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Milford, MA, United States

Avecia was a privately owned group of biotechnology companies with recognised leading positions in process development and manufacture of biological and oligonucleotide pharmaceuticals, and had their international headquarters in Blackley, Manchester, England.The group's Biologics business, based in Billingham UK, was acquired first by Merck and then subsequently became Fujifilm Diosynth Biotechnologies in April 2011. The group's OligoMedicines business was acquired by Nitto Denko in February 2011, and so the Avecia Group no longer exists as a trading company. The trading name is now used by Nitto Denko Avecia Inc. Wikipedia.

Garrity-Ryan L.K.,Paratek Pharmaceuticals Inc. | Kim O.K.,Paratek Pharmaceuticals Inc. | Balada-Llasat J.-M.,Tufts University | Balada-Llasat J.-M.,Ohio State University | And 16 more authors.
Infection and Immunity | Year: 2010

LcrF (VirF), a transcription factor in the multiple adaptational response (MAR) family, regulates expression of the Yersinia type III secretion system (T3SS). Yersinia pseudotuberculosis lcrF-null mutants showed attenuated virulence in tissue culture and animal models of infection. Targeting of LcrF offers a novel, antivirulence strategy for preventing Yersinia infection. A small molecule library was screened for inhibition of LcrF-DNA binding in an in vitro assay. All of the compounds lacked intrinsic antibacterial activity and did not demonstrate toxicity against mammalian cells. A subset of these compounds inhibited T3SS-dependent cytotoxicity of Y. pseudotuberculosis toward macrophages in vitro. In a murine model of Y. pseudotuberculosis pneumonia, two compounds significantly reduced the bacterial burden in the lungs and afforded a dramatic survival advantage. The MAR family of transcription factors is well conserved, with members playing central roles in pathogenesis across bacterial genera; thus, the inhibitors could have broad applicability. Copyright © 2010, American Society for Microbiology. All Rights Reserved.

Selvakumar P.,University of Birmingham | Selvakumar P.,Avecia | Ling T.C.,University of Birmingham | Ling T.C.,University Putra Malaysia | And 3 more authors.
Separation and Purification Technology | Year: 2010

Aqueous two-phase systems (ATPS) are sensitive to loading with more than modest quantities (>5%, w/w, of system) of biological feedstock due to the contribution of contained macromolecular components (additional to phase-forming chemicals) to the phase diagram in respect of the binodal, tie-line length (TLL) and volume ratio. The present work demonstrates the method in the development and monitoring of ATPS loaded with high concentrations of citrated bovine blood (10-70%, w/w, of system) characterised by varied states of lysis. Variation of protein concentration and extent of cell debris could be accounted for in terms of effective tie-line length (TLLe) values determined by distribution analysis of radiolabelled analytes (DARA) and accommodated by adjustments to phase chemical compositions. The method also provided an opportunity for careful design and control of ATPS formed by adding blood feedstocks to previously monophasic systems (i.e. below the binodal) where phenomena associated with interfacial tension and additional phase formation is sensitively balanced. Such a monophasic/biphasic transformation, uniquely initiated by the phase forming properties of the biological feedstock, facilitates a reduction in the inventory of phase-forming chemicals required to achieve separations. © 2010 Elsevier B.V. All rights reserved.

Alam M.R.,University of North Carolina at Chapel Hill | Alam M.R.,Avecia | Ming X.,University of North Carolina at Chapel Hill | Nakagawa O.,University of North Carolina at Chapel Hill | And 3 more authors.
Bioorganic and Medicinal Chemistry | Year: 2013

A continuing problem in the area of oligonucleotide-based therapeutics is the poor access of these molecules to their sites of action in the nucleus or cytosol. A number of approaches to this problem have emerged. One of the most interesting is the use of ligand-oligonucleotide conjugates to promote receptor mediated cell uptake and delivery. Here we provide an overview of recent developments regarding targeted conjugates, including use of peptides, carbohydrates and small molecules as ligands. Additionally we discuss our own experience with this approach and point out both advantages and limitations. © 2013 Elsevier Ltd. All rights reserved.

Zdilla M.J.,Princeton University | Zdilla M.J.,University of Waterloo | Zdilla M.J.,Temple University | Verma A.K.,Princeton University | And 4 more authors.
Inorganic Chemistry | Year: 2011

The reaction of Fe(N{SiMe3}2)2 (1) with 1 equiv of arylthiol (ArSH) results in material of notional composition Fe(SAr)(N{SiMe3}2) (2), from which crystalline Fe 2(μ-SAr)2(N{SiMe3}2) 2(THF)2 (Ar = Mes) can be isolated from tetrahydrofuran (THF) solvent. Treatment of 2 with 0.5 equiv of 1,2-diarylhydrazine (Ar?NH-NHAr?, Ar? = Ph, p-Tol) yields ferric-imide-thiolate cubanes Fe 4(μ3-NAr?)4(SAr)4 (3). The site-differentiated, 1-electron reduced iron-imide cubane derivative [Fe(THF)6][Fe4(μ3-N-p-Tol) 4(SDMP)3(N{SiMe3}2)]2 ([Fe(THF)6][4]2; DMP = 2,6-dimethylphenyl) can be isolated by adjusting the reaction stoichiometry of 1/ArSH/Ar?NHNHAr? to 9:6:5. The isolated compounds were characterized by a combination of structural (X-ray diffraction), spectroscopic (NMR, UV-vis, Mössbauer, EPR), and magnetochemical methods. Reactions with a range of hydrazines reveal complex chemical behavior that includes not only N-N bond reduction for 1,2-di- and trisubstituted arylhydrazines, but also catalytic disproportionation for 1,2-diarylhydrazines, N-C bond cleavage for 1,2-diisopropylhydrazine, and no reaction for hindered and tetrasubstituted hydrazines. © 2011 American Chemical Society.

Parker S.F.,Rutherford Appleton Laboratory | Refson K.,Rutherford Appleton Laboratory | Bewley R.I.,Rutherford Appleton Laboratory | Dent G.,Avecia
Journal of Chemical Physics | Year: 2011

The assignment of the vibrational spectra of lithium hydroxide monohydrate, LiOH·H2O, has been controversial for more than half-a-century. Here we show that only the combination of all three forms of vibrational spectroscopy: infrared, Raman and inelastic neutron scattering spectroscopies coupled with periodic-density functional theory calculations is able to satisfactorily assign the spectra. All previous work based on empirical criteria is, at least partially, incorrect. The librational modes of water do not follow the expected rock > wag > twist order and the calculations indicate that complete or partial deuterium substitution would not be useful in assigning the modes. © 2011 American Institute of Physics.

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