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Gegenava A.V.,Aviakosmicheskaya i Ekologicheskya Meditsina
Aviakosmicheskaya i Ekologicheskaya Meditsina | Year: 2011

Qualitative and quantitative analysis of integument microflora using chromatography-mass spectrometry enables the determination of each crewmember's microflora composition, i.e. families and genders, during space mission. Microbiological investigations of cosmo nauts' integument resulted in identification of 51 taxons and groups of microorganisms. Microbial populations are directly dependent on the environmental factors and mission duration. The most representative diagnostically relevant ("reference") biotopes were brought to light. © State Research Center RF - Institute of Biomedical Problems Russian Academy of Sciences, 2008 All rights reserved. Source


Ushakov I.B.,Aviakosmicheskaya i Ekologicheskya Meditsina | Vasin M.V.,Aviakosmicheskaya i Ekologicheskya Meditsina
Aviakosmicheskaya i Ekologicheskaya Meditsina | Year: 2011

Radiation environment in extended duration exploration missions is scrutinized in the context of the probability of the risks of deterministic and stochastic effects of radiation. Though the probability of severe radiation damage due to solar flare is very low, nonetheless it is requisite that the crew must be provided with appropriate, including pharmacological safeguards. The current nomenclature of radiation protectors composes short-term agents against acute radiation damage. Among the others, preparation B-190 is distinguished by particularly high effectiveness and universal action, and good tolerance even when organism is exposed to the extreme factors of space flight. Regimen of B-290 therapy alone and with combination with aminothiol preparations have been developed to render treatment following multiple solar events. © State Research Center RF - Institute of Biomedical Problems Russian Academy of Sciences, 2008 All rights reserved. Source


Gurfinkel V.S.,Aviakosmicheskaya i Ekologicheskya Meditsina | Panfilov V.E.,Aviakosmicheskaya i Ekologicheskya Meditsina
Aviakosmicheskaya i Ekologicheskaya Meditsina | Year: 2011

Equations were developed to determine the work of transferring the body gravity center for a unit mass in a path unit, and to estimate walk speed at a minimum energy expenditure. It was demonstrated that minimum energy expenditure can be achieved by walking at the pace that corresponds to leg own oscillation frequency. © State Research Center RF - Institute of Biomedical Problems Russian Academy of Sciences, 2008 All rights reserved. Source


Adamian N.Yu.,Aviakosmicheskaya i Ekologicheskya Meditsina | Arutiunian R.S.,Aviakosmicheskaya i Ekologicheskya Meditsina | Karapetian M.A.,Aviakosmicheskaya i Ekologicheskya Meditsina
Aviakosmicheskaya i Ekologicheskaya Meditsina | Year: 2011

Influence of the vault on the impulse activity of respiration center neurons in medulla oblongata and respiration was studied in the norm and during hypoxia. Hypoxia stages served as a test model for ensuing vault effect summation. In normoxia, electrical irritation of the vault had largely an activating effect. Moderate p02 reduction with rising to the altitudes of 4000-5000 m activated pulsation of the respiratory neurons; influence of vault irritation was less evident than in normoxia even though it prevailed over inhibition. The respiratory neurons activity declined conspicuously at the peak altitude of 7500-8000 m and critical hypoxia; it was then that the facilitatory effect of vault irritation was especially strong. On "descent" to normal atmospheric pressure the spontaneous rhythmic activity of neurons and reaction to irritation returned gradually to baseline values. © State Research Center RF - Institute of Biomedical Problems Russian Academy of Sciences, 2008 All rights reserved. Source


Vishnevsky A.A.,Aviakosmicheskaya i Ekologicheskya Meditsina | Dzhantaeva G.A.,Aviakosmicheskaya i Ekologicheskya Meditsina | Zhaparalieva Ch.O.,Aviakosmicheskaya i Ekologicheskya Meditsina
Aviakosmicheskaya i Ekologicheskaya Meditsina | Year: 2011

Oxidative and functional effects of o-iipoic acid (a-LA) were studied in the course of 45-day adaptation to high altitudes (3200 m in the Central Tien Shan, June - August). Comparison of a-LA with mildronate stated similarity of their antioxidant and membrane effects on the third (stable) phase of adaptation (day 45), as both substances demonstrated a distinct lyso- PL-limiting effect and did not change dramatically concentration of diene conjugates (primary products of lipid peroxidation) in brain tissue. a-LA surpassed mildronate in the rate of the compensating effect in respect of behavior disorders and anxiety in rats. Besides, the substances contributed equally to physical performance increment by the end of adaptation. The positive effect of a-LA on the functional characteristics was hand in hand with minimization of the consequences of oxidative stress. These experimental data imply that a-LA can be effective in controlling the long process of adaptation to high altitude conditions. © State Research Center RF - Institute of Biomedical Problems Russian Academy of Sciences, 2008 All rights reserved. Source

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