AZ Sint Jan AV Hospital

Brugge, Belgium

AZ Sint Jan AV Hospital

Brugge, Belgium

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Shuaib A.,University of Alberta | Schwab S.,Friedrich - Alexander - University, Erlangen - Nuremberg | Rutledge J.N.,Brackenridge Medical Center | Starkman S.,University of California at Los Angeles | And 9 more authors.
Journal of NeuroInterventional Surgery | Year: 2013

Background: The magnitude of treatment effect in acute stroke depends on several factors, including time from symptom onset (TFSO) to treatment and severity of the initial insult. Objective: To report further evaluation of NeuroFlo therapy, focusing on the effect of time and stroke severity. Methods: SENTIS was a prospective randomized trial (N=515) comparing standard medical therapy with/without NeuroFlo therapy. For this analysis, we evaluated outcomes in groups of patients based on TFSO and stroke severity: patients randomized <6 h, 6-10 h, and >10 h with mild (NIHSS<8), moderate (8-14), and severe (>14) symptoms at randomization. 90-Day mRS (modified Rankin Scale) scores and stroke-related death rates were compared between treatment groups. Results: For patients randomized <6 h TFSO (n=128), the OR for mRS 0-2 was 3.11 (CI 1.30 to 7.46, p=0.011) for treated versus non-treated patients. In patients with disease of moderate severity (NIHSS 8-14, n=214), NeuroFlo-treated patients were more likely to have a good outcome (mRS 0-2; OR=1.84, CI 1.02 to 3.33, p=0.043). The stroke-related death rate was better in the treated group with TFSO >10 h and NIHSS >14 (n=42) (OR=7.10, CI 1.13 to 44.55, p=0.036). Conclusions: The results of our analysis support the importance of careful selection of outcome measures and the impact that rapid treatment and initial stroke severity have on outcome. Clinical trial registration URL://http.clinicaltrials.gov. Unique identifier: NCT00119717.


De Foer B.,Sint Augustinus Hospital | Kenis C.,Sint Augustinus Hospital | Van Melkebeke D.,Sint Augustinus Hospital | Pouillon M.,Sint Augustinus Hospital | And 3 more authors.
European Journal of Radiology | Year: 2010

There is a large scala of pathology affecting the vestibulocochlear nerve. Magnetic resonance imaging is the method of choice for the investigation of pathology of the vestibulocochlear nerve. Congenital pathology mainly consists of agenesis or hypoplasia of the vestibulocochlear nerve. Tumoral pathology affecting the vestibulocochlear nerve is most frequently located in the internal auditory canal or cerebellopontine angle. Schwannoma of the vestibulocochlear nerve is the most frequently found tumoral lesion followed by meningeoma, arachnoid cyst and epidermoid cyst. The most frequently encountered pathologies as well as some more rare entities are discussed in this chapter. © 2010.


Lambert J.,AZ Sint Jan AV Hospital | Jerjir N.,AZ Sint Jan AV Hospital | Casselman J.,AZ Sint Jan AV Hospital | Steyaert L.,AZ Sint Jan AV Hospital
Clinical Breast Cancer | Year: 2015

The fact that malignant breast lesions can arise inside a benign lesion as a hamartoma is not well known in clinical practice. There are only few case reports on this subject. To our knowledge, this is the first time the use of DCE-MR is illustrated in the context of detection of malignant foci in a hamartoma. Increased awareness and use of this tool can help radiologists with the characterisation of hamartomas with atypical appearance on mammogram and ultrasound in everyday clinical practice. © 2015 Elsevier Inc. All rights reserved.


Courtois F.,Catholic University of Louvain | Borrey D.,AZ Sint Jan AV Hospital | Haufroid V.,Leuven Center for Toxicology and Applied Pharmacology | Hantson P.,Leuven Center for Toxicology and Applied Pharmacology
Indian Journal of Nephrology | Year: 2014

Pregabalin, used for treating partial epilepsy and neuropathic pain, is usually well tolerated. Patients with impaired renal function are at risk to develop more serious adverse events. A 64-year-old woman was admitted in the Emergency Department for altered consciousness and abnormal movements. She recently started to take pregabalin (150 mg/day) for neuropathic pain. The drug was withdrawn 36 h before hospitalization following worsening of neurological symptoms. At physical examination, myoclonus was noted as main finding in the limbs and head, with encephalopathy. Laboratory investigations revealed acute renal failure with serum creatinine at 451.3 μmol/l. Urine output was preserved. After supportive care alone, myoclonus resolved after 24 h and consciousness was normal after 48 h. Renal function was also recovered. At the time of admission, the concentration of plasma pregabalin was 3.42 μg/ml, within therapeutic range. The calculated terminal elimination half-life was 11.5 h. Pregabalin-induced myoclonus may not be strictly related to drug accumulation in acute renal failure, with the possibility of a threshold phenomenon.


Vereecke E.,UZ Gent | Mermuys K.,AZ Sint Jan AV Hospital | Casselman J.,AZ Sint Jan AV Hospital
JBR-BTR | Year: 2015

Calcium hydroxyapatite deposition disease is a common pathology, most frequently located in the rotator cuff tendons of the shoulder, for which different therapeutic approaches are used. Ultrasound guided needle lavage and injection of anesthetic/corticosteroid is a well-known and extensively described treatment for calcific tendinits of the rotator cuff. We present a case of bilateral calcific tendinitis of the gluteus medius tendon, both sides successfully treated using ultrasound guided needle lavage of the deposits and injection of an anesthetic and corticosteroid. We propose to not only use this approach for rotator cuff tendons, but also for calcific tendinitis at other locations. © 2015 The Author(s).


PubMed | AZ Sint Jan AV Hospital
Type: Case Reports | Journal: Acta cardiologica | Year: 2010

We present a case of an obstructive atrial myxoma that was unexpectedly discovered during coronary angiography.


PubMed | AZ Sint Jan AV Hospital and Catholic University of Louvain
Type: Journal Article | Journal: Indian journal of nephrology | Year: 2014

Pregabalin, used for treating partial epilepsy and neuropathic pain, is usually well tolerated. Patients with impaired renal function are at risk to develop more serious adverse events. A 64-year-old woman was admitted in the Emergency Department for altered consciousness and abnormal movements. She recently started to take pregabalin (150 mg/day) for neuropathic pain. The drug was withdrawn 36 h before hospitalization following worsening of neurological symptoms. At physical examination, myoclonus was noted as main finding in the limbs and head, with encephalopathy. Laboratory investigations revealed acute renal failure with serum creatinine at 451.3 mol/l. Urine output was preserved. After supportive care alone, myoclonus resolved after 24 h and consciousness was normal after 48 h. Renal function was also recovered. At the time of admission, the concentration of plasma pregabalin was 3.42 g/ml, within therapeutic range. The calculated terminal elimination half-life was 11.5 h. Pregabalin-induced myoclonus may not be strictly related to drug accumulation in acute renal failure, with the possibility of a threshold phenomenon.

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