Waltham, MA, United States

Avila Therapeutics

www.avilatx.com
Waltham, MA, United States
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Singh J.,Avila Therapeutics | Petter R.C.,Avila Therapeutics | Baillie T.A.,University of Washington | Whitty A.,Boston University
Nature Reviews Drug Discovery | Year: 2011

Covalent drugs haveproved to be successful therapies for various indications, but largely owing to safety concerns, they are rarely considered when initiating a target-directed drug discovery project. There is a need to reassess this important class of drugs, and to reconcile the discordance between the historic success of covalent drugs and the reluctance of most drug discovery teams to include them in their armamentarium. This Review surveys the prevalence and pharmacological advantages of covalent drugs, discusses how potential risks and challenges may be addressed through innovative design, and presents the broad opportunities provided by targeted covalent inhibitors. © 2011 Macmillan Publishers Limited. All rights reserved.


Patent
Avila Therapeutics | Date: 2011-10-31

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.


Patent
Avila Therapeutics | Date: 2011-10-31

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.


Patent
Avila Therapeutics | Date: 2012-04-10

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.


Patent
Avila Therapeutics | Date: 2012-03-08

The present invention provides compounds, compositions thereof, and methods of using the same.


Patent
Avila Therapeutics | Date: 2011-11-08

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.


Patent
Avila Therapeutics | Date: 2011-02-01

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.


Patent
Avila Therapeutics | Date: 2011-02-01

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.


Patent
Avila Therapeutics | Date: 2012-05-31

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.


Patent
Avila Therapeutics | Date: 2011-08-08

The present invention provides a salt form, and compositions thereof, useful as an inhibitor of one or more protein kinases and which exhibits desirable characteristics for the same.

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