Sreelatha S.,National University of Singapore |
Sreelatha S.,SASTRA University |
Padma P.R.,Avinashilingam University For Women |
Umasankari E.,SASTRA University
Journal of Ethnopharmacology | Year: 2011
Ethno pharmacological relevance: The plant Sesbania grandiflora (Fabaceae) is commonly known as "Sesbania" and "agathi" in ayurvedic system of medicine and reputed in the indigenous medicine in India. It is also known as "Agati Sesban" or "humming bird tree" in English. All parts of this unique plant are useful and have a wide spectrum of medicinal properties. The plant has various uses in folk and traditional medicines for headache, swellings, anemia, bronchitis, pains, liver disorders and tumors. Aim of the study: The objective of the present study was to explore the anticancer activity of the ethanol extract of Sesbania grandiflora against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. Materials and methods: Anticancer activity of ethanol extract of Sesbania grandiflora (EESG) of both leaves and flowers were evaluated in Swiss albino mice against Ehrlich Ascites Carcinoma (EAC) cell line at the doses of 100 and 200 mg/kg body weight intraperitoneally. The extracts were administered for 14 consecutive days. Twenty-four hours of last dose and 18 h of fasting, the mice were sacrificed and the anticancer effect of EESG was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight, hematological parameters and biochemical parameters of EAC bearing host. Results: Sesbania grandiflora extracts showed significant decrease in (p < 0.01) tumor volume, viable cell count, tumor weight and elevated the life span of EAC bearing mice. Hematological profile such as RBC, hemoglobin and lymphocyte count reverted to normal level in EESG treated mice. The extracts significantly (p < 0.05) decreased the levels of lipid peroxidation and significantly (p < 0.05) increased the levels of GSH, SOD and CAT. Conclusion: The results showed that the ethanol extract of Sesbania grandiflora was effective in inhibiting the tumor growth in ascitic models and that is comparable to 5-Fluorouracil. © 2011 Elsevier Ireland Ltd.
Rameeja Begum A.,Avinashilingam University For Women |
Poonkothai M.,Avinashilingam University For Women
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013
Objective: To investigate the antimicrobial activity and phytochemical analysis of Brassica oleracea. Methods: The antimicrobial activity was evaluated using agar well diffusion and micro dilution methods against the bacterial (Pseudomonas aeruginosa, Shigella flexneri, E.coli and Klebsiella pneumoniae) and fungal (Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus and Cladosporium species) isolates. The extraction of the vegetable was carried using the solvents namely aqueous, acetone, petroleum ether and chloroform. Phytochemical and FT-IR analysis was carried out in the acetone extract. Results: Among the four extracts tested, acetone extract exhibited maximum activity against Pseudomonas aeruginosa, Shigella flexneri, E.coli and Klebsiella pneumoniae and a narrow range of activity was exhibited against aqueous, petroleum ether and chloroform extracts. Aspergillus flavus and Aspergillus niger was found to be sensitive to acetone extracts when compared with Aspergillus fumigatus and Cladosporium species. Phytochemical analysis of Brassica oleracea extracts showed the presence of secondary metabolites like phenolics, alkaloids, flavonoids and saponins. The FT-IR analysis has revealed the presence phenols, alcohol, amines and carboxylic acid as functional groups in Brassica oleracea. Conclusion: From this study, it can be concluded that Brassica oleracea exhibits antimicrobial activity against certain microorganisms.
Jayanthi P.,Avinashilingam University For Women |
Lalitha P.,Avinashilingam University For Women
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011
Reducing power assay of solvent extracts of Eichhornia crassipes (Mart.) Solms at different concentrations and time delay was evaluated. Reducing power was linearly proportional to the concentration and time and was found to increase with increase in concentration and time. The extracts were compared to standard antioxidant L-ascorbic acid. All extracts showed greater reducing power than that of the standard. The results suggest the potential of development of useful natural antioxidants.
Thirugnanasambantham P.,Avinashilingam University For Women |
Senthil K.,Avinashilingam University For Women
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2016
Withania somnifera, commonly known as Ashwagandha or winter cherry, is a principal medicinal plant that has been used in Ayurvedic and native medicine. In view of its varied therapeutic prospective, it has also been the subject of considerable modern scientific attention. Ashwagandha roots are an integral of over 200 formulations in Ayurveda, Siddha and Unani medicine, which are used in the treatment of various physiological disorders. The major chemical constituents of this plant, the withanolides, are a group of naturally occurring C28-steroidal lactones. It has been extensively investigated in terms of chemistry and bioactivity profiling. However, there exists only very little fragmentary evidence about the dynamics of withanolide biosynthesis. This review examines different in vitro approaches that had been carried out over past decade of years and newly developed omics technologies for the large scale production of withanolides as well as for the analysis of genes associated with withanolide biosynthesis. © 2016 The Authors.
Palaniswamy R.,Avinashilingam University For Women |
Raghunathan P.P.,Avinashilingam University For Women
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013
Objective: The aim of the present study was to study the counteracting effect of Bacopa monnieri leaf extract against oxidative stress induced hepatotoxicity in rats. Methods: Healthy male Wistar albino rats aged 6-8 weeks were randomly divided into control and experimental group. The experimental groups were treated with CCl4 (2.0ml/kg body weight). Silymarin (a standard hepatoprotective antioxidant) was given at a dose of 25mg/kg body weight/day. Methanolic extract of Bacopa monnieri leaves (500mg/kg body weight) were administered to the CCl4 treated rats for 21 days to study its protective effect and the extent of liver damage were evaluated by the activities of the liver marker enzymes and the lipid profile in the serum. Results: On treatment with ethanol, a significant increase (P<0.05) in the activities of all the four serum marker enzymes (AST, ALT, ALP and γ-GT) were observed, which was further augmented on CCl4 administration. The treatment with the plant extract was effective in restoring the activities close to the normal levels. A significant increase in the levels of serum cholesterol, triglycerides, free fatty acids and phospholipids in the alcohol treated group were observed and the levels were further increased in CCl4 and alcohol treated group which was effectively counteracted by Bacopa monnieri leaf extract. The effect of the extract was comparable to the standard antioxidant silymarin. Conclusion: The results of the present study indicate that the leaves of Bacopa monnieri posses hepatoprotective activity and can render protection against alcohol-CCl4 induced toxicity.
