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Tehran, Iran

Avicenna Research Institute ) – affiliated to ACECR – was established in Tehran in order to achieve latest medical technologies through conducting clinical and laboratory research projects in 1998. The institute consists of three research centers including Reproductive Biotechnology Research Center , Monoclonal Antibody Research Center and Nanobiotechnology Research Center . ARI also includes Avicenna Biotechnology Incubator and Avicenna Infertility Clinic .Named after Ibn Sina, the research institute was found in 1998 in Shahid Beheshti University in Tehran.Reproductive Biotechnology Research Center includes Embryology and Andrology, Reproductive Genetics and Biotechnology, Reproductive Immunology, Reproductive Infections and Bio law & Ethics departments.For the purpose of laying a ground to provide therapeutic services and applied research findings in the field of infertility treatment, Avicenna Infertility Clinic was founded. Five specialized clinics including Infertility Treatment, Recurrent Abortion, Perinatology, Sexual Health and Replacement Therapies organize AIC.Monoclonal Antibody Research Center established in 2001 consists of Hybridoma, Immunochemistry and Antibody-Antigen Engineering Departments.Following introduction of nanotechnology and nanobiotechnology as one of the main priorities of the country, Nanobiotechnology Research Center was founded in 2005. Three departments including Nanotechnology, Recombinant Technology and Medical Diagnostic Products form NBRC.Interaction between specialists of various professional fields such as biology, biotechnology and clinical and molecular medicine in 11 research departments provide the ground for educational and scientific activities.Considering modern equipment and enjoying specialized team in Avicenna Research Institute, Medical Biotechnology Incubator initiated its activity under technical, economical and scientific supports of ARI, in 2010.The main activities of this center are summarized in the fields of reproductive biotechnology, monoclonal antibodies, nanobiotechnology, etc. All the established sections in this center have the possibility to benefit from the facilities and services provided by Reproductive Biotechnology Research Center, Monoclonal Antibody Research Center, Nanobiotechnology Research Center and Avicenna Infertility Clinic.Medical Biotechnology Incubator will foster new professions and encourage entrepreneurs working within the newly founded units in the above fields.The most prominent missions of ARI: Conducting basic, applied and therapeutic research projects in the field of reproduction and cancer treatment Identifying and fulfilling requirements related to biotechnologies in diagnostic and therapeutic areas Attracting M.Sc and Ph.D students to conduct thesis Arranging postgraduate courses on modern technologies in collaboration with different universities Giving information, publishing books and journals as well as holding national, regional and international conferences Wikipedia.

Habibi Z.,Shahid Beheshti University | Mohammadi M.,Iran National Institute of Genetic Engineering and Biotechnology | Yousefi M.,Avicenna Research Institute
Process Biochemistry | Year: 2013

This research describes the immobilization of Rhizomucor miehei lipase (RML) and chemically aminated RML (NH2-RML) on different supports including octyl-sepharose (octyl-RML), activated sepharose with cyanogen bromide (CNBr-RML and CNBr-NH2-RML), glyoxyl sepharose (Gx-RML and Gx-NH2-RML) and glyoxyl sepharose dithiothreitol (Gx-DTT-RML and Gx-DTT-NH2-RML). The highest immobilization yield was achieved for octyl-RML (>98%) followed by CNBr-RML (88%). Octyl-RML had the most specific activity (13.6) among all derivatives. The other preparations had moderate activities likely because of chemical reaction during covalent attachment of the enzyme. The catalytic behavior of lipase immobilized in hydrolysis reactions was investigated using methyl, ethyl, propyl, butyl and isobutyl-ibuprofen esters and the influence of the alkyl chain and the alcoholic residue of the ester were studied. Butyl ester was the most interesting ester for carrying out hydrolysis. The highest enantioselectivity of enzyme (E = 8.8) was obtained with isooctane/sodium phosphate buffer pH 7.0 at temperature of 40 °C. Increasing temperature from 40 to 50 °C caused decreasing in enantioselectivities and conversions. Also esterification of ibuprofen was carried out in solvent systems containing isooctane and two ionic liquids (ILs); [BMIM][PF6] and [BMIM][BF4]. Poor conversions and enantioselectivities were observed during esterification in all solvents. © 2013 Elsevier Ltd.

