Avanthi Institute of Pharmaceutical science

andhra Pradesh, India

Avanthi Institute of Pharmaceutical science

andhra Pradesh, India
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Asif H.M.,P.A. College | Rao T.R.,Avanthi Institute of Pharmaceutical science | Anjum M.,P.A. College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Drugs that have narrow absorption window in the gastro-intestinal tract (GIT) will have poor absorption. For these drugs, gastro-retentive drug delivery systems offer the advantages in prolonging the gastric emptying time. Floating and sustained release tablets are developed by using a combination of hydrophilic polymer (Hydroxypropyl methylcellulose) and effervescent substance (Sodium bicarbonate and Citric acid) in different ratios. Percentage swelling, in vitro drug release, floating lag time and total duration of floating was conducted in 0.1N HCl (pH 1.2). The tablets showed acceptable physicochemical properties. The drug release of optimized formulation (F5) follows the Higuchi kinetic model, and the mechanism is found to be non-fickian according to Korsmeyer-Peppas ('n' value is 0.495). The similarity factor (f2) of formulation (F5) is found to be 74.66. Hence, formulation F5 was found to be optimized formulation out of all the floating matrix tablets of Pioglitazone Hydrochloride (F1-F9).


Sahoo D.K.,Avanthi Institute of Pharmaceutical science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: Develop a simple isocratic reverse phase high performance liquid chromatography (RPHPLC) method and validate for the determination of Fenofibrate in bulk and Pharmaceutical dosage forms. Methods: RPHPLC quantification was carried out using Zorbax C-18 column (5μm, 150cm × 4.6mm, ID) with a mobile phase comprising phosphate buffer (pH 3.0): Acetonitrile in the ratio of 30:70 (% v/v) at a flow rate of 1.0 ml/min. The detection was carried out using a diode array detector at 286 nm. Results: The retention time was found to be 19.268 min and produced a linear response in the concentration range of 1-500 μg/mL (R2~0.999). The % RSD was found to be below 2%. The LOD and LOQ were found to be 0.229μg/ml and 0.765μg/ml respectively. Conclusion: Validation of the method was performed for precision, accuracy, linearity, ruggedness, specificity and sensitivity to conform to the ICH guidelines for validation of an analytical method.


Satyanarayana S.,Avanthi Institute of Pharmaceutical science | Mukkanti K.,Jawaharlal Nehru Technological University
American Journal of Drug Discovery and Development | Year: 2011

Unani system of medicine (Unanipathy) originated in Greece, enriched by Persians and Arabs and now became an integral part of Alternative medicinal systems of India. Itrifal Kishneezi is a Unani medicine prescribed for gastric problems, head ache and used as a stimulant. The present study was taken up as there is no published scientific data available. The drug was tested for antioxidant activity, as there is growing evidence of role of free radicals in disease progression in number of diseases and benefits of concomitant antioxidant administration. Itrifal Kshneezi was tested for DPPH* free radical scavenging and Fe2+ metal ion chelating activity using UV-Vis spectrophotometer. It showed considerable in vitro antioxidant activity in a dose dependent manner. © 2011 Academic Journals Inc.


Sreemantula S.,Avanthi Institute of Pharmaceutical science
Pharmacologyonline | Year: 2010

Chronic stress is known to produce a state of dyshomeostasis (allostasis) that involves significant behavioral, endocrinological and neurobiological changes. The underlying mechanisms and complications of which are not clearly understood. The present study aims at investigating the effect of chronic cold restraint (a moderate physical/metabolic stressor) and immobilization (physical and psychological stress) on estrous cycle in rats. It was found that stress produces a significant increase in proestrous phase indicating the non maturation of follicles, supported by histopathological studies. The serum levels of glucose, cholesterol and triglycerides were decreased. Corticosterone levels were increased. Ovary and uterus weight was decreased due to the non availability of hormones. Adrenal gland weight was increased indicating hypertrophy. All the above observations shows stress produces a significant change in the estrous cycle.


Pradeep K.,Avanthi Institute of Pharmaceutical science | Kotra V.,Acharya Nagarjuna University | Priyadarshini R.L.,Acharya Nagarjuna University | Pratap V.,Avanthi Institute of Pharmaceutical science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2015

Objective: Quinoxaline derivatives were reported with wide range of biological activities. Hence it was planned to synthesize and screen for their anti inflammatory (in vivo) activity. Methods: Orthophenylene diamine was reacted with oxalic acid to form quinoxaline 2, 3 dione. Quinoxaline-2, 3 (1H, 4H)-dione was chlorinated by using Phosphorousoxytrichloride (POCl3) in dimethyl formamide, to form 2, 3- dichloroquinoxaline. This dichloride compound was reacted with 4 amino acetophenone in DMF, refluxed for 5 hours to form 1-(4-(3-chloroquinoxalin-2-ylamino) phenyl) ethanone. Similarly 1-(4-(3- chloroquinoxalin-2-ylamino) phenyl) ethanone was reacted with corresponding aromatic aldehydes to form quinoxaline derived chalcone by Claisen Schmidt reaction. Characterization all the compounds was performed by IR, 1H NMR and Mass spectroscopic data and screened for antiinflammatory activity by carrageenan- induced paw edema method. Results: The anti inflammatory data suggested that compounds QCAC 2, 6, 8, 9, 10 and 12 showed significant activity and rest of the compounds exhibited moderate activity compared to the standard compound. Conclusion: The compounds bearing nitro, chloro and methoxy groups have shown prominent activity when compared to compounds without these groups. © 2015, International Journal of Pharmacy and Pharmaceutical Sciences. All rights reserved.


