Singhal S.,AVBRH |
Jaiswa P.,District Tubercular Officer
Asian Pacific Journal of Tropical Biomedicine | Year: 2011
Objective: To investigate different presentations of tuberculosis in HIV positive patients and their treatment outcome with directly observed short course therapy (DOTS). Methods: All patients having tuberculosis-HIV (TB-HIV) co-infection were taken. Different manifestations of tuberculosis in HIV positive patients were analyzed. Outcome of the treatment was observed in 14 patients. The rest of the patients were either transferred to other districts or still continuingtheir DOTS therapy according to the revised national tuberculosis control programme (RNTCP). Results: A total of 901 patients were diagnosed as tuberculosis. Out of these, 227 had positive pulmonary tuberculosis smear, 212 had negative smear and 462 had extra pulmonary tuberculosis. A total of 65 patients suffered from TB-HIV co-infection (7%). Result showed that the incidence of TB-HIV coinfection was the highest in productive age group of 16-45 years old (75%). Treatment completion rate was only 57% and the rate was higher in extra pulmonary tuberculosis patients (83%). Out of 4 sputum positive cases, 3 were declared cured (75%). Conclusions: TBHIVco-infection in wardha (Cental India) is around 7%. Pattern of tuberculosis in HIV positive patient is the same as in HIV negative patient. Pattern of extra-pulmonary tuberculosis in HIV positive patients is mainly in form of tubercular lymphadenitis and pleural effusion. DOTS is the best modality of treatment of tuberculosis.
Journal of Association of Physicians of India | Year: 2011
This paper is designed to review our current understanding of the role of stem and progenitor cells in lung repair after injury and to review the current status of cell therapy approaches for lung diseases. It was found that circulating EPCs (endothelial progenitor cells) play roles in b oth acute lung injury and in fibrotic lung diseases. Circulating fibrocytes can contribute to the pathophysiology of fibrotic lung diseases and thus may be a potential therapeutic target. MSCs (mesenchymal cells) suppress lung injury and inflammation in several mouse models of inflammatory and immune-mediated lung diseases. In addition, novel areas of investigation have developed that include increasing exploration of three-dimensional culture systems and bioengineering approaches to generate functional lung tissue ex vivo and in vivo. © JAPI.
Kakani A.,AVBRH |
Shrivastava D.,AVBRH |
Journal of SAFOG | Year: 2011
Dermoid cyst in postmenopausal women is a rare entity. It is seen most commonly in young reproductive age group. It constitutes about 10 to 20% of all ovarian tumors in pregnancy. Chance of malignancy is about 1-2%, torsion is common. Here, we have presented an unusual case of dermoid cyst in a postmenopausal woman who presented with complaints which were not directly related to the cyst. A 16-week mass per abdomen was not bothering the patient at all, rather she presented in the OPD with a mass coming out per vaginum, which was a third degree uterocervical descent. Patient was posted for vaginal hysterectomy and the cyst was removed perabdominally.
Meshram S.S.,AVBRH |
Nikose S.,AVBRH |
Jain S.,AVBRH |
Indian Journal of Human Genetics | Year: 2014
We report a case of Wildervanck syndrome exhibiting Klippel-Feil anomaly, Duane's retraction syndrome and congenital deafness. Since the first case was reported in 1952, there have been more reports describing this triad either complete or incomplete. Our case has a complete triad of the syndrome along with frontal sinus hypoplasia. Our case is unique as the triad was associated with frontal sinus hypoplasia, which is very rare association.
Singhall S.,AVBRH |
Mahajan S.N.,AVBRH |
Diwan S.K.,AVBRH |
Gaidhane A.,AVBRH |
Indian Journal of Tuberculosis | Year: 2011
Summary Background: In HIV-infected patients, PTB (Pulmonary Tuberculosis) is still the commonest form of TB. The most costeffective method of detecting TB cases among PTB suspects in high-prevalence countries is by sputum smear microscopy. World Health Organisation (WHO) states that sputum positivity decreases accompanying with atypical chest x-ray findings as CD4 count decreases. This expectation that infection with HIV would reduce the sensitivity of acid-fast smears, due to a decreased frequency of cavitary pulmonary MTB, has not been substantiated in a few studies done in the past. This study was undertaken to see the correlation of sputum smear status with CD4 count in cases of Pulmonary Tuberculosis HIV coinfected patients in our institute, being a tertiary referral centre. Methodology: In our hospital based cross-sectional study, 98 patients having PTB-HIV co-infection were followed and acid fast smear positivity status was assessed in correlation with chest radiograph and CD4 count. Results: Acid-fast smear positivity to negativity was almost 1:1 in CD4 count between 0-200 whereas it was 3:1 in cases of CD4 count above 200. There was significant difference (p value 0.013) in two groups with CD4 count cut-off value 200 which endorses the fact by WHO that sputum smear negativity increases with increase in degree of immunosupression. Conclusion: Sputum examination remains an important diagnostic tool for pulmonary tuberculosis in immunocompromised host with CD4 count above 200 but there is an urgent need for better diagnostic methods in CD4 count below 200.