Ghahremanzadeh R.,Avicenna Research Institute | Amanpour T.,Shahid Beheshti University | Bazgir A.,Shahid Beheshti University
Tetrahedron Letters | Year: 2010

An efficient and simple method for the synthesis of new benzopyranopyrimidines via a pseudo four-component reaction of salicylic aldehydes, malononitrile and various amines in the presence of a catalytic amount of LiClO4 is reported. The advantages of this procedure are mild reaction conditions, high yields of products and operational simplicity. © 2010 Elsevier Ltd. All rights reserved.

Yousefi M.,Avicenna Research Institute | Mohammadi M.,Iran National Institute of Genetic Engineering and Biotechnology | Habibi Z.,Shahid Beheshti University
Journal of Molecular Catalysis B: Enzymatic | Year: 2014

Here we report the stereoselective hydrolysis of racemic esters catalyzed by Candida rugosa lipase (CRL) and Rhizopus oryzae lipase (ROL) immobilized on octyl-sepharose via physical adsorption. Hydrophobic immobilization caused to almost six fold hyperactivation with 229.2 and 81.3 U/mg enzyme for immobilized CRL and ROL, respectively (13.2 and 48.75 U/mg for corresponding free enzyme). Based on the preliminary results, CRL was chosen for further investigation. The performance and yield of the reaction were evaluated as a function of the critical reaction parameters such as temperature, enzyme to substrate ratio and organic co-solvent. An increase in the temperature resulted to decrease in enantioselectivity of hydrolysis reaction. The hydrolysis reactions were carried out in presence of two organic solvents; n-hexane and isooctane. Generally n-hexane was a better co-solvent compared to isooctane. High enantioselective hydrolysis of the racemic esters (yielding S(+) ibuprofen; ee ≤ 95%) can be achieved using the immobilized CRL. Among various esters the kinetic resolution of ibuprofen butyl ester yielded the best results (E value 70 and 74; conversion 14.6 and 8.9 in n-hexane and isooctane, respectively). The immobilized derivatives were re-used in four cycles and showed little decrease in enantiomeric excess of (S)-ibuprofen. 96.7 eep and conversion 14.6 in first cycle reached to 90.5 eep and conversion 11.3 in the forth cycle. © 2014 Elsevier B.V.

Sadri-Ardekani H.,Wake Forest Institute of Regenerative Medicine WFIRM | Sadri-Ardekani H.,Avicenna Research Institute | Atala A.,Wake Forest Institute of Regenerative Medicine WFIRM
Stem Cell Research and Therapy | Year: 2014

Male infertility management has made significant progress during the past three decades, especially after the introduction of intracytoplasmic sperm injection in 1992. However, many boys and men still suffer from primary testicular failure due to acquired or genetic causes. New and novel treatments are needed to address these issues. Spermatogenesis originates from spermatogonial stem cells (SSCs) that reside in the testis. Many of these men lack SSCs or have lost SSCs over time as a result of specific medical conditions or toxic exposures. Loss of SSCs is critical in prepubertal boys who suffer from cancer and are going through gonadotoxic cancer treatments, as there is no option of sperm cryopresrvation due to sexual immaturity. The development of SSC transplantation in a mouse model to repopulate spermatozoa in depleted testes has opened new avenues of research in other animal models, including non-human primates. Recent advances in cryopreservation and in vitro propagation of human SSCs offer promise for human SSC autotransplantation in the near future. Ongoing research is focusing on safety and technical issues of human SSC autotransplantation. This is the time to counsel parents and boys at risk of infertility on the possibility of cryopreserving and banking a small amount of testis tissue for potential future use in SSC transplantation. © 2014 Sadri-Ardekani and Atala; licensee BioMed Central Ltd.

Bazgir A.,Shahid Beheshti University | Hosseini G.,Shahid Beheshti University | Ghahremanzadeh R.,Avicenna Research Institute
ACS Combinatorial Science | Year: 2013

A green reaction of isatins, active cyanomethanes, and cyclic 1,3-dicarbonyl derivatives for the efficient and simple one-pot three-component synthesis of spirooxindole fused heterocycles in refluxing water by use of magnetically recoverable and reusable catalyst is reported. The features of this procedure are, the use of magnetically recoverable and reusable catalyst, mild reaction conditions, high to excellent product yields, operational simplicity, and easy workup procedures. Most importantly of all, easy magnetic separation of the catalyst eliminates the requirement of catalyst filtration after completion of the reaction. Furthermore, the catalyst remained highly active even after 5 repeated uses. © 2013 American Chemical Society.

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