletal abnormalities. Results: One skull showed atlanto occipital fusion in zones 1,2,3 on left side and zones 1 and 2 on right side.

Chethan P.,Manipal University India | Prakash K.G.,Azeezia Institute of Medical science | Murlimanju B.V.,Manipal University India | Prashanth K.U.,Manipal University India | And 5 more authors.
Turkish Neurosurgery | Year: 2012

AIM: The objectives were to study the morphology of the foramen magnum in dry skulls and to evaluate its antero-posterior diameter, transverse diameter and the foramen magnum index. MATERIAL and METHODS: The foramen magna of 53 dry human cadaver skulls that were obtained from the neuroanatomy laboratory were examined. Different shapes of the foramen magnum were macroscopically noted and classified. The antero-posterior and transverse diameters were measured and the average foraminal index was calculated. RESULTS: The foramen magnum shapes were determined as a round shape in 22.6% of cases, egg shape in 18.9%, tetragonal in 18.9%, oval in 15.1%, irregular in 15.1%, hexagonal in 5.6% and pentagonal in 3.8% of the cases. In 20.7% of skulls, the occipital condyle was observed to protrude into the foramen. The mean antero-posterior and transverse diameter of the foramen magnum was determined as 31 ± 2.4 mm and 25.2 ± 2.4 mm respectively. The average foramen magnum index was 1.2 ± 0.1. CONCLUSION: The present study has determined the various shapes of foramen magnum and its morphometry. The data obtained may be of useful to the neurosurgeon in analyzing the morphological anatomy of craniovertebral junction. The findings are also enlightening for the anthropologists, morphologists and clinical anatomists.

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