Ramakrishna N.,Avanthi institute of pharmaceutical science
International Journal of PharmTech Research | Year: 2015

In the present work, an attempt has been made to develop fast disintegrating tablets of Telmisartan HCl. In the present work sodium Primogel,Polyplasdone XL and Vivasol were employed as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. Camphor was employed as sublimating agent, due to presence of camphor maximum pores will be formed. As the numbers of pores were more the body fluid will penetrates more easily. All the formulations were prepared by direct compression method using 8mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed god flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F9 formulation showed maximum % drug release i.e., 110.4 % in 2 min hence it is considered as optimized formulation. The F9 formulation contains Vivasol as super disintegrate in the concentration of 20 mg. © 2015, Sphinx Knowledge House. All rights reserved.


Daravath B.,Acharya Nagarjuna University | Tadikonda R.R.,Avanthi institute of Pharmaceutical science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

Objective: The present research is aimed to investigate the effect of polyethylene glycol 4000 and 6000 as solid dispersion carriers on the solubility and dissolution rate of Meclizine hydrochloride. Methods: In this, meclizine hydrochloride solid dispersions were prepared by using solvent evaporation method and evaluated for solubility studies, drug-carrier compatibility studies and in vitro dissolution studies. Formulations F4 and F8 were selected to prepare the tablets and compared with control tablets (conventional tablets using pure drug). Results: From the in vitro dissolution studies, tablets containing polyethylene glycol 6000 showed almost complete drug release within the 20 min. The percent drug release in 20 min (Q20) and initial dissolution rate for formulation F8 was 99.26±1.62%, 4.96%/min. These were very much higher compared to control tablets (44.67±1.48%, 2.23%/min). The relative dissolution rate was found to be 2.22 and dissolution efficiency was found to be 57.94 and it is increased by 3.0 fold with F8 formulation when compared to control tablets (22.05). Conclusion: Formulation of the meclizine hydrochloride-polyethylene glycol solid dispersions is a suitable approach to improve the solubility and dissolution rate.


Sahoo D.K.,Avanthi Institute of Pharmaceutical science
Journal of Liquid Chromatography and Related Technologies | Year: 2015

This paper demonstrates a chemometric-assisted RP-HPLC method for the simultaneous determination of azithromycin, secnidazole, and fluconazole using water:methanol (63:37% v/v) as mobile phase at a flow rate of 1.2 mL · min-1. The separation of the three drugs was achieved on an Xterra RP-18 column (250 × 4.6 mm ID, 5 μM) and the detection of the eluents was realized on a diode array detector at 210 nm wavelength. The combined effects of % methanol (organic phase) and flow rate, each at three levels influencing the chromatographic efficiency were investigated and optimized employing central composite design. Under the optimal condition, the percent relative standard deviations for precision study were in the range of 0.2-0.7% and 0.5-1.2% for standard and formulation, respectively. The limits of detection were 12.5, 0.62, and 1.7 μg · mL-1 and limits of quantification were found 37.5, 1.86, and 5.1 μg · mL-1 for azithromycin, secnidazole, and fluconazole, respectively. Consequently, the method has been effectively applied to their direct determination in the commercial formulation (combi-kit). © 2015 Copyright © Taylor & Francis Group, LLC.


Tadikonda R.R.,Avanthi institute of Pharmaceutical science
Journal of Applied Pharmaceutical Science | Year: 2014

Solid dispersion is one of the most widely used methods to enhance the solubility and dissolution rate of poor water soluble drugs. In the present study, flurbiprofen solid dispersions were prepared using solvent evaporation method by incorporating polyethylene glycol 20000 and evaluated for solubility studies, drug-carrier compatibility studies and in vitro dissolution studies. From the solubility studies, formulations F4 were selected to prepare in the form of tablets and compared with control tablets (conventional tablets using pure drug). From the results of in vitro dissolution study, tablets containing polyethylene glycol 20000 showed almost complete drug release within the 15 min. The percent drug release in 15 min (Q15) and initial dissolution rate for formulation F4 was 99.26±1.12%, 6.62%/min. These were very much higher compared to control tablets (34.95±1.29%, 2.33%/min). The relative dissolution rate was found to be 2.84 and dissolution efficiency was found to be 57.48 and it is increased by 3.5 fold with F4 formulation compared to control tablets (17.91). From the above results, it is concluded that the formulation of solid dispersions using polyethylene glycol 20000 is a suitable approach to improve the solubility and dissolution rate of flurbiprofen. © 2014 Bhaskar Daravath and Rama Rao Tadikonda et al.


Silpavathi L.,Avanthi Institute of Pharmaceutical science
Journal of Chemical and Pharmaceutical Sciences | Year: 2015

Metformin hydrochloride (MF.Hcl) is an anti-diabetic agent of biguanides class used for treating type-II diabetes. A number of generic tablets of MF. Hcl are available in global markets with diversified label claims nowadays. However, hardly any voluntary research organization takes the responsibility of checking the genuinely of the labels claimed by various manufacturers. The rationale of the present study was to quantify eight brands of MF. Hcl tablets marketed in India using non-aqueous titrimetry and UV-spectroscopic method and to ensure whether both the methods give similar results for all the brands as per their corresponding label claims such as uniformity of weight and percentage of purity. The result epitomizes that all the six brads out of eight had passed the assay specified in Indian Pharmacopoeia (IP), and the values obtained from uniformity of weight and weight variation tests were within the range as per the official standard. Nevertheless, the brands F2 and F3 had the highest and lowest percentage of purity respectively. However, the brand F5 failed the test. Thus, the study perhaps justified the fact that some volunteer organization should shoulder the responsibility of checking the pharmaceutical formulations available in the market to ensure that those are as per the prescribed standards of official monographs. © 2015, SPB Pharma Society. All rights reserved.

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