Geetha G.,Avinashilingam University For Women |
Geethalakshmi S.N.,Avinashilingam University For Women
Procedia Engineering | Year: 2012
This paper presents a novel technique for removing the artifacts from the ElectroEncephaloGram (EEG) signals. EEG signals are influenced by different characteristics, like line interference, EOG (electro-oculogram) and ECG (electrocardiogram). The elimination of artifact from scalp EEGs is of substantial significance for both the automated and visual examination of underlying brainwave actions. These noise sources increase the difficulty in analyzing the EEG and obtaining clinical information related to pathology. Hence it is crucial to design a procedure to decrease such artifacts in EEG records. This paper uses Spatially-Constrained Independent Component Analysis (SCICA) to separate the Independent Components (ICs) from the initial EEG signal. As the next step, Wavelet Denoising (WD) is applied to extract the brain activity from purged artifacts, and finally the artifacts are projected back and subtracted from EEG signals to get clean EEG data. Here, thresholding plays an important role in delineating the artifacts and hence a better thresholding technique called Otsu', thresholding is applied. Experimental results show that the proposed technique results in better removal of artifacts.
Geethanjali S.,Avinashilingam University For Women |
Subash A.,Avinashilingam University For Women
Enzyme Research | Year: 2013
The purified fish visceral protease enzyme was immobilized by using various concentrations of sodium alginate and calcium chloride to optimize the best concentration for the formation of the beads. Then it was characterized by assaying the optimal pH, temperature, storage stability and reusability. The results on immobilization with sodium alginate and calcium chloride showed that a combination of 2% sodium alginate and 0.3 M calcium chloride weas found to be the optimum concentration for the formation of spherical and stable beads, this gave a maximal entrapped activity of 48.31%, and there was no change in the optimum pH 8.0 and temperature 40°C of protease before and after entrapment. The results on stability and reusability indicated that it was stable at 4°C retaining 100% residual activity after 5 days of storage and 67% loss of activity after ten days of storage and it retained 100% residual activity on the first reuse, 75% residual activity on the second reuse, 25% residual activity on the third use and complete loss in the activity on the fourth reuse. © 2013 S. Geethanjali and Anitha Subash.
Ali Fathima Sabirneeza A.,Avinashilingam University For Women |
Subhashini S.,Avinashilingam University For Women
Journal of Applied Polymer Science | Year: 2013
A novel water-soluble conducting polymer composite, poly(vinyl alcohol-histidine) was synthesized from aqueous solution by free radical condensation using persulfate. The composite was characterized using UV-Visible, Fourier transform infrared, scanning electron microscopy, thermogravimetric analysis (TG/DTG), and differential scanning calorimetry techniques while its AC conductance was measured by LCZ analyzer. The inhibitive action of the composite on the corrosion behavior of mild steel in 1M HCl was studied by conventional weight loss method, potentiodynamic polarization studies (Tafel), linear polarization studies, and electrochemical impedance spectroscopy. The effects of inhibitor concentrations, exposure time, and temperature have been investigated. The corrosion rate, inhibition efficiency (IE), and other parameters have been evaluated for different inhibitor concentrations. The composite provided more than 95% IE at an optimum concentration of 0.6% by weight. The results showed the composite as an effective mixed type inhibitor. The adsorption of this inhibitor obeyed Temkin adsorption isotherm. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013 Copyright © 2012 Wiley Periodicals, Inc.
Firdhouse M.J.,Avinashilingam University For Women |
Lalitha P.,Avinashilingam University For Women
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013
In order to implement green chemistry techniques in the synthesis of silver nanoparticles and to focus on the importance of plant sources available world-wide, an eco-friendly method of synthesis of silver nanoparticles using aqueous extract of Portulaca oleracea was carried out. Rapid synthesis of silver nanoparticles was seen in sonication method comparing room temperature and higher temperature conditions. The completion of the formation of silver nanoparticles was monitored by UV-visible spectroscopy. The particle size of the synthesized silver nanoparticles was found to be less than 60 nm and confirmed by XRD, Scherrer's formula and SEM analysis.
Uma M.,Avinashilingam University For Women |
Padmavathi G.,Avinashilingam University For Women
International Journal of Network Security | Year: 2013
The role of computers and the Internet in modern society is well recognized. Recent developments in the fields of networking and cyberspace have greatly benefited mankind, but the rapid growth of cyberspace has also contributed to unethical practices by individuals who are bent on using the technology to exploit others. Such exploitation of cyberspace for the purpose of accessing unauthorized or secure information, spying, disabling of networks and stealing both data and money is termed as cyber attack. Such attacks have been increasing in number and complexity over the past few years. There has been a dearth of knowledge about these attacks which has rendered many individuals/agencies/organizations vulnerable to these attacks.  Hence there is a need to have comprehensive understanding of cyber attacks and its classification. The purpose of this survey is to do a comprehensive study of these attacks in order to create awareness about the various types of attacks and their mode of action so that appropriate defense measures can be initiated against such attacks.