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Geng F.-Y.,Aviation Central Hospital of China | Shi X.-X.,Aviation Central Hospital of China | Lu S.-Q.,Aviation Central Hospital of China | Li M.,Aviation Central Hospital of China | And 3 more authors.
Journal of Dalian Medical University | Year: 2010

[Objective] To study the features of the clinical diagnosis and treatment of neuroendocrine carcinoma of the breast. [Methods] Three patients with breast neuroendocrine carcinoma were admitted from January 1990 to March 2009 in Aviation Central Hospital of China. Their clinical and pathological data, treatment and prognosis were analyzed retrospectively. [Results] All the three lesions were palpable, painless and were found by the patients themselves. Molybdenum target film showed no calcification and sentus in any of the three lesions. Ultrasound image presented circumscribed masses with heterogeneously hypoecho, distinct boundary and abundant vascularity. All the patients were diagnosed neuroendocrine carcinoma pathologically. Immunohistochemical results showed Syn(+ +) in 1 case, Syn(+ + +) in 2 cases, CgA(+ +) in 3 cases and NSE(+) in 1 case, NSE(+ +) in 2 cases; Her - 2 was negative in the 3 patients. The 3 patients were followed up for 15 to 96 months. One patient with no lymph node metastasis was still alive without relapse and metastasis 96 months after the treatment. There were two patients with lymph node metastasis. Multiple metastasis were revealed in 1 patients with lymph node metastasis in 12 months after operation and died in 15 months after excision. Bone metastasis was seen in another patient with lymph node metastasis in 36 months after operation and had survived for 60 months after excision. [Conclusion] Neuroendocrine carcinoma is a rare malignant tumor of the breast. No calcification and sentus, heterogeneously hypoecho, distinct boundary, abundant vascularity and negative expression of Her - 2 might be the characteristics of the disease. Diagnosis of this disease should only depend on pathological and immunohistochemical results, neuroendocrine carcinoma of the breast may have no difference from other clinical well - informed breast cancers. Prognosis of the disease is correlated with its pathological types and clinical TNM - Staging.

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