Entity

Time filter

Source Type

Waltham, MA, United States

Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.


Patent
Avedro Inc. | Date: 2014-04-09

A system for applying a treatment to an eye includes a housing having a first end and a second end, a contact element having an open end and a closed end, and a light source disposed within the housing and configured to direct light toward the open end. The contact element is coupled to the first end of the housing at the closed end. The open end is configured to be positioned at an eye.


Patent
Avedro Inc. | Date: 2014-10-06

Embodiments apply a cross-linking agent to a region of corneal tissue. The cross-linking agent improves the ability of the corneal tissue to resist undesired structural changes. For example, the cross-linking agent may be Riboflavin or Rose Bengal, and the initiating element may be photoactivating light, such as ultraviolet (UV) light. In these embodiments, the photoactivating light initiates cross-linking activity by irradiating the applied cross-linking agent to release reactive oxygen radicals in the corneal tissue. The cross-linking agent acts as a sensitizer to convert O


Patent
Avedro Inc. | Date: 2014-03-17

A glaucoma treatment system includes: a cannula body configured to be positioned in an area of Schlemms canal; an illumination guide extending along the cannula body; at least one drug source coupled to the cannula body; a cross-linking agent source coupled to the cannula body; and an illumination source coupled to the illumination guide. The at least one drug source includes a drug that promotes outflow of aqueous humor through the trabecular meshwork and into Schlemms canal. The cannula body delivers the drug from the at least one drug source to the area of Schlemms canal, and in response to changes in the outflow of aqueous humor, delivers the cross-linking agent to the area of Schlemms canal. The illumination guide delivers photo-activating light from the illumination source to the area of Schlemms canal. The photo-activating light activates the cross-linking agent, thereby stabilizing changes in the area of Schlemms canal.


Patent
Avedro Inc. | Date: 2014-03-17

System and methods for a corrective eye procedure include at least one application device configured to be positioned at a selected area of an eye (e.g., equatorial sclera, posterior sclera, cornea, etc.). The at least one device includes at least one channel and at least one illumination guide. A cross-linking agent source is coupled to the at least one channel. An illumination source is coupled to the at least one illumination guide. The at least one device delivers the cross-linking agent to the selected area of the eye. The at least one device delivers photo-activating light from the illumination source to the selected area of the eye after the cross-linking agent has been delivered. The photo-activating light includes one or more doses necessary for activating the cross-linking agent and for activating TGF- isoforms to improve health of extracellular matrices in the selected area of the eye.

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