AVVM Sri Pushpam College Autonomous

Thanjāvūr, India

AVVM Sri Pushpam College Autonomous

Thanjāvūr, India

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Mohamed Jafar O.A.,Jamal Mohamed College Autonomous | Sivakumar R.,Avvm Sri Pushpam College Autonomous
International Review on Computers and Software | Year: 2014

Data Clustering means the act of partitioning a data set into group of similar objects. It is an important activity of data mining. Fuzzy c-means (FCM) is one of the most widely used data clustering methods. However, it suffers from some limitations like easily struck in local minima and sensitive to noise and outlier. Fuzzy possibilistic c-means (FPCM) algorithm is one of the good methods for noisy environment. Partition Index Maximization (PIM) is one of the extensions of FCM algorithm by adding partition coefficient (PC) into FCM objective function. Nature-inspired algorithm such as particle swarm optimization (PSO) is a global optimization technique. It overcomes the problem of local optima. The performance of PSO algorithm can be further improved with the help of fuzzy clustering algorithms. Most of the traditional clustering algorithms are based on Euclidean distance measure. In this paper, two hybrid algorithms namely fuzzy possibilistic c-means based particle swarm optimization algorithm (FPCM-PSO) and fuzzy c-means based particle swarm optimization algorithm with PIM (FUZZY-PSO-PIM) are proposed using different measures including Euclidean, Manhattan and Chessboard distance. Experimental results on well-known real world benchmark UCI repository biomedical data sets and an artificial data set show that Fuzzy-PSO-PIM hybrid algorithm is efficient and report encouraging results than other clustering techniques for all the distance measures. The clustering results are evaluated with respect to many cluster validity measures. It is also observed that hybrid algorithms based on chessboard distance measure produce better results than the other distance measures. © 2014 Praise Worthy Prize S.r.l.-All rights reserved.

Murugesan S.,Avvm Sri Pushpam College Autonomous | Pannerselvam A.,Avvm Sri Pushpam College Autonomous | Tangavelou A.C.,Bio Science Research Foundation
Journal of Applied Pharmaceutical Science | Year: 2011

An ethnomedicinal plant, Memecylon umbellatum Burm. f., was investigated for preliminary phytochemical screening and antimicrobial activity. Preliminary phytochemical screening of various extracts of the leaves revealed the presence of various classes of compounds such as amino acids, carbohydrates, flavonoids, gum, oil & resins, proteins, phenolic groups, saponins, steroids, tannins and terpenoids. Bioassay of antimicrobial activity of leaves of petroleum ether, chloroform and ethanol extracts showed significant activity against the human pathogens such as Streptococcus pneumoniae causing brain abscesses, pneumonia and septic arthritis, Proteus vulgaris, Pseudomonas aeruginosa causing urinary tract infections and septicaemia, Salmonella typhi causing typhoid fever, Vibrio species causing diarrheal infections and the fungus Candida albicans. The antimicrobial activity of the petroleum ether, chloroform and ethanolic leaf extract showed concentration-dependent activity against all the tested bacteria with the zone of inhibition at various concentrations. Thus the findings revealed the medicinal potential of Memecylon umbellatum against various infectious diseases to develop a drug. © 2010 Medipoeia.

Madhumathi V.,Avvm Sri Pushpam College Autonomous | Vijayakumar S.,Avvm Sri Pushpam College Autonomous
Biomedicine and Aging Pathology | Year: 2014

In this research, we have conducted docking study to screen bioactive compounds from Microcystis aeruginosa and Phormidium corium. Among the two blue-green algal species were analyzed for chemical nature of bioactive substances using TLC and GC-MS methods. The antimicrobial compounds identified were phenolics, alkaloids, steroids. In the present study as reported that M. aeruginosa curde extract contained the bioactive compound Microginins, while Cyalobolide B was detected from P. corium. The phytochemical analysis of M. aeruginosa (Microginins), provided ethaneloic acid, Octanal, 3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol (nerolidal), Monomethyl hydrazine and formic acid. The cumulative effect of these phytochemical provided more effective antimicrobial compound in inhibiting microbial growth. The phytochemical analysis of P. corium (Cyalobolide B) exhibited Ethaneloic acid, Dihydrodiplodialide, 3, 7, 11-Trimethyl-1, 6, 10-dodecatrien-3-ol (nerolidal), 1-Dodecanol, 1-Hexadecanol (CAS) and nanonic acid. These compounds together exhibited more effective antimicrobial substance in inhibiting microbial growth. Which members of a community interact with themselves as well as with different host structures and components of Candida albicans and Streptococcus mutans. The pathogenesis of this dental infection is a multi factorial process that results in a serious degenerative disease of the Oral candidiasis. In the present study SAP (secreted aspartyl proteinases in virulence and pathogenesis) is taken as a case study molecule to understand high reactive responses of various drugs administered for the oral candidiasis. The drugs are being compared with the SAP from C. albicans and SpaP (cell surface antigen SpaP gene) from S. mutans. The SAP and SpaP interacted with formic acid, nerolidal, octanol and nonanoic acid using docking methods. The exponentially increasing speed of computational methods makes a more extensive use in the early stages of drug discovery attractive if sufficient accuracy can be achieved. © 2014 Elsevier Masson SAS. All rights reserved.

Abul Hasan M.J.,Avvm Sri Pushpam College Autonomous | Ramakrishnan S.,Avvm Sri Pushpam College Autonomous
Artificial Intelligence Review | Year: 2011

Clustering is a popular data analysis and data mining technique. It is the unsupervised classification of patterns into groups. Many algorithms for large data sets have been proposed in the literature using different techniques. However, conventional algorithms have some shortcomings such as slowness of the convergence, sensitive to initial value and preset classed in large scale data set etc. and they still require much investigation to improve performance and efficiency. Over the last decade, clustering with ant-based and swarm-based algorithms are emerging as an alternative to more traditional clustering techniques. Many complex optimization problems still exist, and it is often very difficult to obtain the desired result with one of these algorithms alone. Thus, robust and flexible techniques of optimization are needed to generate good results for clustering data. Some algorithms that imitate certain natural principles, known as evolutionary algorithms have been used in a wide variety of real-world applications. Recently, much research has been proposed using hybrid evolutionary algorithms to solve the clustering problem. This paper provides a survey of hybrid evolutionary algorithms for cluster analysis. © 2011 Springer Science+Business Media B.V.

Karthika K.,AVVM Sri Pushpam College Autonomous | Ravichandran K.,AVVM Sri Pushpam College Autonomous
Ceramics International | Year: 2015

Undoped and doubly (Mn+Co) doped ZnO nanopowders were synthesized with different doping levels of Co (1, 2, 3, 4 and 5 at%) and constant Mn doping level (10 at%) using a simple soft chemical route. XRD profiles confirmed that the synthesized material is nanocrystalline ZnO with hexagonal wurtzite structure. No peaks other than the characteristic ZnO peaks were observed in the XRD pattern confirming the absence of any secondary phase. Antibacterial activities of synthesized ZnO nanopowders were tested against Staphylococcus aureus bacteria using agar well diffusion method. It was found that the antibacterial efficiency of the doubly doped ZnO nanopowders was remarkably high when the Co doping level was 5 at%. The obtained PL, SEM and TEM results are corroborated well with the antibacterial activity. Magnetic measurements showed that undoped ZnO sample exhibits diamagnetic behavior and as the Co doping level increases, the nanopowder behaves as a ferromagnetic material. © 2015 Elsevier Ltd. and Techna Group S.r.l. All rights reserved.

Rambabu V.,AVVM Sri Pushpam College Autonomous | Vijayakumar S.,AVVM Sri Pushpam College Autonomous
Biomedicine and Aging Pathology | Year: 2014

Hepatocellular carcinoma is the leading cause of death and its incidence is rising year by year. There are numerous antioxidants available in various sources, including microorganisms. We had an attempt on validating the effect of diazepinomicin from Micromonospora strain against human hepatoma cell line (HepG2). Trypan blue exclusion assay was performed to determine the dead cells. Propidium iodide and Hoechst staining was performed to determine the apoptotic bodies. DNA fragmentation was performed on agarose gel electrophoresis and the expression of BAX and Bcl2 proteins were determined. Trypan blue exclusion assay showed dose-dependent cell death. Propidium iodide and Hoechst staining showed apoptotic bodies. DNA fragments were seen in both diazepinomicin 10 and 15 μM/mL treated Hep G2 cells. Western blot assay showed low intensity bands in diazepinomicin 10 and 15 μM/mL treated Hep G2 cells. Thus, the downregulation of these protein expressions reveal that the diazepinomicin has the ability to induce apoptosis. From all the parameters, it could be concluded that the diazepinomicin has anticancer potency against human hepatoma cell line (HepG2). © 2013 Elsevier Masson SAS.

Ravichandran K.,AVVM Sri Pushpam College Autonomous | Thirumurugan K.,AVVM Sri Pushpam College Autonomous
Journal of Materials Science and Technology | Year: 2014

Aluminium doped tin oxide films have been deposited onto glass substrates by using a simplified and low cost spray pyrolysis technique. The Al doping level varies between 0 and 30at.% in the step of 5at.%. The resistivity (ρ) is the minimum (0.38Ωcm) for 20at.% of Al doping. The possible mechanism behind the phenomenal zig-zag variation in resistivity with respect to Al doping is discussed in detail. The nature of conductivity changes from n-type to p-type when the Al doping level is 10at.%. The results show that 20at.% is the optimum doping level for good quality p-type SnO2:Al films suitable for transparent electronic devices. © 2013 .

Snega S.,AVVM Sri Pushpam College Autonomous | Ravichandran K.,AVVM Sri Pushpam College Autonomous | Jabena Begum N.,AVVM Sri Pushpam College Autonomous | Thirumurugan K.,AVVM Sri Pushpam College Autonomous
Journal of Materials Science: Materials in Electronics | Year: 2013

Undoped and Doubly (Magnesium + Fluorine) doped zinc oxide (ZnO:Mg:F) thin films with different Mg doping levels (4, 8, 12 and 16 at.%) and constant F doping level (20 at.%) were fabricated by employing a simplified spray pyrolysis technique. The antibacterial and certain physical properties of the films were studied as a function of Mg doping level. All the films exhibited hexagonal wurtzite structure with preferential orientation along the (002) plane. A lesser electrical resistivity was achieved in the present study than earlier reports of ZnO:Mg films thanks to the simultaneous doping of F with Mg in ZnO films. From the optical studies, it was observed that, all the films showed good transparency (≈85 %) with significant enhancement in the optical band gap with Mg doping level. The obtained PL spectra were well corroborated with the structural and optical studies. Further, it was also found that the antibacterial activity of doubly doped ZnO films was enhanced remarkably by the increasing incorporation of Mg concentration. © 2012 Springer Science+Business Media New York.

Senthamilselvi V.,AVVM Sri Pushpam College Autonomous | Senthamilselvi V.,Kunthavai Naachiyaar Government College for Women Autonomous | Ravichandran K.,AVVM Sri Pushpam College Autonomous | Saravanakumar K.,AVVM Sri Pushpam College Autonomous
Journal of Physics and Chemistry of Solids | Year: 2013

Good stoichiometric CdS films are fabricated using the successive ionic layer adsorption and reaction (SILAR) technique. Several sets of films are prepared by keeping the number of cycles of immersion as 25, 50, 75 and 100 and the effects of number of immersion cycles on the stoichiometry together with their optical and structural properties are studied. The X-ray diffraction studies showed that the films prepared from 100 cycles exhibited good crystallinity. The optical investigations revealed that the transmittance in the visible range is found to be gradually decreased as the number of immersion cycles is increased. The energy dispersive X-ray analysis showed that the stoichiometry of the SILAR deposited CdS films strongly depends on the number of immersion cycles. © 2012 Elsevier Ltd. All rights reserved.

Saravanakumar K.,AVVM Sri Pushpam College Autonomous | Ravichandran K.,AVVM Sri Pushpam College Autonomous
Journal of Materials Science: Materials in Electronics | Year: 2012

Aluminum doped nanocrystalline zinc oxide powders were synthesized using a simple soft chemical method from precursor solutions having different Al doping levels (0-20 at.% in steps of 5 at.%). X-ray diffraction studies showed that the product has pure hexagonal wurtzite structure without any secondary phases such as Al 2O 3 and ZnAl 2O 4 etc. The preferential orientation plane was found to be (101) for all the samples irrespective of the Al doping level. But the degree of crystallinity of the powder gradually decreased as the doping level increased. The SEM images revealed that the crystals have hexagonal prism like structure when the Al doping level was 5 at.% and the shape changes gradually and attains a thread like structure for heavy doping. The EDAX and FTIR studies confirmed the proper incorporation of Al 3+ ions in the Zn 2+ sites of the ZnO lattice even in the heavily doped powders. The optical band gap increased remarkably (from 3.12 to 3.48 eV) with the increase in the Al doping level. © Springer Science+Business Media, LLC 2012.

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